FR2620024A1 - Cosmetic composition containing an anti-free-radical agent, and corresponding agent - Google Patents

Cosmetic composition containing an anti-free-radical agent, and corresponding agent Download PDF

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Publication number
FR2620024A1
FR2620024A1 FR8712516A FR8712516A FR2620024A1 FR 2620024 A1 FR2620024 A1 FR 2620024A1 FR 8712516 A FR8712516 A FR 8712516A FR 8712516 A FR8712516 A FR 8712516A FR 2620024 A1 FR2620024 A1 FR 2620024A1
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cosmetic composition
composition according
hydroxyxanthine
acid
application
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FR8712516A
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FR2620024B1 (en
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Daniel Greff
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DERMATOLOGIQUES ET
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DERMATOLOGIQUES ET
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/06—Preparations for care of the skin for countering cellulitis

Abstract

The anti-free-radical agent is a derivative of a nucleic base selected, in particular, from the group comprising adenine, guanosine, xanthine, hypoxanthine, uric acid, uracil, orotic acid, ribonucleic acid, glycerohydroxyxanthine, ribosylhydroxyxanthine, lysine hydroxyxanthinate, caffeine, theobromine and theophylline. Use in combating skin ageing.

Description

Composition cosmétique comportant UL axent arti- radicaux libres. et agent correspondant
L'invention concerne une composition cosmétique comportant un agent anti-radicaux libres, et l'agent correspondant.Cosmetic composition comprising UL axis free radicals. and corresponding agent
The invention relates to a cosmetic composition comprising an anti-free radical agent, and the corresponding agent.

Le problème du vieillissement de la peau est particulièrement lié à l'action des radicaux libres tels que : hydroxyles, alcoxy, péroxy. Ces radicaux libres sont générés essentiellement par les espèces activées de l'oxygene (oxygène singulet, ion superoxyde. peroxydes), qui ont un effet oxydant puissant. The problem of skin aging is particularly linked to the action of free radicals such as: hydroxyls, alkoxy, peroxy. These free radicals are mainly generated by activated oxygen species (singlet oxygen, superoxide ion. Peroxides), which have a strong oxidizing effect.

Les facteurs de l'initiation radicalaire sont par brdre d'importance
. les mécanismes photochimiques
. les mecanismes de photosensibilisation
. les mécanismes de réactions chimiques
. les mécanismes de reactions enzymatiques.The factors of radical initiation are therefore of importance
. photochemical mechanisms
. photosensitization mechanisms
. chemical reaction mechanisms
. the mechanisms of enzymatic reactions.

Ce sont bien évidemment les mécanismes photochimiques qui son une constante pour tous les sujets et tous les ages, variant d'intensité selon les fréquences d'exposition au soleil. It is obviously the photochemical mechanisms which are a constant for all subjects and all ages, varying in intensity according to the frequency of exposure to the sun.

La photosensibilisation aboutit aux mêmes effets générateurs. Le rayonnement solaire influence une molécule chimique généralement externe et sensible a la lumière, et des mécanismes en cascade, sensiblement identiques à ceux évoqués ci-dessus vont également générer les divers radicaux libres. Photosensitization leads to the same generative effects. Solar radiation influences a generally external and light-sensitive chemical molecule, and cascading mechanisms, substantially identical to those mentioned above, will also generate the various free radicals.

Une fois liberés, les radicaux libres vont avoir divers effets biochimiques qui vont tous participer au vieillissement de la peau. Parmi ces effets, on peut retenir
- les effets de dépolymérisation de macromolécules biologiques telles que
ADN, collagene, acide hyaluroniq,e. Once released, free radicals will have various biochemical effects that will all contribute to the aging of the skin. Among these effects, we can retain
- the effects of depolymerization of biological macromolecules such as
DNA, collagen, hyaluroniq acid, e.

Dépolymérisées, ces molécules perdent l'essentiel de leurs propriétés biologiques et physiques.  Depolymerized, these molecules lose most of their biological and physical properties.

- les effets de péroxydation des lipides membranaires. Ces lipides, qui constituent l'architecture de la membrane cellulaire perdent, sou l'effet des péroxydations, leurs propriété de fluidité ou méme de stabilité;
- les effets d'activation enzymatique qui vont participer directement ou indirectement aux phénomènes d'inflammation et d'oedème que l'on observe fréquemment suite aux expositions solaires trop intenses.- the effects of peroxidation of membrane lipids. These lipids, which constitute the architecture of the cell membrane lose, under the effect of peroxidation, their property of fluidity or even of stability;
- the effects of enzymatic activation which will participate directly or indirectly in the phenomena of inflammation and edema which are frequently observed following excessively intense sun exposure.

Pour bloquer ou diminuer les effets des phenomènes d'oxydation, la cosmétologie utilise des anti-oxydants comme la vitamine C et le glutathion, ou des anti-radicalaires comme la vitamine E et les carotenoïdes. To block or reduce the effects of oxidation phenomena, cosmetology uses antioxidants like vitamin C and glutathione, or anti-free radicals like vitamin E and carotenoids.

La présente invention a pour objet une composition cosmétique caractérisée en ce qu'elle comporte un agent anti-radicaux libres constitué par un dérivé de base nucléique. The present invention relates to a cosmetic composition characterized in that it comprises an anti-free radical agent consisting of a derivative of nucleic base.

Selon d'autres caractéristiques de l'invention:
-le dérivé de base nucléique est pris dans le groupe adénine, guanosi ne, - xanthine, hypoxanthine, acide urique, uracyl, acide orotique, acide ribonucléique, glycéro hydroxyxanthine, ribosyl hydroxyxanthine, hydroxyxanthinate de lysine, caféine, théobromine et théophylline;
-le dérivé de base nucléique est présent en solution;
-le dérivé de base nucléique est présent a l'intérieur de phases lipidiques lamellaires dispersées, c'est-à-dire de liposomes.According to other characteristics of the invention:
-the nucleic base derivative is taken from the adenine, guanosine group, - xanthine, hypoxanthine, uric acid, uracyl, orotic acid, ribonucleic acid, glycero hydroxyxanthine, ribosyl hydroxyxanthine, lysine hydroxyxanthinate, caffeine, theobromine and theophylline;
the nucleic base derivative is present in solution;
the nucleic acid derivative is present inside dispersed lamellar lipid phases, that is to say liposomes.

L'invention a également pour objet l'application d'une composition cosmétique ci-dessus definie à la protection contre le vieillissement de la peau, à la protection contre les inflammations ou érythèmes solaires, à la protection de l'ADN, ou à l'activation de i' adényl cyclase. The subject of the invention is also the application of a cosmetic composition defined above for protection against aging of the skin, for protection against inflammations or erythemas of sun, for the protection of DNA, or for l 'activation of adenyl cyclase.

L'invention a encore pour objet un agent antiradicaux libres, constitué par un dérivé de base nucléique pris dans le groupe : adenine, guanosine, xanthine, hypoxanthine, acide urique, uracyl, acide orotique, acide ribonucléique, glycéro hydroxyxanthine, ribosyl hydroxyxanthine, hydroxyxanthînate de lys ne, caféine, théobromine et théophylline. The subject of the invention is also a free anti-radical agent, consisting of a nucleic acid derivative taken from the group: adenine, guanosine, xanthine, hypoxanthine, uric acid, uracyl, orotic acid, ribonucleic acid, glycero hydroxyxanthine, ribosyl hydroxyxanthine, hydroxyxanthine of lily ne, caffeine, theobromine and theophylline.

Comme exemple pratique de dérivé de base nucléique, on peut retenir l'acide urique et ses dérivés, notamment les urates. L'acide urique n'est autre que la 8-hyaroxyxanthine. As a practical example of a nucleic acid derivative, uric acid and its derivatives, in particular urates, can be used. Uric acid is none other than 8-hyaroxyxanthine.

L'acide urique et les urates ont des effets anti-oxydants qui se manifestent de la manière suivante:
- l'urate est un coilecteur de l'oxygene singulet,
- il est sensible aux radicaux libres hydroxyles issus de l'irradiation,
- il est oxydable par l'hémoglobine et les peroxydes,
- il assure la protection des membranes de globules rouges contre les péroxydations (t-butylhydroperoxyde),
- il assure la protection des globule- rouges contre la lyse par les péroxydes.Uric acid and urates have antioxidant effects that manifest themselves in the following way:
- the urate is a singlet oxygen collector,
- it is sensitive to hydroxyl free radicals from irradiation,
- it can be oxidized by hemoglobin and peroxides,
- it protects the membranes of red blood cells against peroxidation (t-butylhydroperoxide),
- it ensures the protection of red blood cells against lysis by peroxides.

Outre l'effet anti-oxydant évoqué ci-dessus par piégeage des radicaux oxygènes activés et radicaux libres, l'acide urique présente une autre propriété anti-oxydante sans doute liée à sa capacité de former des complexes avec l'ion métallique Fer. Le compiexe urate-Fe inhibe l'oxydation de l'ascorbate catalysée par l'ion Fe ; de façon surprenante, et en opposition avec ce qui est connu des autres pièges à radicaux libres, l'inhibition par l'urate de l'ascorbate ainsi que la peroxydase lipidique n'impliquent pas une oxydation parallèle de l'urate. L'urate peut être un puissant agent anti-oxydant physiologique. In addition to the antioxidant effect mentioned above by trapping activated oxygen radicals and free radicals, uric acid has another antioxidant property probably linked to its ability to form complexes with the metal ion Iron. The urate-Fe compound inhibits the oxidation of ascorbate catalyzed by the Fe ion; surprisingly, and in contrast to what is known from other free radical traps, the urate inhibition of ascorbate as well as lipid peroxidase do not imply a parallel oxidation of the urate. Urate can be a powerful physiological antioxidant.

Les derives de bases nucléiques, notamment adenine, guanosine, xanthine, hypoxanthine, acide urique, uracyl, acide orotique, acide ribonucléique, caféine, théobromîne et théophylline présentent un effet anti-oxydant vis-à-vis de l'oxydation a l'air de l'acide linoléique. Ces dérivés sont donc utilisablea pour éviter l'oxydation des lipides. Leur effet anti.- oxydant est sensible à pH neutre, acide ou legrement basique. The derivatives of nucleic bases, in particular adenine, guanosine, xanthine, hypoxanthine, uric acid, uracyl, orotic acid, ribonucleic acid, caffeine, theobromine and theophylline have an antioxidant effect with respect to air oxidation linoleic acid. These derivatives are therefore usable to avoid the oxidation of lipids. Their antioxidant effect is sensitive to neutral, acidic or slightly basic pH.

Par ailleurs, les dérivés de bases nucleiques, en même temps que leur pouvoir de piéger les radicaux libres, présentent une capacité de chélation des ions metalliques.  In addition, the derivatives of nucleic bases, at the same time as their capacity to trap the free radicals, present a capacity of chelation of the metallic ions.

Il faut retenir également que la caféine est dotee de propriétés de protection contre les effets de dénaturation de l'ADN par les radiations ultraviolettes, et qu'elle joue un rôle d'activateur de l'adenylcyclase. It should also be remembered that caffeine has protective properties against the effects of DNA denaturation by ultraviolet radiation, and that it plays a role in activating adenylcyclase.

L'invention concerne également l'application en cosmétologie des derivés de bases nucléiques, par exemple adénine, guanosine, xanthine, hypoxanth~ne.  The invention also relates to the application in cosmetology of derivatives of nucleic bases, for example adenine, guanosine, xanthine, hypoxanth ~ ne.

acide urique, uracyl, acide orotique, acce ribonucléique, glycèro hydroxyxanthine, ribosyl hydroxyxanthine, hydroxyxanthinate de lysine, cafeine, thesbromine et theophylline.uric acid, uracyl, orotic acid, ribonucleic acce, glycero hydroxyxanthine, ribosyl hydroxyxanthine, lysine hydroxyxanthinate, caffeine, thesbromine and theophylline.

Tous ces derives peuvent être employes e solution aqueuse, dans des émulsions ou dans des phases lamellaires lipidiques dispersées du type liposomes.  All these derivatives can be used in aqueous solution, in emulsions or in dispersed lipidic lamellar phases of the liposome type.

Les compositions cosmétiques correspondantes trouvent leur application chaque fois que des radicaux libres sont produits en quantité importante. C'est le cas, en particulier, dans les tissus inflammes, pour les tissus soumis à une dose excessive de rayons ultraviolets. Elles peuvent également etre utilisées à titre préventif, dans le cadre plus général de la lutte contre le vieillissement de la peau. The corresponding cosmetic compositions find their application whenever free radicals are produced in large quantities. This is the case, in particular, in inflamed tissues, for tissues subjected to an excessive dose of ultraviolet rays. They can also be used as a preventive measure, in the more general context of the fight against aging of the skin.

Des exemples de composition cosmétique selon l'invention sont mentionnés ci-dessous
Exemple 1 : Lait après soleil
glycéryl stéarate (se) ...........Examples of cosmetic composition according to the invention are mentioned below
Example 1: After sun milk
glyceryl stearate (se) ...........

cire d'abeilles ................... beeswax ...................

huile minerale .................... mineral oil ....................

huile minérale + alcool de lanoline
beurre de karite .................... 3,00
carbomer-934 ........................... 0,50
triéthanolamine ........................ 0,35
propylène glycol ....................... 3,00
hydroxyxanthînate de lysine .......mineral oil + lanolin alcohol
shea butter .................... 3.00
carbomer-934 ........................... 0.50
triethanolamine ........................ 0.35
propylene glycol ....................... 3.00
lysine hydroxyxanthînate .......

acide protique ......................... 0,50
eau déminéralisée ...................... qsp100
conservateurs .......................... qs
parfum ................................. qs 2 : Créme amincissante
polysorbate 60 ......................... 3,000
stéarate de sorbitan ................... 3,00
glyceryl stéarate (se) ................. 3,50
alcool oléique ......................... 1,50
octyldodecanol ......................... 10,00
huile minérale ......................... 16,00
caféine ................................ 0,50
theophylline ........................... 0,50
eau déminéralisée ...................... qsp100
conservateur ........................... qs
parfum qs
Exemple 3 : Gel anti-radicaux libres.protic acid ......................... 0.50
demineralized water ...................... qsp100
preservatives .......................... qs
perfume ................................. qs 2: Slimming cream
polysorbate 60 ......................... 3,000
sorbitan stearate ................... 3.00
glyceryl stearate (se) ................. 3.50
oleic alcohol ......................... 1.50
octyldodecanol ......................... 10.00
mineral oil ......................... 16.00
caffeine ................................ 0.50
theophylline ........................... 0.50
demineralized water ...................... qsp100
curator ........................... qs
perfume qs
Example 3: Anti-free radical gel.

carboxyméthyl cellulose ................ 1,20
glycérine .............................. 0,50
propylène glycol ....................... 1.50
8-hydroxyxanthine ...................... 1,00
caféine ................................ 0,50
eau deminéralisée ...................... qsp100
conservateurs .......................... qs
parfum q
Exemple 4 : Emulsion pour la protection de l'ADA.carboxymethyl cellulose ................ 1.20
glycerin .............................. 0.50
propylene glycol ....................... 1.50
8-hydroxyxanthine ...................... 1.00
caffeine ................................ 0.50
demineralized water ...................... qsp100
preservatives .......................... qs
perfume q
Example 4: Emulsion for the protection of ADA.

