FR2487341A1 - Tripeptides inhibiteurs de l'enzyme de transformation de l'angiotensine - Google Patents
Tripeptides inhibiteurs de l'enzyme de transformation de l'angiotensine Download PDFInfo
- Publication number
- FR2487341A1 FR2487341A1 FR8112100A FR8112100A FR2487341A1 FR 2487341 A1 FR2487341 A1 FR 2487341A1 FR 8112100 A FR8112100 A FR 8112100A FR 8112100 A FR8112100 A FR 8112100A FR 2487341 A1 FR2487341 A1 FR 2487341A1
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- Prior art keywords
- proline
- alanyl
- amino
- hydrogen atom
- oxo
- Prior art date
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- 102000015427 Angiotensins Human genes 0.000 title abstract description 5
- 230000009466 transformation Effects 0.000 title abstract description 3
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- 239000003112 inhibitor Substances 0.000 title description 2
- -1 HYDROXYL GROUP Chemical group 0.000 claims abstract description 30
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- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 4
- 239000001257 hydrogen Substances 0.000 claims abstract description 4
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- 229910052717 sulfur Inorganic materials 0.000 claims description 59
- 229960002429 proline Drugs 0.000 claims description 40
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 21
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 7
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- 159000000001 potassium salts Chemical class 0.000 description 1
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
- 229910052939 potassium sulfate Inorganic materials 0.000 description 1
- 235000011151 potassium sulphates Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
- 229960002256 spironolactone Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- AGHANLSBXUWXTB-UHFFFAOYSA-N tienilic acid Chemical compound ClC1=C(Cl)C(OCC(=O)O)=CC=C1C(=O)C1=CC=CS1 AGHANLSBXUWXTB-UHFFFAOYSA-N 0.000 description 1
- 229960000356 tienilic acid Drugs 0.000 description 1
- 229960001288 triamterene Drugs 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 229960004813 trichlormethiazide Drugs 0.000 description 1
- LMJSLTNSBFUCMU-UHFFFAOYSA-N trichlormethiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NC(C(Cl)Cl)NS2(=O)=O LMJSLTNSBFUCMU-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/171,772 US4293481A (en) | 1980-07-24 | 1980-07-24 | Tripeptide inhibitors of angiotensin-converting enzyme |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2487341A1 true FR2487341A1 (fr) | 1982-01-29 |
| FR2487341B1 FR2487341B1 (cg-RX-API-DMAC7.html) | 1984-08-17 |
Family
ID=22625069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8112100A Granted FR2487341A1 (fr) | 1980-07-24 | 1981-06-19 | Tripeptides inhibiteurs de l'enzyme de transformation de l'angiotensine |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4293481A (cg-RX-API-DMAC7.html) |
| JP (1) | JPS5753447A (cg-RX-API-DMAC7.html) |
| CA (1) | CA1187870A (cg-RX-API-DMAC7.html) |
| DE (1) | DE3129297A1 (cg-RX-API-DMAC7.html) |
| FR (1) | FR2487341A1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB2080310B (cg-RX-API-DMAC7.html) |
| IT (1) | IT1211069B (cg-RX-API-DMAC7.html) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2578544A1 (en) * | 1985-03-11 | 1986-09-12 | Usv Pharma Corp | Antihypertension spirocyclic compounds |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4356182A (en) * | 1979-10-22 | 1982-10-26 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of 4-disubstituted prolines |
| US4456761A (en) * | 1981-02-02 | 1984-06-26 | E. R. Squibb & Sons, Inc. | 4-Substituted dehydroprolines |
| US4746676A (en) * | 1984-09-12 | 1988-05-24 | Rorer Pharmaceutical Corporation | Carboxyalkyl dipeptide compounds |
| FR2585709B1 (fr) * | 1985-08-05 | 1987-10-02 | Adir | Nouveaux derives peptidiques a structure lactonique ou cycloamidique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP1874128A1 (en) * | 2005-04-28 | 2008-01-09 | Hindustan Unilever Limited | Peptides having an ace inhibiting effect |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4191753A (en) * | 1978-11-06 | 1980-03-04 | University Of Miami | Anti-hypertensive peptide analogs |
-
1980
- 1980-07-24 US US06/171,772 patent/US4293481A/en not_active Expired - Lifetime
-
1981
- 1981-06-01 CA CA000378750A patent/CA1187870A/en not_active Expired
- 1981-06-11 GB GB8117919A patent/GB2080310B/en not_active Expired
- 1981-06-19 FR FR8112100A patent/FR2487341A1/fr active Granted
- 1981-06-25 IT IT8122566A patent/IT1211069B/it active
- 1981-07-14 JP JP56110623A patent/JPS5753447A/ja active Pending
- 1981-07-24 DE DE19813129297 patent/DE3129297A1/de not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2578544A1 (en) * | 1985-03-11 | 1986-09-12 | Usv Pharma Corp | Antihypertension spirocyclic compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5753447A (en) | 1982-03-30 |
| IT8122566A0 (it) | 1981-06-25 |
| FR2487341B1 (cg-RX-API-DMAC7.html) | 1984-08-17 |
| DE3129297A1 (de) | 1982-05-13 |
| US4293481A (en) | 1981-10-06 |
| GB2080310A (en) | 1982-02-03 |
| IT1211069B (it) | 1989-09-29 |
| GB2080310B (en) | 1983-11-16 |
| CA1187870A (en) | 1985-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |