FR2527443B1 - Composition contenant de l'endotoxine raffinee et medicament la contenant - Google Patents

Composition contenant de l'endotoxine raffinee et medicament la contenant

Info

Publication number
FR2527443B1
FR2527443B1 FR8308585A FR8308585A FR2527443B1 FR 2527443 B1 FR2527443 B1 FR 2527443B1 FR 8308585 A FR8308585 A FR 8308585A FR 8308585 A FR8308585 A FR 8308585A FR 2527443 B1 FR2527443 B1 FR 2527443B1
Authority
FR
France
Prior art keywords
endotoxin
refined
medicament
composition containing
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8308585A
Other languages
English (en)
Other versions
FR2527443A1 (fr
Inventor
Edgar Ernst Ribi
Steven Marc Schwartzman
John Leonard Cantrell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ribi Immunochem Research Inc
Original Assignee
Ribi Immunochem Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribi Immunochem Research Inc filed Critical Ribi Immunochem Research Inc
Publication of FR2527443A1 publication Critical patent/FR2527443A1/fr
Application granted granted Critical
Publication of FR2527443B1 publication Critical patent/FR2527443B1/fr
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
FR8308585A 1982-05-26 1983-05-25 Composition contenant de l'endotoxine raffinee et medicament la contenant Expired FR2527443B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/382,405 US4436728A (en) 1982-05-26 1982-05-26 Refined detoxified endotoxin product

Publications (2)

Publication Number Publication Date
FR2527443A1 FR2527443A1 (fr) 1983-12-02
FR2527443B1 true FR2527443B1 (fr) 1986-11-21

Family

ID=23508808

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8308585A Expired FR2527443B1 (fr) 1982-05-26 1983-05-25 Composition contenant de l'endotoxine raffinee et medicament la contenant

Country Status (7)

Country Link
US (1) US4436728A (fr)
JP (1) JPS58222025A (fr)
CA (1) CA1217136A (fr)
DE (1) DE3318567C2 (fr)
FR (1) FR2527443B1 (fr)
GB (1) GB2122083B (fr)
IT (1) IT1164243B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2596990A1 (fr) * 1986-04-15 1987-10-16 Ribi Immunochem Research Inc Adjuvant immunologique a base d'emulsion de lipide et d'un adjuvant bacterien

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4866034A (en) * 1982-05-26 1989-09-12 Ribi Immunochem Research Inc. Refined detoxified endotoxin
US4505900A (en) * 1982-05-26 1985-03-19 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
CA1225592A (fr) * 1983-08-26 1987-08-18 Ribi Immunochem Research Inc. Endotoxine detoxifiee raffinee
US4987237A (en) * 1983-08-26 1991-01-22 Ribi Immunochem Research, Inc. Derivatives of monophosphoryl lipid A
US4663306A (en) * 1983-09-23 1987-05-05 Ribi Immunochem Research, Inc. Pyridine-soluble extract-refined detoxified endotoxin composition and use
NL8401226A (nl) * 1984-04-16 1985-11-18 Univ Utrecht Farmaceutisch produkt met anti-tumorwerking; gebruik van een farmaceutisch produkt of van farmaceutische samenstellingen in een anti-tumortherapie.
US4629722A (en) * 1984-07-12 1986-12-16 Ribi Immunochem Research, Inc. Method of inhibiting the onset of acute radiation syndrome
US4844894A (en) * 1984-07-12 1989-07-04 Ribi Immunochem Research Inc. Method of inhibiting the onset of septicemia and endotoxemia
US4803070A (en) * 1986-04-15 1989-02-07 Ribi Immunochem Research Inc. Immunological emulsion adjuvants for polysaccharide vaccines
US4877611A (en) * 1986-04-15 1989-10-31 Ribi Immunochem Research Inc. Vaccine containing tumor antigens and adjuvants
US4929604A (en) * 1986-05-28 1990-05-29 Board Of Regents, The University Of Texas System Lipopolysaccharides of reduced toxicity and the production thereof
US4845036A (en) * 1987-02-03 1989-07-04 The United States Of America As Represented By The Department Of Health And Human Services Process for isolation of the B oligomer of pertussis toxin
DE58903323D1 (de) * 1988-06-04 1993-03-04 Sartorius Gmbh Oberschalige elektronische waage.
US5416070A (en) * 1988-07-08 1995-05-16 Immunotherapeutics, Inc. Composition for macrophage activation
US4950645A (en) * 1988-07-08 1990-08-21 Immunotherapeutics, Inc. Composition for macrophage activation
US6218166B1 (en) 1994-12-09 2001-04-17 John Wayne Cancer Institute Adjuvant incorporation into antigen carrying cells: compositions and methods
AU704829B2 (en) * 1994-12-28 1999-05-06 University Of Kentucky Murine anti-idiotype antibody 3H1
US6949244B1 (en) 1995-12-20 2005-09-27 The Board Of Trustees Of The University Of Kentucky Murine monoclonal anti-idiotype antibody 11D10 and methods of use thereof
US6235280B1 (en) 1996-04-12 2001-05-22 Malaya Chatterjee Methods of delaying development of CEA-associated tumors using anti-idiotype antibody 3H1
US20020041872A1 (en) * 1996-04-12 2002-04-11 Malaya Chatterjee Methods of delaying development of CEA-associated tumors using anti-idiotype antibody 3H1
US6468782B1 (en) * 1996-12-05 2002-10-22 Quadrant Healthcare (Uk) Limited Methods of preserving prokaryotic cells and compositions obtained thereby
US6491919B2 (en) * 1997-04-01 2002-12-10 Corixa Corporation Aqueous immunologic adjuvant compostions of monophosphoryl lipid A
US20020098190A1 (en) * 1997-06-13 2002-07-25 Malaya Chatterjee Compositions and methods for treating tumors bearing HMFG and CEA antigens
US6274143B1 (en) 1997-06-13 2001-08-14 Malaya Chatterjee Methods of delaying development of HMFG-associated tumors using anti-idiotype antibody 11D10
US20020122807A1 (en) * 1998-07-07 2002-09-05 Dan Michael D. Antigen binding fragments, designated 4B5, that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers
US6355244B1 (en) 1997-11-17 2002-03-12 University Of Kentucky Research Foundation Methods and compositions for the treatment of psoriasis
US7534443B1 (en) 1998-07-16 2009-05-19 Ichiro Azuma Preparations for immunotherapy for cancer having bacterial somatic constituent as the active ingredient
US7026155B2 (en) 1999-02-02 2006-04-11 Regents Of The University Of California Method of reducing bacterial proliferation
US20020068068A1 (en) * 1999-02-02 2002-06-06 Mahan Michael J. Method of creating antibodies and compositions used for same
AU4057300A (en) 1999-03-30 2000-10-16 Board Of Regents, The University Of Texas System Compositions and methods for modifying toxic effects of proteinacious compounds
US20040002068A1 (en) 2000-03-01 2004-01-01 Corixa Corporation Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
US20030031684A1 (en) 2001-03-30 2003-02-13 Corixa Corporation Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA)
AU2003213640A1 (en) * 2002-02-28 2003-09-16 Corixa Corporation Methods of modulating dendritic cells using adjuvants
US20030224013A1 (en) * 2002-04-19 2003-12-04 Cole Garry T. Methods for protection against Coccidioides spp. infection using Coccidioides spp. urea amidohydrolase (Ure) protein
WO2004005308A2 (fr) 2002-07-08 2004-01-15 Corixa Corporation Procedes de production d'immunoeffecteurs sous forme d'aminoalkyle glucosaminide phosphate et de disaccharide, et intermediaires desdits immunoeffecteurs
NZ537690A (en) 2002-07-15 2009-07-31 Univ Texas Antibodies binding to anionic phospholipids and aminophospholipids and their use in treating viral infections
EP1547607A4 (fr) * 2002-08-02 2008-11-26 Dainippon Sumitomo Pharma Co Preparation d'un compose bacterien de squelette de paroi cellulaire
US20040265337A1 (en) * 2002-08-21 2004-12-30 Zsebo Krisztina M. Method of generating an immune response and compositions used for same
ES2422171T3 (es) * 2004-02-11 2013-09-09 Ligocyte Pharmaceuticals Inc Antígenos de carbunco y procedimientos de uso
EP1741438A4 (fr) * 2004-04-22 2009-08-26 Dainippon Sumitomo Pharma Co Préparation pharmaceutique contenant un composant du squelette de la paroi de cellules bactériennes
US8153116B2 (en) 2006-07-11 2012-04-10 University Of Connecticut Use of conditional plasmodium strains lacking an essential gene in malaria vaccination
US8128921B2 (en) * 2006-07-11 2012-03-06 University Of Connecticut Use of conditional plasmodium strains lacking nutrient transporters in malaria vaccination
WO2011034950A1 (fr) 2009-09-16 2011-03-24 Vaxart, Inc. Stratégie d'immunisation pour empêcher une infection par le h1n1
CA2909221A1 (fr) 2013-04-18 2014-10-23 Immune Design Corp. Monotherapie par gla pour une utilisation dans le traitement du cancer
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
EP3632458A1 (fr) 2013-07-26 2020-04-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés et compositions pharmaceutiques pour le traitement d'infections bactériennes
CN105555306B (zh) 2013-09-19 2019-12-03 诺瓦瓦克斯股份有限公司 免疫原性中东呼吸综合征冠状病毒(MERS-CoV)组合物和方法
CN106255508B (zh) 2014-02-20 2020-07-07 瓦克萨特公司 用于小肠递送的制剂
WO2016180852A1 (fr) 2015-05-12 2016-11-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de préparation de cellules t spécifiques de l'antigène à partir d'un échantillon de sang de cordon ombilical
WO2016200951A1 (fr) 2015-06-12 2016-12-15 Vaxart, Inc. Formulations pour l'administration dans l'intestin grêle d'antigènes du rsv et des norovirus
CN109069440A (zh) 2016-03-02 2018-12-21 得克萨斯州大学系统董事会 用于免疫治疗的激活sting的纳米疫苗
US11850279B2 (en) 2016-07-13 2023-12-26 Ohio State Innovation Foundation Platforms and methods for optimizing host antigen presentation and host antitumor and antipathogen immunity
US11376320B2 (en) 2020-03-05 2022-07-05 Iowa State University Research Foundation, Inc. Immunogenic and vaccine compositions against SARS-CoV-2

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2596990A1 (fr) * 1986-04-15 1987-10-16 Ribi Immunochem Research Inc Adjuvant immunologique a base d'emulsion de lipide et d'un adjuvant bacterien
FR2598622A1 (fr) * 1986-04-15 1987-11-20 Ribi Immunochem Research Inc Adjuvants immunologiques pour vaccins polysaccharidiques

Also Published As

Publication number Publication date
IT1164243B (it) 1987-04-08
GB2122083A (en) 1984-01-11
DE3318567A1 (de) 1984-01-12
JPS6256135B2 (fr) 1987-11-24
DE3318567C2 (de) 1987-01-29
FR2527443A1 (fr) 1983-12-02
US4436728A (en) 1984-03-13
JPS58222025A (ja) 1983-12-23
CA1217136A (fr) 1987-01-27
IT8321288A0 (it) 1983-05-25
GB8313053D0 (en) 1983-06-15
GB2122083B (en) 1985-12-18

Similar Documents

Publication Publication Date Title
FR2527443B1 (fr) Composition contenant de l'endotoxine raffinee et medicament la contenant
ES8203599A1 (es) Un aparato terapeutico para uso en crioterapia
IT8321287A0 (it) Procedimento per l'ottenimento della endotossina, disintossicata, raffinata, la endotossina ottenuta e l'impiego terapeutico di essa.
FR2527444B1 (fr) Composition therapeutique contenant une endotoxine raffinee debarrassee de sa toxicite
IT8224839A0 (it) Polimeri reattivi per la cura di affezioni cutanee.
NO158741C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive kvartaere dibenzotiepin-n-alkyl-norskopinetere.
BE875634A (fr) Compositions pharmaceutiques et leur utilisation pour le traitement prophylactique et therapeutique de l'hyperplasie de la prostate
IT7928079A0 (it) Dispositivo per interventi chirurgici in cavita' del corpo umano.
ES290656Y (es) Dispositivo para recoger y mantener vivos los cultivos del cuerpo del paciente.
BE896027A (fr) Nouvelles glycoproteines, procedes de production et agents therapeutiques pour le traitement de tumeurs en contenant
SE8404707D0 (sv) Komposition innehallande pyridinlosligt extrakt och raffinerat detoxifierat endotoxin samt anvendning derav
SE8404283L (sv) Anvendning av ett specifikt tumorassocierat antigen, nemligen sialosyllaktotetraos, for diagnostiska och terapeutiska forfaranden vid cancersjukdomar
DE3261760D1 (en) Pharmaceutical compositions for the treatment of skin
NO162557C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive (pyrrol-1-yl)-fenyldihydropyridazinoner.
FR2532309B1 (fr) Perfluorocycloamines et preparation d'emulsions therapeutiques contenant ces perfluorocycloamines
EP0147707A3 (en) 1,7-diphenyl-3-methylaza-7-cyano-8-methylnonane useful in combating diseases
DE3674321D1 (de) Behandlung geschmeidiger gewebe.
IT7824578A0 (it) Composizione farmaceutica per la terapia di stati di frigidita' ed impotenza.
IT1159815B (it) Composizione medicinale per il trattamento di certe neurovirosi
MA19965A1 (fr) 3',5'-diarabinosides, leur preparation et leur application en therapeutique
DK224788A (da) Bestraalingsanordning til brug ved medicinsk behandling
ZA885625B (en) Therapeutic agents containing enantiomers of propafenone
ZA824362B (en) Device for the energetic re-balancing of the human body organs
DE3374066D1 (en) N-acyl derivatives of peptides, their manufacture and use in combating diseases and means therefor
SE8201308D0 (sv) Alkylendiaminderivat och forfarande for framstellning derav

Legal Events

Date Code Title Description
ST Notification of lapse