FR2677040B1 - PROCESS FOR THE PRODUCTION OF GLYCOSYLTRANSFERASES, HYBRID VECTOR AND YEAST STRAINS USED FOR THIS PURPOSE. - Google Patents

PROCESS FOR THE PRODUCTION OF GLYCOSYLTRANSFERASES, HYBRID VECTOR AND YEAST STRAINS USED FOR THIS PURPOSE.

Info

Publication number
FR2677040B1
FR2677040B1 FR9206482A FR9206482A FR2677040B1 FR 2677040 B1 FR2677040 B1 FR 2677040B1 FR 9206482 A FR9206482 A FR 9206482A FR 9206482 A FR9206482 A FR 9206482A FR 2677040 B1 FR2677040 B1 FR 2677040B1
Authority
FR
France
Prior art keywords
glycosyltransferases
production
yeast strains
strains used
hybrid vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9206482A
Other languages
French (fr)
Other versions
FR2677040A1 (en
Inventor
Watzele Dr Gabriele
Eric G Dr Berger
Meyhack Dr Bernd
Watzele Dr Manfred
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of FR2677040A1 publication Critical patent/FR2677040A1/en
Application granted granted Critical
Publication of FR2677040B1 publication Critical patent/FR2677040B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
FR9206482A 1991-05-31 1992-05-27 PROCESS FOR THE PRODUCTION OF GLYCOSYLTRANSFERASES, HYBRID VECTOR AND YEAST STRAINS USED FOR THIS PURPOSE. Expired - Fee Related FR2677040B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP91810414 1991-05-31
EP92810167 1992-03-04

Publications (2)

Publication Number Publication Date
FR2677040A1 FR2677040A1 (en) 1992-12-04
FR2677040B1 true FR2677040B1 (en) 1995-07-13

Family

ID=26130266

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9206482A Expired - Fee Related FR2677040B1 (en) 1991-05-31 1992-05-27 PROCESS FOR THE PRODUCTION OF GLYCOSYLTRANSFERASES, HYBRID VECTOR AND YEAST STRAINS USED FOR THIS PURPOSE.

Country Status (6)

Country Link
KR (1) KR920021709A (en)
CH (1) CH685057A5 (en)
DE (1) DE4217616A1 (en)
FR (1) FR2677040B1 (en)
GB (1) GB2256197B (en)
NL (1) NL9200943A (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07505771A (en) * 1992-03-09 1995-06-29 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Constructs and methods for the identification and synthesis of sialyltransferases
DE60140936D1 (en) * 2000-04-13 2010-02-11 Biotica Tech Ltd GLYCOSYLATED HYBRID COMPOUNDS, THEIR PREPARATION AND USE
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US20070026485A1 (en) 2003-04-09 2007-02-01 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US20080300173A1 (en) 2004-07-13 2008-12-04 Defrees Shawn Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1]
US20080176790A1 (en) 2004-10-29 2008-07-24 Defrees Shawn Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf)
EP1858543B1 (en) 2005-01-10 2013-11-27 BioGeneriX AG Glycopegylated granulocyte colony stimulating factor
US9187546B2 (en) 2005-04-08 2015-11-17 Novo Nordisk A/S Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
DE102005060813A1 (en) * 2005-12-20 2007-06-28 Rheinisch-Westfälische Technische Hochschule Aachen Selective labeling of glycans of antibodies with modified nucleotide sugars as substrates of recombinant galactosyltransferases
CN101516388B (en) 2006-07-21 2012-10-31 诺和诺德公司 Glycosylation of peptides via O-linked glycosylation sequences
US8969532B2 (en) 2006-10-03 2015-03-03 Novo Nordisk A/S Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
DK2144923T3 (en) 2007-04-03 2013-05-13 Biogenerix Ag METHODS OF TREATMENT WITH USING GLYCOPEGYLATED G-CSF
ES2551123T3 (en) 2007-06-12 2015-11-16 Ratiopharm Gmbh Improved process for the production of nucleotide sugars
CN101965200B (en) 2008-02-27 2013-06-19 诺沃-诺迪斯克有限公司 Conjugated factor VIII molecules
CN113481180A (en) * 2021-07-05 2021-10-08 吉林大学 Alkaline thermophilic inorganic pyrophosphatase and application thereof in enhancing polymerase chain reaction and UDP-galactose synthesis reaction
CN114369584B (en) * 2022-02-06 2023-09-22 北京睿脉医药科技有限公司 Recombinant human source fucosyltransferase variant and application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY103358A (en) * 1987-04-15 1993-06-30 Novartis Ag Process for the production of protiens.
AU4751990A (en) * 1988-12-13 1990-07-10 La Jolla Cancer Research Foundation Nucleotides encoding human b1, 4-galactosyltransferase and uses thereof
US5032519A (en) * 1989-10-24 1991-07-16 The Regents Of The Univ. Of California Method for producing secretable glycosyltransferases and other Golgi processing enzymes
EP0515536B1 (en) * 1990-02-14 2000-01-19 The Regents Of The University Of Michigan Methods and products for the synthesis of oligosaccharide structures on glycoproteins, glycolipids, or as free molecules
JPH05501359A (en) * 1990-04-27 1993-03-18 バイオジェン，インコーポレイテッド Fucosyltransferase involved in adhesion molecule expression

Also Published As

Publication number Publication date
FR2677040A1 (en) 1992-12-04
NL9200943A (en) 1992-12-16
DE4217616A1 (en) 1992-12-03
GB2256197A (en) 1992-12-02
GB2256197B (en) 1995-11-22
KR920021709A (en) 1992-12-18
CH685057A5 (en) 1995-03-15
GB9208211D0 (en) 1992-05-27

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