FR2531858A1 - CHEMICAL CASTRATION PROCESS OF MALE MAMMALS - Google Patents

Abstract

TO CHEMICALLY CASTRESS MALES MAMMALS WITH EXTERNAL TESTICLES, SOLUTIONS OF LOWER CARBOXYLIC ACIDS OR THEIR DERIVATIVES ARE INJECTED, PREFERABLY AQUEOUS SOLUTIONS AT 1-90, IN THE TWO TESTICULES, IN THE TWO PINIFIC CANALS OR IN THE EPIDIDYMS OF THE MAMMALS IN QUESTION.

Description

Process for chemical castration of male mammals.

  The invention relates to a method of castration and chemical contraception for male mammals which have external testes. According to this method, a suitable preparation is injected into the vas deferens, testes or epididymis of male animals. Castration can be carried out by surgical intervention which can lead via the open wound to complications and infections

  such as tetanus and, therefore, to death.

  Stress related to surgical castration and pain

  have effects that have repercussions in animals

  for at least two weeks on their cor-

porel.

  We have already tried on several occasions to

  chemical castration A large number of reactions

  tives and chemical mixtures both natural and also synthetic have been studied. Thus agents with sclerosing activity have been administered in the organs of

  male reproduction to prevent the passage of sperm.

  All the processes have drawbacks which consist of a lack of efficiency, and / or the maintenance of

  libido and / or causing necrotic damage

  uncontrollable tissue ticks.

  The testes have two main functions.

  One consists in the production of sperm which flows into the seminal canaliculi, the second consists in the production of androgenic substances (testosterone and

  dihydrotestosterone) which are secreted in the glands

  terstitial (interstitial cells of the testicle or

Leidig).

  After their genesis in the testes, the sperm-

  tozoids are released in the head of the epididymis and move from there to the tail of

  the epididymis, a cavernous network of spiral tubes.

  The function of epididymis consists in transport,

  in development to maturity, in con-

  sperm centering and storage During ejaculation, seminal cells are released to

  outside from epididymis in defected canals

  rents and finally through the penis The two defective channels

  rents are used for cleaning, gas exchange and thermal regulation of the testes through

of the Pampiniform Plexus.

  In this complex set, the method according to the

  vention intervenes in that the reagent to be used, by injection in the two vas deferens has the effect of the atrophy of the testes by destruction of the vascular system and, consequently, loss of spermatogenesis and libido, or by direct injection in the two testicles has the effect of atrophy and the loss of spermatogenesis and libido or by injection into the epididymis certainly results in sterilization

  (contraception) with maintenance, however, of the libido.

  The method can be used in mammals insofar as the method is not limited by the size and the inappropriate shape of the male genital organs as in the case of boars, stallions and male cats It can be particularly well used in dogs, steers, sheep and goats As

  aqueous solutions for injection to be used for the pro-

  yielded according to the invention, the solutions of mono and dicarboxylic acids have proved to be particularly effective

  with up to 4 carbon atoms, their hydroxy-

  substituted and their anhydrides, in particular acetic acid, propionic acid, butyric acid, glycolic acid, oxalic acid, malonic acid, acid

  succinic, malic acid, tartaric acid, anhy-

  acetic dride and especially lactic acid and lactide

  lactic acid should be recommended as a

  particularly suitable an aqueous acid solution

  1-90% lactic acid at a dose of 0.1 20 ml, essential

  0.25 ti 16 ml For the sterilization of bulls and male dogs, an aqueous solution of lactic acid at 5-85% can be successfully used When

  it is injected into the vas deferens or into the epi-

  didymes of male dogs, an aqueous solution of lactic acid at 5-25% is to be advised particularly Les

  lactic acid solutions used have little ef-

  secondary effects, do not cause ulceration and give reproducible results Lactic acid is a reagent which exists in nature, harmless from the point of view of toxicity and which, moreover, can be demonstrated in a simple way in samples of

tissue and residue.

  As a mode of application, the choice of the two vas deferens has proved to be particularly suitable because in this form of injection, only a very small area is destroyed unlike the complete testes; in

  the case of young bulls that weigh less than 45 kg, the injection

  tion in the testicles should, however, be preferred since it is easier to inject at this point and only a small amount of tissue can be destroyed. The chemical castration process can be used with particular success and profit in bulls and male dogs; even in the united states of america there are every

  year about 20 to 30 million young bulls to be neutered.

  The method according to the invention offers great utility for stemming the population of dogs; for example as an economical method for sterilization

  male dogs in pet stores or kennels.

  The process according to the invention has proved to be a safe, fast, economical, practical and simple method

  to handle after a single demonstration

  that appear during surgical castration

  wedge does not manifest itself, chemical castration is therefore cleaner, safer and considerably easier In addition, the slowdown in growth that is observed during surgical castration

  does not appear with chemical castration By comparison

  due to previous methods of chemical castration, the invention offers a dose dependence,

  high efficiency, it prevents unconventional damage

  controlled by tissues, it offers multiple possibilities in its applicability with, depending on desire, maintenance or elimination of libido respectively; she offers in

  besides various possibilities in the treatment of different

  animal rents; for example, by varying the volume

  and the size of the needle according to the different animals.

  In what follows, the method according to the invention will be better explained with the aid of nonlimiting examples.

EXAMPLE i -

  We studied the activity of a reagent containing lactic acid on a total of 173 bulls weighing between 45 and 286 kg To do this, we injected different

  concentrations and different volumes of reagent in each

  none of the vas deferens As controls, 4 bulls were surgically castrated 37 of the 173 bulls weighed more than 225 kg It appeared from the studies that better results could be obtained when the process was used on bulls weighing less than 225 kg Thus, the treatment was successfully carried out on 98 of the 136 bulls (72%) weighing less than 225 kg, while in the 37 bulls weighing more than 225 kg,

  the process only had a positive result in 24 animals

  ailments (65%) In addition, there was a clear dependence on the dose proportional to the body weight so that it can be recommended as a dose for bulls weighing up to 90 kg, 2 ml (93% efficiency ), sleds weighing from 90 to 135 kg, 4 ml (100% efficiency) and bulls weighing from 135 to 225 kg, 8 ml (82% efficiency),

85% lactic acid solution.

  If we want to increase the degree of efficiency, it

  just administered higher doses.

EXAMPLE 2 -

  By injection of 8 ml of a lac-

  85% tick in both vas deferens, one should

  ability to determine the most favorable injection site

  ble To do this, the agent was injected into 20 bulls, on the one hand directly above the testicles and on the other hand, 2.5 to 3.75 cm above the testicles in

  the vas deferens The results showed that the

  jection directly above the testicles was more favorable with a degree of efficiency of 95 against%.

EXAMPLE 3 -

  1 and 2 ml of an 85% lactic acid solution have

  been injected directly into the testes of 5 tau-

  Holstein-type rillons (O to 33 days old) The result

  positive in all calves has shown definitively

  However, the process according to the invention can be used.

  tion even in the case of very young calves.

EXAMPLE 4 -

  Lactic acid has been studied as a sterilizing agent.

  Possible chemical sation for dogs The results obtained with injections of lactic acid into the epididymis and into the pampiniform plexus of the vas deferens have clearly shown that a 5 to 25% solution of lactic acid is a sterilizing agent.

  effective chemical results show for solu-

  25%, 20%, 15% and 10% lactic acid

  cited as% of 82% (14 of 17), 100 (6 of 6), 92% (12

out of 13) and 80% (4 out of 5).

Claims (6)

REVENDI CATIONS   1 Composition for castration or contraception   chemical of male mammals with ex testes   dull, characterized in that it is essentially cons-   titrated with an aqueous solution for injection containing 5 to   % of at least one compound chosen from mono- acids   or dicarboxylics having up to 4 carbon atoms,   pre-substituted hydroxysubstituted mono or dicarboxylic acids   smelling up to 4 carbon atoms, and the anhydrides of these acids.   2 Composition for castration or contraception.   chemical of male mammals with ex testes   dull, characterized in that it is in the form of injectable unit doses essentially constituted by an injectable aqueous solution containing 5 to 85%   at least one compound chosen from mono or di- acids   carboxylic having up to 4 carbon atoms,   hydroxysubstituted mono or dicarboxylic acids present   both up to 4 carbon atoms, and the anhydrides of these   acids and having a volume of 0.25 to 8 ml.   3 Composition according to claim 1 or 2, charac-   terized in that the compound chosen is lactic acid.   4 Composition for the chemical castration of tau-   reaux, characterized in that it is in the form of injectable unit doses essentially consisting of an injectable aqueous solution containing 5 to 85%   at least one compound chosen from mono or di- acids   carboxylic having up to 4 carbon atoms,   hydroxysubstituted mono or dicarboxylic acids present   both up to 4 carbon atoms, and the anhydrides of these   acids - and having a volume of 1 to 8 ml.   Composition for the chemical castration of bulls, characterized in that it is in the form of injectable unit doses essentially consisting of an aqueous injectable solution containing from 5 to 85%   lactic acid and having a volume of 1 to 8 ml.   6 Composition for the chemical castration of dogs, characterized in that it is in the form of injectable unit doses essentially consisting of an injectable aqueous solution containing 5 to 85% of at least one compound chosen from mono or dicarboxylic acids having   up to 4 carbon atoms, mono or dicarboxy acids   hydroxysubstituted lics having up to 4 carbon atoms, and the anhydrides of these acids and having a 0.25 to 1 ml volume.   7 Composition for the chemical castration of dogs, characterized in that it is in the form of injectable unit doses essentially consisting of an injectable aqueous solution containing 5 to 85% acid   lactic and having a volume of 0.25 to 1 ml.