FR2648346A1 - SOLID TOOTHPASTE COMPOSITIONS - Google Patents

SOLID TOOTHPASTE COMPOSITIONS Download PDF

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Publication number
FR2648346A1
FR2648346A1 FR8908356A FR8908356A FR2648346A1 FR 2648346 A1 FR2648346 A1 FR 2648346A1 FR 8908356 A FR8908356 A FR 8908356A FR 8908356 A FR8908356 A FR 8908356A FR 2648346 A1 FR2648346 A1 FR 2648346A1
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composition according
hydroxyethyl
tablets
component
powder
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FR2648346B1 (en
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Priority to FR8908356A priority Critical patent/FR2648346B1/en
Priority to CA002034498A priority patent/CA2034498A1/en
Priority to AU59315/90A priority patent/AU5931590A/en
Priority to JP50939490A priority patent/JPH04500368A/en
Priority to EP19900910124 priority patent/EP0429635A1/en
Priority to PCT/FR1990/000444 priority patent/WO1990015591A1/en
Publication of FR2648346A1 publication Critical patent/FR2648346A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

A tooth-paste composition, in solid form, for human and animal use, is characterised by the fact that it contains at least one component with an antiseptic and/or an antimicrobic quality; at least one abrasive component; at least one component which delays tartar deposition; at least one component able to attack dental plaque and which possibly has antimicrobic properties; and at least one compound as a fluorine source.

Description

La présente invention concerne une nouvelle forme de présentation des compositions à usage d'hygiène.buccale et de dentifrice, ainsi qu'une composition, également nouvelle en elle-meme, et particulièrement adaptée à ladite forme. The present invention relates to a new form of presentation of the compositions for oral hygiene use and of toothpaste, as well as a composition, also new in itself, and particularly suitable for said form.

On sait que les compositions à usage de dentifrice sont actuellement présentées le plus souvent sous forme de pate, de gel ou de poudre. Pour leur utilisation, il est nécessaire d'en prélever une certaine quantité et l'appliquer sur les dents au moyen d'une brosse. It is known that compositions for use as a toothpaste are currently presented most often in the form of a paste, gel or powder. For their use, it is necessary to take a certain amount and apply it to the teeth using a brush.

L'usage d'une telle brosse représente une contrainte pour de multiples raisons c'est, entre autres, la raison pour laquelle il est difficile d'obtenir des enfants qu'ils se brossent régulièrement les dents. De meme, hors de chez soi, il n'est pas possible de se nettoyer les dents après un repas ou avant une visite. II est également très difficile de parvenir à nettoyer les dents des animaux, notamment des chiens. The use of such a brush represents a constraint for multiple reasons, this is, among others, the reason why it is difficult to get children to brush their teeth regularly. Similarly, outside your home, it is not possible to clean your teeth after a meal or before a visit. It is also very difficult to manage to clean the teeth of animals, especially dogs.

Pour éliminer ces limitations, il a été proposé de présenter la composition sous forme d'une solution appliquée sous forme d'aérosol, ce qui évite l'utilisation d'une brosse. Cette nouvelle présentation offre effectivement de très importants avantages. To eliminate these limitations, it has been proposed to present the composition in the form of a solution applied in the form of an aerosol, which avoids the use of a brush. This new presentation does indeed offer very significant advantages.

Toutefois son mode d'application impose une teneur très faible en constituants solides, notamment les corps abrasifs indispensables, même sous forme micronisée.However, its mode of application requires a very low content of solid constituents, in particular the essential abrasive bodies, even in micronized form.

Au surplus, la mise en solution implique inévitablement une certaine dilution des ingrédients actifs, ce qui risque d'en diminuer l'efficacité.In addition, dissolving inevitably involves a certain dilution of the active ingredients, which risks reducing their effectiveness.

L'invention élimine ces inconvénients grâce à une composition dentifrice solide présentée sous forme de comprimés ou de tablettes à croquer. The invention eliminates these drawbacks thanks to a solid toothpaste composition presented in the form of tablets or chewable tablets.

Une composition particulièrement adaptée à ce mode d'application comprend, selon l'invention
- au moins un composant possédant une activité antiseptique et/ou antibactérienne,
- au moins un composant exerçant une action abrasive,
- au moins un composant exerçant une action retard sur le dépôt de tartre,
- au moins un composant possédant la propriété de s'attaquer à la plaque dentaire, et ayant éventuellement des propriétés anti-microbiennes,
- et au moins un composé constituant une source de Fluor, subsidiairement un anti-inflammatoire local contre les gingivites, un appétent et/ou arome, un colorant et/ou un composé pour traiter la mauvaise haleine, le tout étant en solution solide (comprimé ou croquette).A composition particularly suited to this mode of application comprises, according to the invention
- at least one component having an antiseptic and / or antibacterial activity,
- at least one component exerting an abrasive action,
- at least one component exerting a delayed action on the scale deposit,
- at least one component having the property of attacking dental plaque, and possibly having anti-microbial properties,
- and at least one compound constituting a source of Fluoride, in the alternative a local anti-inflammatory against gingivitis, an appetite and / or aroma, a colorant and / or a compound to treat bad breath, the whole being in solid solution (tablet or croquette).

Une telle composition est entièrement originale et possède un ensemble d'actions nouvelles très importantes
- Par une action de contact sur la plaque dentaire, elle retarde son apparition et sa transformation en plaque dure.Such a composition is entirely original and has a set of very important new actions
- By a contact action on the dental plaque, it delays its appearance and its transformation into hard plaque.

- Son action antiseptique retarde la transformation de la pellicule neutre recouvrant les dents en plaque molle.  - Its antiseptic action delays the transformation of the neutral film covering the teeth into a soft plate.

- Elle renforce la protection de l'émail dentaire contre les caries en fixant certains de ses constituants directement sur celui-ci. - It strengthens the protection of dental enamel against cavities by fixing some of its constituents directly on it.

- Son agent filmogène protège les dents contre les dépôts de tartre et contre l'apparition de tartre dû à des dépôts de nicotine chez les fumeurs. - Its film-forming agent protects the teeth against tartar deposits and against the appearance of tartar due to nicotine deposits in smokers.

II est à noter que ces actions sont de longue durée et qu'elles protègent les dents, même sans brossage. It should be noted that these actions are long lasting and that they protect the teeth, even without brushing.

De plus, I'agent abrasif doux permet, avec l'action conjointe de la mastication, un effet de nettoyage et de polissage à minima. In addition, the mild abrasive agent allows, with the joint action of chewing, a minimal cleaning and polishing effect.

L'effet conjugué de ces différents éléments permet d'avoir une action intéressante en hygiène dentaire avec des éléments s'attaquant å la physiopathologie de l'apparition de la plaque dentaire et du dépôt de tartre et une action préventive anti-carie ainsi qu'une protection de l'émail dentaire avec un résultat visible en laissant les dents lisses et brillantes. The combined effect of these different elements makes it possible to have an interesting action in dental hygiene with elements attacking the pathophysiology of the appearance of dental plaque and tartar deposit and a preventive anti-caries action as well as protection of the dental enamel with a visible result leaving the teeth smooth and shiny.

Chez l'homme et l'enfant, L'usage de cette composition est surtout intéressante en complément du brossage permettant ainsi de protéger les dents entre deux brossage et de rafraîchir l'haleine. In men and children, the use of this composition is especially advantageous in addition to brushing, thus making it possible to protect the teeth between two brushing and to refresh the breath.

Chez le chien, elle apporte une solution nouvelle à un problème jusqu'ici difficile à traiter: diminuer le dépôt de tartre et améliorer l'haleine. In dogs, it provides a new solution to a problem hitherto difficult to treat: to reduce the deposit of tartar and to improve the breath.

Cette composition est bien entendu essentiellement destinée à être utilisée par des humains. Dans ce cas, elle est présentée en comprimés ou en tablettes, qu'il suffit de croquer pour qu'elle s'applique sur les dents. Les deux exemples ci-après illustrent à titre non limitatif deux compositions destinées respectivement aux adultes et aux enfants
Exemple 1:
Composition dentifrice solide pour adultes
Composants Pourcentage (écart type)
Amines Fluorées
- Hydrofluorure de cétylamine (CF) 0,1 - 0,3
- Dihydrofluorure de bis (hydroxyéthyl)-amino
propyl-N-hydroxyéthyl-octadècylamine (BF) 1,2 - 1,6
- Diméthicone S (diméthyl polysiloxane) 2 - 7
Benzoate de Na 0-0,5
Saccharinate de Na 0-0,5
Dentazium (compiexes Enzymatiques) 1- 6
Lysozime 0-3
Lactoférine 0-1,5
Parfum (chlorophyle) 0,1-0,5
Poudre Silice 2-7
Sorbitol (poudre QSP) 60 - 90
Xylitol 1-6
Exemple 2:
Composition dentifrice solide pour enfants
Composants Pourcentage (écart type)
Amines Fluorées
- Hydrofluorure de cétylamine (CF) 0,1 - 0,3
- Dihydrofluorure de bis (hydroxyéthyl)-amino
propyl-N-hydroxyéthyl-octadécylamine (BF) 0,2 - 1,2
- Diméthicone S (diméthyl polysiloxane) 1 - 5
Benzoate de Na 0-0,2
Saccharinate de Na 0-0,1
Dentazium (complexes Enzymatiques) 0,5 - 4
Lysozime 0-2
Lactoférine 0-1
Parfum, (fraise) 0,1-0,5
Poudre Silice 1-6
Sorbitol (poudre QSP) 60-90 Xylitol . 1-6
Toutefois, elle peut également être utilisée par des animaux (chien, chats etc...) à titre d'exemple, on donne ci-après, une composition selon l'invention, apte à s'appliquer sur les dents après avoir été croquée sous forme de comprimés tablettes- Lyocs - plastique ou caoutchouc recouverts des produits actifs (os factice par exemple).This composition is of course essentially intended for use by humans. In this case, it is presented in tablets or tablets, which it suffices to chew for it to be applied to the teeth. The two examples below illustrate, without limitation, two compositions intended respectively for adults and for children.
Example 1:
Solid toothpaste composition for adults
Components Percent (standard deviation)
Fluorinated Amines
- Cetylamine hydrofluoride (CF) 0.1 - 0.3
- bis (hydroxyethyl) -amino dihydrofluoride
propyl-N-hydroxyethyl-octadecylamine (BF) 1.2 - 1.6
- Dimethicone S (dimethyl polysiloxane) 2 - 7
Na benzoate 0-0.5
Na saccharin 0-0.5
Dentazium (Enzymatic compounds) 1- 6
Lysozime 0-3
Lactoferin 0-1.5
Perfume (chlorophyle) 0.1-0.5
Silica powder 2-7
Sorbitol (QSP powder) 60 - 90
Xylitol 1-6
Example 2:
Solid toothpaste composition for children
Components Percent (standard deviation)
Fluorinated Amines
- Cetylamine hydrofluoride (CF) 0.1 - 0.3
- bis (hydroxyethyl) -amino dihydrofluoride
propyl-N-hydroxyethyl-octadecylamine (BF) 0.2 - 1.2
- Dimethicone S (dimethyl polysiloxane) 1 - 5
Na benzoate 0-0.2
Na saccharin 0-0.1
Dentazium (Enzymatic complexes) 0.5 - 4
Lysozime 0-2
Lactoferin 0-1
Perfume, (strawberry) 0.1-0.5
Silica powder 1-6
Sorbitol (QSP powder) 60-90 Xylitol. 1-6
However, it can also be used by animals (dogs, cats, etc.) by way of example, a composition according to the invention is given below, suitable for applying to the teeth after being chewed in the form of tablet tablets - Lyocs - plastic or rubber covered with active products (artificial bone for example).

Exemple 3:
Composition dentifrice solide pour chiens.Example 3:
Solid toothpaste composition for dogs.

Comtcsants Pourcentage (écart typez
Amines Fluorées
- Hydrofluorure de cétylamine (CF) 0,1 - 0,3
- Dihydrofluorure de bis (hydroxyéthyl)-amino
propyl-N-hydroxyéthyl-octadécylamine (BF) 0,3 - 1
- Diméthicone S (diméthyl polysiloxane) 2 - 6
Benzoate de Na 0 -0,2
Bromochlorophène 0,05 - 0,25
Apétant 0,10 - 0.20
Parfum (arome réglisse) 0,1 -û,5
Dentazium (complexes Enzymatiques) : - 5
Lysozime 0-2
Lactoférine 0-
Silice (micronisée) 2-7
Sorbitol (poudre QSP) 60-90
Xylitol 0-3
Stéarate de Magnésium 1-4
Ac 18 B Glycérhétinique 0,1-3
Dans ces trois exemples, les rôles respectifs de divers constituant sont les suivants:
Complexes Enzymatiques : - anti-plaque dentaire
- anti-bactérien biologique
* Lysozyme : - antibiotique léger
- anti-phlogistique
- anti-inflammatoire
* Simethicone : - agent filmogène
(Diméthyl polysiloxane) - anti-fixation de tartre
- évite le dépôt de taches (nicotine, etc...)
'Amines fluorées (BF et CF) - apport de Fluor organique
- anti-caries
- propriétés antiseptiques et reminéralisantes
Extraits de silice micronisée : - abrasif doux
Excipients 8 - sorbitol
- xylitol
- saccharinate de Na
- arme
- colorant alimentaire
- Benzoate de Na
Bien entendu, les exemples ci-dèssus n'ont qu'un caractère illustratif et ne constituent pas une limitation à l'objet de l'invention. Counters Percent (difference type
Fluorinated Amines
- Cetylamine hydrofluoride (CF) 0.1 - 0.3
- bis (hydroxyethyl) -amino dihydrofluoride
propyl-N-hydroxyethyl-octadecylamine (BF) 0.3 - 1
- Dimethicone S (dimethyl polysiloxane) 2 - 6
Na benzoate 0 -0.2
Bromochlorophene 0.05 - 0.25
Appetizing 0.10 - 0.20
Perfume (licorice aroma) 0.1 -û, 5
Dentazium (Enzymatic complexes): - 5
Lysozime 0-2
Lactoferin 0-
Silica (micronized) 2-7
Sorbitol (QSP powder) 60-90
Xylitol 0-3
Magnesium stearate 1-4
Ac 18 B Glycerhetinic 0.1-3
In these three examples, the respective roles of various constituents are as follows:
Enzymatic complexes: - anti-dental plaque
- biological anti-bacterial
* Lysozyme: - light antibiotic
- anti-phlogiston
- anti-inflammatory
* Simethicone: - film-forming agent
(Dimethyl polysiloxane) - anti-scale fixation
- avoids the deposit of stains (nicotine, etc ...)
'' Fluorinated amines (BF and CF) - contribution of organic fluorine
- anti-cavities
- antiseptic and remineralizing properties
Micronized silica extracts: - mild abrasive
Excipients 8 - sorbitol
- xylitol
- Na saccharinate
- weapon
- food coloring
- Na benzoate
Of course, the above examples are only illustrative and do not constitute a limitation on the subject of the invention.

Claims (8)

REVENDICATIONS 1. Composition dentifrice à usage humain et animal, caractérisé en ce qu'elle se présente sous forme solide.1. Toothpaste composition for human and animal use, characterized in that it is in solid form. 2. Composition dentifrice selon la revendication 1, caractérisé en ce qu'elle se présente sous forme de comprimés, tablettes ou croquettes à croquer.2. Toothpaste composition according to claim 1, characterized in that it is in the form of tablets, tablets or chewable kibbles. 3. Composition dentifrice selon la revendication 1, caractérisé en ce qu'elle se présente sous forme d'une couche recouvrant un support en plastique ou en caoutchouc.3. Toothpaste composition according to claim 1, characterized in that it is in the form of a layer covering a plastic or rubber support. 4. Composition dentifrice selon l'une quelconque des revendications 1 à 3, caractérisé en ce qu'elle comprend 4. Toothpaste composition according to any one of claims 1 to 3, characterized in that it comprises - au moins un composant possédant une activité antiseptique et/ou antimicrobienne, - at least one component having an antiseptic and / or antimicrobial activity, - au moins un composant exerçant une action abrasive, - at least one component exerting an abrasive action, - au moins un composant exerçant une action retard sur ie dépôt de tartre, - at least one component exerting a delay action on the scale deposit, - au moins un composant possédant la propriété de s'attaquer à la plaque dentaire, et ayant éventuellement des propriétés anti-microbiennes, - at least one component having the property of attacking dental plaque, and possibly having anti-microbial properties, - et au moins un composé constituant une source de Fluor. - And at least one compound constituting a source of fluorine. 5. Composition dentifrice selon la revendication 4, caractérisé en ce qu'elle contient au surplus 5. Toothpaste composition according to claim 4, characterized in that it contains in addition - un anti-inflammatoire local contre les gingivite, - a local anti-inflammatory against gingivitis, - un arôme, - an aroma, - un colorant - a dye - et/ou un composé pour traiter la mauvaise haleine. - and / or a compound to treat bad breath. 6. Composition selon les revendication 4 et 5, caractérisée en ce qu'elfe 6. Composition according to claims 4 and 5, characterized in that elf comprend, sous forme de comprimés ou tablettes, destinés aux humais adultes includes, in the form of tablets or tablets, intended for adult humans Comsants Pourcentage (écart tvDe)  Comsants Percentage (tvDe gap) Amines Fluorées Fluorinated Amines - Hydrofluorure de cétylamine (CF) 0,1 - 0,3 - Cetylamine hydrofluoride (CF) 0.1 - 0.3 - Dihydrofluorure de bis (hydroxyéthyl)-amino - bis (hydroxyethyl) -amino dihydrofluoride propyl-N-hydroxyéthyl-octadécylamine (6F) 1,2 - 1,6  propyl-N-hydroxyethyl-octadecylamine (6F) 1.2 - 1.6 - Diméthicone S (diméthyl polysiloxane) 2 - 7  - Dimethicone S (dimethyl polysiloxane) 2 - 7 Benzoate de Na 0-0.5  Na benzoate 0-0.5 Saccharinate de Na 0 - 0.5  Na saccharin 0 - 0.5 Dentazium (complexes Enzymatiques) 1 - 6 Dentazium (Enzymatic complexes) 1 - 6 Lysozime - 3  Lysozime - 3 Lactoférine 0-1.5 Lactoferin 0-1.5 Parfum (chlorophyle) 0,1-0.5  Perfume (chlorophyle) 0.1-0.5 Poudre Silice 2 - 7  Silica powder 2 - 7 Sorbitol (poudre OSP) 60-90  Sorbitol (OSP powder) 60-90 Xylitol 1-6 Xylitol 1-6 7. Composition selon les revendications 4 et 5, caractérisée en ce qu'elle comprend sous forme sous forme de comprimés ou tablettes, destinés aux enfants: 7. Composition according to Claims 4 and 5, characterized in that it comprises, in the form of tablets or tablets, intended for children: Comnosants Pourcentaoe (écart type) Compounds Percentaoe (standard deviation) Amines Fluorées Fluorinated Amines - Hydrofluorure de cétylamine (CF) 0,1-0,3  - Cetylamine hydrofluoride (CF) 0.1-0.3 - Dihydrofluorure de bis (hydroxyéthyl)-amino- - bis (hydroxyethyl) -amino- dihydrofluoride propyl-N-hydroxyéthyl-octadécylamine (BF) 0,2 - 1,2  propyl-N-hydroxyethyl-octadecylamine (BF) 0.2 - 1.2 - Diméthicone S (diméthyl polysiloxane) 1 - 5 - Dimethicone S (dimethyl polysiloxane) 1 - 5 Benzoate de Na 0-0,2 Na benzoate 0-0.2 Saccharinate de Na 0-0,1 Na saccharin 0-0.1 Dentazium (complexes Enzymatiques) 0,5 - 4 Dentazium (Enzymatic complexes) 0.5 - 4 Lysozime 0-2 Lysozime 0-2 Lactoférine 0- 1 Lactoferin 0- 1 Parfum (fraise) 0,1 -0,5  Fragrance (strawberry) 0.1 -0.5 Poudre Silice 1-6 Silica powder 1-6 Sorbitol (poudre QSP) 60-90 Sorbitol (QSP powder) 60-90 Xylitol 1-6 Xylitol 1-6 8. Composition selon les revendications 4 et 5, caractérisée en ce qu'elle comprend sous forme d'une couche déposée sur un support en plastique ou en caoutchouc: 8. Composition according to Claims 4 and 5, characterized in that it comprises, in the form of a layer deposited on a plastic or rubber support: Composants Pourcentace (écart type) Components Percent (standard deviation) Amines Fluorées Fluorinated Amines - Hydrofluorure de cétylamine (CF) 0,1 - 0,3 - Cetylamine hydrofluoride (CF) 0.1 - 0.3 - Dihydrofluorure de bis (hydroxyéthyl)-amino - bis (hydroxyethyl) -amino dihydrofluoride propyl-N-hydroxyéthyl-octadécylamine (BF) 0,3 - 1  propyl-N-hydroxyethyl-octadecylamine (BF) 0.3 - 1 - Diméthicone S (diméthyl polysiloxane) 2 - 6 - Dimethicone S (dimethyl polysiloxane) 2 - 6 Benzoate de Na 0-0,2 Bromochlorophène 0,05 - 0,25  Na benzoate 0-0.2 Bromochlorophene 0.05 - 0.25 Apétant 0, - 0,20 Appetizing 0, - 0.20 Parfum (arome réglisse) 0,1-0,5  Fragrance (licorice aroma) 0.1-0.5 Dentazium (complexes Enzymatiques) 1- 5 Dentazium (Enzymatic complexes) 1- 5 Lysozime 0-2 Lysozime 0-2 Lactoférine 0-2 Lactoferin 0-2 Silice (micronisée) 2-7 Silica (micronized) 2-7 Sorbitol (poudre QSP) 60- 90 Sorbitol (QSP powder) 60-90 Xylitol 0-3 Xylitol 0-3 Stéarate de Magnésium 1-4  Magnesium stearate 1-4 Ac 18 B Glycérhétinique 0,1-3 et est destinée plus spécialement aux animaux.  Ac 18 B Glycérhétinique 0,1-3 and is intended more especially for animals.
FR8908356A 1989-06-20 1989-06-20 SOLID TOOTHPASTE COMPOSITIONS Expired - Fee Related FR2648346B1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR8908356A FR2648346B1 (en) 1989-06-20 1989-06-20 SOLID TOOTHPASTE COMPOSITIONS
CA002034498A CA2034498A1 (en) 1989-06-20 1990-06-20 Compositions de pate dentifrice solide
AU59315/90A AU5931590A (en) 1989-06-20 1990-06-20 Solid tooth-paste compositions
JP50939490A JPH04500368A (en) 1989-06-20 1990-06-20 solid toothpaste composition
EP19900910124 EP0429635A1 (en) 1989-06-20 1990-06-20 Solid tooth-paste compositions
PCT/FR1990/000444 WO1990015591A1 (en) 1989-06-20 1990-06-20 Solid tooth-paste compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8908356A FR2648346B1 (en) 1989-06-20 1989-06-20 SOLID TOOTHPASTE COMPOSITIONS

Publications (2)

Publication Number Publication Date
FR2648346A1 true FR2648346A1 (en) 1990-12-21
FR2648346B1 FR2648346B1 (en) 1993-10-08

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FR8908356A Expired - Fee Related FR2648346B1 (en) 1989-06-20 1989-06-20 SOLID TOOTHPASTE COMPOSITIONS

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EP (1) EP0429635A1 (en)
JP (1) JPH04500368A (en)
AU (1) AU5931590A (en)
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FR3106059A1 (en) 2020-01-14 2021-07-16 Jean Dominque DANA EDIBLE TO SUCK OR CHEW TOOTHPASTE COMPOSITION, PROCESS FOR PREPARING THE SAID TOOTHPASTE COMPOSITION

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ES2079325B1 (en) * 1994-08-18 1996-10-16 Bio Cosmetics S L LOW ABRASIVITY DENTRIFY, WHITENING, ANTI-PLATE AND ANTI-TARE PASTA.
US5665333A (en) * 1995-01-17 1997-09-09 Homola; Andrew M. Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth
US5961958A (en) * 1996-07-16 1999-10-05 Four Star Partners Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth
DK1050295T3 (en) * 1997-11-14 2002-07-22 Biocosmetics Sl Bleaching, tartar preventive toothpaste with low abrasive effect and plaque effect
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FR2383661A1 (en) * 1977-03-19 1978-10-13 Blendax Werke Schneider Co PRODUCT FOR DENTAL AND ORAL CARE
EP0003545A1 (en) * 1978-01-31 1979-08-22 Ferrero oHG Tooth decay preventing, sugar, especially saccharose containing food and pharmaceutical compositions with low water content as well as a method for their preparation
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EP1010430A1 (en) * 1998-04-30 2000-06-21 Snow Brand Milk Products, Co., Ltd. Preventives and ameliorating agents for periodontosis
EP1010430A4 (en) * 1998-04-30 2004-03-31 Snow Brand Milk Products Co Ltd Preventives and ameliorating agents for periodontosis
FR3106059A1 (en) 2020-01-14 2021-07-16 Jean Dominque DANA EDIBLE TO SUCK OR CHEW TOOTHPASTE COMPOSITION, PROCESS FOR PREPARING THE SAID TOOTHPASTE COMPOSITION
WO2021144211A1 (en) 2020-01-14 2021-07-22 Jean Dominique Dana Edible toothpaste composition to be sucked or chewed, method for preparing said toothpaste composition

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FR2648346B1 (en) 1993-10-08
JPH04500368A (en) 1992-01-23
CA2034498A1 (en) 1990-12-21
EP0429635A1 (en) 1991-06-05
WO1990015591A1 (en) 1990-12-27
AU5931590A (en) 1991-01-08

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