FR2766369A1 - Use of polyvinyl pyrrolidone - Google Patents

Abstract

Use of an organic chemical, specifically polyvinylpyrrolidone (povidone), of mol. wt. 10000 to over 2800000, (which may be crosslinked), in reducing or eliminating variations in waist size and in diminishing the effect of constipation resulting from taking activated charcoal or clay, is new.

Description

 The invention relates to the use of at least one organic chemical compound, to reduce or eliminate variations in the waist during the day.

 The invention also relates to a reduction in the constipating effect of certain chemical compounds.

 Eating habits and lifestyles in industrial countries favor physiological imbalances and imbalances.

 The present inventor was able to observe that these disorders had as a consequence for the subjects concerned, and more particularly for urban women or men, a variation in waist size during the day, and the consequences of which are a feeling of compression in the clothing, skirts or pants.

 The present inventor has been able to observe that certain agents favorable to the reduction of the waist circumference produce an undesirable constipating effect.

 The object of the present invention is therefore to provide solutions which make it possible to reduce or eliminate variations in the waist size, while eliminating the effects in question.

 The invention provides a new solution, technically reliable, satisfactory on an industrial scale, in the field of production of either comfort products, dietary supplements, or food products which do not favor variations in waist size.

 The interest of this new solution also lies in the fact that it is completely harmless to the body.

 Thus, according to a first aspect, the invention relates to the use of at least one chemical agent, of organic origin, to reduce the effects of variation in the waist circumference, linked to the lifestyle and to the eating habits of the population. in industrialized countries.

 According to a second aspcct, the invention also relates to the use of at least one chemical agent, an organic ougin, to reduce the effect of constipation of certain components such as clay.

 According to another embodiment, the agent in question is a polyvinylpyrrolidone (PVP). The term polyvinylpyrrolidone includes all polyvinylpyrrolidones cn in particular polyvinylpyrrolidones having a molecular weight between 10,000 and more than 2.8 million, soluble or insoluble, crosslinked or noncrosslinked. Insoluble polyvinylpyrrolidones are also sometimes called polyvinylpolypyrrolidones. Therefore, the invention also covers polyvinylpolypyrrolidones. Such polyvinylpyrrolidones or polyvinylpolypyrrolidones are available, in particular from GAF, an American company, under the names Plasdones for soluble polyvinylpyrrolidones and Polyplasdone @, for insoluble polyvinylpyrrolidones or polyvinylpolypyrrolidones.

 According to another advantageous embodiment, the agent is present in the form of a distinct composition to be absorbed separately from food.

 According to another advantageous embodiment, the above-mentioned agent is incorporated directly into one or more foods.

 The agent can be formulated in different gallenic forms. Such gallenic forms and their methods of preparation are familiar to those skilled in the art.

 According to another advantageous embodiment of the invention, the concentration of the above-mentioned agent is between a homeopathic concentration and 100% by weight or by volume.

 According to another embodiment, the agent in question, that is to say preferably PVP, can be formulated in synergy with another compound chosen from the group consisting of an activated carbon, a clay, preferably a montmorillonite, kaolinite, attapulgite, sepiolite, smectite and bentonite clay. It has been found that preparations containing PVP in combination with one or more active compounds mentioned above produce synergistic effects while reducing the cost price.

 PVP is already used in food compositions as an additive with the technological function of firming agent, stabilizer (INS 1201).

 According to the patent of the applicant registered with INPUT under number 9603276, PVP can be used as a mixture in food compositions, to reduce or eliminate the side effects linked to the absorption of sweetening agents. These effects are for example electrolyte disorder, diarrhea, feeling of digestive twist.

PVP has also been used therapeutically and has received marketing authorizations as a medicine, particularly in the case of gastro-intestinal diseases. We find in particular the drug known in
France under the AMM numbers 307 529.2 and 314 449.0.

In this enterogastric area, there are many other drugs based on proton pump inhibitors, prostaglandins, topical anti-ulcers, locally acting antacids. These drugs can also include clay, activated carbon, polyvinylpyrrolidone, silicones and many other available molecules. These drugs are found in
France under AMM numbers: 319 230.7 / 319 231.3 / 322 970.8 / 322 971.4 / 300 071.0 / 300 072.7 / 330 605.5 / 300 606.1 / 329 851.4 / 330 869.0. All of these products have in common the treatment of diseases.

 On the other hand, in the context of the present invention, the aim is to develop a comfort product. The objective is to treat mainly the food bowl so that it does not cause disorders and imbalances increasing the variation in waist circumference.

 In the context of the present invention, the aim is also to reduce the constipating effects of other agents, such as clays, which have already been used in the field of digestive disorders.

 The invention also covers a composition, such as food composition, drink, characterized in that it contains at least one chemical agent of organic origin, preferably polyvinylpyrrolidone in an amount effective to reduce or eliminate variations in the waist. .

