FR2609397A1 - Use of a substance or composition of carbohydrate nature as active principle of a dermatological and/or cosmetological and/or pharmaceutical and/or cell-stimulating composition, and composition containing such a substance or composition of carbohydrate nature - Google Patents

Abstract

The invention relates to the use of a substance or composition of carbohydrate nature as active principle of a dermatological and/or cosmetic and/or pharmaceutical and/or protective and/or structuring and/or bioenergising composition or composition increasing cell or tissue energy reserves. This substance of carbohydrate nature is preferably chosen from monosaccharide, glycoside and heteroside structures. An improvement in cosmetodynamic activity is obtained.

Description

Use of a substance or composition of a carbohydrate nature as active principle of a dermatological and / or cosmetological and / or pharmaceutical and / or cellular stimulant composition, and composition containing such a substance or composition of a carbohydrate nature.

 The present invention essentially relates to a use of a substance, and a composition of a carbohydrate nature as an active principle of a dermatological and / or cosmetic and / or pharmaceutical and / or cellular stimulant composition, and composition containing such a substance or composition of carbohydrate.

 More particularly, the invention relates to the use of a substance or composition of a carbohydrate nature of natural, animal, plant, micro-organic (bacteria, yeast, fungi), extractive or biotechnological or of biosynthetic origin, as principle. active ingredient of a dermatological and / or cosmetic and / or pharmaceutical and / or protective or and / or structuring and / or bioenergizing or increasing energetic reserve of cellular, cellular, tissue membranes composition.

 According to an advantageous embodiment of the invention, this substance or composition of carbohydrate nature is present alone or in combination with other substances of carbohydrate nature or in combination with other active principles, in particular of protein, oligo- or poly-peptide, amino acid or lipid, this association thus making it possible to improve and / or supplement their abovementioned activity.

 According to a particular embodiment, this substance or composition of a carbohydrate nature is incorporated in vesicles of the liposome type or in hydrated lipid lamellar phases.

 This carbohydrate type substance is, according to a preferred embodiment, chosen from osic, osidic and heterosidic structures.

The dares can be defined as follows o OSES
- Aldoses, in particular chosen from the group comprising
D-Glyceraldehyde, Threose, Erythrose, Lyxose, Xylose,
Arabinose, Ribose, Talose, Galactose, Idose, Gulose,
Mannose, Glucose, Altrose, Allose
- Ketoses, in particular chosen from the group comprising
Dihydroxyacetone, Erythrulose, Xylulose, Ribulose,
Ribose, Tagatose, Sorbose, Fructose, Allulose, as well
that their deoxy counterpart such as deoxyribose
- Glucosamine, Acetylglucosamine.

-Uronic acids, especially chosen from the group
including D-glucuronic acid, D-galacturonic,
D-mannuronic
- Complex bones, in particular chosen from the com group
taking ketodeoxyoctulosonic acid, mura acid
mique, neuramine.

The osides are advantageously chosen from
- Diholosides
Reducers like lactose, maltose, cello
biosis, gentiobiosis, melibiose,
non-reducing, such as sucrose, trehalose
- Triholosides, such as gentianose, raffi
nose, melezitosis
- Polysaccharides
It could be
a homopolyholoside, animal or micro plant
organic (bacteria, yeast, fungi)
Glucans (starch, glycogen, cellulose)
Galactans (sulfates / agar-agar, carrageenan, or
not sulfated)
Mannans (mucilages)
Fructosanes (inulin)
Arabanes
Xylanes
and their derivatives such as Chitin, Chitosans
a heteropolyholoside
Galactomannan
Hemicellulose
Erasers and mucilages
. a polyuronide
Vegetable or bacterial pectin
Alginic acid
Gum arabic
. acid mucopolysaccharides such as
chrondroitin sulfate, dermatan sulfate,
used free or associated with a polypepti part
dique in the form of acid proteoglycans, kera
tane sulfates, hyaluronic acid
Teichoic acid.

The heterosides will advantageously be chosen from
. Anthraquinone heterosides
. Coumarinated heterocyclic oxygen heterosides,
flavonics, anthocyanins (family of Compounds)
. tannins
. saponosides, in particular Liliaceae,
Caryophyllaceae,
. conjugates, glucoronic
glycolipids
These carbohydrate or carbohydrate substances may be used alone or in combination and incorporated into preparations of the cream, gel, lotion, milk or balm type to form dermatological and / or cosmetological and / or pharmaceutical compositions for reinforcing the bioenergetic cell or tissue potential. aiming, structuring, or aiming or tissue.

 These compositions can act in the direction of improving skin comfort, thanks to their hydrating, softening, softening and energizing effect.

 Another activity presented by these carbohydrates consists of an astringent, haemostatic, venous toning action, an anti-inflammatory action, protective cell or tissue.

 The use of simple oses or polysaccharides gives them a more specifically hydrating, nourishing action.

 We can add mucilage to them to give them a softening action.

In addition, the use of vegetable glucosides is particularly advantageous by conferring on them an anti-inflammatory, astringent, healing, venous or photoprotective action. The plant glucosides are advantageously chosen from the tannins of conifers, cupulifers,
Ericaceae, Labiatae, Legumes, Myrtaceae,
Polygonaceae, Rosaceae, Rubiaceae, various heterosides, flavonoids of Polygonaceae, Rutaceae, Legumes, Umbelliferae or Compositae.

 A coupling of the various carbohydrate-type substances makes it possible to obtain a superior cosmetic-dynamic action.

 The present invention also covers a composition, in particular a dermatological and / or cosmetic and / or pharmaceutical and / or cellular protective composition, characterized in that it contains at least one substance or composition of carbohydrate nature as defined above. The proportion of the substance of a carbohydrate nature is preferably from 0.01 to 20% by weight relative to the total weight of the composition.

 According to a particularly advantageous embodiment, the substance of the above-mentioned carbohydrate nature is incorporated in vesicles of the liposome type or in hydrated lipid lamellar phases, in particular at a proportion substantially equal by weight of the vesicles or lipid lamellar phases relative to the aqueous phase. This composition can be in the form of a cream, gel, lotion.

 A particularly interesting combination of carbohydrates is the combination of sucrose, dextrose, fructose.

 Other goals, characteristics and decisive advantages of the invention will appear clearly in the light of the explanatory description which will follow made with reference to various examples of dermatological and / or cosmetological and / or pharmaceutical and / or cellular protective compositions, given simply by way of illustration and which therefore cannot in any way limit the scope of the invention. In the examples, all the percentages are given by weight, unless otherwise indicated.

 In each case, phases A and B, previously heated to around 800C, are mixed and emulsified and then cooled.

 Finally, if necessary, the remaining phases are added.

EXAMPLE 1 Cream with Hydrating and Nourishing Aim
Phase A: PROPYLENE GLYCOL 5.00
PEG-100 3.00
SACCHAROSE 2.00
DEXTROSE 1.00
FRUCTOSE 2.50
CHONDROITINE SULFATE 0.50
METHYLPARABEN 0.50
DISTILLED WATER 66.50
Phase B: PARAFFIN OIL 11.00
GLYCERYL STEARATE 5.00
LIOLID LANOLIN 3.00
The mixing of these constituents is carried out in the usual manner.

EXAMPLE 2 Face gel
Phase A: GLYCOGENE 0.15
MANNITOL 0.50
COMPOUND EXTRACT 1.00
SORBITOL 0.30
CONSERVATIVE 0.20
DISTILLED WATER 82.35
GLYCERINE 2.00
* PEG 1500 8.00
Phase B: CARPOBOL R 5.00
TRIETHANOLAMINE 0.50 * PEG = Polyethylene glycol
Conventionally, with stirring, all the components are added in water (with the exception of carbopoR and then carbopolR for R is added to gel the solution.

EXAMPLE 3 Soothing Lotion
Phase A: EXTRACTS OF COMPOUNDS 2.50
LABIE EXTRACT 1.00
EXTRACT OF ROSACEOUS 1.00
GUAR GUM 1.00
METHYLPARABEN 0.30
GLYCERINE 2.50
DISTILLED WATER 91.55
Phase C: PERFUME 0.15
EXAMPLE 4 Nourishing Cream
Phase A: SACCHAROSE 2.50
DEXTROSE 1.80
FRUCTOSE 0.80
CHRONDROITINE SULFATE 0.01
METHYLPARABEN 0.20
DISTILLED WATER 69.34
Phase B: CHOLESTEROL 0.50
TWEEN 60 1.50
ISOPROPYLE MYRISTATE 5.00
SPAN 40 2.20
VASELINE 6.00
LANOLINE 10.00
Phase C: PERFUME 0.15
EXAMPLE 5 Hydrating cream
Phase A: GLYCOGENE 0.05
MANNITOL 0.20
METHYLPARABEN 0.10
PROPYLENE GLYCOL 2.50
DISTILLED WATER 69.50
PEG 100 5.00
Phase B: CHOLESTEROL 0.50
GLYCEROL AE STEARATE 5.00
VASELIN OIL 2.00
ISOPROPYLE MYRISTATE 15.00
Phase C: PERFUME 0.15
We can associate them with other active principles, of a protein, polypeptide, oligopeptide or amino acid nature in doses of 0.01 to 50%, which will complete their cosmetic dynamic activity.

 For example, in the area of wound healing, the addition of nutritional factors will have a beneficial effect.

EXAMPLE 6 Regenerating Cream
Phase A: COLLAGENE 5.00
GLUCOSE 5.00
DNA 0.20
L-LYSINE 0.10
L-ALANINE 2.55
GALACTOSE 1.50
METHYLPARABEN 0.15
DISTILLED WATER 47.85
Phase B: BRIJ 58 2.00
(polyethylene glycol cetyl ether)
PARAFFIN OIL 5.00
GLYCERINE 10.00
SPAN 60 2.50
PEG STEARATE 5.00
MIGLYOL 892 8.00
VASELINE 5.00
Phase C: PERFUME 0.15
EXAMPLE 7 Hydrating, nourishing, anti-inflammatory cream
Phase A: D-GLUCOSAMINE 0.25
GLUTAMIC ACID 0.10
D-GLUCOSE 1.00
GLYCOGENE 1.50
EXTRACT OF RUTACEES 1.00
METHYLPARABEN 0.20
DISTILLED WATER 64.30
Phase B: CARNAUBA WAX 3.50
LANOLINE 15.00
ISOPROPYLE MYRISTATE 10.00
ARLACEL C 3.00
Phase C: PERFUME 0.15
EXAMPLE 8 Softening cream
Phase A: L-LYSINE 0.30
L-CYSTEINE 0.25
COMPOUND EXTRACT 2.00
METHYLPARABEN 0.30
ADRAGANANT ERASER 1.00
PECTIN 2,00
DISTILLED WATER 74.95
PROPYLENE GLYCOL 5.00
Phase B: PARAFFIN OIL 10.00
GLARCEROL AE STEARATE 2.00
LIOLID LANOLIN 2.00
Phase C: PERFUME 0.20
EXAMPLE 9 Repairing gel
Phase A: HYALURONIC ACID 0.50
N-ACETYL GLUCOSAMINE 1.00
MUCILAGE 1.00
CHONDROITINE SULFATE 0.50
COLLAGEN 1.00
ELASTINE 0.50
METHYLPARABEN 0.30
DISTILLED WATER 84.00
Phase C: CARBOPOL 10, zoo
TRIETHANOLAMINE 1.00
Phase D: PERFUME 0.20
EXAMPLE 10 Hydrating Cream
Phase A: SUCROSE 2.00
DEXTROSE 3.00
OH-PROLINE 0.50
L-ALANINE 0.50
PROPYLENE GLYCOL 2.50
METHYLPARABEN 0.20
DISTILLED WATER 62.15
Phase B: CARNAUBA WAX 2.00
ISOPROPYLE MYRISTATE 25.00
PARAFFIN OIL 2.00
Phase C: PERFUME 0.15
These active ingredients used, alone or in combination, can be advantageously presented in liposomal form, according to the following technique
The active ingredients are prepared in the form of an aqueous solution. The liposome membrane will consist of
- phospholipids, of natural or synthetic origin
- phospholipids associated with glycerides
- cholesterol, natural
-'phospholipids associated with glycolipids
- lipoproteins associated with. cerebrosides
. sphinogolipids
. cephalins
. phospho-amino lipids
. cerebroglucosides
gangliosides
These two components are first dissolved in a volatile solvent, varying according to the type of phospholipids chosen, for example chloroform, methanol.

 The mixture is placed in a flask and then evaporated under reduced pressure in a rotary evaporator, until a film is formed on the walls of the flask.

 Then, with constant stirring, the aqueous solution of active ingredients to be encapsulated is added.

 The suspension obtained is fractionated with ultrasound in the form of microglobules or microspherules.

 A suspension of active liposomes is thus obtained.

 The encapsulation of the active ingredients leads to an optimization of their cosmetic-dynamic activity.

EXAMPLE 11
- Phospholipid phase
PHOSPHOLIPIDS 90.00
CHOLESTEROL 10.00
- Active aqueous phase
SACCHAROSE 2.50
DEXTROSE 1.80
FRUCTOSE 0.80
CHONDROITINE SULFATE 0.01
METHYLPARABEN 0.20
DISTILLED WATER qs 100.00
The preparation will be done according to the technique described above.

EXAMPLE 12
- Phospholipid phase
PHOSPHOLIPIDS 90.00
CHOLESTEROL 10.00
- Active aqueous phase
GLYCOGENE 6.00
MANNITOL 5.00
METHYLPARABEN 0.20
DISTILLED WATER qs 100.00
The preparation will be done according to the technique described above.

EXAMPLE 13
- Phospholipid phase
PHOSPHOLIPIDS 90.00
CHOLESTEROL 10.00
- Active aqueous phase
SACCHAROSE 2.00
DEXTROSE 3.00
OH-PROLINE 0.50
L-ALANINE 0.50
METHYLPARABEN 0.20
DISTILLED WATER qs 100.00
The preparation will be done according to the technique described above.

EXAMPLE 14
- Lipid phase
GLYCOSPHINGOLIPIDS 100
- Active aqueous phase
D-GLUCOSAMINE 0.25
L-ARGININE HYDROCHLORIDE 0.10
D-GLUCOSE 1.00
GLYCOGENE 1.50
EXTRACT OF RUTACEOUS + CARYOPHYLACEOUS 1.00
METHYLPARABEN 0.20
DISTILLED WATER qs 100.00 same preparation as in examples 11 to 13.

EXAMPLE 15
- Phospholipid phase
PHOSPHOLIPIDS 90
CHOLESTEROL 10
- Active aqueous phase
COLLAGEN 5.00
GLUCOSE 5.00
DNA 0.10
L-ALANINE 0.10
GALACTOSE 1.50
METHYLPARABEN 0.20
DISTILLED WATER qs 100.00 same preparation as in examples 11 to 13.

EXAMPLE 16
- Phospholipid phase
PHOSPHOLIPIDS 90
CHOLESTEROL 10
- Active aqueous phase
PLASMATIC AMINO ACIDS 1.00
SACCHAROSE 2.50
GUAR GUM 1.00
LABIE EXTRACT 1.00
EXTRACT OF ROSACEOUS 1.00
METHYLPARABEN 0.20
DISTILLED WATER qs 100.00 same preparation as in examples 11 to 15.

EXAMPLE 17
- Phospholipid phase
PHOSPHOLIPIDS 90
CHOLESTEROL 10
- Active aqueous phase
PLASMATIC POLYPEPTIDES 0.15
RIBOSE 0.50
COMPOUND EXTRACT 1.00
SORBITOL 0.30
METHYLPARABEN 0.20
DISTILLED WATER qs 100.00 same preparation as in examples II to 16.

EXAMPLE 18
- Phospholipid phase
PHOSPHOLIPIDS 90
CHOLESTEROL 10
- Active aqueous phase
FRUCTOSE 0.25
CHONDROITINE SULFATE 0.50
METHYLPARABEN 0.50
DISTILLED WATER qs 100.00 same preparation as in examples 11 to 17.

 It can be seen from the examples above 11 to 18 that, when the active principles are present in liposomal form, they may be incorporated into various cosmetic preparations of the gel, cream, lotion type, the active phase of which is approximately equal in weight to the phase phospholipid.

 Thanks to the incorporation in liposomal form, one obtains a superiority of the activity whether it is concerning the hydrating, softening, softening, energizing, anti-inflammatory, healing, astringent, hemostatic, venous toning, stimulating, cell protective activity.

 Naturally, the invention includes all the means constituting technical equivalents of the means described as well as their various combinations.

Claims (12)

 1. Use of a substance or composition of a carbohydrate nature of natural, animal, vegetable, micro-organic origin (bacteria, yeasts, fungi), extractive or biotechnological or of synthetic origin, as active ingredient of a dermatological composition and / or cosmetological and / or pharmaceutical and / or protective or bioenergizing, or increasing the energy reserves of living cells, living tissues or cell membranes.  2. Use according to claim 1, characterized in that the substance or composition is present alone or in combination with other substances of carbohydrate nature or in combination with other active ingredients, in particular of protein, oligo- or poly- peptide, amino acid or lipid, this combination thus making it possible to improve and / or supplement their abovementioned activity.  3. Use according to claim 1 or 2, characterized in that the substance or composition of carbohydrate nature is incorporated in vesicles of liposome type or in hydrated lipid lamellar phases.  4. Use according to one of claims 1 to 3, characterized in that the carbohydrate type substance is chosen from osic, osidic and hetero-oidic structures.  5. Use according to claim 4, characterized in that the dares are chosen from  - Aldoses, in particular chosen from the group comprising  D-Glyceraldehyde, Threose, Erythrose, Lyxose, Xylose,  Arabinose, Ribose, Talose, Galactose, Idose, Gulose,  Mannose, Glucose, Altrose, Allose  - Ketoses, in particular chosen from the group comprising  Dihydroxyacetone, Erythrulose, Xylulose, Ribulose,  Tagatose, Sorbose, Fructose, Allulose, as well as their  deoxy counterpart such as deoxyribose  - Glucosamine, Acetylglucosamine  - Uronic acids, in particular chosen from the group  including D-glucuronic acid, D-galacturonic,  D-mannuronic  - Complex bones, in particular chosen from the com group  taking ketodeoxyoctulosonic acid, mura acid  mique, neuramine.  6.Use according to any one of claims 1 to 5, characterized in that the substance or composition of the above-mentioned carbohydrate type is used in pairs, three to three, etc.  example, Glucocerebrosides or galactocerebrosides)  . glycolipids (Glyco and galactolipids by  glucuronic conjugates  or Caryophyllaceae,  . saponosides, especially Liliaceae  . tannins  flavonics, anthocyanins (family of Compounds)  . Coumarinated heterocyclic oxygen heterosides,  . Anthraquinone heterosides  - The heterosides are chosen from  acids, keratan sulfate, hyaluronic acid  polypeptide in the form of proteoglycans  used free or associated with a game  chrondroltine sulfate, dermatan sulfate,  . acid mucopolysaccharides such as  Gum arabic  Alginic acid  Vegetable or bacterial pectin  . a polyuronide  Erasers and mucilages  Galactomannan Hemicellulose  . a heteropolyholoside  and their derivatives such as Chitin, Chitosan  Xylanes  Arabanes  Fructosanes (inulin)  Mannans (mucilages)  not sulfated)  Galactans (sulfates / agar-agar, carrageenan, or  Glucans (starch, glycogen, cellulose)  organic (bacteria, yeast, fungi)  a homopolyholoside, animal or micro plant  - Polysaccharides  nose, melezitosis  - Triholosides, such as gentianose, raffi  . non-reducing, such as sucrose, trehalose  biosis, gentiobiosis, melibiose,  Reducers like lactose, maltose, cello  - Diholosides - The osides are chosen from  7. Use according to any one of claims 1 to 6, characterized in that the substance of the aforementioned glucidic nature is a vegetable glucoside, advantageously a tannin of Conifers, Cupulifers, Ericaceae, Labiatae, Legumes, Myrtaceae, Polygonaceae, Rutaceae, Legumes, Umbelliferae or Compositae.  8. Composition, in particular dermatological and / or cosmetic and / or pharmaceutical, characterized in that it contains at least one substance or composition of a carbohydrate nature as defined in any one of claims for use 1 to 7.  9. Composition according to claim 8, characterized in that the proportion of the substance of carbohydrate nature is from 0.01 to about 20% by weight relative to the total weight of the composition.  10. Composition according to one of claims 8 to 10, characterized in that the substance of carbohydrate nature is incorporated in vesicles of liposome type or in hydrated lipid lamellar phases, in particular at a substantially equal proportion by weight of the vesicles or lamellar phases lipid relative to the aqueous phase.  11. Composition according to one of claims 8 to 10, characterized in that it is in the form of a cream, gel, lotion, containing liposomes whose walls are phospholipids or glygolipids or a combination of the two.  12. Composition according to one of claims 8 to 11, characterized in that it comprises a combination of sucrose, dextrose and fructose.