FR2492381B1 - - Google Patents

Info

Publication number
FR2492381B1
FR2492381B1 FR8022438A FR8022438A FR2492381B1 FR 2492381 B1 FR2492381 B1 FR 2492381B1 FR 8022438 A FR8022438 A FR 8022438A FR 8022438 A FR8022438 A FR 8022438A FR 2492381 B1 FR2492381 B1 FR 2492381B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8022438A
Other languages
French (fr)
Other versions
FR2492381A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Priority to FR8022438A priority Critical patent/FR2492381A1/fr
Priority to MX8571A priority patent/MX155032A/es
Priority to YU2454/81A priority patent/YU42587B/xx
Priority to ES506222A priority patent/ES8301927A1/es
Priority to IL64075A priority patent/IL64075A0/xx
Priority to AR287128A priority patent/AR228621A1/es
Priority to DK460181A priority patent/DK162444C/da
Priority to GR66308A priority patent/GR75389B/el
Priority to PH26368A priority patent/PH17338A/en
Priority to PT73857A priority patent/PT73857B/pt
Priority to FI813279A priority patent/FI73678C/fi
Priority to DD81234232A priority patent/DD201891A5/de
Priority to DE8181401642T priority patent/DE3165428D1/de
Priority to ZA817251A priority patent/ZA817251B/xx
Priority to SU813346599A priority patent/SU1138022A3/ru
Priority to NO813541A priority patent/NO155098C/no
Priority to CA000388374A priority patent/CA1183140A/fr
Priority to NZ198701A priority patent/NZ198701A/en
Priority to IE2460/81A priority patent/IE51823B1/en
Priority to EG81609A priority patent/EG15419A/xx
Priority to EP81401642A priority patent/EP0051020B1/fr
Priority to US06/313,184 priority patent/US4397857A/en
Priority to AT81401642T priority patent/ATE8892T1/de
Priority to AU76624/81A priority patent/AU540609B2/en
Priority to MA19509A priority patent/MA19307A1/fr
Priority to HU813066A priority patent/HU185058B/hu
Priority to KR1019810004015A priority patent/KR860001877B1/ko
Priority to JP56168516A priority patent/JPS5798281A/ja
Priority to OA57525A priority patent/OA06930A/xx
Priority to FR8206899A priority patent/FR2525604B2/fr
Publication of FR2492381A1 publication Critical patent/FR2492381A1/fr
Application granted granted Critical
Publication of FR2492381B1 publication Critical patent/FR2492381B1/fr
Priority to JP60252137A priority patent/JPS61126025A/ja
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
FR8022438A 1980-10-21 1980-10-21 Nouveaux acides aza bicyclo alcane carboxyliques substitues leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme Granted FR2492381A1 (fr)

Priority Applications (31)

Application Number Priority Date Filing Date Title
FR8022438A FR2492381A1 (fr) 1980-10-21 1980-10-21 Nouveaux acides aza bicyclo alcane carboxyliques substitues leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
MX8571A MX155032A (es) 1980-10-21 1981-10-06 Procedimiento para preparar acidos azabiciclo octano carboxilicos
YU2454/81A YU42587B (en) 1980-10-21 1981-10-13 Process for producing aza-bicyclo-octane-carboxylic acids
ES506222A ES8301927A1 (es) 1980-10-21 1981-10-13 Procedimiento de preparacion de acidos azabiciclohexano car-boxilicos y de sus sales
AR287128A AR228621A1 (es) 1980-10-21 1981-10-19 Procedimiento de preparacion de derivados de acido n-(mercapto o carboxialquilamino)-azabiclico-octano-3-carboxilico
DK460181A DK162444C (da) 1980-10-21 1981-10-19 Analogifremgangsmaade til fremstilling af azabicyklooctancarboxylsyrer og farmaceutisk acceptable salte heraf
IL64075A IL64075A0 (en) 1980-10-21 1981-10-19 Substituted azabicyclooctane-carboxylic acids,their preparation and pharmaceutical compositions containing them
EP81401642A EP0051020B1 (fr) 1980-10-21 1981-10-20 Acides aza bicyclooctane carboxyliques, leur préparation et compositions pharmaceutiques les contenant
PT73857A PT73857B (fr) 1980-10-21 1981-10-20 Procede de preparation d'acides aza-bicyclo-octane carboxy- liques
FI813279A FI73678C (fi) 1980-10-21 1981-10-20 Foerfarande foer framstaellning av farmaceutiskt anvaendbara azabicyklo-oktankarboxylsyror.
DD81234232A DD201891A5 (de) 1980-10-21 1981-10-20 Verfahren zur herstellung von aza-biozyklo-oktan-karboxylsaeuren
DE8181401642T DE3165428D1 (en) 1980-10-21 1981-10-20 Substituted azobicyclooctanecarboxylic acids, process for their preparation und pharmaceutical compositions containing them
ZA817251A ZA817251B (en) 1980-10-21 1981-10-20 Substituted azabicyclooctane carboxylic acids,their preparation and pharmaceutical compositions containing them
SU813346599A SU1138022A3 (ru) 1980-10-21 1981-10-20 Способ получени азабициклооктанкарбоновых кислот в виде рацематов или оптического изомера,или их солей
NO813541A NO155098C (no) 1980-10-21 1981-10-20 Analogifremgangsmaate ved fremstilling av farmasoeytisk aktive aza-bicyklo-oktan-karboksylsyrer.
CA000388374A CA1183140A (fr) 1980-10-21 1981-10-20 Procede de preparation d'acides aza-bicyclo-octane carboxyliques
GR66308A GR75389B (US08063081-20111122-C00044.png) 1980-10-21 1981-10-20
IE2460/81A IE51823B1 (en) 1980-10-21 1981-10-20 Substituted azabicyclo-octane-carboxylic acids,their preparation and pharmaceutical compositions containing them
EG81609A EG15419A (en) 1980-10-21 1981-10-20 Process for preparing azabicyclooctane-carboxylic acids
PH26368A PH17338A (en) 1980-10-21 1981-10-20 Substituted azabicyclo-octane-carboxylic acids,their preparation and pharmaceutical compositions containing them
US06/313,184 US4397857A (en) 1980-10-21 1981-10-20 Azabicyclooctane-carboxylic acids and pharmaceutical compositions containing them and antihypertensive use thereof
AT81401642T ATE8892T1 (de) 1980-10-21 1981-10-20 Substituierte azabicyclooctancarboxylsaeure, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
AU76624/81A AU540609B2 (en) 1980-10-21 1981-10-20 Aza-bicyclo-octane carboxylic acid derivatives
MA19509A MA19307A1 (fr) 1980-10-21 1981-10-20 Procede de preparation d'acide aza-bicyclo octane carboxyliques.
NZ198701A NZ198701A (en) 1980-10-21 1981-10-20 Certain azabicyclooctane carboxylic acids and pharmaceutical compositions containing such
HU813066A HU185058B (en) 1980-10-21 1981-10-21 Process for producing aza-bicyclo-octane-carboxylic acids
KR1019810004015A KR860001877B1 (ko) 1980-10-21 1981-10-21 아자비시클로-옥탄-카복실산의 제조방법
JP56168516A JPS5798281A (en) 1980-10-21 1981-10-21 Azabicyclooctane-carboxylic acid, manufacture and pharmaceutical composition containing same
OA57525A OA06930A (fr) 1980-10-21 1981-10-21 Procédé de préparation d'acides aza-bicyclo-octane carboxyliques.
FR8206899A FR2525604B2 (fr) 1980-10-21 1982-04-22 Acides aza bicyclo heptane carboxyliques substitues, leur preparation et leur application en therapeutique
JP60252137A JPS61126025A (ja) 1980-10-21 1985-11-12 アザビシクロオクタン‐カルボン酸を含有する医薬組成物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8022438A FR2492381A1 (fr) 1980-10-21 1980-10-21 Nouveaux acides aza bicyclo alcane carboxyliques substitues leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme

Publications (2)

Publication Number Publication Date
FR2492381A1 FR2492381A1 (fr) 1982-04-23
FR2492381B1 true FR2492381B1 (US08063081-20111122-C00044.png) 1983-08-12

Family

ID=9247120

Family Applications (2)

Application Number Title Priority Date Filing Date
FR8022438A Granted FR2492381A1 (fr) 1980-10-21 1980-10-21 Nouveaux acides aza bicyclo alcane carboxyliques substitues leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR8206899A Expired FR2525604B2 (fr) 1980-10-21 1982-04-22 Acides aza bicyclo heptane carboxyliques substitues, leur preparation et leur application en therapeutique

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR8206899A Expired FR2525604B2 (fr) 1980-10-21 1982-04-22 Acides aza bicyclo heptane carboxyliques substitues, leur preparation et leur application en therapeutique

Country Status (29)

Country Link
US (1) US4397857A (US08063081-20111122-C00044.png)
EP (1) EP0051020B1 (US08063081-20111122-C00044.png)
JP (2) JPS5798281A (US08063081-20111122-C00044.png)
KR (1) KR860001877B1 (US08063081-20111122-C00044.png)
AR (1) AR228621A1 (US08063081-20111122-C00044.png)
AT (1) ATE8892T1 (US08063081-20111122-C00044.png)
AU (1) AU540609B2 (US08063081-20111122-C00044.png)
CA (1) CA1183140A (US08063081-20111122-C00044.png)
DD (1) DD201891A5 (US08063081-20111122-C00044.png)
DE (1) DE3165428D1 (US08063081-20111122-C00044.png)
DK (1) DK162444C (US08063081-20111122-C00044.png)
EG (1) EG15419A (US08063081-20111122-C00044.png)
ES (1) ES8301927A1 (US08063081-20111122-C00044.png)
FI (1) FI73678C (US08063081-20111122-C00044.png)
FR (2) FR2492381A1 (US08063081-20111122-C00044.png)
GR (1) GR75389B (US08063081-20111122-C00044.png)
HU (1) HU185058B (US08063081-20111122-C00044.png)
IE (1) IE51823B1 (US08063081-20111122-C00044.png)
IL (1) IL64075A0 (US08063081-20111122-C00044.png)
MA (1) MA19307A1 (US08063081-20111122-C00044.png)
MX (1) MX155032A (US08063081-20111122-C00044.png)
NO (1) NO155098C (US08063081-20111122-C00044.png)
NZ (1) NZ198701A (US08063081-20111122-C00044.png)
OA (1) OA06930A (US08063081-20111122-C00044.png)
PH (1) PH17338A (US08063081-20111122-C00044.png)
PT (1) PT73857B (US08063081-20111122-C00044.png)
SU (1) SU1138022A3 (US08063081-20111122-C00044.png)
YU (1) YU42587B (US08063081-20111122-C00044.png)
ZA (1) ZA817251B (US08063081-20111122-C00044.png)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19575012I2 (de) * 1980-10-23 2002-01-24 Schering Corp Carboxyalkyl-Dipeptide Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
IE54551B1 (en) * 1982-01-22 1989-11-22 Ici Plc Amide derivatives
DE3227055A1 (de) * 1982-07-20 1984-01-26 Hoechst Ag, 6230 Frankfurt Neue derivate der 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure als zwischenstufe und verfahren zu deren herstellung
DE3246757A1 (de) * 1982-12-17 1984-06-20 Hoechst Ag, 6230 Frankfurt Neue 2-azabicyclo(2.2.1)heptan-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-azabicyclo(2.2.1)heptan-derivate als zwischenprodukte und verfahren zu deren herstellung
DE3303344A1 (de) 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern
US4693996A (en) * 1985-12-23 1987-09-15 Warner-Lambert Company Method of treating heart failure and medicaments therefor
DE3707911C1 (de) * 1987-03-12 1988-03-31 Texaco Ag Bicyclische Aminkatalysatoren
FR2619813B1 (fr) * 1987-08-28 1991-05-03 Adir Nouveaux derives de l'acide aza - 2 bicyclooctane carboxylique - 3, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2635684A1 (fr) * 1988-08-24 1990-03-02 Adir Utilisation de derives de l'acide aza - 2 bicyclooctane (2.2.2) carboxylique - 3 pour l'obtention de medicaments destines au traitement des maladies consecutives a l'alteration de la paroi vasculaire ainsi qu'aux troubles de la microcirculation
JPH0426348U (US08063081-20111122-C00044.png) * 1990-06-25 1992-03-02
TW197945B (US08063081-20111122-C00044.png) * 1990-11-27 1993-01-11 Hoechst Ag
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
EP0796855B1 (de) 1996-03-20 2002-02-06 Hoechst Aktiengesellschaft Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US20040077605A1 (en) * 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
AU2001288213B2 (en) 2000-06-28 2005-04-14 Bristol-Myers Squibb Company Selective androgen receptor modulators and methods for their identification, design and use
US7001911B2 (en) 2000-06-28 2006-02-21 Bristol-Myers Squibb Company Fused cyclic modulators of nuclear hormone receptor function
EP1854798A3 (en) 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US6953679B2 (en) 2000-09-19 2005-10-11 Bristol-Myers Squibb Company Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
WO2003053358A2 (en) * 2001-12-19 2003-07-03 Bristol-Myers Squibb Company Fused heterocyclic compounds and analogs thereof: modulators of nuclear hormone receptor function

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE94175C (US08063081-20111122-C00044.png) *
GB1095105A (en) * 1965-04-12 1967-12-13 Scherico Ltd Novel n-(phenyl-sulfonyl)-isoquinuclidine-carboxamides
US3741973A (en) * 1967-09-11 1973-06-26 Upjohn Co Oxygenated 3-azabicyclo(3.3.1)nonanes
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids

Also Published As

Publication number Publication date
JPS6146453B2 (US08063081-20111122-C00044.png) 1986-10-14
DD201891A5 (de) 1983-08-17
PT73857A (fr) 1981-11-01
JPS6112911B2 (US08063081-20111122-C00044.png) 1986-04-10
NZ198701A (en) 1984-07-06
EP0051020A1 (fr) 1982-05-05
ES506222A0 (es) 1983-01-01
YU42587B (en) 1988-10-31
JPS5798281A (en) 1982-06-18
PH17338A (en) 1984-08-01
ES8301927A1 (es) 1983-01-01
PT73857B (fr) 1983-01-25
FR2525604A2 (fr) 1983-10-28
FI73678B (fi) 1987-07-31
HU185058B (en) 1984-11-28
JPS61126025A (ja) 1986-06-13
DK162444C (da) 1992-03-23
FI73678C (fi) 1987-11-09
KR830007570A (ko) 1983-10-21
DE3165428D1 (en) 1984-09-13
SU1138022A3 (ru) 1985-01-30
EP0051020B1 (fr) 1984-08-08
FR2525604B2 (fr) 1985-06-07
KR860001877B1 (ko) 1986-10-24
EG15419A (en) 1986-03-31
GR75389B (US08063081-20111122-C00044.png) 1984-07-13
NO155098B (no) 1986-11-03
IE812460L (en) 1982-04-21
AR228621A1 (es) 1983-03-30
NO813541L (no) 1982-04-22
OA06930A (fr) 1983-05-31
FR2492381A1 (fr) 1982-04-23
IL64075A0 (en) 1982-01-31
DK162444B (da) 1991-10-28
YU245481A (en) 1984-04-30
NO155098C (no) 1987-02-11
FI813279L (fi) 1982-04-22
ATE8892T1 (de) 1984-08-15
ZA817251B (en) 1982-09-29
CA1183140A (fr) 1985-02-26
DK460181A (da) 1982-04-22
MX155032A (es) 1988-01-21
MA19307A1 (fr) 1982-07-01
US4397857A (en) 1983-08-09
AU7662481A (en) 1982-04-29
IE51823B1 (en) 1987-04-01
AU540609B2 (en) 1984-11-29

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse