FR2483078A1 - Rotating assembly for simultaneous analysis of biological fluid - uses cells equipped for centrifugal ejection, cleaning and drying - Google Patents
Rotating assembly for simultaneous analysis of biological fluid - uses cells equipped for centrifugal ejection, cleaning and drying Download PDFInfo
- Publication number
- FR2483078A1 FR2483078A1 FR8011511A FR8011511A FR2483078A1 FR 2483078 A1 FR2483078 A1 FR 2483078A1 FR 8011511 A FR8011511 A FR 8011511A FR 8011511 A FR8011511 A FR 8011511A FR 2483078 A1 FR2483078 A1 FR 2483078A1
- Authority
- FR
- France
- Prior art keywords
- cells
- reagent
- peripheral
- cell
- orifice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/07—Centrifugal type cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
Abstract
Description
ispositif d'analyse simultanée perfectionné
L'invention concerne un dispositif d'analyse, du type de ceux utilisant un support solide d'accrochage destiné à capter suecessi vement une quantité d'un premier réactif tel qu'un liquide biologique (sérum ou plasma par exemple) contenant la substance à dose, puis une quantité d'un deuxième réactif contenant une protéine sur laquelle est fixé un indicateur biologique (par exemple un enzymeS ou un radioisotope pour la radio-immunologie).advanced simultaneous analysis device
The invention relates to an analysis device, of the type using those of a solid attachment support intended for sensing a quantity of a first reagent such as a biological liquid (serum or plasma for example) containing the substance to be dose, then an amount of a second reagent containing a protein to which a biological indicator is attached (for example an enzymeS or a radioisotope for radioimmunology).
Les techniques actuelles utilisent un support solide d'accrochage qui est usuellement une bille sphérique en polystyrène recousent d'une protéine ayant des propriétés de type anti-corps (par exemple un polypeptide provenant d'un animal vacciné). Current techniques use a solid hooking support which is usually a spherical polystyrene ball stitched with a protein having anti-body type properties (for example a polypeptide from a vaccinated animal).
Il a déjà été proposé par le demandeur dans la demande de brevet français nO 79 26615 déposée le 26 octobre 1979 un dispositif fiable, de conception simple, et parfaitement adapté à une analyse simultanée avec plusieurs dosages, avec le minimum de manipulations, essentiellement constitué d'un rotor d'analyse comportant d'une part une pluralité de cellules périphériques contenant chacune au moins une bille d'accrochage, et d'autre part des moyens permettant l'acheminement d'un liquide de lavage vers chaque cellule, chacune desdites cellules étant munie d'un orifice périphérique d'éjection de liquide, et présen- tant une portion supérieure munie d'un orifice d'admission d'un réactif et une portion inférieure recevant ledit réactif et dont le fond permet de remonter la ou les billes sensiblement au niveau dudit orifice périphérique lorsque le dispositif est soumis à une centrifugation de façon à pouvoir rincer énergiquement la ou les billes au moyen du liquide de lavage admis dans ladite cellule. It has already been proposed by the applicant in French patent application No. 79 26615 filed on October 26, 1979 a reliable device, of simple design, and perfectly suited to a simultaneous analysis with several dosages, with the minimum of manipulations, essentially consisting of '' an analysis rotor comprising on the one hand a plurality of peripheral cells each containing at least one attachment ball, and on the other hand means allowing the delivery of a washing liquid to each cell, each of said cells being provided with a peripheral liquid ejection orifice, and having an upper portion provided with a reagent inlet orifice and a lower portion receiving said reagent and the bottom of which allows the ball or balls to be raised substantially at the level of said peripheral orifice when the device is subjected to centrifugation so as to be able to rinse vigorously the ball or balls by means of the washing liquid admitted into said cell.
Ce dispositif d'analyse peut présenter en outre l'une au moins des caractéristiques suivantes
- les moyens permettant l'acheminement du liquide de lavage sont essentiellement constitués par un orifice central d'admission duquel partent des conduits radiaux reliant ledit orifice central à chacune des cellules périphériques ; de préférence, les conduits radiaux sont dans un plan essentiellement perpendioulaire à l'axe de rotation du dispositif, et débouchent dans chaque cellule sensi blement au même niveau que l'orifice périphérique d'éjection de liquide de ladite cellule,
- les orifices d'admission du réactif sont équidistants de l'axe du rotor,
- le rotor est obtenu par superposition de deux portions coaxiales dont les bords périphériques en contact définissent directement les orifices périphériques des cellules.This analysis device can also have at least one of the following characteristics
- The means allowing the delivery of the washing liquid are essentially constituted by a central inlet orifice from which leave radial conduits connecting said central orifice to each of the peripheral cells; preferably, the radial conduits are in a plane essentially perpendicular to the axis of rotation of the device, and open into each cell substantially at the same level as the peripheral liquid ejection orifice of said cell,
- the reagent inlet ports are equidistant from the axis of the rotor,
- The rotor is obtained by superposition of two coaxial portions whose peripheral edges in contact directly define the peripheral orifices of the cells.
Dans le mode de réalisation décrit dans la demande de brevet précitée, le fond de chaque cellule présente une allure générale inclinée déterminée de telle façon que d'une part la portion inférieure de la cellule présente un volume suffisant pour recevoir une bille et la quantité de réactif la recouvrant, et que d'autre part ladite bille soit guidée sensiblement jusqu'au niveau de l'orifice périphérique de ladite cellule lors de la centrifugation ; il a été en outre indiqué que, de préférence, les parois définissant la portion inférieure de chaque cellule permettent une analyse photométrique simultanée. In the embodiment described in the aforementioned patent application, the bottom of each cell has a generally inclined appearance determined so that on the one hand the lower portion of the cell has a volume sufficient to receive a ball and the amount of reagent covering it, and on the other hand said ball is guided substantially up to the level of the peripheral orifice of said cell during centrifugation; it has also been indicated that, preferably, the walls defining the lower portion of each cell allow simultaneous photometric analysis.
L'invention a pour but de simplifier le dispositif décrit cidessus. The invention aims to simplify the device described above.
Dans le dispositif selon la présente invention, le support solide d'accrochage est constitué par la paroi de la portion inférieure de chaque cellule, dont les faces interne et externe sont parallèles, la face externe présentant en outre un déversoir latéral terminé par l'orifice d'éjection et permettant l'évacuation totale du liquide de lavage lors de la centrifugation. In the device according to the present invention, the solid attachment support is constituted by the wall of the lower portion of each cell, the internal and external faces of which are parallel, the external face also having a lateral overflow terminated by the orifice. ejection and allowing the total evacuation of the washing liquid during centrifugation.
D'autres caractéristiques et avantages de l'invention apparaitront plus clairement à la lumière de la description qui va suivre, donnée à titre illustratif mais nullement limitatif, en référence aux figures du dessin annexé, où :
- la figure 1 est une coupe axiale partielle montrant schématiquement le dispositif conforme à l'invention.Other characteristics and advantages of the invention will appear more clearly in the light of the description which follows, given by way of illustration but in no way limiting, with reference to the figures of the appended drawing, where:
- Figure 1 is a partial axial section schematically showing the device according to the invention.
- la figure 2 est une vue en perspective de la portion inférieure d'une cellule du dispositif selon l'invention. - Figure 2 is a perspective view of the lower portion of a cell of the device according to the invention.
Comme dans la demande de brevet précitée, le dispositif d'analyse conforme à l'invention, est essentiellement constitué d'un rotor comportant d'une part une pluralité de cellules périphériques 2, et d'autre part de moyens permettant l'acheminement d'un liquide de lavage vers chaque cellule. Plusieurs moyens sont possibles pour acheminer un liquide de lavage : on a illustré ici une possibilité particulièrement simple et efficace en prévoyant un orifice central d'admission 4 duquel partent des conduits radiaux 5 reliant ledit orifice central à chaque cellule périphérique 2, lesdits conduits étant dans un plan essentiellement perpendiculaire à l'axe de rotation 6 du dispositif ; on pourrait aussi bien prévoir une gouttière annulaire à la place de l'orifice central 4, de laquelle partiraient des conduits de raccordement radiaux vers chaque cellule périphérique.Il est à noter que les conduits radiaux 5 sont ici définis par deux portions complémentaires formées sur chacune des deux parties formant le rotor 1, mais que tout autre type de conduit serait envisageable, tel par exemple qu'un bord plat sur une partie du rotor (donc sa face interne) et une rainure sur l'autre partie. As in the aforementioned patent application, the analysis device according to the invention essentially consists of a rotor comprising on the one hand a plurality of peripheral cells 2, and on the other hand means allowing the routing of '' washing liquid to each cell. Several means are possible for conveying a washing liquid: a particularly simple and effective possibility has been illustrated here by providing a central intake orifice 4 from which radial conduits 5 connecting said central orifice to each peripheral cell 2, said conduits being in a plane essentially perpendicular to the axis of rotation 6 of the device; one could also provide an annular gutter in place of the central orifice 4, from which would leave radial connection conduits towards each peripheral cell. It should be noted that the radial conduits 5 are here defined by two complementary portions formed on each of the two parts forming the rotor 1, but that any other type of duct could be envisaged, such as for example a flat edge on one part of the rotor (therefore its internal face) and a groove on the other part.
Chaque cellule 2 est par ailleurs munie d'un orifice périphérique 7 d'éjection de liquide, ici défini directement par superposition des bords périphériques des deux portions coaxiales-formant le rotor, et présente une portion supérieure munie d'un orifice 8 d'admission. Each cell 2 is moreover provided with a peripheral orifice 7 for ejecting liquid, here defined directly by superposition of the peripheral edges of the two coaxial portions-forming the rotor, and has an upper portion provided with an orifice 8 for admission .
L'homme de l'art choisira tout moyen pour la liaison et le positionnement respectif des deux portions formant le rotor. Those skilled in the art will choose any means for the connection and the respective positioning of the two portions forming the rotor.
Selon l'invention, le support solide d'accrochage est constitué par la paroi de la portion inférieure des cellules 2 qui est recouverte d'une protéine ayant des propriétés de type anti-corps. Avantageusement les faces interne 21 et externe 22 de la cellule au niveau de cette portion inférieure sont parallèles. De plus la face externe 22 présente un déversoir latéral 23 terminé par l'orifice d'éjection 7, ce déversoir étant positionné, comme représenté, à la partie postérieure de la cellule par rapport au sens de rotation. According to the invention, the solid attachment support consists of the wall of the lower portion of cells 2 which is covered with a protein having properties of the anti-body type. Advantageously, the internal 21 and external 22 faces of the cell at the level of this lower portion are parallel. In addition, the external face 22 has a lateral overflow 23 terminated by the ejection orifice 7, this overflow being positioned, as shown, at the rear part of the cell with respect to the direction of rotation.
Comme dans le dispositif décrit dans la demande précitée, le rotor est disposé sous un dispositif d'alimentation, de façon à injecter dans chaque cellule 2 par son orifice 8, un volume (de préférence calibré) d'un premier réactif tel que sérum, plasma ou tout autre liquide biologique contenant la substance à doser ; après cette injection, on laisse reposer pendant le temps d'incubation nécessaire. As in the device described in the aforementioned application, the rotor is placed under a supply device, so as to inject into each cell 2 through its orifice 8, a volume (preferably calibrated) of a first reagent such as serum, plasma or any other biological fluid containing the substance to be measured; after this injection, it is left to stand for the necessary incubation time.
Le rotor est ensuite mis en rotation par des moyens d'entrai- nement tout à fait classiques, et on injecte du liquide de lavage par -l'orifice central 4. Avantageusement on prévoit à la sortie des conduits 5 des moyens 24 formant chicanes de manière à bien diriger le liquide de lavage vers le fond de la cellule. Pour chaque cellule, la centrifugation a pour effet d'éjecter l'excès de réactif par l'orifice périphérique 7. En outre, le liquide de lavage, dont la bonne répartition peut être favorisée par la présence d'une protubérance centrale 14, passe par les conduits radiaux 5, et vient laver énergiquement les parois de la portion interne de chaque cellule 2, ledit liquide s'échappant par les orifices périphériques 7, l'évacuation étant complète du fait de la présence du déversoir latéral 24. The rotor is then rotated by entirely conventional drive means, and washing liquid is injected through the central orifice 4. Advantageously, means 24 forming baffles are provided at the outlet of the conduits. so as to direct the washing liquid towards the bottom of the cell. For each cell, the centrifugation has the effect of ejecting the excess of reagent through the peripheral orifice 7. In addition, the washing liquid, the good distribution of which can be favored by the presence of a central protuberance 14, passes by the radial conduits 5, and comes to vigorously wash the walls of the internal portion of each cell 2, said liquid escaping through the peripheral orifices 7, the evacuation being complete due to the presence of the lateral overflow 24.
Après le lavage on peut procéder facultativement à un séchage
en coupant l'admission du liquide de lavage tout en maintenant la
centrifugation.After washing, drying can be optional
by shutting off the wash fluid inlet while maintaining the
centrifugation.
Ces opérations sont ensuite réitérées avec le deuxième réactif,
qui contient une protéine sur laquelle est fixé un indicateur biolo
giquetel par exemple qu'un enzyme ou un radio-isotope. Une fois
le rotor arrêté, on peut procéder une analyse simultanée, analyse
directe avec un compteur si l'on utilise des radio-isotopes, ou
indirecte si l'on utilise en plus un réactif coloré et éventuelle
ment un réactif de stoppage de réaction.These operations are then repeated with the second reagent,
which contains a protein to which a biological indicator is attached
giquetel for example as an enzyme or a radioisotope. Once
rotor stopped, simultaneous analysis can be carried out, analysis
direct with a counter if radioisotopes are used, or
indirect if we also use a colored reagent and possible
a reaction stop reagent.
Le parallélisme des faces interne et externe de la portion
inférieure des cellules facilite bien évidemment les analyses photo
métriques au niveau de chaque cellule. The parallelism of the internal and external faces of the portion
lower cells obviously facilitates photo analyzes
metrics at the level of each cell.
Claims (4)
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8011511A FR2483078A1 (en) | 1980-05-23 | 1980-05-23 | Rotating assembly for simultaneous analysis of biological fluid - uses cells equipped for centrifugal ejection, cleaning and drying |
IN756/DEL/80A IN154925B (en) | 1979-10-26 | 1980-10-14 | |
IL61287A IL61287A (en) | 1979-10-26 | 1980-10-16 | Simultaneous analysis apparatus |
AT80106373T ATE7738T1 (en) | 1979-10-26 | 1980-10-20 | SIMULTANEOUS ANALYZER. |
US06/198,323 US4314968A (en) | 1979-10-26 | 1980-10-20 | Simultaneous analysis apparatus |
DE8080106373T DE3068054D1 (en) | 1979-10-26 | 1980-10-20 | Simultaneous-analysis device |
EP80106373A EP0027986B1 (en) | 1979-10-26 | 1980-10-20 | Simultaneous-analysis device |
BR8006761A BR8006761A (en) | 1979-10-26 | 1980-10-21 | ANALYSIS DEVICE |
NZ195349A NZ195349A (en) | 1979-10-26 | 1980-10-23 | Simultaneous centrifugal analysis apparatus |
ES496250A ES8107393A1 (en) | 1979-10-26 | 1980-10-24 | Simultaneous-analysis device. |
CA000363248A CA1139202A (en) | 1979-10-26 | 1980-10-24 | Simultaneous analysis device |
MX184467A MX148876A (en) | 1979-10-26 | 1980-10-24 | IMPROVEMENTS TO AN APPARATUS FOR BIOCHEMICAL ANILYSIS |
IE2210/80A IE50394B1 (en) | 1979-10-26 | 1980-10-24 | Simultaneous analysis apparatus |
AR282998A AR221190A1 (en) | 1979-10-26 | 1980-10-24 | ANALYSIS DEVICE |
SU802997519A SU959613A3 (en) | 1979-10-26 | 1980-10-24 | Apparatus for conducting analysis |
DK451680A DK156405C (en) | 1979-10-26 | 1980-10-24 | APPARATUS FOR IMMUNKEMIC ANALYSIS |
AU63695/80A AU534275B2 (en) | 1979-10-26 | 1980-10-24 | Analysis cuvette rotor |
EG650/80A EG14889A (en) | 1979-10-26 | 1980-10-26 | Dispositif d'analyse simultanee |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8011511A FR2483078A1 (en) | 1980-05-23 | 1980-05-23 | Rotating assembly for simultaneous analysis of biological fluid - uses cells equipped for centrifugal ejection, cleaning and drying |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2483078A1 true FR2483078A1 (en) | 1981-11-27 |
FR2483078B1 FR2483078B1 (en) | 1982-05-28 |
Family
ID=9242269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8011511A Granted FR2483078A1 (en) | 1979-10-26 | 1980-05-23 | Rotating assembly for simultaneous analysis of biological fluid - uses cells equipped for centrifugal ejection, cleaning and drying |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2483078A1 (en) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2280895A1 (en) * | 1974-07-30 | 1976-02-27 | Intertechnique Sa | IMPROVEMENTS TO LIQUID SAMPLE FRACTIONING DEVICES, ESPECIALLY FOR ANALYSIS |
FR2362660A1 (en) * | 1976-08-30 | 1978-03-24 | Byk Mallinckrodt Chem Prod | CONTAINER USABLE TO PERFORM IMMUNOCHEMICAL OR ENZYMATIC OPERATIONS, AND METHODS FOR ITS PREPARATION AND USE |
US4116638A (en) * | 1977-03-03 | 1978-09-26 | Warner-Lambert Company | Immunoassay device |
FR2400700A1 (en) * | 1977-08-18 | 1979-03-16 | Guigan Jean | CONDITIONING DEVICE FOR A LIQUID SAMPLE FOR ANALYSIS |
FR2418463A1 (en) * | 1978-02-28 | 1979-09-21 | Nal Transfusion Sanguine Centr | PROCESS FOR THE SCREENING OR IDENTIFICATION, IN A BIOLOGICAL ENVIRONMENT, OF VIRAL ANTIGENS, ERYTHROCYTAL OR CELLULAR ANTIGENS OR ANTIBODIES |
FR2421382A1 (en) * | 1978-03-31 | 1979-10-26 | Union Carbide Corp | SEPARATION AND REACTION METHOD AND DEVICE FOR IMMUNOLOGICAL ANALYSIS |
-
1980
- 1980-05-23 FR FR8011511A patent/FR2483078A1/en active Granted
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2280895A1 (en) * | 1974-07-30 | 1976-02-27 | Intertechnique Sa | IMPROVEMENTS TO LIQUID SAMPLE FRACTIONING DEVICES, ESPECIALLY FOR ANALYSIS |
FR2362660A1 (en) * | 1976-08-30 | 1978-03-24 | Byk Mallinckrodt Chem Prod | CONTAINER USABLE TO PERFORM IMMUNOCHEMICAL OR ENZYMATIC OPERATIONS, AND METHODS FOR ITS PREPARATION AND USE |
US4116638A (en) * | 1977-03-03 | 1978-09-26 | Warner-Lambert Company | Immunoassay device |
FR2400700A1 (en) * | 1977-08-18 | 1979-03-16 | Guigan Jean | CONDITIONING DEVICE FOR A LIQUID SAMPLE FOR ANALYSIS |
FR2418463A1 (en) * | 1978-02-28 | 1979-09-21 | Nal Transfusion Sanguine Centr | PROCESS FOR THE SCREENING OR IDENTIFICATION, IN A BIOLOGICAL ENVIRONMENT, OF VIRAL ANTIGENS, ERYTHROCYTAL OR CELLULAR ANTIGENS OR ANTIBODIES |
FR2421382A1 (en) * | 1978-03-31 | 1979-10-26 | Union Carbide Corp | SEPARATION AND REACTION METHOD AND DEVICE FOR IMMUNOLOGICAL ANALYSIS |
Also Published As
Publication number | Publication date |
---|---|
FR2483078B1 (en) | 1982-05-28 |
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