SE468623B - Toothpaste CONTAINING HYDRATIZED ALUMINUM OXIDE AS POLISHING AGENT AND HYDROXYTHYL CELLULOSA AS GELING AGENT - Google Patents

Description

Try to overcome the problems of lump formation without other problems, such as poor "dimensional stability", arising by mixing different types of sodium carboxymethylcellulose or mixing sodium carboxymethylcellulose with other gelling agents, such as synthetic inorganic silicic acid clay (eg materials available under the trademarks "Laponite" and "Veegum"), thickeners such as silicic acid thickeners available from Huber under the trademark "Zeosyl", eg Zeosyl 200, and from Rhone-Poulenc as Tixosil and as Tixosil 33J, or available from Wacker under the name "HDK N 2 O 4, and liquid phase materials, such as polyethylene glycol 600, have not been satisfactory.

Hydroxyethylcellulose has been proposed as an alternative gelling agent to sodium carboxymethylcellulose and in fact grades of hydroxyethylcellulose, such as Natrosol M, have been used in commercially available toothpastes, and grades have been described, for example, in U.S. Pat. Nos. 3,862,307 (Natrosol G), 3 070 510 (viscosity 75-125 ° C; 20 ° C; 2 s; in water) and 4,022 881 (Natrosol 250 H, a high viscosity material). These degrees of hydroxyethylcellulose, although generally satisfactory, can tend to cause toothpastes to undergo considerable rheology by forming a visible "tail" during filling of the container and when squeezed on a toothbrush. For example, "thread" is described in U.S. Patent No. 4,022,881 to toothpastes containing a thickening mixture of 30% hydroxyethylcellulose and 70% sodium carboxymethylcellulose. A non-threaded toothpaste containing calcium carbonate as an abrasive and with a thickening mixture of 10% hydroxyethylcellulose and 90% sodium carboxymethylcellulose is also described. In accordance with the present invention, a mixture of gelling agents with little tendency to clump upon aging and with other desirable rheological properties, such as good "shape strength", is provided by no "tail" formation of a squeezed strand of toothpaste. as well as good gloss in the string. Furthermore, the toothpaste can be easily prepared with this mixture without any significant modification of the process applied when sodium carboxymethylcellulose is the only gelling agent. The gelling agent with which sodium carboxymethylcellulose is preferably mixed in a particular weight ratio is hydroxyethylcellulose. Nor has this material, although generally good, been quite satisfactory in rheological terms when used alone or in admixture with thickeners or gelling agents other than sodium carboxymethylcellulose. Toothpastes containing such types of hydroxyethylcellulose as Natrosol 250 M, dicalcium phosphate and a fluorine-releasing compound actually show a "tail formation" and / or poor "shape stability" when types such as Natrosol 250 M are the only gelling agent or are present together with sodium carboxymethylcellulose in a weight ratio of sodium carboxymethylcellulose to hydroxyethylcellulose (Natrosol 250 M and the like) lower than about 2: 3, eg about 1:10 and 3: 7.

Prior art U.S. Pat. No. 4,022,881 discloses a toothpaste which contains as a thickener 5-30% highly viscous hydroxyethylcellulose (e.g. Natrosol 250 H) and 70-95% sodium carboxymethylcellulose to stabilize the sodium carboxymethylcellulose against degradation. However, these relative amounts (e.g., 10: 1 and 7: 3) are not satisfactory because they do not prevent surface roughness, which, however, is the case with the present invention. An advantage of the present invention is that it provides a gelling agent system for a toothpaste which remains uniform in dynamic aging and has other generally desirable rheological properties.

A particular advantage of the present invention is that the tail formation of the toothpaste is avoided and that the dimensional stability is improved even when hydroxyethylcellulose is the predominant component of the gelling system. These advantages can be particularly evident when the toothpaste is filled in or squeezed out of a container operating through a pressure difference or mechanically operated or a toothpaste tube, especially when the polish is hydrated alumina.

The great advantages can be obtained with a gelling agent mixture of sodium carboxymethylcellulose and hydroxyethylcellulose in a special weight ratio or, when the hydroxyethylcellulose has a high viscosity, without the presence of sodium carboxymethylcellulose being necessary.

A further advantage of the present invention is that it provides toothpastes containing a fluorine source, for example a binary fluorine source of sodium monofluorophosphate and sodium fluoride, and a polishing agent comprising calcium phosphate.

Other advantages will become apparent upon study of the following description.

The present invention relates to a toothpaste comprising 20-75% by weight of a polishing agent, at least half of which consists of hydrated alumina, and 20-80% by weight, based on the weight of the toothpaste, of a liquid phase containing water, humectants or a mixture thereof and 0.5-5% by weight, based on the weight of the toothpaste, of a gelling agent consisting essentially of hydroxyethylcellulose having a viscosity in a range whose average is at least 24,000 cP, determined by a Brookfield viscometer in a 2% by weight solution of water: glycerol (1: 1.56) at 20 ° C, with a No 6 spindle, at 20 rpm.

In accordance with certain further objects, the present invention relates to a toothpaste as described in the above section, which toothpaste comprises a compound which emits at least about 100 ppm fluorine and about 40-75% by weight of a dentally acceptable, non-toxic, water-insoluble polish containing calcium phosphate in an amount of at least about 35% by weight of the toothpaste.

The gelling agent is present in the toothpaste in an amount of about 0.5-5% by weight, preferably about 0.8-2% and more preferably about 0.9-1.1%, and the ratio of sodium carboxymethylcellulose to hydroxyethylcellulose is about 3: 2 to 2: 3, typically 1: 1 and preferably less than 1: 1 to 2: 3 (eg 49:51, 9:11 or 2: 3).

Sodium carboxymethylcellulose is commercially available from Hercules as CMC-7MXF and 7MFD, which are the preferred types in the practice of the present invention. The types may have a degree of polymerization in the vicinity of 500, corresponding to a molecular weight in the vicinity of 100,000.

The viscosity is medium to high, eg about 300 to 3000 cP or more, typically about 300-1200 cP and preferably about 300-500 cP (Brookfield, 2%, 25 ° C). CMC-7MXF contains about 0.7 sodium carboxymethyl groups per anhydroglucose unit. a 10 15 20 25 30 35 The following table indicates desirable commercially available types of sodium carboxymethylcellulose (CMC) (when the viscosity is measured other than with a Brookfield viscometer in 2% by weight aqueous solution at 25 ° C, the differences are indicated): Table 1 Supplier Hercules Il II ll ll Il II Wolff Walsrode Nyma Enka Cros Uddeholm Hoechst CMC grad 7MXF 7MFD 9M3lF 9M31xF l2M3lXF 7MF l2M3lPD 7M8sxF Wäknel CRTl000 PA 07 Nymcel ZMF.33 * Viskositet 300-S200-100-100000000 -500 900-1200 200-800 700-1200 50-80 Akucell ACl642 * 80-120 Akucell ACl632 * 60-120 Cellogen HP-SA 700-900 Cekol MVEP Tylose CB200 ** * 1% solution (Brookfie1d; 2s ° c) ** Hoeppler Viscometer (2%: 20 ° C) 500-800 120-260 Hydroxyethylcellulose is commercially available from Hercules as Natrosol 250 M, which is a preferred type in the practice of the present invention. nä 4. ". 10 15 20 25 30 35 468 625 The types may have a degree of polymerization in the vicinity of 750, corresponding to a molecular weight in the vicinity of 190,000. The viscosity is moderate to high, eg about 3,000 to 120,000 cP or more , typically about 3000-7000 cP and preferably about 4500-ssoo CP (srOokfie1d; 2%; 2s ° c), when the viscosity is measured other than with a Brookfield viscometer in 2 wt% aqueous solution at 25 ° C indicate the differences.