polysorbate 60 ....................... polysorbate 60 .......................

stéarate de sorbitan ................. sorbitan stearate .................

alcool de lanoline acétyle ......... acetylated lanolin alcohol .........

alcool pléique ....................... pleic alcohol .......................

cétéaryl-octanoate î,e
stéaryl-heptanoate .................... 2.00
buile minérale ........................ 10,00
sorbitol .............................. 3,00
silicate d'aluminium & de magnésium
hypoxanthine ..........................cetaryl-octanoate î, e
stearyl-heptanoate .................... 2.00
mineral buil ........................ 10.00
sorbitol .............................. 3.00
aluminum & magnesium silicate
hypoxanthine ..........................

guanosine ............................. guanosine .............................

eau déminéralisée .................... qspl
conservateurs ......................... qs
parfum ................................ qs Exemple 5 : Creme anti-vieillissement. demineralized water .................... qspl
preservatives ......................... qs
perfume ................................ qs Example 5: Anti-aging cream.

PEG-30 glycéryl stéarate .............. PEG-30 glyceryl stearate ..............

huile végétale ........................ vegetable oil ........................

huile minèrale ........................ mineral oil ........................

huile de silicone ................... 1,50
stérols de soja ........................silicone oil ................... 1.50
soy sterols ........................

stéaryl-heptanoate .................... 2,00
cétéaryl-octanoate .................... 1,00
isopropyl-myristate ................... 2,00
carbomer-940 .......................... 0,30
triéthanolamine ....................... 0,20
propylène glycol ...................... 3,00
8-hydroxyxanthine ..................... 1,00
uracyle ............................... 0,50
adenine ............................... 0,50
eau déminéralisée .................... qspl
conservateurs ......................... qs
parfum ................................ qs stearyl heptanoate .................... 2.00
cetearyl octanoate .................... 1.00
isopropyl-myristate ................... 2.00
carbomer-940 .......................... 0.30
triethanolamine ....................... 0.20
propylene glycol ...................... 3.00
8-hydroxyxanthine ..................... 1.00
uracyle ............................... 0.50
adenine ............................... 0.50
demineralized water .................... qspl
preservatives ......................... qs
perfume ................................ qs

Claims (9)

RevendicationsClaims 1. Composition cosmétique, caractérisée en ce qu'elle comporte un agent anti-radicaux libres constitué par un dérive de base nucléique. 1. Cosmetic composition, characterized in that it comprises an anti-free radical agent consisting of a nucleic acid derivative. 2. Composition cosmétique selon la revendication l, caractérisée en ce que le derivé de base nucléique est pris dans le groupe adénine, guanosine, xanthine, hypoxanthine, acide urique, uracyl, acide orotique, acide ribonucléique, glycéro hydroxyxanthine, ribosyi hydroxyxanthine, hydroxyxanthinate de lysine, caféine, théobromine et théophylline. 2. Cosmetic composition according to claim l, characterized in that the nucleic acid derivative is taken from the group adenine, guanosine, xanthine, hypoxanthine, uric acid, uracyl, orotic acid, ribonucleic acid, glycero hydroxyxanthine, ribosyi hydroxyxanthine, hydroxyxanthinate lysine, caffeine, theobromine and theophylline. 3. Composition cosmétique selon la revendication l, caractérisée en ce que le dérivé de base nucléique est présent en solution. 3. Cosmetic composition according to claim l, characterized in that the nucleic acid derivative is present in solution. 4. Composition cosmétique selon la revendication i, caractérisée en ce que le dérivé de base nucléique est present a l'intérieur de phases lipidiques lamella res dispersées, c'est-a-dire de liposomes.  4. Cosmetic composition according to claim i, characterized in that the nucleic acid derivative is present inside dispersed lamella lipid phases, that is to say liposomes. 5. Application d'une composition cosmétique selon l'une des revenaications l a 4, a la protection contre le vieillissement de la peau. 5. Application of a cosmetic composition according to one of the claims 1 to 4, for protection against aging of the skin. 6. Application d'une composition cosmétique selon l'une des revendications 1 à 4 à la protection contre les inflammations ou les érythèmes solaires. 6. Application of a cosmetic composition according to one of claims 1 to 4 for protection against inflammation or solar erythema. 7. Application d'une composition cosmétique selon l'une des revendications 1 à 4 à l'activation de l'adenyi cyclase. 7. Application of a cosmetic composition according to one of claims 1 to 4 to the activation of adenyi cyclase. 8. Application d'une composition cosmétique selon l'une des revendications 1 à 4 à la protection de l'ADN. 8. Application of a cosmetic composition according to one of claims 1 to 4 for the protection of DNA. 9. Agent anti-radicaux libres constitue par un dérivé de base nucléique pris dans le groupe : adénine, guanosine, xanthine, hypoxanthine, acide urique, uracyl, acide orotique, acide ribonucléique, glycéro hydroxyxanthine, ribosyl hydroxyxanthine, hydroxy- xanthinate de lysine, caféine, théobrom~ne et theophylline.  9. Anti-free radical agent constituted by a nucleic base derivative taken from the group: adenine, guanosine, xanthine, hypoxanthine, uric acid, uracyl, orotic acid, ribonucleic acid, glycero hydroxyxanthine, ribosyl hydroxyxanthine, lysine hydroxy-xanthinate, caffeine, theobromine and theophylline.
FR8712516A 1987-09-09 1987-09-09 COSMETIC COMPOSITION COMPRISING A FREE ANTIRADICAL AGENT, AND CORRESPONDING AGENT Expired - Fee Related FR2620024B1 (en)

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EP0504040A1 (en) * 1991-03-13 1992-09-16 L'oreal Use of lactoferrin to protect hair keratin from atmospheric aggressions, particularly light, and process for protecting the hair using this compound
DE4323615A1 (en) * 1993-07-12 1995-01-19 Schreiner Edelgard Compositions to prevent premature ageing of the skin
US5540914A (en) * 1989-12-15 1996-07-30 The Board Of Regents Of The University Of Oklahoma Pigmentation enhancer and method
DE19911053A1 (en) * 1999-03-12 2000-09-21 Cognis Deutschland Gmbh Cosmetic and / or pharmaceutical preparations
US6316012B1 (en) 1992-09-01 2001-11-13 L'oreal Cosmetic or pharmaceutical composition comprising, in combination, a peroxidase and an anti-singlet oxygen agent
US6383514B1 (en) 1996-11-28 2002-05-07 Henkel Kommanditgesellschaft Auf Aktien Use of mixtures of active substances for the production of hypocholesterolemic agents
US6623746B1 (en) 1998-07-16 2003-09-23 Cognis Deutschland Gmbh & Co. Kg PIT emulsions, methods of softening paper using the same, and paper substrates treated therewith
WO2003084485A1 (en) 2002-04-09 2003-10-16 Otsuka Pharmaceutical Co., Ltd. Composition for cell proliferation
EP1396261A1 (en) * 2002-09-06 2004-03-10 Alcina Cosmetic, Dr. Kurt Wolff GmbH & Co.KG Skincare composition containing caffeine
EP1562423A2 (en) * 2002-10-31 2005-08-17 Eric F. Bernstein Compositions and methods for prevention of photoaging
WO2007101493A1 (en) * 2006-03-07 2007-09-13 Henkel Ag & Co. Kgaa Cosmetic agents comprising purine and/or purine deratives ii
EP2465581A1 (en) * 2010-12-15 2012-06-20 Han-Min Chen Composition for promoting hair growth
FR2975595A1 (en) * 2011-05-24 2012-11-30 Oreal Cosmetic use of guanosine and/or its derivative to prevent an alteration of, and/or maintain the homeostasis of the skin

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WO1990000894A1 (en) * 1988-07-19 1990-02-08 Laboratoires Serobiologiques Cyto-photo-protector agent based on nucleic acids and/or their derivatives
US5628987A (en) * 1989-12-15 1997-05-13 The Board Of Regents Of The University Of Oklahoma Pigmentation enhancer and method
US5540914A (en) * 1989-12-15 1996-07-30 The Board Of Regents Of The University Of Oklahoma Pigmentation enhancer and method
US5589161A (en) * 1989-12-15 1996-12-31 The Board Of Regents Of The University Oklahoma Pigmentation enhancer and method
US5591423A (en) * 1989-12-15 1997-01-07 The Board Of Regents Of The University Of Oklahoma Pigmentation enhancer and method
EP0504040A1 (en) * 1991-03-13 1992-09-16 L'oreal Use of lactoferrin to protect hair keratin from atmospheric aggressions, particularly light, and process for protecting the hair using this compound
FR2673839A1 (en) * 1991-03-13 1992-09-18 Oreal USE OF LACTOFERRIN FOR THE PROTECTION OF HAIR KERATIN AGAINST ATMOSPHERIC AGGRESSIONS, IN PARTICULAR LIGHT, AND HAIR PROTECTION METHOD USING THE SAME.
US6316012B1 (en) 1992-09-01 2001-11-13 L'oreal Cosmetic or pharmaceutical composition comprising, in combination, a peroxidase and an anti-singlet oxygen agent
DE4323615A1 (en) * 1993-07-12 1995-01-19 Schreiner Edelgard Compositions to prevent premature ageing of the skin
US6383514B1 (en) 1996-11-28 2002-05-07 Henkel Kommanditgesellschaft Auf Aktien Use of mixtures of active substances for the production of hypocholesterolemic agents
US6623746B1 (en) 1998-07-16 2003-09-23 Cognis Deutschland Gmbh & Co. Kg PIT emulsions, methods of softening paper using the same, and paper substrates treated therewith
DE19911053B4 (en) * 1999-03-12 2004-10-28 Biotec Asa Cosmetic and / or pharmaceutical preparations
WO2000054743A1 (en) * 1999-03-12 2000-09-21 Biotec Asa Cosmetic and/or pharmaceutical preparations
US6706696B1 (en) 1999-03-12 2004-03-16 Biotec Asa Cosmetic and/or pharmaceutical preparations
DE19911053A1 (en) * 1999-03-12 2000-09-21 Cognis Deutschland Gmbh Cosmetic and / or pharmaceutical preparations
WO2003084485A1 (en) 2002-04-09 2003-10-16 Otsuka Pharmaceutical Co., Ltd. Composition for cell proliferation
EP1498101A1 (en) * 2002-04-09 2005-01-19 Otsuka Pharmaceutical Company, Limited Composition for cell proliferation
EP1498101A4 (en) * 2002-04-09 2007-09-12 Otsuka Pharma Co Ltd Composition for cell proliferation
EP1396261A1 (en) * 2002-09-06 2004-03-10 Alcina Cosmetic, Dr. Kurt Wolff GmbH & Co.KG Skincare composition containing caffeine
EP1562423A2 (en) * 2002-10-31 2005-08-17 Eric F. Bernstein Compositions and methods for prevention of photoaging
EP1562423A4 (en) * 2002-10-31 2007-03-14 Eric F Bernstein Compositions and methods for prevention of photoaging
WO2007101493A1 (en) * 2006-03-07 2007-09-13 Henkel Ag & Co. Kgaa Cosmetic agents comprising purine and/or purine deratives ii
EP2465581A1 (en) * 2010-12-15 2012-06-20 Han-Min Chen Composition for promoting hair growth
FR2975595A1 (en) * 2011-05-24 2012-11-30 Oreal Cosmetic use of guanosine and/or its derivative to prevent an alteration of, and/or maintain the homeostasis of the skin

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