 According to another aspect, the invention relates to a composition such as food composition, drink, characterized in that it contains at least one chemical agent of organic origin, preferably polyvinylpyrrolidone, in synergistic association with another agent, in particular clay, cn an effective amount to reduce or eliminate the variations of the waist and constipation related to the other agent.

 Another object of the present invention is to provide compositions in which the main active component will be at least one chemical agent of organic abovementioned, preferably PVP, alone or in combination in synergy with other active compounds such as carbon, clay, concentration of agent, preferably in PVP varying between a homeopathic concentration and 100% by weight or by volume, the other components being able to be concentrated from 99.9% to 0%. These compositions will prescntécs either in different galenical forms (capsules, tablets, cachets, granules), or in the form of food anti-variations of the waist size such as drinks, oils for salads, drinking water, chewinggum.

 The invention also relates to a method for treating the food bowl, characterized in that it comprises the administration to a human being eating with said food bowl, simultaneously or separately to said food bowl of an effective amount of at least a chemical agent, preferably polyvinylpyrrolidone, formulated alone or in combination with other agents such as activated carbon, clay, preferably a clay chosen from a montmorillonite, kaolinite, attapulgite, sepiolite, smectite and bentonite clay , to reduce or eliminate variations in waist size or to reduce the constipating effects of such other agents and in particular clays.

 For any of the aspects of the invention, at least one chemical agent of organic origin mentioned above, advantageously a polyvinylpyrrolidone or polyvinylpolypyrrolidone, can be used at a concentration from a homeopathic concentration up to 100% by weight or by volume according to that the composition is solid or liquid. An advantageous concentration is approximately at least 10 -12 g to 100% by weight or by volume of the food composition or bowl, to be absorbed separately or preferably incorporated directly into one or more foods. A more preferred dose will be of the order of 10 -12 g to 1 g per unit dose, or per 100 g of product to be chewed, such as chewing gum, or to be consumed.

 The invention can be formulated in the form of various galenical forms such as capsules, tablets, granules, as a mixture in food compositions such as drinkable or sweet compositions, compositions of edible oils, drinking water, chewing gums, and the examples given. below are an integral part of the present invention, in the most general characteristics.

 Other objects, characteristics and advantages of the invention will appear clearly to those skilled in the art from the following description made with reference to several embodiments given simply by way of illustration, which therefore will not be known. no way to limit the scope of the invention. In the examples, all the proportions are given by weight unless otherwise indicated.

EXAMPLE 1
PVP formulated in different dosage forms
PVP is the only active component, formulated as tablets, capsules or granules.

a) Cases of capsules
Capsules are prepared in a conventional manner which contain approximately 0.1 g per capsule of polyvinylpyrrolidone, for example Plasdonew K29-32 or
Polyplasdone INF 10, commercially available from GAPS, USA, which are in powder form. The composition of the capsule is conventional and can, for example, be made of gelatin.

 We can absorb up to 6 capsules per day, before or after the main meals, so as to provide 0.3 to 0.6 g per day of polyvinylpyrrolidone, the presence of which in the body will reduce or eliminate the variations in waist size caused by eating habits.

b) Cases of eom premiums
In this case, the polyvinylpyrrolidone can be mixed with a conventional excipient in the powder state, and then compressed into tablets.

The excipient which can be used is any food or medically acceptable excipient such as gelatin, magnesium stearate. In this context, the proportion of PVP in the tablet will be provided so as to provide an amount of the order of 0.05 g to 3 g per day, either in one tablet or in several tablets.

c) Case of granules
The granules can be formulated to be swallowed easily with a little water. In this case, the PVP may or may not be combined with an excipient, then a grain may be produced dry or wet. As part of a dosage, for example dc 0.5 g per day, one can prepare a sachet of 5 g of granules containing 0.5 g of PVP.

EXAMPLE 2
PVP formulated as a mixture in food compositions a) Sweet oral composition
The PVP according to the invention can be incorporated from the initial formulation of the oral compositions. These are oral compositions sweetened or containing sweeteners other than sugar.

For example, in a coca drink, we will incorporate
Plasdone K29-32 or K90 commercially available from GARS, USA, by simple mixing during manufacture.

b) Composition of edible oil
In this case, the PVP is incorporated as a mixture after the extraction phase. For example, 2 grams of PVP will be incorporated into 1 liter of salad oil.

c) Incorporation into drinking water
PVP can be added directly to drinking water. 0.5 g of Polyplasdone INF 10, available from GAF #, USA, can be mixed with 1 liter of mineral water before being bottled.

d) Composition of chewing gum
In a conventional chewing gum composition, 0.5 g of PVP and 0.2 g of montmorillonite clay will be added per 100 g of chewy paste.

COMPARATIVE TESTS DEMONSTRATING THE DECREASE IN
VARIATIONS IN SIZE AND CONSTIPATION BY
ABSORPTION OF PVP ACCORDING TO THE INVENTION AFTER MEALS.

EXAMPLE 3
PVP formulated in preparation with montmonllonite clay
Tablets dosed at 30 mg dc PVP and 50 mg dc montmorillonite with an average particle size dc of the order of 20 µm are produced according to the invention, and tablets dosed with 300 mg dc montmorillonite. Dcs placcbos are made by replacing the aforementioned agents by the compression agent.

 Lc tcst is performed over 21 days, during which the subjects consume two tablets after the three main meals, ie 6 tablets per day.

 A division is made between three groups, a control group A consuming a placcbo, a group B consuming the montmorillonite tablets, and a group C consuming the PVP + montmorillonite tablets.

The abdominal perimeter is measured on days D1, D3, D5, D8,
D10, D12, D15, D17 and D19, for the midday meal. For each evaluation day, the measurement was carried out at the following times: H-1, HO (tablet absorption time), H0.25, .H0.5, Hî, H1.5.

The results are expressed in average variation of the abdominal perimeter after meals compared to H-1, in centimeters:
GROUP: HO: +1.5 / H0.95:: + 2.0 / H0.5: + 1.9 / H1: + 1.9 / H1.5: +1.3
GROUP B: HO: + 1.3 / H0.25: + 1.3 / H0.5: + 1.0 / H1: + 0.9 / H1.5: +0.6
GROUPEC: H0: +1, ^ / H0.95: + 1.1 / H0.5: + 1.0 / H1: + 0.8 / H1.5 + 0.5
Statistical analysis of these results shows that the difference between the placebo group and the other two groups is significant.

Tolerance to treatment was:
GROUP A: no particular feeling
GROUP B: constipation problems, especially the first week
GROUP C: no particular problem
It is thus found that the use of PVP associated with montmorillonite according to the present invention develops a synergy favoring the reduction in the variation in waist size after meals. In addition, it solves the problem of constipation encountered with clay.

EXAMPLE 4
Chewing gum containing PVP
The test is carried out on two groups, a control group A, consuming normal chewing gum, and a group B which consumes chewing gum added with Polyplasdonc INF 10 at a concentration of 0.7 g per 100 g of dough to chew. The prisc is a chewing gum after each meal.

The test is carried out according to the following procedure:
Week 1 day 1: group A: feelings of compression after meals
group B: nothing to report day 2: witness A: abdominal swelling after meals
group B: feeling of well-being after meals day 3: witness A: abdominal swelling after meals
group B: impression of a better belly shape
It is then left to stand for a week (7 days), then the intake is reversed, group A taking the product to which the PVP according to the present invention has been added, and group B becoming the control group B without PVP. The intake is always three chewing gums per day, one after each meal.

Week 2 day 1: group A: ricn to report
group B: feelings of compression after meals day 2: witness A: feeling of well-being after meals
group B: abdominal swelling after meals
The invention thus makes it possible, once again, to reduce the sensations of compression and swelling linked to variations in the waist size and caused by the mode of feeding.

Claims (7)

 1. Use of at least one chemical agent of organic origin to reduce or eliminate variations in waist size.  2. Use of at least one chemical agent of organic origin to reduce the constipation effect of certain components such as clay.  3. Use according to one of the preceding claims, characterized in that the aforementioned agent is a polyvinylpyrrolidone, in particular a polyvinylpyrrolidone having a molecular weight between 10,000 and more than 2.8 million, soluble or insoluble, crosslinked or not crosslinked.  A. Use according to claims 1 to 3, characterized in that the agent is present in the form of a separate composition to be absorbed separately from food.  5. Use according to claims 1 to 4, characterized in that the agent is incorporated directly into one or more foods.  6. Use according to one of the preceding claims, characterized in that the concentration of the agent is between a homeopathic concentration and 100% by weight or by volume.  7. Use according to one of the preceding claims, characterized in that the aforementioned chemical agent is formulated alone or in combination in synergy with other agents such as activated carbon, clay, preferably a montmorillonite clay, kaolinite , attapulgite, sepiolite, smectite and bentonite.  8. Composition, such as food composition, drink, characterized in that it contains at least one chemical agent of organic origin, preferably a polyvinylpyrrolidone, at a concentration which is effective in reducing or eliminating the variations in size, tcl that defined in claim 3.  9. Composition, such as food composition, drink, characterized in that it contains at least one chemical agent of organic origin, preferably a polyvinylpyrrolidone, in synergistic association with another agent as defined in claim 7, in an amount effective to decrease or eliminate variations in waist and constipation related to the other agent.  10. Composition according to claim 8 or 9, characterized in that the concentration of the aforementioned chemical agent of organic origin is between a homeopathic concentration and 100% by weight or by volume, advantageously between at least 10-12 g and 100% by weight or volume, even better between about 10-12 g and 1 g per unit dose per 100 g of chewable or absorbed products.