The following table shows desirable commercially available types of hydroxyethylcellulose (HEC): Table 2 Supplier - HEC Viscosity srëâ Hercules Natrosol 250M 4500-6500 and MR "Natrosol 250 HR * 1500-2500 and 250 H *" Natrosol 250 HHR * 3400-5000 and 250 HH BP Chemicals Cellobond 5000A 4200-5600 "Cellobond 7000A 6000-7000 Hoechst Tylose H 4000P ** 3000-5000" Tylose Hl0000P ** 7000-12000 * 1% solution (Brookfield; 25 ° C) ** Hoeppler Viscometer (2%; ZOOC) The sodium carboxymethylcellulose and the hydroxyethylcellulose may be mechanically mixed together before being mixed with the liquid phase constituting the vehicle of the toothpaste, or they may be mixed separately with the liquid phase 00.a 10 15 20 25 30 35. The rheological benefits of the present invention are apparent when the toothpaste contains a compound which emits at least about 100 ppm fluorine, typically about 100-10,000 ppm and for example about 750-2000 ppm Compounds which emit fluoride are sodium fluoride, stannous fluoride, potassium fluoride - rid, potassium tin (II) fluoride, sodium hexafluorostannate, stannous chlorofluoride and sodium monofluorophosphate. Most typically according to the present invention, sodium monofluorophosphate or a mixture of sodium monofluorophosphate and sodium fluoride is used. The rheological benefits are also evident when a calcium phosphate polish, in particular dicalcium phosphate, is present in an amount of at least about 35% by weight of the toothpaste.

This toothpaste typically contains about 35-75% by weight, preferably about 40-55% by weight of a dentally acceptable water-insoluble polish which consists mainly of calcium phosphate, such as dicalcium phosphate in dihydrated or anhydrous form or a mixture thereof in a good - proportional ratio, tricalcium phosphate and calcium pyrophosphate. Most typically, the dicalcium phosphate is used, generally in the form of the dihydrate. Dicalcium phosphate is typically the only polish, but if desired, minor amounts (eg up to about 5% by weight of the toothpaste and up to about 12% by weight of the total amount of polish) of other dentally acceptable water-insoluble polishes may be present. which do not significantly impair the ability of the composition of the invention to favorably affect oral hygiene. Typical polishes are alumina, silicic acid, sodium aluminosilicate, etc. A small amount of hydrated alumina (eg about 1%) reduces or even eliminates the tendency of some toothpastes to separate or "bleed" in the tube.

The toothpaste typically contains sodium monofluorophosphate or a mixture of sodium monofluorophosphate and sodium fluoride in an amount which releases about 100-10000ppm of fluorine, for example * x e. S 10 15 20 25 30 35 JE-O -2000 ppm, in particular about 1400-2000 ppm, such as about 1400-170 ppm A binary fluoride system of sodium monofluorophosphate and sodium fluoride is advantageously used in which about 30-40% of the fluorine (eg about 30-35%, ie about 300-580 ppm) is derived from sodium fluoride.

The gelling agent system is particularly desirable as a gelling component in toothpastes containing the binary fluorine mixture and dicalcium phosphate polish described in British Patent Specification 20 68 727 A (application 79/43642), and the description in this patent application is hereby incorporated by reference. Thus, in a typical toothpaste, sodium monofluorophosphate is typically included in the binary system in an amount that emits about 700-1090 ppm fluorine in the toothpaste, in which the total amount of fluorine is about 1000-1670 ppm with about 30-35% by weight of the total amount of fluorine derived from sodium fluoride (about 300-580 ppm).

This corresponds to about 0.5-1.2% by weight of sodium monofluorophosphate and about 0.05-0.1% by weight of sodium fluoride. Preferably the toothpaste contains about 1000-1500 ppm, more preferably about 950-1000 ppm fluorine derived from sodium monofluorophosphate and about 450-500 ppm derived from sodium fluoride.

Sodium monofluorophosphate, Na2PO3F, which is commercially available, can vary considerably in purity. It can be used in any suitable purity provided that any contaminants do not have a markedly unfavorable effect on the desired properties. In general, the purity is preferably at least 80%. To achieve the best results, it should be at least 85% and preferably at least 90% by weight of sodium monofluorophosphate, the remainder being primarily impurities or by-products of the preparation, such as sodium fluoride and water-soluble sodium phosphate salt. In other words, the sodium monofluorophosphate used should have a total fluoride content higher than 12%, preferably higher than 12.7%, a content not higher than 1.5% and preferably not higher than 1.2% of free sodium fluoride; and a sodium monofluorophosphate content of at least 12%; preferably at least 12.1%, all calculated as fluoride.

As mentioned above, sodium fluoride is the second separate fluorine-containing component of the binary mixture, apart from sodium monofluorophosphate. About 300-580 ppm fluorine is preferably delivered to the sodium fluoride toothpaste.

In accordance with certain further objects, the present invention relates to a toothpaste containing about 20-75% by weight of a polishing agent, of which at least half consists of hydrated alumina, about 20-80% by weight, based on the weight of the toothpaste, of a liquid phase. containing water, humectants or a mixture thereof, and about 0.5-5% by weight, based on the weight of the toothpaste, of a gelling agent consisting mainly of hydroxyethylcellulose having a high viscosity in a range whose average is at least about 24%. 000 cP, determined with a Brookfield viscometer at 20 ° C in an aqueous glycerol solution (1: 1, 56) with a No 6 spindle at 20 rpm.

In this embodiment of the invention, the gelling agent is present in the toothpaste in an amount of about 0.5-5% by weight, preferably about 0.8-2% and most preferably about 0.9 - 1.4%. A typical grade of hydroxyethylcellulose which is advantageous in this embodiment of the invention is Tylose H10000P, which can be obtained from Farbwerke Hoechst, Fnukfurt am Main, Germany.

In accordance with certain further objects, the present invention relates to a toothpaste containing a binary fluorine source consisting of a mixture of sodium monofluorophosphate and sodium fluoride, wherein about 30-40% by weight of the fluorine is derived from sodium fluoride in an amount emitting a total of about 750-2000 ppm fluorine in ionic form, about 35-75% by weight of polishing agent mainly consisting of calcium phosphate, a dental vehicle amounting to about 20-80% by weight, based on the weight of the toothpaste, and constituting a liquid phase containing water , humectants or a mixture thereof, and about 0.5-5% by weight, based on the weight of the toothpaste, of a gelling agent consisting mainly of high viscosity hydroxyethylcellulose in an area whose average is at least about 24,000 cP, determined with a Brookfield viscometer in a 2% aqueous glycerol solution (1: 1, 56) at ZOOC with a No 6 spindle at 20 rpm.

Binary fluorine sources have been described above. The gelling agent in this embodiment of the invention is present in the toothpaste in an amount of about 0.5-5% by weight, preferably about 0.8-2% and most preferably about 0.9-1.1%. Tylose H100000P is a typical grade of hydroxyethylcellulose which is advantageous in this embodiment of the invention.

Tylose H 10000? and other types of hydroxyethylcellulose have, according to the present invention, viscosities in a range whose average is at least about 24,000 cP, determined with a Brookfield viscometer at 20 ° C, in a water: glycerol solution (1: 1, 56) with a No. 6 spindle at 20 rpm. The values given in this way differ from various determined values previously stated in the description. Types of high viscosity hydroxyethylcellulose that can be used in these embodiments of the present invention are shown in the following table: 10 15 20 25 30 35 l2 Table Supplier HEC type Viscosity Hercules Natrosol 250HR and 17000-31000 250 H Natrosol ZSOHHR and 250 HH 37000-41000 Do you need Tylose H 10000? 20000-30000 Types of hydroxyethylcellulose, whose viscosity does not reach an average of about 24000 cP, such as Hercules 250 M and MR (average viscosity l5500 cP) and Hoechst Tylose H 4000 P (viscosity of up to 23000 cP), do not give the desired rheology when used as the sole gelling agent.

In the embodiment of the invention in which the toothpaste contains about 20-75% by weight of polishing agent, of which at least half is hydrated alumina, up to about half of the total amount of polishing agent may, if desired, consist of other dentally acceptable polishing agents such as silicic acid, dicalcium phosphate, calcined alumina, zirconium silicate, insoluble sodium metaphosphate, etc. Preferably, about 40-55% polish is present and typically all in the form of hydrated alumina.

The hydrated alumina used according to the present invention preferably has a small particle size, i.e. at least about 85% of the particles are less than 20 .mu.m, such as that classified as gibbsite (alpha alumina trihydrate) and usually has the chemical designation Al . 3H2O or Al (OH) 3.

Alpha-alumina trihydrate can have a particle size in the range of about 2.6-10 Pm. Detalpha alumina trihydrate sold by Alcoa as C333 is a fine grade of gibbsite v n. 10 15 20 25 30 35 4; Ox co O \ I ~ J o: 13 which is particularly highly desirable. The average particle size of C333 alumina is about 7-9 μm (Coulter-Counter). It is obtained by fine grinding of the type of alumina sold by Alcoa as C33.

Other types of hydrated alumina that can be used are AF 260 and AF 230 which are sold by the British Aluminum Company, and SH l00 which is sold by Rhone-Poulenc.

Hydrated alumina toothpaste is typically packaged in a container from which it can be easily squeezed, such as a pressure difference dispensing or mechanically dispensing toothpaste container or an internally coated or uncoated aluminum tube or lead tube or a laminated tube. The rheological properties are particularly desirable when a mechanically dispensing container of the type described in British Patent Application 2,070,695A is used. This dispensing container comprises a distributing nozzle, a clamping device, a piston and a hand control. The description in this published patent application is hereby incorporated by reference.

The pressure-dispensing containers can be of the aerosol or vacuum type.

Hydrated alumina toothpaste may comprise a compound which releases fluorine or binary fluorine sources, as described above.

The calcium phosphate toothpaste typically contains about 35-75% by weight, preferably 40-55% of a dentally acceptable water-insoluble polish, which consists mainly of calcium phosphate, such as dicalcium phosphate in dihydrated or anhydrous form or as a mixture thereof in any arbitrary and tricyclic ratio, calcium pyrophosphate. Most often, dicalcium phosphate is used, usually in the form of 47:.

G \ CD 14 of the dihydrate. Dicalcium phosphate is typically the only polish, but if desired, smaller amounts (eg up to about 5% by weight of the toothpaste and up to about 12% by weight of the total amount of polish) of other dentally acceptable water-insoluble polishes may be present. present, which do not significantly reduce the ability of the composition according to the invention to favorably influence oral hygiene. Typical polishes are alumina, silicic acid, sodium aluminosilicate, etc. A small amount of hydrated alumina (eg about 1%) reduces or even eliminates the tendency of some toothpastes to separate or "bleed" in the tube.

In the toothpaste compositions, the dental vehicle is a liquid phase which is balanced against the gelling agents to give an sprayable, creamy mass of the desired consistency. Generally, the liquids in the toothpaste should consist mainly of water, glycerol, sorbitol, polyethylene glycol 400, propylene glycol or the like, including suitable mixtures thereof. It is generally advantageous to use a mixture of both water and a humectant or binder, such as glycerol or sorbitol; typically about 10-30% by weight of water and about 15-50% by weight of humectants. The use of glycerol or sorbitol is preferred. The total liquid content should generally be about 20-80% by weight of the composition.

Any suitable surfactant or cleansing material may be included in the toothpaste compositions. Such compatible materials are desirable to provide additional cleaning, foaming or antibacterial properties, depending on the particular type of surfactant, and are selected accordingly. The surfactants are usually water-soluble compounds and may have an anionic, nonionic or cationic structure. It is generally preferred to use water-soluble, non-soap or synthetic organic surfactants. Suitable cleaning materials are known and include, for example, the water-soluble salts of Jv. l0 15 20 25 30 35 -Iï O \ oo Ox NJ u! Higher fatty acid monoglyceride monosulphate surfactants (eg sodium coconut fatty acid monoglyceride monosulphate), higher alkyl sulphate (eg sodium lauryl sulphate), alkylaryl sulphonate (eg sodium dodecylbenzenesulphonate, higher fatty acid esters of 1,2-likeulphonate;

Other surfactants are mainly saturated higher aliphatic acylamides of lower aliphatic aminocarboxylic acid compounds, such as those having 12-16 carbon atoms in the acyl group. The amino acid moiety is usually derived from the lower aliphatic saturated monoaminocarboxylic acids having about 2-6 carbon atoms, generally the monocarboxylic acid compounds. Suitable compounds are fatty acid amides of glycine, sarcosine, alanine, 3-aminopropionic acid and valine having about 12-16 carbon atoms in the acyl group. However, the use of the N-lauroyl, myristoyl and palmitoyl sarcoside compounds is preferred to achieve the best possible results.

The amide compound may be inserted in the form of the free acid or preferably as the water-soluble salt thereof, such as alkali metal, ammonium, amine and alkylolamine salts.

Particular examples of these are the sodium and potassium N-lauroyl, myristoyl and palmitoyl sarcosides, ammonium and ethanolamine N-lauroyl glycide and alanine. For the sake of simplicity, "aminocarboxylic acid compound", "sarcoside" and the like refer to such compounds having a f- carboxyl group, or the water-soluble carboxylate salts.

These materials were used in pure or substantially pure form.

They must be as free as possible from soap or similar higher fatty acid materials, which tend to impair the action of the compounds. In general, the amount of the higher fatty acid material is less than 15% by weight of the amide and insufficient to substantially adversely affect it, and preferably less than 10% of the amide material. 10 15 20 25 30 35 O \ CD CN 16 Various other materials can be included in the toothpastes according to the invention. Examples are dyes or bleaches, preservatives, stabilizers, tetrasodium pyrophosphate, silicones, chlorophyll compounds and ammonium-containing materials such as urea, diammonium phosphate and mixtures thereof. These additives are incorporated into the compositions in question in amounts which do not appreciably adversely affect the desired properties and peculiarities, and are suitably selected and used in a conventional manner.

To achieve certain objects, it may be desirable to include antibacterial agents in the compositions of the invention. Typical antibacterial agents that can be used in amounts of about 0.01% to about 5%, preferably about 0.05% to about 1.0% by weight of the toothpaste composition are: N1-4- (chlorobenzyl) -N5- (2, 4-dichlorobenzyl) biguanide; p-chlorophenyl biguanide; 4-chlorobenzihydryl biguanide; 4-chlorobenzihydrylguanylurea; N-3-lauroxypropyl-N5-p-chlorobenzyl biguanide; 1,6-di-p-chlorophenyl biguanide hexane; 1- (lauryl dimethylammonium) -8- (p-chlorobenzyldimethylammonium octane dichloride): 5,6-dichloro-2-guanidinobenzimidazole; N1-p-chlorophenyl-NS-lauryl biguanide; 5-amino-1,3-bis- (2-ethylhexyl) -5-methylhexahydropyrimidine; and the non-toxic acid addition salts thereof.

Any suitable flavoring or sweetening agent may be used to flavor the compositions of the present invention. Examples of suitable flavoring components are aromatic oils, such as oils of green mint, peppermint, winter greens, sassafras, cloves, sage, eucalyptus, marjoram, cinnamon, lemon and orange, as well as methyl salicylate. Suitable sweeteners are sucrose, lactose, maltose, sorbitol, sodium cyclamate, sodium saccharin dipeptides according to US 3,939,261 and oxithiazine salts according to US 3,932,606.

The flavoring and sweetening agents may suitably together comprise between about 0.01 and 5% or more of the composition.

The toothpastes must have a pH that is suitable for practical use. A pH range of 5-9 is especially desirable. When the polish consists mainly of hydrated alumina, the pH value can be between 3 and 10.5. The information regarding the pH value refers to direct determination of the pH in the toothpastes. If desired, materials such as benzoic acid or citric acid may be added to adjust the pH to, for example 5.5-6.5 in general, or eg 4-7.5 in the case of hydrated alumina toothpaste.

The toothpaste is usually packaged in a compressible tube, such as generally in internally coated or uncoated aluminum or lead tubes or laminated tubes, and especially in the case of hydrated alumina toothpaste in mechanically dispensing containers.

The following examples further illustrate the features of the invention, but of course the scope of the invention is not limited by these. The compositions are prepared in the usual manner and all amounts of the various components are by weight unless otherwise indicated. 10 15 20 25 30 468 623 Example gel 18 Highly viscous hydroxyethylcellulose - hydrated alumina - no fluoride or binary fluorine sources.

The following toothpastes were prepared in a conventional manner in the manufacture of toothpaste. The toothpastes A and B were filled in the mechanically dispensing device described in British patent application 2,070 69SA. The toothpaste C was filled in an internally uncoated aluminum toothpick tube and the toothpaste D was filled in an internally coated aluminum toothpaste tube.

Sorbitol (70% solution) Glycerol Hydroxyethylcellulose (Hercules Natrosol 250M) Hydroxyethylcellulose A 23,000 (Hoechst Tylose H l0000P) 1.00 Alpha-alumina trihydrate (Alcoa C333) Cl2-Cl8-alcohol-Nasulfate (100% AI) Zinc sulphate .7H2O Aluminum sulfate.18H2O Sodium saccharin Methyl p-hydroxybenzoate Sodium monofluorophosphate Sodium fluoride Pyridylcarbinol Allantoin Flavor 52,000 0.5 0.17 0.08 0.76 0.10 0.10 0.15 1.20 Parts BCD 23,000 - 23,000 _ 20.20 - 1100 _ _ - 1.30 1.00 52 000 52 000 52 000 0.5 1.5 1.5 _ _ _ _ 0.17 0.20 0.17 0.08 0.08 - 0176 _ '_ 3 oylo _ _ 0.10' '0.15 0.15' 1.20 1.00 1.20 l0 15 19 Phosphoric acid (85%) 0.14 Deionized water qs to 100 0.14 q.s. to 100 q.s. to 100 OD CI \ k) O! q.s. to 100 During the filling and after the spraying, the surfaces of the toothpastes A, C and D were smooth with the rheologically desired properties, while the toothpaste B underwent a significant deformation during the filling and after it was sprayed out of the container. The same rheological effects as in toothpastes A, C and D were obtained when Tylose H 100000P in toothpastes A, C and D was replaced by Natrosol 250 H and Natrosol 250 HH. Tail formation occurred when toothpaste B (with Natrosol 250 M) was filled into a toothpaste tube. Although the invention has been illustrated by means of special examples and certain variations thereof, those skilled in the art will of course recognize that various modifications may be made which fall within the scope of the invention.

Claims (8)

10 15 20 25 ~ F => O \ CO C \ PO Ox '20 P a t e n t k r a v Toothpaste characterized in that it comprises 20-75% by weight of a polishing agent, at least half of which consists of hydrated alumina, and 20-80% by weight, based on the weight of the toothpaste, of a liquid phase containing water, humectants or a mixture of such and 0.5-5% by weight, based on the weight of the toothpaste, of a gelling agent consisting mainly of hydroxyethylcellulose having a viscosity in a range whose average is at least 24,000 cP, determined with a Brookfield viscometer in a 2% by weight % solution of water: glycerol (1: 1, 56) at 2000, with a No 6 spindle, at 20 rpm. Toothpaste according to claim 1, characterized in that 40-55% polishing agent of alpha-alumina trihydrate is present. Toothpaste according to claims 1-2, characterized in that a fluorine-releasing compound is present in an amount emitting 100 - 10,000 ppm fluorine. Toothpaste according to claim 3, characterized in that the fluorine is released by sodium monofluorophosphate in an amount of 750 - 2,000 ppm. Toothpaste according to claim 3, characterized in that 750 - 2,000 ppm fluorine is released by a binary fluoride system of sodium monofluorophosphate and sodium fluoride, wherein 30-40% by weight of the fluorine is released by sodium fluoride. Toothpaste according to claims 1 - 3 and 5, characterized in that zinc sulphate or aluminum sulphate is present in an amount of 0.05 - 1.5% by weight. 7. t e c k n a d of that which has a viscosity Toothpaste according to or 20,000 - 30,000. Toothpaste according to characterized in that having a viscosity 21 any of claims 1 - 6, feel - the hydroxyethylcellulose is of a type of 17,000 - 31,000, 37,000 - 41,000 any of claims 1 - 7, may the hydroxyethylcellulose is of a type of 20,000 - 30,000.