FR2502496A2 - Fractions nouvelles extraites de bacteries aerobies, douees de proprietes antitumorales, antibacteriennes et inductrices d'interferon, et leur procede de preparation - Google Patents
Fractions nouvelles extraites de bacteries aerobies, douees de proprietes antitumorales, antibacteriennes et inductrices d'interferon, et leur procede de preparation Download PDFInfo
- Publication number
- FR2502496A2 FR2502496A2 FR8106294A FR8106294A FR2502496A2 FR 2502496 A2 FR2502496 A2 FR 2502496A2 FR 8106294 A FR8106294 A FR 8106294A FR 8106294 A FR8106294 A FR 8106294A FR 2502496 A2 FR2502496 A2 FR 2502496A2
- Authority
- FR
- France
- Prior art keywords
- sep
- fractions
- gel
- delipidated
- whole cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 16
- 241000186216 Corynebacterium Species 0.000 title claims description 22
- 230000003308 immunostimulating effect Effects 0.000 title abstract description 7
- 229960001438 immunostimulant agent Drugs 0.000 title abstract 2
- 239000003022 immunostimulating agent Substances 0.000 title abstract 2
- 239000002671 adjuvant Substances 0.000 title description 6
- 230000000844 anti-bacterial effect Effects 0.000 title description 4
- 102000014150 Interferons Human genes 0.000 title description 3
- 108010050904 Interferons Proteins 0.000 title description 3
- 230000001939 inductive effect Effects 0.000 title description 3
- 229940079322 interferon Drugs 0.000 title description 3
- 230000001580 bacterial effect Effects 0.000 title 1
- 230000002924 anti-infective effect Effects 0.000 claims abstract description 15
- 229940079593 drug Drugs 0.000 claims abstract description 12
- 241001148470 aerobic bacillus Species 0.000 claims abstract description 10
- 239000000499 gel Substances 0.000 claims description 31
- 241000894006 Bacteria Species 0.000 claims description 16
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 16
- 239000001506 calcium phosphate Substances 0.000 claims description 13
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 13
- 235000011010 calcium phosphates Nutrition 0.000 claims description 13
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- 239000000243 solution Substances 0.000 claims description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 10
- 238000001990 intravenous administration Methods 0.000 claims description 9
- 238000001179 sorption measurement Methods 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 229940024546 aluminum hydroxide gel Drugs 0.000 claims description 5
- SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 claims description 5
- 239000011780 sodium chloride Substances 0.000 claims description 5
- 239000000725 suspension Substances 0.000 claims description 5
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 4
- 239000011707 mineral Substances 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 238000007920 subcutaneous administration Methods 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- 229940024545 aluminum hydroxide Drugs 0.000 claims description 2
- 239000011575 calcium Substances 0.000 claims description 2
- 229910052791 calcium Inorganic materials 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 229940087373 calcium oxide Drugs 0.000 claims 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims 1
- 229910000397 disodium phosphate Inorganic materials 0.000 claims 1
- 235000019800 disodium phosphate Nutrition 0.000 claims 1
- 239000000644 isotonic solution Substances 0.000 claims 1
- 238000002483 medication Methods 0.000 claims 1
- 238000004062 sedimentation Methods 0.000 claims 1
- 239000001488 sodium phosphate Substances 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 description 29
- 241000186779 Listeria monocytogenes Species 0.000 description 23
- 210000004027 cell Anatomy 0.000 description 22
- 208000015181 infectious disease Diseases 0.000 description 18
- 239000000047 product Substances 0.000 description 18
- 230000034994 death Effects 0.000 description 10
- 231100000517 death Toxicity 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 8
- 238000011282 treatment Methods 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 229960005475 antiinfective agent Drugs 0.000 description 6
- 239000004599 antimicrobial Substances 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 230000001681 protective effect Effects 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 4
- 241001464975 Cutibacterium granulosum Species 0.000 description 3
- 238000010253 intravenous injection Methods 0.000 description 3
- 238000002203 pretreatment Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 241000186781 Listeria Species 0.000 description 2
- 206010024641 Listeriosis Diseases 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 210000000865 mononuclear phagocyte system Anatomy 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 108010023063 Bacto-peptone Proteins 0.000 description 1
- -1 CBA-LS Chemical compound 0.000 description 1
- 101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 239000002269 analeptic agent Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000015961 delipidation Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 210000002557 fixed macrophage Anatomy 0.000 description 1
- 210000002080 free macrophage Anatomy 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 230000001571 immunoadjuvant effect Effects 0.000 description 1
- 238000002650 immunosuppressive therapy Methods 0.000 description 1
- 239000012678 infectious agent Substances 0.000 description 1
- 238000011368 intensive chemotherapy Methods 0.000 description 1
- 239000002799 interferon inducing agent Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
- A61K2039/55594—Adjuvants of undefined constitution from bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8106294A FR2502496A2 (fr) | 1981-03-30 | 1981-03-30 | Fractions nouvelles extraites de bacteries aerobies, douees de proprietes antitumorales, antibacteriennes et inductrices d'interferon, et leur procede de preparation |
| US06/254,254 US4479935A (en) | 1980-04-22 | 1981-04-15 | Fractions extracted from aerobic bacteria, endowed with antitumoral, antibacterial and interferon inducing properties, and process for their preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8106294A FR2502496A2 (fr) | 1981-03-30 | 1981-03-30 | Fractions nouvelles extraites de bacteries aerobies, douees de proprietes antitumorales, antibacteriennes et inductrices d'interferon, et leur procede de preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2502496A2 true FR2502496A2 (fr) | 1982-10-01 |
| FR2502496B2 FR2502496B2 (enExample) | 1984-04-27 |
Family
ID=9256758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8106294A Granted FR2502496A2 (fr) | 1980-04-22 | 1981-03-30 | Fractions nouvelles extraites de bacteries aerobies, douees de proprietes antitumorales, antibacteriennes et inductrices d'interferon, et leur procede de preparation |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2502496A2 (enExample) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2035805A1 (enExample) * | 1968-08-20 | 1970-12-24 | Miles Lab | |
| FR2160326A1 (enExample) * | 1971-11-19 | 1973-06-29 | Anvar | |
| FR2181426A1 (enExample) * | 1972-04-06 | 1973-12-07 | Pasteur Institut | |
| FR2218888A1 (enExample) * | 1973-02-23 | 1974-09-20 | Wellcome Found | |
| FR2374042A1 (fr) * | 1976-06-04 | 1978-07-13 | Merieux Inst | Nouveau medicament immunostimulant et son procede de preparation |
| FR2410476A1 (fr) * | 1977-11-30 | 1979-06-29 | Inst Nat Sante Rech Med | Application des peptidoglycanes extraits de bacteries, en particulier des bacillus a titre de medicaments, notamment stimulant l'immunite antitumorale |
| EP0024941A2 (en) * | 1979-08-30 | 1981-03-11 | Yamanouchi Pharmaceutical Co., Ltd. | Water-soluble extract from nonpathogenic aerobic corynebacteria, production thereof and compositions containing the extract |
-
1981
- 1981-03-30 FR FR8106294A patent/FR2502496A2/fr active Granted
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2035805A1 (enExample) * | 1968-08-20 | 1970-12-24 | Miles Lab | |
| FR2160326A1 (enExample) * | 1971-11-19 | 1973-06-29 | Anvar | |
| FR2181426A1 (enExample) * | 1972-04-06 | 1973-12-07 | Pasteur Institut | |
| FR2218888A1 (enExample) * | 1973-02-23 | 1974-09-20 | Wellcome Found | |
| FR2374042A1 (fr) * | 1976-06-04 | 1978-07-13 | Merieux Inst | Nouveau medicament immunostimulant et son procede de preparation |
| FR2410476A1 (fr) * | 1977-11-30 | 1979-06-29 | Inst Nat Sante Rech Med | Application des peptidoglycanes extraits de bacteries, en particulier des bacillus a titre de medicaments, notamment stimulant l'immunite antitumorale |
| EP0024941A2 (en) * | 1979-08-30 | 1981-03-11 | Yamanouchi Pharmaceutical Co., Ltd. | Water-soluble extract from nonpathogenic aerobic corynebacteria, production thereof and compositions containing the extract |
Non-Patent Citations (1)
| Title |
|---|
| EXBK/75 * |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2502496B2 (enExample) | 1984-04-27 |
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