FR2462432B2 - - Google Patents

Info

Publication number
FR2462432B2
FR2462432B2 FR7919990A FR7919990A FR2462432B2 FR 2462432 B2 FR2462432 B2 FR 2462432B2 FR 7919990 A FR7919990 A FR 7919990A FR 7919990 A FR7919990 A FR 7919990A FR 2462432 B2 FR2462432 B2 FR 2462432B2
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7919990A
Other languages
French (fr)
Other versions
FR2462432A2 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7919990A priority Critical patent/FR2462432A2/fr
Priority to CH551180A priority patent/CH646694A5/fr
Priority to CA000356675A priority patent/CA1155121A/en
Priority to SE8005300A priority patent/SE8005300L/xx
Priority to GR62561A priority patent/GR68073B/el
Priority to IT23763/80A priority patent/IT1219979B/it
Priority to DE19803028912 priority patent/DE3028912A1/de
Priority to LU82677A priority patent/LU82677A1/fr
Priority to ZA00804709A priority patent/ZA804709B/xx
Priority to AU61003/80A priority patent/AU6100380A/en
Priority to JP10632080A priority patent/JPS5626885A/ja
Priority to GB8025200A priority patent/GB2057433B/en
Priority to ES493931A priority patent/ES8107195A1/es
Priority to MX10155280U priority patent/MX6334E/es
Priority to BE0/201625A priority patent/BE884602R/fr
Priority to NL8004434A priority patent/NL8004434A/nl
Publication of FR2462432A2 publication Critical patent/FR2462432A2/fr
Priority to ES499814A priority patent/ES8301944A1/es
Application granted granted Critical
Publication of FR2462432B2 publication Critical patent/FR2462432B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
FR7919990A 1977-04-19 1979-08-03 Nouveaux derives de la 3,4,5 trimethoxy cinnamoyle piperazine, leur procede de preparation et leur application en therapeutique Granted FR2462432A2 (fr)

Priority Applications (17)

Application Number Priority Date Filing Date Title
FR7919990A FR2462432A2 (fr) 1979-08-03 1979-08-03 Nouveaux derives de la 3,4,5 trimethoxy cinnamoyle piperazine, leur procede de preparation et leur application en therapeutique
CH551180A CH646694A5 (fr) 1979-08-03 1980-07-18 Derives de la 3,4,5-trimethoxy cinnamoyle piperazine et leur procede de preparation.
CA000356675A CA1155121A (en) 1979-08-03 1980-07-21 Derivatives of 3,4,5-trimethoxy cinnamoyl piperazine, the process for preparing the same and their use in therapeutics
SE8005300A SE8005300L (sv) 1979-08-03 1980-07-22 Nya derivat 3,4,5-trimetoxicinnamoylpiperazin, deras framstellning och anvendning som lekemedel
GR62561A GR68073B (enrdf_load_stackoverflow) 1979-08-03 1980-07-28
IT23763/80A IT1219979B (it) 1977-04-19 1980-07-29 Derivati della 3,4,5-trimetossicinnamoil-piperazina,loro procedimento di preparazione e loro applicazione terapeutica
DE19803028912 DE3028912A1 (de) 1979-08-03 1980-07-30 Neue derivate des 3,45-trimethoxycinnamoyl-piperazins, verfahren zu ihrer herstellung und solche derivate
BE0/201625A BE884602R (fr) 1979-08-03 1980-08-01 Nouvelles cinnamoyles piperazines et homopiperazines leur procede de preparation et leur application en therapeutique
LU82677A LU82677A1 (fr) 1979-08-03 1980-08-01 Nouveaux derives de la 3,4,5-trimethoxy cinnamoyle piperazine,leur procede de preparation et leur application en therapeutique
JP10632080A JPS5626885A (en) 1979-08-03 1980-08-01 Novel derivative of piperazine
GB8025200A GB2057433B (en) 1979-08-03 1980-08-01 3,4,5-trimethoxy cinnamoyl piperazine derivatives processes for preparing the same and their use in therapeutics
ES493931A ES8107195A1 (es) 1979-08-03 1980-08-01 Procedimiento de preparacion de nuevos derivados de la 3,4,5-trimetoxi-cinamoil-piperazina
MX10155280U MX6334E (es) 1979-08-03 1980-08-01 Procedimiento para preparar derivados de la 3,4,5-trimetoxi-cinamoil piperazina
ZA00804709A ZA804709B (en) 1979-08-03 1980-08-01 Novel derivatives of 3,4,5-trimethoxy cinnamoyl piperazine,the process for preparing the same and their use in therapeutics
AU61003/80A AU6100380A (en) 1979-08-03 1980-08-01 Derivatives of 3,4,5-trimethoxy cinnamoyl piperazine
NL8004434A NL8004434A (nl) 1979-08-03 1980-08-04 Nieuwe 3,4,5-trimethoxy-cinnamoylpiperazine- verbindingen, werkwijze voor hun bereiding en hun toepassing als geneesmiddelen.
ES499814A ES8301944A1 (es) 1979-08-03 1981-02-26 Un procedimiento de preparacion de ((metil-3)-n-butiloxicar-bonil-8-benzodioxan-1,4-il)-oxi-3-((trimetoxi-3,4,5-cinamo- il)-4-piperazin-1-il)-1-propanol-2 (s(-))

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7919990A FR2462432A2 (fr) 1979-08-03 1979-08-03 Nouveaux derives de la 3,4,5 trimethoxy cinnamoyle piperazine, leur procede de preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2462432A2 FR2462432A2 (fr) 1981-02-13
FR2462432B2 true FR2462432B2 (enrdf_load_stackoverflow) 1983-05-27

Family

ID=9228620

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7919990A Granted FR2462432A2 (fr) 1977-04-19 1979-08-03 Nouveaux derives de la 3,4,5 trimethoxy cinnamoyle piperazine, leur procede de preparation et leur application en therapeutique

Country Status (14)

Country Link
JP (1) JPS5626885A (enrdf_load_stackoverflow)
AU (1) AU6100380A (enrdf_load_stackoverflow)
BE (1) BE884602R (enrdf_load_stackoverflow)
CA (1) CA1155121A (enrdf_load_stackoverflow)
CH (1) CH646694A5 (enrdf_load_stackoverflow)
DE (1) DE3028912A1 (enrdf_load_stackoverflow)
ES (2) ES8107195A1 (enrdf_load_stackoverflow)
FR (1) FR2462432A2 (enrdf_load_stackoverflow)
GB (1) GB2057433B (enrdf_load_stackoverflow)
GR (1) GR68073B (enrdf_load_stackoverflow)
LU (1) LU82677A1 (enrdf_load_stackoverflow)
NL (1) NL8004434A (enrdf_load_stackoverflow)
SE (1) SE8005300L (enrdf_load_stackoverflow)
ZA (1) ZA804709B (enrdf_load_stackoverflow)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2507604A2 (fr) * 1977-04-19 1982-12-17 Delalande Sa Nouvelles trimethoxy-3,4,5 cinnamoyle piperazines, leur procede de preparation et leur application en therapeutique
US4558129A (en) * 1983-05-18 1985-12-10 Syntex (U.S.A.) Inc. Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade
US4567264A (en) * 1983-05-18 1986-01-28 Syntex (U.S.A.) Inc. Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry
US4499100A (en) * 1983-05-18 1985-02-12 Syntex (U.S.A.) Inc. Benzodioxanyl-hydroxyethyleneamino-piperidinyl acetanilides, ketones, esters and carbamates which effect immunity and calcium entry and β-blockade
US4997836A (en) * 1988-11-11 1991-03-05 Takeda Chemical Industries, Ltd. Trisubstituted piperazine compounds, their production and use
US6514996B2 (en) 1995-05-19 2003-02-04 Kyowa Hakko Kogyo Co., Ltd. Derivatives of benzofuran or benzodioxole
EP0943613A4 (en) * 1996-11-19 2002-07-10 Kyowa Hakko Kogyo Kk Oxygenic heterocyclic compounds
WO2008144933A1 (en) 2007-05-29 2008-12-04 Université de Montréal Cinnamoyl inhibitors of transglutaminase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2387971A1 (fr) * 1977-04-19 1978-11-17 Delalande Sa Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique

Also Published As

Publication number Publication date
ZA804709B (en) 1981-10-28
SE8005300L (sv) 1981-02-04
GB2057433A (en) 1981-04-01
JPS634827B2 (enrdf_load_stackoverflow) 1988-02-01
CA1155121A (en) 1983-10-11
ES499814A0 (es) 1982-12-16
JPS5626885A (en) 1981-03-16
AU6100380A (en) 1981-02-05
LU82677A1 (fr) 1982-05-10
ES493931A0 (es) 1981-10-01
ES8301944A1 (es) 1982-12-16
ES8107195A1 (es) 1981-10-01
NL8004434A (nl) 1981-02-05
GR68073B (enrdf_load_stackoverflow) 1981-10-29
GB2057433B (en) 1983-08-10
CH646694A5 (fr) 1984-12-14
DE3028912A1 (de) 1981-09-24
FR2462432A2 (fr) 1981-02-13
BE884602R (fr) 1981-02-02

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