FR2532841A1 - DENTAL CREAM - Google Patents

Abstract

DENTAL CREAM CONTAINING HYDROXYETHYL-CELLULOSE AS A GELIFYING AGENT. THE DENTAL CREAM HAS ADVANTAGEOUS RHEOLOGICAL CHARACTERISTICS SUCH AS SOFTNESS, GOOD "HOLD" ON A TOOTHBRUSH AND ABSENCE OF "TAIL" FORMATION WHEN GELING AGENTS, CARBOXY-METHYL-SODIUM ETHYLYDROX CARBOXY-CELLULOSE CELLULOSE, ARE PRESENT IN A WEIGHT RATIO OF ABOUT 3: 2 TO 2: 3, FOR EXAMPLE OF ABOUT 49:51 TO 2: 3. THESE ADVANTAGES SHALL BE PARTICULARLY APPEARING WHEN THE DENTAL CREAM CONTAINS A COMPOUND WHICH PROVIDES FLUOR, SUCH AS SODIUM MONOFLUOROPHOSPHATE OR A BINARY SYSTEM OF SODIUM MONOFLUOROPHOSPHATE AND SODIUM FLUORIDE, AND CALEMPHOSPHATE OF SODIUM AND SODIUM FLUORIDE, CALEMPHOSPHATE, EXPLE PHOSPHATE, EXPLE PHOSPHATE, PAREMPHOSPHATE, PAREMPHOSPHATE, EXAMPLE AGENT DICALCIC. SIMILAR ADVANTAGES COME WHEN THE GELING AGENT IS HIGH VISCOSITY HYDROXYETHYL-CELLULOSE, IN WHICH SODIUM CARBOXYMETHYL-CELLULOSE IS NOT REQUIRED. WHEN THE BINARY FLUORINE SYSTEM IS PRESENT, AND HYDRATED ALUMINA IS USED AS A POLISHING AGENT, HYDROXYETHYL-CELLULOSE OF HIGH VISCOSITY EFFECTIVELY REDUCES TAIL FORMATION WHEN DENTAL CREAM IS INTRODUCED INTO OR EXPULTED. A CONTAINER WITH A PRESSURE DIFFERENCE OR MECHANICALLY OPERATED, OR A DENTAL CREAM TUBE.

Description

-532841

  Sodium carboxymethylcellulose is generally employed as the commercial type gelling agent in dental creams because it is commercially available and

  it confers rheological properties generally

  satisfactory for dental creams, especially when

  these are manufactured and used in temperate climates.

  In tropical climates the dental cream can undergo a

decomposition by cellulase.

  It is observed that tooth creams formulated with many grades of sodium carboxymethylcellulose tend to take on a rough appearance (formation of lumps or soft blocks) even at room temperature, particularly when subjected to dynamic aging, c. that is, when a tube of cream is extracted from a tube

  2 cm long twice daily for two

  which simulates the normal use of a cream

me dental by one person.

  Even the qualities of sodium carboxymethylcellulose that do not become rough when subjected to

  dynamic aging can present other problems

  my rheological, for example bad qualities of yours ", that is to say that the ribbon of cream flattens quickly

  after expulsion, or thickens with time.

  It is interesting to note that the trend of

  dent to become rough when subjected to a

  dynamic aging is observed particularly when

  it contains a compound that provides fluorine and phospha-

  As a polishing agent, there is little problem when the fluoride comes from sodium monofluorophosphate or from a mixture of sodium monofluorophosphate and

  sodium fluoride and that the polishing agent is a

  However, the problem is obvious when

  the fluorine comes from sodium monofluorophosphate or a

  sodium monofluorophosphate and sodium fluoride

  dium in a dental cream containing at least about 35%

  by weight of a calcium phosphate serving as a polishing substance

  health, such as dicalcium phosphate.

  Attempts to overcome the problem of roughness

  without causing other problems such as a bad "hand-

  "mix" with different grades of carbox-

  sodium methylcellulose or by mixing carboxymethyl-

  sodium cellulose with other gelling agents such as

  synthetic mineral silicic clay (for example

  products available under the trademarks "Laponite" and "Veegum"), thickeners such as silica-based thickeners supplied by Huber under the trademark "Zeosyl" under the name Zeosyl 200 and by Rhone Poulenc under the name of Tixosil and under the name of Tixosil 33 J or provided by Wacker

  under the designation "HDK N 20", and a substance in phase

  such as polyethylene glycol 600, have not

proved satisfactory.

  Hydroxyethyl cellulose has been proposed as a general agent

  lifiant replacement of carboxymethyl cellulose

  dium, and it is a fact that qualities of hydroxyethyl-cel-

  such as Natrosol M have been used in

  my dental trade, and qualities have been described, for example in US Patents 3,862,307 (Natrosol G) and 3,070,510 (viscosity of 75125 m Pa s-Brookfield, 20 C, 2% in water) and 4,022,881 (Natrosol 250 H, a high viscosity substance). These qualities of hydroxyethylcellulose, although

  that they are generally satisfactory, may have

  to provoke a rheology of extension of dental creams.

  res by forming a visible "tail" during the filling of the

  container and during extrusion on a toothbrush.

  For example, U.S. Patent 4,022,881 has described the "fibrous character" of toothpastes containing a thickening mixture.

  30% hydroxyethyl cellulose and 70% carboxymethyl

  sodium cellulose A non-fibrous toothpaste

  calcium carbonate as an abrasive with a mixture of

  10% hydroxyethyl cellulose thickener and 90%

  sodium boxymethylcellulose has also been described.

  According to embodiments of the present invention,

  a mixture of gelling agents is provided which

  low susceptibility to roughness during aging

  and other rheological properties such as a good "hold", the absence of a "tail" on a ribbon expelled from dental cream and a beautiful shiny ribbon. dental can be

  easily made with this mixture without significant modification

  of the procedures used when carboxymethyl-

  sodium cellulose is the only gelling agent The substance

  gelling agent with which it is advantageous to mix the car-

  sodium boxymethylcellulose in a weight ratio of

  particular is hydroxyethyl cellulose This substance

  also, although generally good, did not give full

  the rheological point of view when it was

  alone or mixed with thickening substances or

  gelling agents other than sodium carboxymethylcellulose.

  Indeed, dental creams containing hydrophilic qualities

  such as Natrosol 250 'M, phosphate di-

  calcium and a compound that provides fluorine exhibit "tail formation" and / or "poor"

  Such qualities as Natrosol 250M are the only gel agent

  or are present with the starboxymethylcellulose

  dium in a weight ratio of sodium carboxymethyl cellulose to hydroxyethyl cellulose (Natrosol 250 M and pror

  related products) of less than about 2: 3, for example

1:10 and 3: 7 -

  In U.S. Patent 4,022,881 of the previous literature,

  mentioned above, a toothpaste is described which

  as a thickening agent of 5 to 30% hydroxyethylcellulose

  high viscosity lulose (eg Natrosol 250 H) and 95% sodium carboxymethyl cellulose for protection

  sodium carboxymethyl cellulose against degradation.

  However, these relative quantities (for example 10: 1 and 7: 3) are not satisfactory in that they do not make it possible to avoid the surface roughness, which is eliminated by the

present invention.

  This is an advantage of the modes of implementation of the pre-

  invention to provide a system of gelling agents for

  a dental cream that stays smooth during an aging

  dynamically and has other Theological properties

generally advantageous.

  It is a particular advantage of the embodiments of the present invention to prevent the formation of a tail of dental cream and to improve the maintenance of this cream.

  even when hydroxyethyl cellulose predominates in the system

  This advantage can be particularly

  obvious when the dental cream is introduced into or expelled from a pressure differential container or

  mechanical work or a tube for dental cream, especially

  especially with hydrated alumina as a polishing agent.

  The improved benefits can be met with a

  mixture of carboxymethylcellulose gelling agents of

  dium and hydroxydthylcellulose in a particular weight ratio, or when the hydroxyethylcellulose has a

  viscosity, without the presence of carboxymethyl-cellulose

sodium lulose is necessary.

  Additional advantages of the modes of implementation

  of the present invention are provided in creams of

  containing a source of fluorine, for example a binary source of fluorine from sodium monofluorophosphate and sodium fluoride, and a polishing agent comprising a

calcium phosphate.

  Other benefits will become apparent at the sight of

following description.

  According to some of its modes of implementation, the pre-

  This invention relates to a dental cream comprising a

  dental port consisting of about 20 to 80 per cent by weight

  weight of the dental cream of a liquid phase containing

  water, by wetting, or a mixture of both, and about 0.5 to 5 wt% by weight of the weight of the

  dental cream of a gelling agent containing carboxy-

  sodium methylcellulose and hydroxyethylcellulose, each in a weight ratio of about 3: 2 to 2: 3 relative to the other. Previous numerical references

  as regards the viscosity in the present description

  refer to measured viscosities with a viscometer

  Brookfield in a 2% by weight aqueous solution at 25 ° C.

  According to some others of its modes of implementation,

  the present invention relates to a dental cream such as

  is described in the preceding paragraph, characterized in that the dental cream contains a compound which provides at least about 100 ppm of fluorine and about 40 to 75% of

  weight of a water-insoluble, non-toxic, polishing agent

  that, and acceptable from a dental point of view, containing a quantity of calcium phosphate that is at least about

% by weight of the dental cream.

  The gelling agent is present in the dental cream in an amount of about 0.5-5% by weight, preferably about 0.8-2%, and more preferably about 0.9-1.1%, the ratio of the sodium carboxymethylcellulose with hydroxyethylcellulose being from about 3: 2 to about 2: 3, typically about 1: 1, and preferably less than about 1: 1, and

  2: 3 (for example 49:51, 9:11 or 2: 3).

  Sodium carboxymethyl cellulose is commercially available from Hercules under the designations CC-7 MXF

  and 7 MFDs, which are the preferred qualities in the implementation of

  of the present invention The qualities may have a

  degree of polymerisation in the vicinity of 500, which

  corresponds to a molecular weight in the vicinity of 100,000.

  The viscosity has medium to high values, for example about 300 to 3,000 m Pa S or more, typically about 300-1200 m Pa S preferably about 300-500 m Pa s

  (Brookfield, 2%, 25 C) The CMC-7 MXF contains about 0.7

  sodium carboxymethyl per unit of anhydro-glucose.

  The following table illustrates the qualities of carboxymethyl

  Sodium thyl cellulose (C 1 M) advantageous and available

  (when the viscosity is measured on a screw

  meter other than Brookfield in a 2% by weight aqueous solution at 25 ° C, the differences are shown):

TABLE 1

SUPPLIER QUALITY VISCOSITY

  Hercules 7? MXF 300-500 Tt 7 MFD 300-500 "Tt 9 b M 31 F 900-1200

"9 M 31 XF 900-1200

"12, 131 XF 900-1200

"7 F 300-500

"'O 12 M 31 PD 900-1200

  "n 7 M 8 SXF 200-800 Wolff Walsrode Walocel CRT 1000

-PA 07 700-1200

  Nyma Nymcel ZM Fo 33 * 50-80 Enka Akucell AC 1642 * 80-120 T "Akucell AC 1632 * 60-120 Cros Cellogen HP-SA 700-900 Uddeholm Cekol MVEP 500-800 Hoechst Tylose CB 200 ** 120-260 * solution at 1 o (Brookfield, 25 C) ** Hoeppler viscometer (2 S, 20 C) Hydroxyethyl cellulose is commercially available, supplied by Hercules under the name Natrosol 250 M which is a preferred quality in the setting The qualities can have a degree of polymerization close to 750, which corresponds to a molecular weight in the region of 190 000. The viscosity has medium to high values, for example approximately 3000 to 12000 m Pa. S or more, typically about 3000-7000 m Pa S and preferably about 4500-6500 m Pa S (Brookfield, 2%; C) When the viscosity is measured on a viscometer other than Brookfield in a 2% by weight aqueous solution at 25 ° C.,

the different ones are indicated.

  The following table illustrates the qualities of hydroxyethyl-

  cellulose (HEC) advantageous and commercially available

TABLE 2

SUPPLIER QUALITY VISCOSITY

  HEC Hercules Natrosol 250 M and 4500-6500 MR "Natrosol 250 HR * 15002500 and 250 H *" Natrosol 250 HHR * 3400-5000 and 250 HH BP Chemicals Cellobond 5000 A 4200 = 5600 t '"Cellobond 7000 A 6000-7000 Hoechst Tylose H 4000 P ** 3000-5000 "Tylose HL OOOOP ** 7000-12 o 000 * 1% solution (Brookfield; 25 C) ** Hoeppler viscometer (2%; 20 OC)

  Sodium carboxymethyl cellulose and hydroxyethyl

  cellulose can be mixed together mechanically before being mixed with the liquid phase of the vehicle of the dental cream or can be mixed separately with the liquid phase. The rheological advantages of the present invention are evident when the dental cream contains a compound which

  provides at least about 100 ppm of fluorine, typically

  about 100-10000 ppm, specifically about 750-

  2000 ppm Among the compounds that provide fluoride are

  sodium fluoride, stannous fluoride, fluorine

  of potassium, potassium stannofluoride, hexafluoro-

  sodium stannate, stannous chlorofluoride and mono-

  Sodium fluorophosphate More typically according to the present invention, sodium monofluorophosphate or a mixture of sodium monofluorophosphate and

  Sodium fluoride The rheological advantages are also

  evident when a polishing agent of the phosphate type

  Calcium, in particular dicalcium phosphate, is

  in an amount of at least about 35% by weight of the cream.

me dental.

  Characteristically, this dental cream con-

  about 35-75% by weight, preferably about 40-55%, of a dental-acceptable water-insoluble polishing substance which consists essentially of a calcium phosphate, such as dicalcium phosphate its dihydrate form or its anhydrous form, or mixtures of

  two in any desired ratio, trical phosphate

  and calcium pyrophosphate.

  dicalcium phosphate, usually in its dihy-

  Characteristically, dicalcium phosphate is the only polishing agent employed, but if desired secondary amounts (e.g., up to about 5% by weight of the dental cream and up to about 12% by weight).

  total polishing substance) other polishing agents

  insoluble in water acceptable from the point of view of

  and which does not hinder the improvement of the hy-

  oral composition by the composition of the present invention can

  Characteristic polishing agents are alumina, silica, sodium aluminosilicate and so on. A small amount of hydrated alumina (e.g.

  1%) also inhibits or even eliminates the trend that

  dental creams to separate or to form veins

"in their tubes.

  Characteristically, the dental cream contains

  sodium monofluorophosphate or a mixture of monofluoro-

  sodium phosphate and sodium fluoride in a quantity

  which provides about 100-10000 ppm of fluorine, for example

  750-2000 ppm, more particularly about 1400-2000, for example about 1400-1670 ppm. A binary system of fluorine of sodium monofluorophosphate and sodium fluoride is advantageously used in which about 30-40% of the fluorine (e.g. 30-35%, ie about 300-580 ppm) is derived from sodium fluoride The agent mixing system

  gelling agents is particularly advantageous as a

  gelling of dental creams containing the mixture bi = -

  fluorine and the dicalcium phosphate polishing agent disclosed in British Patent Specification No. 20 68 727 A (Patent Application

  79/43642), the description of which is incorporated herein by way of

  Thus, in a typical dental cream, the mono-

  Sodium fluorophosphate is typically used

  tick in the binary system in such quantity as it provides

  about 700-1090 ppm of fluoride to the dental cream in which

  the the total amount of fluorine is about 1000-1670 ppm

  with about 30-35% by weight of the total fluorine

  sodium (approximately 300 = 580 ppm) This corresponds to approxi-

  0.5-1.2% by weight of sodium monofluorophate and about 5% by weight of sodium fluoride. Preferably, this dental cream contains about 1000-1500 ppm, of pre =

  about 950-1000 ppm of fluorine from monofluoro-

  sodium phosphate and about 450 = 500 ppm from fluorine

sodium chloride.

  Sodium monofluorophosphate, Na 2 PO 3 P, as found commercially 2 can vary considerably in purity. It can be used with any purity as long as the impurities deny substantially no effect.

  on the desired properties In general, it is advantageous

  that the purity is at least 80% For best results, it should be at least 85%, and preferably at least 90% by weight of sodium monofluorophosphate, the remainder being mainly impurities or sub- manufacturing products such as sodium fluoride and phosphate

  In other words, the mono-

  sodium fluorophosphate used must have a total

  fluorine content greater than 12 F, preferably greater than 12.7%, a free sodium fluoride content not exceeding

  not 1.5%, preferably not more than 1.2%; and a

  sodium monofluorophosphate of at least 12%,

  preferably at least 12.1%, all calculated in fluorine.

  As indicated previously, fluoride

  dium of the binary mixture is a compound containing fluorine

  distinct from sodium monofluorophosphate.

  Viron 300-580 ppm of fluoride from the dental cream come from

sodium fluoride.

  According to some additional embodiments of the present invention, the latter relates to a cream

  approximately 20-75% of a polystyrene

  wise, at least about half of which is a hydrated alumina

  and a dental support comprising about 20-80% by weight based on the weight of the dental cream of a liquid phase containing water, a humectant, or a mixture of both, and about 0.05-5% in weight by weight

  of the dental cream of a gelling agent consisting essentially of

  hydroxyethylcellulose having a viscosity in a range averaging at least about 24000 m Pa s,

  determined on a Brookfield viscometer at 20 C, in a

  water-glycerin solution (1: 1,56) with a rotating Na 6 needle

at 20 rpm.

  The gelling agent of this mode of implementation of the

  The present invention is present in the dental cream in

  about 0.5-5% by weight, preferably about 0.8-

  2%, and more preferably around 0.9-1.4%.

  of hydroxyethyl cellulose effective in the implementation of

  practice of the present invention is Tylose Hl OOOOP, which is

  Denied by Farbwerke Hoechst from Frankfurt on the Main R F A.

  According to some additional modes of implementation

  of the present invention, the latter relates to a

  dental apparatus comprising a fluorine binary source consisting of a mixture of sodium monofluorophosphate and sodium fl uoride, wherein about 30-40% by weight of the fluorine comes from said sodium fluoride in an amount sufficient to provide about 750-2000 total ppm about 35-75% by weight of a polishing agent consisting essentially of

  calcium phosphate and a dental support

  holding about 20-80% by weight based on the weight of the

  cream of a liquid phase containing water, a human

  midifier, or a mixture of both, and about 0.5-5% by weight

  relative to the weight of the dental cream of a gel agent

  essentially consisting of hydroxyethyl cellulose having a high viscosity in a range whose average

  is at least about 24000 m Pa s, determined on a viscomè-

  Brookfield in a solution of water and glycerin (1: 1,56)

  at 20 ° C. with an N 6 needle rotating at 20 rpm.

  The binary sources of fluorine are described above.

  The gelling agent of this embodiment of the present invention

  The invention is present in the dental cream in an amount of

  0.5-5% by weight, preferably about 0.8-2%, and more preferably about 0.9-1.1%. Tylose H 1 OOOOP is a typical quality of hydroxyethylcellulose effective in the setting

  in practice of the present invention.

  Tylose H 100 000 P and other hydroxyethyl

cellulose according to the present invention have viscosities

  killed in a range averaging at least about 24000 m Pa S determined on a Brookfield viscometer at 20 CP in a solution of water and glycerin (1: 1.56) with an N 6 needle rotating at 20 rpm The values thus expressed differ from the values determined differently and presented

  previously described in the description

  high viscosity ethyl cellulose which can be used

  in these modes of implementation of the present invention.

  are presented in the following table:

BOARD

SUPPLIER QUALITY HEC VISCOSITE

  Hercules Natrosol 250 HR and 250 H 17000-31000 Natrasol 250 HHR and 250 HH 37000-41000 Hoechst Tylose H 1 OOOOP 20000-30000 Hydroxyethylcellulose grades whose viscosity does not reach an average of about 24000 m Pa s , as

  Hercules 250 M and MR (average viscosity of 15500 m Pa s) and Ty-

  lose H 4000 P from Hoechst (viscosity up to 23000 m Pa s)

  do not provide the desired rheology when they are used

  as the sole gelling agent.

  In the embodiment of the present invention wherein the dental cream contains about 20-75% by weight of a polishing agent of which at least half is hydrated alumina, if desired, almost half all of the polishing agent may be a further dental compliant polishing material, such as silica, dicalcium phosphate, calcined alumina,

  zirconium silicate, insoluble sodium metaphosphate

  Preferably, there is about 40-55% polishing substance, typically only hydrated alumina. The hydrated alumina used according to the present invention

  is preferably of small particle size, i.e.

  say that at least about 85% of the particles are less than 20 microns, such as the particles of this designated alumina

  under the name of gibbsite (alpha alumina trihydrate) and normal

  Chemically represented by A 1203 3H20 or Al (OH) 3.

  The alpha alumina trihydrate should have a size between about 2.6 and 10 microns The alumina trihydrate alumina sold by Alcoa under the designation C 333 is a

  gibbsite of good quality and is particularly advantageous.

  The average particle size of C 333 alumina is approximately

  7-9 micron (Coulter-Counter) It is finely ground by the quality of alumina trihydrate sold by Alcoa under the

  designation C 330 Other qualities of hydrated alumina

  to be used include AF 260 and AF 230 sold by

  the British Aluminum Company and SH 100 sold by Rhône-Pou-

  The dental cream containing hydrated alumina is typically packaged in a container from which it can be easily expelled, as a dispenser.

  denture cream with differential pressure or implemented

  canically either a doubled or unlined aluminum tube or a lead tube or a laminated tube The rheolo =

  are particularly desirable when using

  is a dispensing container mechanically implemented

  type described in British Patent Application 2,070,695 A,

  September 9, 1981 This dispensing container includes a dispensing tip, a tie rod, a piston, and a control

  order manual The description of this patent application

  The present invention is incorporated herein by reference. The dispensing container has a pressure differential

  can Jet of the aerosol or vacuum type.

  The dental cream with hydrated alumina may contain a compound that provides a fluoride or binary sources of

  fluorine, as previously described.

  Dental cream with calcium phosphate contains

  typically about 35-75% by weight, preferably

  40-55%, of an insoluble polishing

  water, acceptable from the dental point of view, which is essential

  calcium phosphate, such as phosphorus

  dicalcium phatee in dihydrate or anhydrous form or

  both of them in any desired ratio, the phos-

  tricalcium phate and calcium pyrophosphate Dicalcium phosphate is generally used in general

  in its dihydrate form Typically, phosphorus

  dicalcium phate is the only polishing agent, but if one

  desires, secondary quantities (eg until

  3% by weight of the dental cream and up to about 12% by weight of the total polishing substance) other water-insoluble polishing agents acceptable from the dental point of view, and which hardly interfere with the power of the composition of the present invention

  to improve oral hygiene, may be present

  Characteristic polishing agents are alumina, silica,

  1 sodium aluminosilicate, etc. A small amount of aluminum

  hydrated mine (eg about 1 ro) also inhibits or even eliminates the tendency of some creams to separate

  or to form "veinlets" in their tubes.

  In dental cream formulations the dental vehicle comprises a liquid phase in proportion to the

  gelling agents so as to form a creamy mass which can be expelled of desirable consistency.

  dental cream mainly include water, glycerin, sorbitol, polyethylene glycol 400, propylene glycol, or related compounds, including

  appropriate mixtures of these products. It is generally

  to use a mixture of both water and

  or a binder such as glycerin or sorbitol; of

  typically about 10-30% by weight of water and

  15-50 wt% of wetting agent Glycerol or sorbitol is preferred. The total liquid content is

  generally about 20 to 80 gb by weight of the formulation.

  Any suitable surfactant or detergent

  may be included in dental cream compositions.

  These compatible substances are advantageous in that they

  confers detergent, foaming and antibacterial properties

  supplementary substances according to the specific type of substance

  surfactants and are selected in the same way.

  In general, these compounds are water-soluble compounds and can be of anionic, nonionic or cationic structure.

  usually prefers to use hyaline organic detergents

  non-soap or synthetic drosoluble substances.

  appropriate tersives are known and include, for example,

  the water-soluble salts of mono-monosulfate detergent

  higher fatty acid ceride (eg, coconut fatty acid monoglyceride sodium monosulfate), higher alkyl sulphate (eg sodium lauryl sulphate), alkyl aryl sulphonate (e.g., dodecyl benzene sulphonate

  sodium, a higher fatty acid ester sulfonate of 1,2-

  dihydroxypropane) and related compounds Other surfactants include acylamides

  higher saturated aliphatics of amino acids

  lower aliphatic carboxylic acids, such as those having from 12 to 16 carbon atoms in the acyl radical

  The amino acid is generally derived from monoaminocarboxylic acids.

  Aliphatic saturated liquefied acids having from about 2 to 6 carbons, generally monocarboxylic acids. Suitable compounds are glycine fatty acid amides, sarcosine, alaeine, 3-aminopropanoic acid and the like.

  valine, having from about 12 to 16 carbons in the acyl group.

  However, it is preferred to use N-lauroyl, myristoyl and palmate

  mitoyl sarcosides, for maximum effects.

  The amide can be used in the form of the free acid or preferably in the form of its water-soluble salts,

  such as the alkali metal, ammonium, amine and

  canolamine Specific examples of these products are the N-lauroyl, myristoyl and palmitoyl sarcosides of sodium and

  potassium, N-lauroyl glycide and N-lauroyl alanine from am-

  monium and ethanolamireo For convenience here, the terms' tacit

  "aminocarboxylic acid", "sarcoside" and related terms

  compounds such as these having a carboxylic group

  that free or water soluble carboxylates

  These substances are used pure or practically

  They should be as free as possible of soap or similar higher fatty acid which tend to reduce the activity of these compounds In practice

  usual, the amount of these higher fatty acids is

  less than 15% by weight of the amide and is insufficient to have a truly deleterious effect on this activity, and

  preferably it is less than about 10% of said amide.

  Various other substances can be incorporated into the dental creams of the present invention. Examples of such substances include coloring or bleaching agents, preservatives, stabilizers, tetrasodium pyrophosphate, silicones, chlorophyll compounds, and the like. Axmmonium compounds such as urea, diammonium phosphate and mixtures thereof. These adjuvants are incorporated in the present compositions in amounts which do not have any truly deleterious effects on the desired properties and characteristics, and are chosen so

  appropriate and used in conventional quantities.

  In some cases, it may be advantageous to include

  antibacterial agents in the compositions of the present invention.

  As characteristic antibacterial agents which can be used in amounts of from about 0.01% to about 5%, preferably from about 0.05% to about 1.0%, by weight of the dentifrice composition, mention may be made of: N 1-4 (chlorobenzyl) -N 5- (2,4-dichlorobenzyl) biguanide; p-chlorophenyl biguanide; 4-chlorobenzhydrylbiguanide; 4chlorobenzhydrylguanylurea N-3-lauroxypropyl-N 5-pchlorobenzylbiguanide; 1,6-di-p-chlorophenylbiguanidehexane;

  1- (lauryldimethylammonium) -8-p-chlorobenzyl dichloride

  dimethylammonium) octane; 5,6-dichloro-2-guanidinobenzimidazole; Nlp-chlorophenyl-N 5-laurylbiguanide; 5-amino-1,3-bis (2-ethylhexyl) -5-methylhexahydropyrimidine;

  and their addition salts with a non-toxic acid.

  Any flavoring or sweetening substances

  The following are examples of suitable flavoring components that may be mentioned: flavored oils, for example spearmint, peppermint, wintergreen, sassafras, peppermint oils and the like. clove, sage, eucalyptus, marjoram, cinnamon, lemon and orange, as well as methyl salicylate Suitable sweetening agents include sucrose, lactose,

  maltose, sorbitol, sodium cyclamate, dipepti-

  sodium saccharin of U.S. Patent No. 3,939,261 and

  oxathiazine salts of US Pat. No. 3,932,606.

  appropriate, the perfume and the sweetening agent may

  seems to be about 0.01 to 5% or more of the composition.

  tion. Dental creams must have a p H that allows their use An interval of p H ranging from 5 to 9 is

  particularly advantageous when the simple polishing agent

  If p is hydrated alumina, the pH may vary from 3 to 10.5.

  The p H we are talking about is supposed to be the p H determined directly-

  on toothpastes. If desired, it is possible to add

  substances such as benzoic acid or the acid

  to adjust the p H between, for example, 5.5 and 6.5 in

  general, or for example between 4 and 7.5 for dental creams.

res with hydrated alumina.

  The dental cream is typically packaged

  in a tube allowing its expulsion, as usually lined or unlined aluminum or lead tubes, or rolled tubes, and in particular in the case of a cream

  with hydrated alumina, in mechanical dispensers

picnics.

  The following examples illustrate in more detail the

  of the present invention, but it is understood that they do not limit it. The compositions are prepared in a conventional manner and all the amounts of the various ingredients are

  data by weight, unless otherwise indicated.

  EXAMPLE 1-3 MIXTURE OF GELIFYING AGENTS-CALCIUM PHOSPHATE

  SINGLE SOURCES AND B FLUORINE

EOEMPLE 1

  The following dental creams are prepared by a conventional dental tooth formulation technique with

  sodium carboxymethylcellulose and hydroethylethylcellulose

  separately added to a prem 6 mixture of glycerin and water.

  The whole is introduced into aluminum tubes for dental cream and dynamically aged by extrusion of a tape 2 cm long of dental cream, twice a day,

  five days a week for two weeks.

PARTS

A B

  Glycerine 22.00 22.00 Sodium carboxymethylcellulose (7 MFD Hercules) 0.44 0.45 Hydroxyethylcellulose (250 M Natrosol Hercules) 0, 46 0.50 Dicalcium phosphate dihydrate 48.00 48.00 Sodium lauryl sulfate 1.50 1.50 Sodium saccharin 0.20 0.20 Sodium monofluorophosphate 0.76 0.76 Sodium fluoride 0.10 0.10 Scent 0.90 0.90 Deionized water qs 100 qs 100 o After aging dynamic for two weeks,

  the surfaces of dental creams are smooth and rheological-

  The creams do not form a tail when

  are expelled from the tube and hold well on the

toothbrushes.

  Similar rheological effects are obtained for a weight ratio of sodium carboxymethylcellulose to

hydroxyethyl cellulose of 3: 2.

  When the formulas are modified so that the weight ratio of sodium carboxymethylcellulose is greater than 3: 2 (7: 3 and 10: 1) a roughness of

  the surface after dynamic aging; when the carbo

  sodium xymethylcellulose is only present as gelling agent (0, 90 parts), the surface may become lumpy

  after two weeks of dynamic aging.

  When the ratio of the amounts of carboxymethyl cellulose

  lose of sodium and hydroxyethyl cellulose is less than 2: 3, dental creams do not hold well but

  quickly form flattened ribbons Also when 1 ex-

  drive is over, the ribbons form queues.

  tail formation is also evident when hydroxyethyl-

  cellulose is the only gelling agent.

EXAMPLE 2

  The dental cream A of Example 1 is modified from

  to use 0.36 parts of sodium carboxymethylcellulose and 0.54 parts of hydroxyethylcellulose.

  is smooth, the dental cream does not form a tail and

hold well.

EXAMPLE 3

  The dental cream A of Example 1 is modified from

  to use 0.45 parts of sodium carboxymethylcellulose (7 MFD of Hercules) and 0.45 parts of hydroxyethyl = cellulose (250 M Hercules) The surface is smooth, the dental cream does not form a tail and A similar advantageous rheology is observed when the dental cream A of Example 1 is modified so as to employ 0.50 parts of sodium carboxymethylcellulose (7 MF of Hercules) and 0.50 parts of hydroxyethyl Cellulose (250 mg of Hercules) with 0.25 parts of trasodium pyrophosphate is also present. Effects similar to those described in Examples 1-3 are obtained when other quality grades are used.

  sodium carboxymethylcellulose (for example 7 MXF from Hercu-

  the Walocel CRT 1000 Pa A 107 by Wolff Walsrode, Nymcel X> Fo 33

  Nyma and Akucel AC 1632 from Enka) and hydroxyethylcellulose

  se (eg Natrosol 250 HR and Natrosol 250 HHR from Her-

  cules and Tylose H 4000 P from Hoechst).

  Effects analogous to those described in Examples 1-3 are obtained when 1.15 parts of monofluorophosphate

  of sodium are present and that sodium fluoride is omitted.

  EXAMPLE 4 HYDROXYETHYL CELLULOSE WITH HIGH VISCOSITY-ALUMINA

  HYDRATEE-NO FLUORIDES AND BINARY FLUORINE SOURCES

  The following dental creams are prepared by a

  classic technique for the formulation of dental cream

  my teeth A and B are introduced into the dispenser

  The dental cream C is introduced into an unlined aluminum dental cream tube and the dental cream D is introduced into a doubled cream tube. dental aluminum

PARTS

A B

  Sorbitol (70% solution) 23,000 23,000 Glycerine Hydroxyethylcellulose (250 M Natrosol from Hercules) 1,00 Hydroxyethylcellulose (Tylose H 10,000 P from Hoechst) 1,00 Alpha alumina trihydrate (Alcoa C 333) 52,000 52,000 Alcohol Cf C 18) Na sulfate (100% AI) 0.5 0.5 Zinc sulphate 7 H 20 Aluminum sulphate 18 H 20 Sodium saccharin 0.17 0.17 Methyl hydroxybenzoate 0.08 0.08 Sodium monofluorophosphate , 76 0, 76 Sodium fluoride 0.10 0.10 Pyridyl carbinol 0.10 0.10 Allantoi: ne 0.15 0.15 Perfume 1.20 1.20 CD

23,000

20

1.30 1.00

52,000 52, 000

1.5 0.48 0.20 0.08 0.15 1.00 1.5

O 0.78

  O, 17 1.20 PARTS (continued) Phosphoric acid (85%) Deionized water 0.14 q s p. 0.14 q O s p q s po qo S opo During filling and after extrusion the surfaces of dental creams A, C and D are smooth and rheologically

  nice, while cream B undergoes a rheology of exten-

  During the filling and expulsion out of the container rheological effects similar to those presented by dental creams A, C and D are obtained when the Tylose H OOOOP dental creams A, C and D is replaced by Natrosol 250 H and Natrosol 250 HH The formation of a

  tail occurs when the dental cream B (with the Natro-

  250 M soil) is introduced into a tube for dental cream.

  EXAMPLE 5 HYDROXYETHYL-CELLULOSE WITH HIGH VISCOSITY-PHOSPHATE

  OF CALCIUM-FLUORINE BINARY SOURCES

  The following dental cream is prepared by a technique

  than conventional dental cream formulation, placed in

  a tube for aluminum dental cream and expelled in ex-

  pulsing a ribbon of cream twice a day, five days a week for two weeks: Glycerine Hydroxyethylcellulose viscosity 2000030000 (Hoechst's Tylose Hl OOOOP) Dicalcium phosphate dihydrate Sodium lauryl sulphate Sodium saccharine Sodium monofluorophosphate Sodium fluoride Perfume Deionized water

PARTS

22.00 1.00

48.00 -

  1.50 0.20 0.76 O, 10 O, 90 q s p 100 The dental cream does not form a tail after expulsion

and is rheologically pleasant.

  Rheology is also nice when Tylose

  H 1 OOOOP is replaced by Natrosol 250 H and by Natrosol

sol 25 OHH.

  When hydroxyethyl cellulose grades of

  weaker costies such as Natrosol 250 M (Hercules) and Tylose H 400 OP replace Tylose 1000 P, a tail is

  form after extrusion of the dental cream.

  Although the present invention has been illustrated by

  specific examples and some variations of these examples.

  ples, it will become clear to the skilled person that various

  changes may be made which are part of the

of the present invention.

The

-Z 532841

R EV E N DI C A T IO N S

  1 Dental cream comprising a dental vehicle con-

  of about 20 to 80% by weight based on the weight of the dental cream of a liquid phase containing water, a humectant, or a mixture of both, and about 0.5-5% by weight.

  weight relative to the weight of the dental cream of a general

  containing sodium carboxymethylcellulose and hydroxyethylcellulose, each of which is present in a

  weighted from about 3: 2 to 2: 3 relative to each other.

  2 Dental cream comprising a dental vehicle con-

  of about 20 to 80% by weight based on the weight of the dental cream of a liquid phase containing water, a hovering agent, or a mixture of both, and about 0.5 = 5% by weight

  the weight of the dental cream of a gel agent

  containing sodium carboxymethylcellulose and hydroxyethylcellulose in a weight ratio of 49:51

at 2: 3.

  3 dental cream according to one of claims 1 or

  2 wherein there is present a compound which provides at least about 100 ppm of fluorine, and said dental cream also contains about 40-75% by weight of a polishing agent

  insoluble in water acceptable from the dental point of view

  holding a calcium phosphate in an amount of at least about 1% by weight of said dental cream

  Dental cream according to claim 3, in which

  about 750-2000 ppm of ionic fluorine comes from a fluorine source selected from sodium monofluorophosphate and a mixture of sodium monofluorophosphate and fluoride of

  sodium in which about 30-40% by weight of the fluorine comes.

said sodium fluoride.

  Dental cream according to claim 4 wherein said mixture of sodium monofluorophosphate and sodium fluoride is present, and wherein said sodium fluoride

  provides about 30-35% by weight of said fluorine.

  Dental cream according to claim 3, in which

  dicalcium phosphate is present as a

  polishing in an amount of about 40-50% by weight.

  7 Dental cream according to one of claims 5 or

  6, characterized in that said carboxymethyl cellulose of

  sodium has a viscosity of about 300-500 m Pa S and said hydro-

  xylethyl cellulose a viscosity of about 4500-6500 m Pa s,

  each viscosity being based on a measurement made on a visco-

  Brookfield simulator at 25 ° C with a 2% aqueous solution.

* 8 Dental cream containing about 20-75% by weight of a polishing substance, at least about half of which is hydrated alumina, and about 20-80% by weight based on the weight of the dental cream. a liquid phase containing water, moistening, or a mixture of both, and about 0.5-5% by weight based on the weight of the cream

  of a gelling agent consisting essentially of hyaluronic acid

  hydroxyethylcellulose having a viscosity in a range averaging at least about 24,000 mPas, determined on a Brookfield Viscometer in a 2% by weight solution of water and glycerin (1: 1, 56) at 20 ° C. C, with a N 6 needle

rotating at 20 rpm.

  9 Dental cream according to claim 8 in which

  about 40-55% of alphaalumine trihydrate is present

as a polishing agent.

  Dental crust according to one of claims 8

  or 9, characterized in that said dental cream is

  naked in a pressure differential container, a mechanically dispensed dispensing container or a tube for dental cream.

  11 Dental cream according to claim 10 characterized

  in that said dental cream is contained in a

  Dispenser container mechanically implemented from

from which she can be expelled.

  12 Dental cream according to claim 10, characterized

  in that said dental cream is contained in a

tube for dental cream.

  13 Dental cream according to claim 12, characterized

  in that said tube for dental cream is a tube

in unlined aluminum.

  14 Dental cream according to any of the claims

  cations 8 to 13 in which is present a compound provided

  fluorine in an amount that provides approximately 100-10000 ppm

of fluorine.

  Dental cream is 16 N claim 14 in the-

  which said fluorine comes from sodium monofluorophosphate

  in an amount of about 750-2000 ppm.

  Dental cream according to claim 14 in the

  which said fluorine comes from about 750 = 2000 ppm of a binary fluoride system consisting of monofluorophosphate

  of sodium and sodium fluoride in which about 30-

  U by weight of the fluorine comes from sodium fluoride.

  17 Dental cream according to any of the claims

  cations 8 to 14 and 16 which contains zinc sulphate or aluminum sulphate in an amount of about 0.05-1.5%

in weight.

  18 Dental cream comprising a binary fluorine source consisting of a mixture of sodium monofluorophosphate and sodium fluoride in which about 30-40% by weight of said fluorine comes from said sodium fluoride, in an amount that provides about 750-2000 total ppm ionic fluoride, approximately

  -75% by weight of a polishing agent is essential-

  calcium phosphate and a com-

  taking about 20-80% by weight based on the weight of the

  cream of a liquid phase containing water, a human

  midifier, or a mixture of both, and about 0.5-5% by weight

  relative to the weight of the dental cream of a gel agent

  essentially consisting of hydroxyethyl cellulose having a viscosity in a range of

  at least about 24000 m Pa s, determined on a Brook-Brook

  field in a 2% solution of water and glycerin (1: 1,56)

  at 20 C with an N 6 needle rotating at 20 tkmn.

  19 Dental cream according to claim 18 in the

  which said binary source of fluorine provides about 1400-

2000 ppm of ionic fluorine.

  Dental cream according to one of claims 18

  or 19 wherein dicalcium phosphate is present as a polishing agent in an amount of about 40-75% by weight.

  21 Dental cream according to any of the claims

  cations 8 to 20 wherein said hydroxyethylcellulose is in an amount having a viscosity of about 17000-31000;

  about 37000-41000 or about 20000-30000 m Pa s.

  22 Dental cream according to claim 21 in the

  which said hydroxyethylcellulose has a viscosity of about

20000-30000 m Pa s.

  23 Dental cream according to any of the claims

  cations 1 to 22 wherein said gelling agent is present

  in an amount of about 0.8-2% by weight.

J