FR2483771A1 - Dispositif intravaginal pour administration de substances actives et son procede de realisation - Google Patents
Dispositif intravaginal pour administration de substances actives et son procede de realisation Download PDFInfo
- Publication number
- FR2483771A1 FR2483771A1 FR8111152A FR8111152A FR2483771A1 FR 2483771 A1 FR2483771 A1 FR 2483771A1 FR 8111152 A FR8111152 A FR 8111152A FR 8111152 A FR8111152 A FR 8111152A FR 2483771 A1 FR2483771 A1 FR 2483771A1
- Authority
- FR
- France
- Prior art keywords
- film
- skeleton
- molding
- active ingredient
- silicone rubber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 8
- 239000013543 active substance Substances 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 claims abstract description 22
- 229920002379 silicone rubber Polymers 0.000 claims abstract description 14
- 239000004945 silicone rubber Substances 0.000 claims abstract description 14
- 229920000642 polymer Polymers 0.000 claims abstract description 9
- 231100000252 nontoxic Toxicity 0.000 claims abstract description 4
- 230000003000 nontoxic effect Effects 0.000 claims abstract description 4
- 238000000465 moulding Methods 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 11
- 238000002347 injection Methods 0.000 claims description 9
- 239000007924 injection Substances 0.000 claims description 9
- 238000000605 extraction Methods 0.000 claims description 7
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims description 6
- 229920001971 elastomer Polymers 0.000 claims description 6
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 4
- 239000005977 Ethylene Substances 0.000 claims description 4
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims description 4
- 229940011871 estrogen Drugs 0.000 claims description 4
- 239000000262 estrogen Substances 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 4
- 238000004073 vulcanization Methods 0.000 claims description 4
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 3
- 238000010348 incorporation Methods 0.000 claims description 3
- 239000000186 progesterone Substances 0.000 claims description 3
- 229960003387 progesterone Drugs 0.000 claims description 3
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 2
- 239000004698 Polyethylene Substances 0.000 claims description 2
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 2
- 229910052796 boron Inorganic materials 0.000 claims description 2
- 239000010941 cobalt Substances 0.000 claims description 2
- 229910017052 cobalt Inorganic materials 0.000 claims description 2
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 2
- 239000010949 copper Substances 0.000 claims description 2
- 229910052802 copper Inorganic materials 0.000 claims description 2
- -1 polypropylene Polymers 0.000 claims description 2
- 239000011669 selenium Substances 0.000 claims description 2
- 229910052711 selenium Inorganic materials 0.000 claims description 2
- 229960003604 testosterone Drugs 0.000 claims description 2
- 239000011573 trace mineral Substances 0.000 claims description 2
- 235000013619 trace mineral Nutrition 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims 7
- 210000000056 organ Anatomy 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
- 241001465754 Metazoa Species 0.000 abstract description 13
- 239000000126 substance Substances 0.000 abstract description 13
- 238000001746 injection moulding Methods 0.000 abstract description 3
- 239000005556 hormone Substances 0.000 abstract description 2
- 229940088597 hormone Drugs 0.000 abstract description 2
- 244000144972 livestock Species 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 210000003041 ligament Anatomy 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 229940088679 drug related substance Drugs 0.000 description 3
- 230000006651 lactation Effects 0.000 description 3
- 230000036651 mood Effects 0.000 description 3
- 241001494479 Pecora Species 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000012173 estrus Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 235000014101 wine Nutrition 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- RGLYKWWBQGJZGM-ISLYRVAYSA-N diethylstilbestrol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(\CC)C1=CC=C(O)C=C1 RGLYKWWBQGJZGM-ISLYRVAYSA-N 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 230000001076 estrogenic effect Effects 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002366 mineral element Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Materials For Medical Uses (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ19397680 | 1980-06-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2483771A1 true FR2483771A1 (fr) | 1981-12-11 |
| FR2483771B1 FR2483771B1 (enExample) | 1985-03-22 |
Family
ID=19919207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8111152A Granted FR2483771A1 (fr) | 1980-06-09 | 1981-06-05 | Dispositif intravaginal pour administration de substances actives et son procede de realisation |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4449980A (enExample) |
| JP (1) | JPS5722750A (enExample) |
| AU (1) | AU538961B2 (enExample) |
| CA (1) | CA1182695A (enExample) |
| DE (2) | DE3122506A1 (enExample) |
| FR (1) | FR2483771A1 (enExample) |
| GB (1) | GB2079158B (enExample) |
| GR (1) | GR72701B (enExample) |
| IE (1) | IE51701B1 (enExample) |
| NL (1) | NL8102782A (enExample) |
| NZ (1) | NZ193976A (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ200564A (en) * | 1982-05-10 | 1987-03-06 | Ahi Operations Ltd | Device for slowly releasing chemicals into body cavities of animals |
| FR2536987B1 (fr) * | 1982-07-19 | 1985-10-31 | Serimed | Sterilet endo-uterin pour les animaux tels que les chiennes |
| EP0149367A1 (fr) * | 1984-01-18 | 1985-07-24 | Société Civile française dite "Européenne de Recherche d'Instrumentations Médicales S E R I M E D" | Stérilet endo-utérin pour les animaux tels que les chiennes |
| NZ207341A (en) * | 1984-03-01 | 1988-02-29 | Harvey Alex Ind Ltd | Device containing chemical impregnants for insertion into a body cavity of an animal |
| EP0180264A1 (en) * | 1984-10-12 | 1986-05-07 | Akzo N.V. | Release system for two or more active substances |
| US5238517A (en) * | 1987-10-15 | 1993-08-24 | Cmb Foodcan Plc | Production of laminated materials |
| BE1002600A3 (fr) * | 1988-11-23 | 1991-04-09 | Wildemeersch Dirk | Dispositif intra-uterin perfectionne. |
| BR8907903A (pt) * | 1989-09-05 | 1992-08-04 | Kevin Graham Doole | Conectores para madeira de construcao |
| FI84017B (fi) * | 1990-03-16 | 1991-06-28 | Kms Myynti Om Kerstin Margaret | Foerfarande foer framstaellning av intranterina preventivmedel. |
| US5242391A (en) * | 1990-04-25 | 1993-09-07 | Alza Corporation | Urethral insert for treatment of erectile dysfunction |
| US5224493A (en) * | 1991-01-30 | 1993-07-06 | Cadco Corporation | Contraceptive intracervical device and novel nonsystemic agents for the prevention of conception and disease |
| WO1994016652A1 (en) * | 1993-01-26 | 1994-08-04 | Page Hanes, Inc. | Disposable vaginal device |
| UY23740A1 (es) * | 1993-03-12 | 1994-08-09 | Enrique Horacio Turin | Dispositivo intrauterino bovino |
| AU6936394A (en) * | 1993-06-10 | 1995-01-03 | Kawatetu Galvanizing Co., Ltd. | Method for producing fluororesin-coated steel sheet |
| US5543150A (en) * | 1993-09-15 | 1996-08-06 | Columbia Laboratories, Inc. | Method of progesterone delivery and affect thereof |
| ZA97797B (en) * | 1996-02-01 | 1997-07-31 | Enrique Horacio Turin | Method for improving fattening and new intrauterine device for its insertion. |
| US5816248A (en) * | 1996-03-29 | 1998-10-06 | Iotek, Inc. | Channeled vaginal insert and method for treating urogenital disorders |
| US5988169A (en) * | 1996-03-29 | 1999-11-23 | Iotek, Inc. | Vaginal insert and method for treating urogenital disorders |
| US6030375A (en) * | 1996-03-29 | 2000-02-29 | Iotek, Inc. | Compressible vaginal insert and method for treating urogenital disorders |
| NZ286492A (en) * | 1996-05-01 | 1998-02-26 | Dec International Nz Ltd Subst | Intra vaginal devices for synchronising oestrus of animals is made up of cured silicone rubber material with 5% by weight of progesterone |
| DE69809222T2 (de) * | 1997-05-07 | 2003-08-14 | Galen (Chemicals) Ltd., Dublin | Vorrichtungen zur intravaginalen verabreichung von testosteron und testosteron-vorläuferverbindungen |
| NZ336241A (en) | 1999-06-11 | 2001-12-21 | Interag | Liquid delivery device, typically in form of bolus, with battery powered circuit to generate gas and move piston to expel gas |
| GB0009914D0 (en) * | 2000-04-20 | 2000-06-07 | Metris Therapeutics Limited | Device |
| DE20021114U1 (de) | 2000-12-13 | 2001-05-10 | Lau, Verena, 64289 Darmstadt | Wattepreßling mit Rückholbändchen |
| NZ509894A (en) * | 2001-02-09 | 2002-11-26 | Interag | A "T" or "Y" shaped intravaginal device suitable for delivery of pharmaceuticals such as progesterone |
| AR026386A1 (es) * | 2001-10-24 | 2003-02-12 | Massara Julio Eduardo | Un dispositivo intravaginal que contiene progesterona, util como inductor de celo en bovinos productores de carne y leche, y el procedimiento paraprepararlo |
| EP1933810B1 (en) | 2005-08-11 | 2012-10-10 | Massachusetts Institute of Technology | Intravesical drug delivery device and method |
| US7784466B2 (en) * | 2007-09-07 | 2010-08-31 | Julie Clodius-Talmadge | Protective shields and covers and methods for installing the same |
| US7913694B2 (en) * | 2007-09-07 | 2011-03-29 | Julie Clodius-Talmadge | Protective shield and cover |
| EA201070703A1 (ru) | 2007-12-11 | 2010-12-30 | Массачусетс Инститьют Оф Текнолоджи | Имплантируемое устройство для доставки лекарства и способы лечения мочевого пузыря и других полостей тела или трубчатых органов |
| EA201170297A1 (ru) | 2008-08-09 | 2011-08-30 | Массачусетс Инститьют Оф Текнолоджи | Имплантируемое устройство для доставки лекарственных средств и способ лечения мужской мочеполовой системы и окружающих тканей |
| FR2946526B1 (fr) | 2009-06-16 | 2012-05-11 | Cl Investissements | Sterilet |
| CA2765630C (en) | 2009-06-26 | 2016-07-05 | Taris Biomedical, Inc. | Solid drug tablets for implantable drug delivery devices |
| US9017312B2 (en) | 2009-09-10 | 2015-04-28 | Taris Biomedical Llc | Implantable device for controlled drug delivery |
| JP2014503554A (ja) | 2011-01-10 | 2014-02-13 | タリス バイオメディカル，インコーポレイテッド | 膀胱痛及び刺激性排尿の持続的治療の使用のためのリドカインレジメン |
| ES2637388T3 (es) | 2011-02-04 | 2017-10-13 | Taris Biomedical, Inc. | Dispositivo implantable para la liberación controlada de un fármaco de baja solubilidad |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| RS62297B1 (sr) | 2011-11-23 | 2021-09-30 | Therapeuticsmd Inc | Prirodne kombinovane hormonske supstitucione formulacije i terapije |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| PL2968880T3 (pl) | 2013-03-15 | 2025-06-23 | Taris Biomedical Llc | Urządzenia do dostarczania leku ze składnikiem przepuszczalnym dla leku |
| IL299897B2 (en) | 2013-08-19 | 2024-02-01 | Taris Biomedical Llc | Devices and methods for administering multiple units of drug |
| RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
| EP4744688A2 (en) | 2015-04-23 | 2026-05-20 | Janssen Biotech Inc | DRUG DELIVERY DEVICES WITH A DRUG-PERMEABLE COMPONENT AND METHODS |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| AU201617347S (en) * | 2016-12-23 | 2017-01-23 | Jurox Pty Ltd | intravaginal device |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1196678A (en) * | 1967-04-24 | 1970-07-01 | Chemolimpex | Improvements in Contraceptive Devices |
| GB1278899A (en) * | 1969-11-06 | 1972-06-21 | Ralph Rollin Robinson | Intrauterine element |
| US3683906A (en) * | 1970-08-28 | 1972-08-15 | Ralph R Robinson | Shielded intrauterine device |
| FR2250520A1 (enExample) * | 1973-11-09 | 1975-06-06 | Cournut Rene | |
| FR2287917A1 (fr) * | 1974-10-18 | 1976-05-14 | Schering Ag | Anneau vaginal |
| GB2026320A (en) * | 1978-07-25 | 1980-02-06 | Gutnick Morton | Devices for the prevention of venereal disease |
| GB1568419A (en) * | 1976-08-11 | 1980-05-29 | Pope M | Improvements in iucds |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3710795A (en) * | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
| US3703896A (en) * | 1970-12-29 | 1972-11-28 | Abcor Inc | Intrauterine contraceptive device |
| JPS4959497A (enExample) * | 1972-09-06 | 1974-06-10 | ||
| US3854476A (en) * | 1973-04-05 | 1974-12-17 | R Dickinson | Intra-vaginal device and method |
| DE2401361C3 (de) * | 1974-01-11 | 1978-06-08 | Abbott Laboratories, Chicago, Ill. (V.St.A.) | Medikamentträgeranker zum Verbleib in Körperhöhlen |
| JPS5318430B2 (enExample) * | 1974-01-17 | 1978-06-15 | ||
| DE2445971A1 (de) * | 1974-09-24 | 1976-04-08 | Schering Ag | Arzneimittelwirkstofftraeger ii |
| US4094313A (en) * | 1975-06-13 | 1978-06-13 | Takeo Komamura | Intra-uterine device and tool for insertion of same |
| US4202329A (en) * | 1978-05-05 | 1980-05-13 | Kortum William M | Method and apparatus for inducing immunological and resistant response in mammary glands |
| FR2475890A1 (fr) * | 1980-02-18 | 1981-08-21 | Roussel Uclaf | Dispositif pour l'administration de matieres medicamenteuses |
-
1981
- 1981-05-21 GB GB8115685A patent/GB2079158B/en not_active Expired
- 1981-05-21 AU AU70919/81A patent/AU538961B2/en not_active Ceased
- 1981-05-26 NZ NZ193976A patent/NZ193976A/en unknown
- 1981-06-03 US US06/269,974 patent/US4449980A/en not_active Expired - Fee Related
- 1981-06-03 IE IE1229/81A patent/IE51701B1/en not_active IP Right Cessation
- 1981-06-05 DE DE19813122506 patent/DE3122506A1/de active Granted
- 1981-06-05 CA CA000379088A patent/CA1182695A/en not_active Expired
- 1981-06-05 FR FR8111152A patent/FR2483771A1/fr active Granted
- 1981-06-05 GR GR65166A patent/GR72701B/el unknown
- 1981-06-05 DE DE8116797U patent/DE8116797U1/de not_active Expired
- 1981-06-09 NL NL8102782A patent/NL8102782A/nl not_active Application Discontinuation
- 1981-06-09 JP JP8875881A patent/JPS5722750A/ja active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1196678A (en) * | 1967-04-24 | 1970-07-01 | Chemolimpex | Improvements in Contraceptive Devices |
| GB1278899A (en) * | 1969-11-06 | 1972-06-21 | Ralph Rollin Robinson | Intrauterine element |
| US3683906A (en) * | 1970-08-28 | 1972-08-15 | Ralph R Robinson | Shielded intrauterine device |
| FR2250520A1 (enExample) * | 1973-11-09 | 1975-06-06 | Cournut Rene | |
| FR2287917A1 (fr) * | 1974-10-18 | 1976-05-14 | Schering Ag | Anneau vaginal |
| GB1568419A (en) * | 1976-08-11 | 1980-05-29 | Pope M | Improvements in iucds |
| GB2026320A (en) * | 1978-07-25 | 1980-02-06 | Gutnick Morton | Devices for the prevention of venereal disease |
Also Published As
| Publication number | Publication date |
|---|---|
| DE8116797U1 (de) | 1988-02-18 |
| NL8102782A (nl) | 1982-01-04 |
| GB2079158B (en) | 1985-01-09 |
| DE3122506A1 (de) | 1982-03-25 |
| GR72701B (enExample) | 1983-12-01 |
| CA1182695A (en) | 1985-02-19 |
| AU7091981A (en) | 1981-12-17 |
| NZ193976A (en) | 1984-10-19 |
| US4449980A (en) | 1984-05-22 |
| GB2079158A (en) | 1982-01-20 |
| AU538961B2 (en) | 1984-09-06 |
| FR2483771B1 (enExample) | 1985-03-22 |
| IE811229L (en) | 1981-12-09 |
| DE3122506C2 (enExample) | 1990-08-16 |
| IE51701B1 (en) | 1987-02-18 |
| JPS5722750A (en) | 1982-02-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4449980A (en) | Methods of making intra-vaginal devices and/or intra-vaginal devices | |
| US4585451A (en) | Devices which are adapted to slowly release chemicals, such as hormones, drugs and minerals | |
| US5176151A (en) | Oral prophylactics | |
| US4292965A (en) | Intravaginal ring | |
| EP0435983B1 (fr) | Prothese pour empecher les reflux gastriques dans l'oesophage | |
| FR2778557A3 (fr) | Rondelle de retenue rabatable pour tubes de gastrotomie et autres et tube correspondant | |
| HRP20050340A2 (en) | A delivery system and a manufacturing process of a delivery system | |
| FR2533443A1 (fr) | Stylet perfectionne pour tube d'alimentation | |
| JPH10290840A (ja) | 薬剤投与用の移植可能な円筒形装置 | |
| WO1998055101A1 (fr) | Implants pour la liberation controlee de principes pharmaceutiquement actifs et procede pour leur fabrication | |
| US3703898A (en) | Teat dilator | |
| FR2475890A1 (fr) | Dispositif pour l'administration de matieres medicamenteuses | |
| JP7719066B2 (ja) | 組織インターフェースコンポーネントを製造するための方法 | |
| JPH0374575B2 (enExample) | ||
| EP1562549B1 (fr) | Support appetent pour medicament destine a un animal | |
| EP1263361B1 (fr) | Dispositif d'insertion pour la mise en place d'un dispositif intra-uterin du type en forme de t | |
| AU2002334476B2 (en) | Intraruminal device | |
| AU2002334476A1 (en) | Intraruminal device | |
| JPS58208213A (ja) | 肛門の疾患を治療するための肛門座薬及び方法 | |
| US20040247665A1 (en) | Pill carrier and method | |
| FR2754711A1 (fr) | Dispositif de liberation avec effet retard d'une substance active, notamment veterinaire | |
| CN214596792U (zh) | 一种开塞露负压给药器 | |
| WO1984004666A1 (fr) | Contraceptif pour animaux | |
| KR20260004874A (ko) | 동물용 마이크로니들 패치 | |
| EP0149367A1 (fr) | Stérilet endo-utérin pour les animaux tels que les chiennes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |