FR2635524B1 - Nouveaux derives de benzopyrrolidinone, leur procede de preparation et les compositions pharmaceutiques les renfermant - Google Patents
Nouveaux derives de benzopyrrolidinone, leur procede de preparation et les compositions pharmaceutiques les renfermantInfo
- Publication number
- FR2635524B1 FR2635524B1 FR8811057A FR8811057A FR2635524B1 FR 2635524 B1 FR2635524 B1 FR 2635524B1 FR 8811057 A FR8811057 A FR 8811057A FR 8811057 A FR8811057 A FR 8811057A FR 2635524 B1 FR2635524 B1 FR 2635524B1
- Authority
- FR
- France
- Prior art keywords
- benzopyrrolidinone
- hydrogen
- optionally substituted
- derivatives
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000004044 bronchoconstricting agent Substances 0.000 abstract 1
- 230000002741 bronchospastic effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8811057A FR2635524B1 (fr) | 1988-08-19 | 1988-08-19 | Nouveaux derives de benzopyrrolidinone, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| US07/391,936 US4968705A (en) | 1988-08-19 | 1989-08-10 | Benzopyrrolidinone compounds as bronchospastic agents |
| DK405589A DK405589A (da) | 1988-08-19 | 1989-08-17 | Benzopyrrolidinonderivater fremgangsmaade til deres fremstilling og farmaceutiske midler indeholdende dem |
| ES89402303T ES2045502T3 (es) | 1988-08-19 | 1989-08-18 | Derivados de benzopirrolidinona, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. |
| OA59626A OA09127A (fr) | 1988-08-19 | 1989-08-18 | Nouveaux dérivés de benzopyrrolidinone, leur procédé de préparation et les compositions pharmaceutiques les renfermant. |
| CA000608748A CA1327581C (fr) | 1988-08-19 | 1989-08-18 | Derives de benzopyrrolidinone, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| AT89402303T ATE81126T1 (de) | 1988-08-19 | 1989-08-18 | Benzopyrrolidinon-derivate, verfahren zu ihrer herstellung und arzneimittel, die sie enthalten. |
| DE8989402303T DE68903077T2 (de) | 1988-08-19 | 1989-08-18 | Benzopyrrolidinon-derivate, verfahren zu ihrer herstellung und arzneimittel, die sie enthalten. |
| EP89402303A EP0356323B1 (fr) | 1988-08-19 | 1989-08-18 | Dérivés de benzopyrrolidinone, leur procédé de préparation et les compositions pharmaceutiques les renfermant |
| JP1212847A JPH02108689A (ja) | 1988-08-19 | 1989-08-18 | ベンゾピロリジノン誘導体 |
| IE265389A IE64349B1 (en) | 1988-08-19 | 1989-08-18 | New benzopyrrolidinone derivatives a process for the preparation therof and pharmaceutical compositions containing them |
| PT91485A PT91485B (pt) | 1988-08-19 | 1989-08-18 | Processo para a preparacao de novos derivados de benzopirrolidinona |
| ZA896318A ZA896318B (en) | 1988-08-19 | 1989-08-18 | Benzopyrrolidinone derivatives,a process for the preparation thereof and pharmaceutical compositions containing them |
| AU39984/89A AU617849B2 (en) | 1988-08-19 | 1989-08-18 | New benzopyrrolidinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing them |
| NZ230355A NZ230355A (en) | 1988-08-19 | 1989-08-18 | 4-substituted piperidinoalkyl (iso) oxindole derivatives |
| GR920403108T GR3006670T3 (enExample) | 1988-08-19 | 1992-12-24 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8811057A FR2635524B1 (fr) | 1988-08-19 | 1988-08-19 | Nouveaux derives de benzopyrrolidinone, leur procede de preparation et les compositions pharmaceutiques les renfermant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2635524A1 FR2635524A1 (fr) | 1990-02-23 |
| FR2635524B1 true FR2635524B1 (fr) | 1992-04-24 |
Family
ID=9369428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8811057A Expired - Lifetime FR2635524B1 (fr) | 1988-08-19 | 1988-08-19 | Nouveaux derives de benzopyrrolidinone, leur procede de preparation et les compositions pharmaceutiques les renfermant |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4968705A (enExample) |
| EP (1) | EP0356323B1 (enExample) |
| JP (1) | JPH02108689A (enExample) |
| AT (1) | ATE81126T1 (enExample) |
| AU (1) | AU617849B2 (enExample) |
| CA (1) | CA1327581C (enExample) |
| DE (1) | DE68903077T2 (enExample) |
| DK (1) | DK405589A (enExample) |
| ES (1) | ES2045502T3 (enExample) |
| FR (1) | FR2635524B1 (enExample) |
| GR (1) | GR3006670T3 (enExample) |
| IE (1) | IE64349B1 (enExample) |
| NZ (1) | NZ230355A (enExample) |
| OA (1) | OA09127A (enExample) |
| PT (1) | PT91485B (enExample) |
| ZA (1) | ZA896318B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5459151A (en) * | 1993-04-30 | 1995-10-17 | American Home Products Corporation | N-acyl substituted phenyl piperidines as bronchodilators and antiinflammatory agents |
| GB2308362A (en) * | 1995-12-19 | 1997-06-25 | Lilly Industries Ltd | Pharmaceutical indole derivatives |
| TW202247838A (zh) | 2015-07-02 | 2022-12-16 | 美商地平線罕見醫學製藥有限責任公司 | Ado抗性半胱胺類似物及其用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2695290A (en) * | 1952-03-28 | 1954-11-23 | Hoffmann La Roche | Derivatives of indole and method for the production thereof |
| FR1545549A (fr) * | 1966-11-30 | 1968-11-08 | Hoffmann La Roche | Procédé pour la préparation de composés hétérocycliques |
| YU39992B (en) * | 1976-04-02 | 1985-06-30 | Janssen Pharmaceutica Nv | Process for obtaining new piperazine and piperidine derivatives |
| GR65270B (en) * | 1978-10-10 | 1980-07-31 | Fujisawa Pharmaceutical Co | Isatin derivatives and processes for the preparation thereof |
| US4261990A (en) * | 1979-03-09 | 1981-04-14 | Ciba-Geigy Corporation | N-alkyleneiminoalkyl-dicarboximides as antiallergics and antiasthmatics |
| US4540780A (en) * | 1983-06-02 | 1985-09-10 | Warner-Lambert Company | Diphenylmethylene piperidines |
| JPH0660160B2 (ja) * | 1985-12-13 | 1994-08-10 | テルモ株式会社 | アミド誘導体およびこれを含有する抗アレルギ−剤 |
-
1988
- 1988-08-19 FR FR8811057A patent/FR2635524B1/fr not_active Expired - Lifetime
-
1989
- 1989-08-10 US US07/391,936 patent/US4968705A/en not_active Expired - Fee Related
- 1989-08-17 DK DK405589A patent/DK405589A/da not_active Application Discontinuation
- 1989-08-18 ES ES89402303T patent/ES2045502T3/es not_active Expired - Lifetime
- 1989-08-18 IE IE265389A patent/IE64349B1/en not_active IP Right Cessation
- 1989-08-18 CA CA000608748A patent/CA1327581C/fr not_active Expired - Fee Related
- 1989-08-18 EP EP89402303A patent/EP0356323B1/fr not_active Expired - Lifetime
- 1989-08-18 JP JP1212847A patent/JPH02108689A/ja active Pending
- 1989-08-18 OA OA59626A patent/OA09127A/xx unknown
- 1989-08-18 ZA ZA896318A patent/ZA896318B/xx unknown
- 1989-08-18 AT AT89402303T patent/ATE81126T1/de not_active IP Right Cessation
- 1989-08-18 AU AU39984/89A patent/AU617849B2/en not_active Ceased
- 1989-08-18 PT PT91485A patent/PT91485B/pt active IP Right Grant
- 1989-08-18 DE DE8989402303T patent/DE68903077T2/de not_active Expired - Fee Related
- 1989-08-18 NZ NZ230355A patent/NZ230355A/en unknown
-
1992
- 1992-12-24 GR GR920403108T patent/GR3006670T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE68903077D1 (de) | 1992-11-05 |
| CA1327581C (fr) | 1994-03-08 |
| OA09127A (fr) | 1991-10-31 |
| PT91485B (pt) | 1995-05-04 |
| DK405589A (da) | 1990-02-20 |
| DK405589D0 (da) | 1989-08-17 |
| DE68903077T2 (de) | 1993-04-29 |
| NZ230355A (en) | 1991-03-26 |
| IE64349B1 (en) | 1995-07-26 |
| ES2045502T3 (es) | 1994-01-16 |
| ATE81126T1 (de) | 1992-10-15 |
| US4968705A (en) | 1990-11-06 |
| AU617849B2 (en) | 1991-12-05 |
| GR3006670T3 (enExample) | 1993-06-30 |
| IE892653L (en) | 1990-02-19 |
| ZA896318B (en) | 1990-05-30 |
| EP0356323B1 (fr) | 1992-09-30 |
| JPH02108689A (ja) | 1990-04-20 |
| FR2635524A1 (fr) | 1990-02-23 |
| AU3998489A (en) | 1990-02-22 |
| PT91485A (pt) | 1990-03-08 |
| EP0356323A1 (fr) | 1990-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |