FR2499570A1 - Nouveaux derives du b-amino-3 nor-tropane et leur procede de preparation - Google Patents

Nouveaux derives du b-amino-3 nor-tropane et leur procede de preparation Download PDF

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Publication number
FR2499570A1
FR2499570A1 FR8102714A FR8102714A FR2499570A1 FR 2499570 A1 FR2499570 A1 FR 2499570A1 FR 8102714 A FR8102714 A FR 8102714A FR 8102714 A FR8102714 A FR 8102714A FR 2499570 A1 FR2499570 A1 FR 2499570A1
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FR
France
Prior art keywords
sep
formula
benzyl
cal
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8102714A
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English (en)
French (fr)
Other versions
FR2499570B1 (esLanguage
Inventor
Philippe Dostert
Thierry Imbert
Bernard Bucher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR8102714A priority Critical patent/FR2499570A1/fr
Priority to FR8102928A priority patent/FR2499992B2/fr
Publication of FR2499570A1 publication Critical patent/FR2499570A1/fr
Application granted granted Critical
Publication of FR2499570B1 publication Critical patent/FR2499570B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8102714A 1981-02-11 1981-02-11 Nouveaux derives du b-amino-3 nor-tropane et leur procede de preparation Granted FR2499570A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR8102714A FR2499570A1 (fr) 1981-02-11 1981-02-11 Nouveaux derives du b-amino-3 nor-tropane et leur procede de preparation
FR8102928A FR2499992B2 (fr) 1981-02-11 1981-02-13 Nouveaux derives du b-amino-3 nor-tropane et leur procede de preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8102714A FR2499570A1 (fr) 1981-02-11 1981-02-11 Nouveaux derives du b-amino-3 nor-tropane et leur procede de preparation

Publications (2)

Publication Number Publication Date
FR2499570A1 true FR2499570A1 (fr) 1982-08-13
FR2499570B1 FR2499570B1 (esLanguage) 1983-08-05

Family

ID=9255095

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8102714A Granted FR2499570A1 (fr) 1981-02-11 1981-02-11 Nouveaux derives du b-amino-3 nor-tropane et leur procede de preparation

Country Status (1)

Country Link
FR (1) FR2499570A1 (esLanguage)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984000166A1 (fr) * 1982-06-29 1984-01-19 Sandoz Ag Derives d'ester piperidyl d'acide benzoique et procede de production et d'utilisation de ces composes
FR2546169A1 (fr) * 1983-05-20 1984-11-23 Delalande Sa N-oxydes de derives aminocycliques, leur procede de preparation et leur application en therapeutique
FR2551064A1 (fr) * 1983-08-26 1985-03-01 Sandoz Sa Nouveaux esters et amides aromatiques, leur preparation et leur utilisation comme medicaments
EP0115933A3 (en) * 1983-01-29 1985-11-06 Beecham Group Plc Amide derivatives of azabicycloalkanes with dopamine activity
WO2005021536A3 (en) * 2003-08-29 2005-10-13 Sanofi Aventis Adamantane and azabicyclo-octane and nonane derivatives, process of their preparation and their use as dpp-iv inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1162129A (fr) * 1954-10-20 1958-09-09 Sandoz Ag Dérivés amidés du tropane et leur préparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1162129A (fr) * 1954-10-20 1958-09-09 Sandoz Ag Dérivés amidés du tropane et leur préparation

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984000166A1 (fr) * 1982-06-29 1984-01-19 Sandoz Ag Derives d'ester piperidyl d'acide benzoique et procede de production et d'utilisation de ces composes
FR2531083A1 (fr) * 1982-06-29 1984-02-03 Sandoz Sa Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
EP0115933A3 (en) * 1983-01-29 1985-11-06 Beecham Group Plc Amide derivatives of azabicycloalkanes with dopamine activity
FR2546169A1 (fr) * 1983-05-20 1984-11-23 Delalande Sa N-oxydes de derives aminocycliques, leur procede de preparation et leur application en therapeutique
EP0127529A3 (fr) * 1983-05-20 1987-10-14 Delalande S.A. N-oxydes de dérivés aminocycliques, leur procédé de préparation et leur application en thérapeutique
FR2551064A1 (fr) * 1983-08-26 1985-03-01 Sandoz Sa Nouveaux esters et amides aromatiques, leur preparation et leur utilisation comme medicaments
WO1985001048A1 (en) * 1983-08-26 1985-03-14 Sandoz Ag Aromatic esters or amides of carboxylic acid and sulfonic acid
WO2005021536A3 (en) * 2003-08-29 2005-10-13 Sanofi Aventis Adamantane and azabicyclo-octane and nonane derivatives, process of their preparation and their use as dpp-iv inhibitors
AU2004268832B2 (en) * 2003-08-29 2011-04-28 Sanofi-Aventis Adamantane and azabicyclo-octane and nonane derivatives, process of their preparation and their use as DPP-IV inhibitors

Also Published As

Publication number Publication date
FR2499570B1 (esLanguage) 1983-08-05

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