FR2486657A1 - Procede de detection et de dosage d'une substance biologique par erythroadsorption - Google Patents
Procede de detection et de dosage d'une substance biologique par erythroadsorption Download PDFInfo
- Publication number
- FR2486657A1 FR2486657A1 FR8015293A FR8015293A FR2486657A1 FR 2486657 A1 FR2486657 A1 FR 2486657A1 FR 8015293 A FR8015293 A FR 8015293A FR 8015293 A FR8015293 A FR 8015293A FR 2486657 A1 FR2486657 A1 FR 2486657A1
- Authority
- FR
- France
- Prior art keywords
- erythrocytes
- red blood
- serum
- substance
- blood cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000126 substance Substances 0.000 title claims abstract description 64
- 238000000034 method Methods 0.000 title claims abstract description 57
- 210000003743 erythrocyte Anatomy 0.000 claims abstract description 68
- 239000003446 ligand Substances 0.000 claims abstract description 37
- 238000010168 coupling process Methods 0.000 claims abstract description 34
- 230000008878 coupling Effects 0.000 claims abstract description 30
- 238000005859 coupling reaction Methods 0.000 claims abstract description 30
- 239000007788 liquid Substances 0.000 claims abstract description 4
- 210000002966 serum Anatomy 0.000 claims description 28
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 20
- 239000000427 antigen Substances 0.000 claims description 20
- 102000036639 antigens Human genes 0.000 claims description 20
- 108091007433 antigens Proteins 0.000 claims description 20
- 238000003556 assay Methods 0.000 claims description 14
- 108090001008 Avidin Proteins 0.000 claims description 11
- 229960002685 biotin Drugs 0.000 claims description 11
- 239000011616 biotin Substances 0.000 claims description 11
- 241001494479 Pecora Species 0.000 claims description 10
- 235000020958 biotin Nutrition 0.000 claims description 10
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 9
- 239000003153 chemical reaction reagent Substances 0.000 claims description 7
- 108060003951 Immunoglobulin Proteins 0.000 claims description 6
- 210000000601 blood cell Anatomy 0.000 claims description 6
- 102000018358 immunoglobulin Human genes 0.000 claims description 6
- 239000005556 hormone Substances 0.000 claims description 4
- 229940088597 hormone Drugs 0.000 claims description 4
- 238000005406 washing Methods 0.000 claims description 4
- 239000008188 pellet Substances 0.000 claims description 3
- 238000010521 absorption reaction Methods 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 230000002934 lysing effect Effects 0.000 claims description 2
- 239000012429 reaction media Substances 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims 1
- 239000000376 reactant Substances 0.000 claims 1
- 230000000007 visual effect Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 abstract description 4
- 230000003100 immobilizing effect Effects 0.000 abstract description 2
- 229940088598 enzyme Drugs 0.000 description 11
- 108090000790 Enzymes Proteins 0.000 description 10
- 102000004190 Enzymes Human genes 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 238000011534 incubation Methods 0.000 description 8
- 230000003172 anti-dna Effects 0.000 description 6
- 238000003018 immunoassay Methods 0.000 description 6
- 229920000136 polysorbate Polymers 0.000 description 6
- 108010062580 Concanavalin A Proteins 0.000 description 5
- 239000008363 phosphate buffer Substances 0.000 description 5
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 4
- 102000001554 Hemoglobins Human genes 0.000 description 4
- 108010054147 Hemoglobins Proteins 0.000 description 4
- 229940098773 bovine serum albumin Drugs 0.000 description 4
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 3
- GPUBPSKTFNYPHI-AYGRAXKESA-N 3-[5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoyl]-1-hydroxypyrrolidine-2,5-dione Chemical compound O=C1N(O)C(=O)CC1C(=O)CCCC[C@H]1[C@H]2NC(=O)N[C@H]2CS1 GPUBPSKTFNYPHI-AYGRAXKESA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 239000012736 aqueous medium Substances 0.000 description 3
- 239000013060 biological fluid Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000007822 coupling agent Substances 0.000 description 3
- 230000002255 enzymatic effect Effects 0.000 description 3
- 230000035931 haemagglutination Effects 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- GEYOCULIXLDCMW-UHFFFAOYSA-N 1,2-phenylenediamine Chemical compound NC1=CC=CC=C1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 description 2
- JRBJSXQPQWSCCF-UHFFFAOYSA-N 3,3'-Dimethoxybenzidine Chemical compound C1=C(N)C(OC)=CC(C=2C=C(OC)C(N)=CC=2)=C1 JRBJSXQPQWSCCF-UHFFFAOYSA-N 0.000 description 2
- 108010015776 Glucose oxidase Proteins 0.000 description 2
- 239000004366 Glucose oxidase Substances 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 108090001090 Lectins Proteins 0.000 description 2
- 102000004856 Lectins Human genes 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 244000309466 calf Species 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 229940116332 glucose oxidase Drugs 0.000 description 2
- 235000019420 glucose oxidase Nutrition 0.000 description 2
- 230000001744 histochemical effect Effects 0.000 description 2
- 229940072221 immunoglobulins Drugs 0.000 description 2
- 239000002523 lectin Substances 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 210000001541 thymus gland Anatomy 0.000 description 2
- HBOMLICNUCNMMY-KJFJCRTCSA-N 1-[(4s,5s)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound O=C1NC(=O)C(C)=CN1C1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-KJFJCRTCSA-N 0.000 description 1
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 101000904208 Aspergillus niger Glucose oxidase Proteins 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000581364 Clinitrachus argentatus Species 0.000 description 1
- GUBGYTABKSRVRQ-WFVLMXAXSA-N DEAE-cellulose Chemical compound OC1C(O)C(O)C(CO)O[C@H]1O[C@@H]1C(CO)OC(O)C(O)C1O GUBGYTABKSRVRQ-WFVLMXAXSA-N 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 102000004407 Lactalbumin Human genes 0.000 description 1
- 108090000942 Lactalbumin Proteins 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000007975 buffered saline Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- BFMYDTVEBKDAKJ-UHFFFAOYSA-L disodium;(2',7'-dibromo-3',6'-dioxido-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury;hydrate Chemical compound O.[Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C([O-])C([Hg])=C1OC1=C2C=C(Br)C([O-])=C1 BFMYDTVEBKDAKJ-UHFFFAOYSA-L 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 210000004201 immune sera Anatomy 0.000 description 1
- 229940042743 immune sera Drugs 0.000 description 1
- 229940127121 immunoconjugate Drugs 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- HOVAGTYPODGVJG-VEIUFWFVSA-N methyl alpha-D-mannoside Chemical compound CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O HOVAGTYPODGVJG-VEIUFWFVSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- -1 physiological media Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000012207 quantitative assay Methods 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/586—Liposomes, microcapsules or cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/809—Multifield plates or multicontainer arrays
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/819—Multifunctional antigen or antibody
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/825—Pretreatment for removal of interfering factors from sample
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/827—Lectins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8015293A FR2486657A1 (fr) | 1980-07-09 | 1980-07-09 | Procede de detection et de dosage d'une substance biologique par erythroadsorption |
| BE0/205355A BE889557A (fr) | 1980-07-09 | 1981-07-08 | Procede de detection et de dosage d'une substance biologique par eruthroadsorption |
| DE8181902035T DE3166948D1 (en) | 1980-07-09 | 1981-07-08 | Method for detecting and determining a biological substance by erythroadsorption |
| JP56502386A JPS57500997A (cg-RX-API-DMAC7.html) | 1980-07-09 | 1981-07-08 | |
| EP81902035A EP0055751B1 (fr) | 1980-07-09 | 1981-07-08 | Procede de detection et de dosage d'une substance biologique par erythroadsorption |
| PCT/FR1981/000090 WO1982000203A1 (fr) | 1980-07-09 | 1981-07-08 | Procede de detection et de dosage d'une substance biologique par erythroadsorption |
| US06/807,773 US4729961A (en) | 1980-07-09 | 1985-12-11 | Process for the detection and assay by erythroadsorption |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8015293A FR2486657A1 (fr) | 1980-07-09 | 1980-07-09 | Procede de detection et de dosage d'une substance biologique par erythroadsorption |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2486657A1 true FR2486657A1 (fr) | 1982-01-15 |
| FR2486657B1 FR2486657B1 (cg-RX-API-DMAC7.html) | 1984-12-07 |
Family
ID=9244036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8015293A Granted FR2486657A1 (fr) | 1980-07-09 | 1980-07-09 | Procede de detection et de dosage d'une substance biologique par erythroadsorption |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4729961A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0055751B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPS57500997A (cg-RX-API-DMAC7.html) |
| BE (1) | BE889557A (cg-RX-API-DMAC7.html) |
| FR (1) | FR2486657A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO1982000203A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0103139B1 (en) * | 1982-08-11 | 1990-01-03 | Kabushiki Kaisha Toshiba | Reagent composition for immunoassay and immunoassay using the same |
| FR2534030A1 (fr) * | 1982-10-01 | 1984-04-06 | Pasteur Institut | Procede de detection et de dosage d'une substance biologique par erythroadsorption |
| US4663277A (en) * | 1983-05-20 | 1987-05-05 | Profile Diagnostic Sciences Inc. | Virus detection method and materials |
| US5866350A (en) * | 1985-03-19 | 1999-02-02 | Helen Hwai-An Lee | Method for the immunological determination of a biological material in a sample |
| EP0222781A1 (en) * | 1985-06-03 | 1987-05-27 | American National Red Cross | Microtiter - surface - flocculation assay for antigen or antibody screening |
| DE3609217A1 (de) * | 1986-03-19 | 1987-09-24 | Boehringer Mannheim Gmbh | Verfahren und reagenz zur bestimmung eines reaktionspartners einer immunologischen reaktion |
| CA1313616C (en) * | 1987-06-01 | 1993-02-16 | Robert B. Sargeant | Lateral flow, non-bibulous membrane protocols |
| US4943522A (en) * | 1987-06-01 | 1990-07-24 | Quidel | Lateral flow, non-bibulous membrane assay protocols |
| DE69229334T2 (de) * | 1991-01-11 | 1999-12-16 | Quidel Corp., San Diego | Einstufiges querfluss analysenverfahren und ein darin verwendeter nichtsaugfähiger träger |
| ES2101763T3 (es) * | 1992-02-25 | 1997-07-16 | Stiftung Fur Diagnostische For | Acoplamiento de antigenos y anticuerpos a eritrocitos no fijados. |
| EP0857377B1 (en) * | 1995-10-19 | 2006-08-16 | The University Of Melbourne | Embedded data link and protocol |
| WO1997025074A2 (en) * | 1996-01-12 | 1997-07-17 | Redcell Canada, Inc. | Cellular and serum protein anchors for diagnostic imaging |
| US20090087925A1 (en) * | 2007-10-01 | 2009-04-02 | Zyomyx, Inc. | Devices and methods for analysis of samples with depletion of analyte content |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1026726A (en) * | 1962-11-23 | 1966-04-20 | Ici Ltd | New assay technique |
| FR1516640A (fr) * | 1966-03-24 | 1968-03-08 | Organon Nv | Procédé pour améliorer les caractéristiques mécaniques des érythrocytes |
| NL130516C (cg-RX-API-DMAC7.html) * | 1966-11-08 | |||
| US3553310A (en) * | 1967-12-28 | 1971-01-05 | Miles Lab | Immunologically reactive particles |
| US3852157A (en) * | 1971-05-14 | 1974-12-03 | Syva Corp | Compounds for enzyme amplification assay |
| US4130634A (en) * | 1974-03-15 | 1978-12-19 | University Of Illinois Foundation | Method for detecting and quantifying antigens |
| FR2334106A1 (fr) * | 1975-12-02 | 1977-07-01 | Pasteur Institut | Gel magnetique convenant pour dosages immunoenzymatiques |
| FR2334107A1 (fr) * | 1975-12-05 | 1977-07-01 | Pasteur Institut | Procede de couplage de substances biologiques par des liaisons covalentes |
| SE7608297L (sv) * | 1976-07-21 | 1978-01-22 | Orion Yhtymae Oy | Forbettrat forfarande for framstellning av indikatorsystem for antigen-antikroppsreaktioner |
| US4134792A (en) * | 1976-12-06 | 1979-01-16 | Miles Laboratories, Inc. | Specific binding assay with an enzyme modulator as a labeling substance |
| US4320111A (en) * | 1977-06-14 | 1982-03-16 | American Home Products Corporation | Immunologic compositions methods of preparation and use |
| US4152411A (en) * | 1977-07-27 | 1979-05-01 | Akzona Incorporated | High specific activity labeled substances |
| JPS5510590A (en) * | 1978-05-04 | 1980-01-25 | Wellcome Found | Enzyme immunity quantity analysis |
| US4228237A (en) * | 1978-09-21 | 1980-10-14 | Calbiochem-Behring Corp. | Methods for the detection and determination of ligands |
| FR2455743A1 (fr) * | 1979-05-02 | 1980-11-28 | Goella Laboratoires | Procede et dispositif pour le dosage des lipoproteines seriques |
| US4342826A (en) * | 1980-02-04 | 1982-08-03 | Collaborative Research, Inc. | Immunoassay products and methods |
| DE3172879D1 (en) * | 1980-05-22 | 1985-12-19 | Pasteur Institut | Coupled product between a lectin and a specific ligand, obtention and use in the biological field |
| US4403037A (en) * | 1980-10-10 | 1983-09-06 | American Hoechst Corporation | Erythrocyte preparations and use thereof in hemagglutination tests |
-
1980
- 1980-07-09 FR FR8015293A patent/FR2486657A1/fr active Granted
-
1981
- 1981-07-08 WO PCT/FR1981/000090 patent/WO1982000203A1/fr not_active Ceased
- 1981-07-08 BE BE0/205355A patent/BE889557A/fr not_active IP Right Cessation
- 1981-07-08 JP JP56502386A patent/JPS57500997A/ja active Pending
- 1981-07-08 EP EP81902035A patent/EP0055751B1/fr not_active Expired
-
1985
- 1985-12-11 US US06/807,773 patent/US4729961A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1982000203A1 (fr) | 1982-01-21 |
| EP0055751B1 (fr) | 1984-10-31 |
| JPS57500997A (cg-RX-API-DMAC7.html) | 1982-06-03 |
| US4729961A (en) | 1988-03-08 |
| EP0055751A1 (fr) | 1982-07-14 |
| FR2486657B1 (cg-RX-API-DMAC7.html) | 1984-12-07 |
| BE889557A (fr) | 1982-01-08 |
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| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |