FR2474867A1 - Procede pour augmenter la fecondite d'un troupeau de moutons ou de chevres - Google Patents
Procede pour augmenter la fecondite d'un troupeau de moutons ou de chevres Download PDFInfo
- Publication number
- FR2474867A1 FR2474867A1 FR8102269A FR8102269A FR2474867A1 FR 2474867 A1 FR2474867 A1 FR 2474867A1 FR 8102269 A FR8102269 A FR 8102269A FR 8102269 A FR8102269 A FR 8102269A FR 2474867 A1 FR2474867 A1 FR 2474867A1
- Authority
- FR
- France
- Prior art keywords
- steroid
- herd
- process according
- flock
- conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract description 36
- 230000035558 fertility Effects 0.000 title claims abstract description 25
- 230000008569 process Effects 0.000 title claims description 18
- 150000003431 steroids Chemical class 0.000 claims abstract description 41
- 244000144992 flock Species 0.000 claims abstract description 28
- 230000002163 immunogen Effects 0.000 claims abstract description 17
- 241001494479 Pecora Species 0.000 claims abstract description 15
- 239000003098 androgen Substances 0.000 claims abstract description 14
- 230000007423 decrease Effects 0.000 claims abstract description 13
- 241000283707 Capra Species 0.000 claims abstract description 5
- 244000144980 herd Species 0.000 claims description 45
- 230000003053 immunization Effects 0.000 claims description 43
- 238000002649 immunization Methods 0.000 claims description 40
- 230000013011 mating Effects 0.000 claims description 29
- 241001465754 Metazoa Species 0.000 claims description 24
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 22
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 22
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 claims description 21
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 claims description 18
- 229960003399 estrone Drugs 0.000 claims description 18
- 102000004169 proteins and genes Human genes 0.000 claims description 18
- 108090000623 proteins and genes Proteins 0.000 claims description 18
- 229940011871 estrogen Drugs 0.000 claims description 13
- 239000000262 estrogen Substances 0.000 claims description 13
- AEMFNILZOJDQLW-QAGGRKNESA-N androst-4-ene-3,17-dione Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 AEMFNILZOJDQLW-QAGGRKNESA-N 0.000 claims description 9
- 229960005471 androstenedione Drugs 0.000 claims description 7
- AEMFNILZOJDQLW-UHFFFAOYSA-N androstenedione Natural products O=C1CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 AEMFNILZOJDQLW-UHFFFAOYSA-N 0.000 claims description 7
- 230000003637 steroidlike Effects 0.000 claims description 7
- 102000007562 Serum Albumin Human genes 0.000 claims description 4
- 108010071390 Serum Albumin Proteins 0.000 claims description 4
- 230000001571 immunoadjuvant effect Effects 0.000 claims description 4
- 239000000568 immunological adjuvant Substances 0.000 claims description 4
- 230000012173 estrus Effects 0.000 claims description 2
- 230000027758 ovulation cycle Effects 0.000 claims description 2
- 230000032696 parturition Effects 0.000 claims description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 2
- 230000001548 androgenic effect Effects 0.000 claims 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 1
- 229940098773 bovine serum albumin Drugs 0.000 claims 1
- 229960003604 testosterone Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 7
- 210000002966 serum Anatomy 0.000 abstract description 5
- 230000008878 coupling Effects 0.000 abstract description 4
- 238000010168 coupling process Methods 0.000 abstract description 4
- 238000005859 coupling reaction Methods 0.000 abstract description 4
- 230000005875 antibody response Effects 0.000 abstract description 3
- 230000016087 ovulation Effects 0.000 description 24
- 230000004044 response Effects 0.000 description 9
- 241000283903 Ovis aries Species 0.000 description 8
- 238000002347 injection Methods 0.000 description 8
- 239000007924 injection Substances 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 241000283690 Bos taurus Species 0.000 description 6
- 239000000427 antigen Substances 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- 229940088597 hormone Drugs 0.000 description 5
- 239000005556 hormone Substances 0.000 description 5
- 244000144972 livestock Species 0.000 description 5
- 229920002307 Dextran Polymers 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 4
- NXQOQNROJJFYCJ-FZFXZXLVSA-N androst-16-ene Chemical compound C1CCC[C@]2(C)[C@H]3CC[C@](C)(C=CC4)[C@@H]4[C@@H]3CCC21 NXQOQNROJJFYCJ-FZFXZXLVSA-N 0.000 description 4
- 238000009395 breeding Methods 0.000 description 4
- 230000001488 breeding effect Effects 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 230000035935 pregnancy Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 102000009027 Albumins Human genes 0.000 description 3
- 108010088751 Albumins Proteins 0.000 description 3
- 238000001839 endoscopy Methods 0.000 description 3
- 230000004720 fertilization Effects 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 229960005486 vaccine Drugs 0.000 description 3
- XSDCLHQDGODZPZ-WWNBULGVSA-N Estra-1,3,5-(10)-trien-17-one-3-oxyacetic acid Chemical compound OC(=O)COC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 XSDCLHQDGODZPZ-WWNBULGVSA-N 0.000 description 2
- 235000019687 Lamb Nutrition 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 229940030486 androgens Drugs 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 150000001718 carbodiimides Chemical class 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 150000002167 estrones Chemical class 0.000 description 2
- OSVMTWJCGUFAOD-KZQROQTASA-N formestane Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1O OSVMTWJCGUFAOD-KZQROQTASA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000001672 ovary Anatomy 0.000 description 2
- 230000002787 reinforcement Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- -1 steroid compounds Chemical class 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- HFZCCNBQRXFUNV-FQQAFBJJSA-N (8s,9s,10r,13s,14s)-10,13-dimethyl-2,6,8,9,11,12,14,15,16,17-decahydro-1h-cyclopenta[a]phenanthrene-3,7-dione Chemical class C1CC(=O)C=C2CC(=O)[C@H]3[C@@H]4CCC[C@@]4(C)CC[C@@H]3[C@]21C HFZCCNBQRXFUNV-FQQAFBJJSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- WSCUHXPGYUMQEX-CRIVMUBDSA-N 11-Hydroxyandrostenedione Chemical compound O=C1CC[C@]2(C)[C@H]3C(O)C[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 WSCUHXPGYUMQEX-CRIVMUBDSA-N 0.000 description 1
- 241001125840 Coryphaenidae Species 0.000 description 1
- 229920002491 Diethylaminoethyl-dextran Polymers 0.000 description 1
- 208000009701 Embryo Loss Diseases 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 102000006771 Gonadotropins Human genes 0.000 description 1
- 108010086677 Gonadotropins Proteins 0.000 description 1
- 206010018691 Granuloma Diseases 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 206010024769 Local reaction Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- VCCZBYPHZRWKFY-UHFFFAOYSA-N Oxazolam Chemical compound O1C(C)CN2CC(=O)NC3=CC=C(Cl)C=C3C21C1=CC=CC=C1 VCCZBYPHZRWKFY-UHFFFAOYSA-N 0.000 description 1
- 201000005702 Pertussis Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000007854 aminals Chemical class 0.000 description 1
- 238000003975 animal breeding Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000012888 bovine serum Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 231100001041 changes in fertility Toxicity 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 210000003022 colostrum Anatomy 0.000 description 1
- 235000021277 colostrum Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001268 conjugating effect Effects 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 230000006003 cornification Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 231100000557 embryo loss Toxicity 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 239000002622 gonadotropin Substances 0.000 description 1
- 210000000548 hind-foot Anatomy 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 231100000508 hormonal effect Toxicity 0.000 description 1
- 239000003688 hormone derivative Substances 0.000 description 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000006054 immunological memory Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000005567 liquid scintillation counting Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- CXHHBNMLPJOKQD-UHFFFAOYSA-N methyl hydrogen carbonate Chemical compound COC(O)=O CXHHBNMLPJOKQD-UHFFFAOYSA-N 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 150000002923 oximes Chemical class 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 210000001625 seminal vesicle Anatomy 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 150000003515 testosterones Chemical class 0.000 description 1
- 201000010653 vesiculitis Diseases 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/811—Drug, bio-affecting and body treating compositions involving sex selection or contraception
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPE227480 | 1980-02-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2474867A1 true FR2474867A1 (fr) | 1981-08-07 |
| FR2474867B1 FR2474867B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1984-12-28 |
Family
ID=3768429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8102269A Granted FR2474867A1 (fr) | 1980-02-06 | 1981-02-05 | Procede pour augmenter la fecondite d'un troupeau de moutons ou de chevres |
Country Status (6)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4457914A (en) * | 1980-02-06 | 1984-07-03 | Commonwealth Scientific And Industrial Research Organization | Fecundity of domestic livestock |
| NZ196126A (en) * | 1980-02-07 | 1985-05-31 | Commw Scient Ind Res Org | Increasing ovulation rate in female cattle |
| GB8428201D0 (en) * | 1984-11-08 | 1984-12-19 | Glaxo Group Ltd | Biological preparations |
| NZ213974A (en) * | 1985-10-29 | 1989-08-29 | Nz Ministry Agriculture & Fisheries | Milk protein/4-androstene-3,17-dione conjugates and veterinary compositions |
| AU614496B2 (en) * | 1986-07-28 | 1991-09-05 | Board Of Trustees Of The University Of Illinois, The | Improved female mammals |
| US5874062A (en) * | 1991-04-05 | 1999-02-23 | Imarx Pharmaceutical Corp. | Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents |
| WO1999007381A1 (en) * | 1997-08-11 | 1999-02-18 | Weider Nutrition International, Inc. | Compositions and treatments to reduce side effects of administration of androgenic testosterone precursors |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1451626A (en) * | 1972-10-25 | 1976-10-06 | Miles Yeda Ltd | 7-substituted steroids and steroid-protein conjugates |
| FR2395507A1 (fr) * | 1977-06-21 | 1979-01-19 | Morinaga Milk Industry Co Ltd | Procede de preparation d'un polymere de latex sensibilise par un produit conjugue steroide/serum-albumine, et reactif de latex obtenu par ce procede |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4122166A (en) * | 1976-08-17 | 1978-10-24 | Philips Roxane, Inc. | Injectable contraceptive and method |
| US4123519A (en) * | 1976-08-17 | 1978-10-31 | Philips Roxane, Inc. | Injectable contraceptive vaccine and method |
-
1981
- 1981-01-21 US US06/226,990 patent/US4331657A/en not_active Expired - Lifetime
- 1981-01-27 NZ NZ196125A patent/NZ196125A/en unknown
- 1981-01-28 IE IE157/81A patent/IE50712B1/en not_active IP Right Cessation
- 1981-01-29 GB GB8102697A patent/GB2071107B/en not_active Expired
- 1981-02-04 ZA ZA00810737A patent/ZA81737B/xx unknown
- 1981-02-05 FR FR8102269A patent/FR2474867A1/fr active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1451626A (en) * | 1972-10-25 | 1976-10-06 | Miles Yeda Ltd | 7-substituted steroids and steroid-protein conjugates |
| FR2395507A1 (fr) * | 1977-06-21 | 1979-01-19 | Morinaga Milk Industry Co Ltd | Procede de preparation d'un polymere de latex sensibilise par un produit conjugue steroide/serum-albumine, et reactif de latex obtenu par ce procede |
Non-Patent Citations (3)
| Title |
|---|
| BIOLOGICAL ABSTRACTS, vol. 68, no. 3, 1979, Philadelphia-Pennsylvania (US), résumé no. 14896 * |
| BIOLOGICAL ABSTRACTS, vol. 70, no. 5, 1980, Philadelphia Pensylvania (US), réf. no. 32667 * |
| NATURE, vol. 269, 27 octobre 1977, Londres (GB) * |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2071107A (en) | 1981-09-16 |
| ZA81737B (en) | 1982-03-31 |
| IE810157L (en) | 1981-08-06 |
| GB2071107B (en) | 1984-07-25 |
| IE50712B1 (en) | 1986-06-25 |
| US4331657A (en) | 1982-05-25 |
| FR2474867B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1984-12-28 |
| NZ196125A (en) | 1985-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |