FR2457303A1 - Procede de preparation d'une forme cristalline de flunisolide, le produit obtenu et son utilisation comme produit pharmaceutique - Google Patents

Procede de preparation d'une forme cristalline de flunisolide, le produit obtenu et son utilisation comme produit pharmaceutique

Info

Publication number
FR2457303A1
FR2457303A1 FR8011254A FR8011254A FR2457303A1 FR 2457303 A1 FR2457303 A1 FR 2457303A1 FR 8011254 A FR8011254 A FR 8011254A FR 8011254 A FR8011254 A FR 8011254A FR 2457303 A1 FR2457303 A1 FR 2457303A1
Authority
FR
France
Prior art keywords
flunisolide
crystalline form
preparation
product
product obtained
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8011254A
Other languages
English (en)
Other versions
FR2457303B1 (fr
Inventor
Richard E Jones
Et Jacquelyn A Smithers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Palo Alto LLC
Original Assignee
Roche Palo Alto LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Palo Alto LLC filed Critical Roche Palo Alto LLC
Publication of FR2457303A1 publication Critical patent/FR2457303A1/fr
Application granted granted Critical
Publication of FR2457303B1 publication Critical patent/FR2457303B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

L'INVENTION CONCERNE UN PROCEDE DE PREPARATION D'UNE NOUVELLE FORME CRISTALLINE DE FLUNISOLIDE. LA NOUVELLE FORME CRISTALLINE DE FLUNISOLIDE EST PREPAREE PAR CRISTALLISATION A PARTIR D'UNE SOLUTION ALCANOLIQUE DANS UN ALCANOL DE 3 OU 4 ATOMES DE CARBONE TEL QUE LE N-BUTANOL, CONTENANT 0,2 A 5 ET DE PREFERENCE 1,0 A 4,0 EN VOLUME D'EAU. LE FLUNISOLIDE OU 6A-FLUORO-11B,21-DIHYDROXY-16A, 17A-ISOPROPYLIDENEDIOXYPREGNA-1,4-DIENE-3,20-DIONE APPARTIENT A UNE CLASSE DE COMPOSES DOUES D'ACTIVITE ANTI-INFLAMMATOIRE ET ANTI-PYRETIQUE ET POUVANT ETRE UTILISES PRINCIPALEMENT DANS LE TRAITEMENT DES INFLAMMATIONS TOPIQUES.
FR8011254A 1979-05-21 1980-05-20 Procede de preparation d'une forme cristalline de flunisolide, le produit obtenu et son utilisation comme produit pharmaceutique Granted FR2457303A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4083079A 1979-05-21 1979-05-21

Publications (2)

Publication Number Publication Date
FR2457303A1 true FR2457303A1 (fr) 1980-12-19
FR2457303B1 FR2457303B1 (fr) 1983-05-13

Family

ID=21913206

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8011254A Granted FR2457303A1 (fr) 1979-05-21 1980-05-20 Procede de preparation d'une forme cristalline de flunisolide, le produit obtenu et son utilisation comme produit pharmaceutique

Country Status (17)

Country Link
JP (1) JPS55154997A (fr)
AU (1) AU532084B2 (fr)
BE (1) BE883381A (fr)
CA (1) CA1153761A (fr)
CH (1) CH643567A5 (fr)
DE (1) DE3019250C2 (fr)
DK (1) DK162530C (fr)
FR (1) FR2457303A1 (fr)
GB (1) GB2052506B (fr)
HK (1) HK40784A (fr)
IL (1) IL60128A (fr)
IT (1) IT1133092B (fr)
MY (1) MY8500694A (fr)
NL (1) NL189201C (fr)
NZ (1) NZ193778A (fr)
SE (1) SE431549B (fr)
SG (1) SG37585G (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1121513B (it) * 1979-05-28 1986-04-02 Chiesi Farma Spa Processo per la conversione di umo steroide antiinfiammatorio in una forma suscettibile di essere somministarta come aerosol

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX3864E (es) * 1975-05-27 1981-08-26 Syntex Corp Un proceso para prepara el compuesto cristalino 6-fluiro-11b 21-dihiroxi-16 17-isopropilidendioxipregna-1 4-dien-3 20-diona

Also Published As

Publication number Publication date
DK162530B (da) 1991-11-11
DK219280A (da) 1980-11-22
SE8003761L (sv) 1980-11-22
HK40784A (en) 1984-05-18
NL8002902A (nl) 1980-11-25
AU532084B2 (en) 1983-09-15
IT8067791A0 (it) 1980-05-20
IL60128A (en) 1984-01-31
JPS55154997A (en) 1980-12-02
FR2457303B1 (fr) 1983-05-13
CH643567A5 (de) 1984-06-15
SG37585G (en) 1986-01-17
GB2052506B (en) 1983-01-19
AU5856680A (en) 1980-11-27
MY8500694A (en) 1985-12-31
NL189201C (nl) 1993-02-01
DE3019250A1 (de) 1980-12-04
BE883381A (fr) 1980-11-20
SE431549B (sv) 1984-02-13
GB2052506A (en) 1981-01-28
IT1133092B (it) 1986-07-09
DE3019250C2 (de) 1982-11-11
DK162530C (da) 1992-03-30
JPS6258360B2 (fr) 1987-12-05
NZ193778A (en) 1982-03-16
IL60128A0 (en) 1980-07-31
CA1153761A (fr) 1983-09-13
NL189201B (nl) 1992-09-01

Similar Documents

Publication Publication Date Title
US4216224A (en) Methods and compositions for treating psoriasis with retinoyl compounds
EP0036663B1 (fr) Dérivés de l'acide oxiranne-butyrique, leur préparation et leur utilisation ainsi que médicaments les contenant
US3470249A (en) 1 - (m - hydroxyphenyl) - 2 - dialkylamino methyl - cycloalkenes and the salts thereof and the process of perparing the same
FR2457303A1 (fr) Procede de preparation d'une forme cristalline de flunisolide, le produit obtenu et son utilisation comme produit pharmaceutique
US3534139A (en) 17alpha - ethynyl - 8alpha - h - delta**5(10) - estrene - 17beta - ol-3-one,process of preparation,therapeutic administration and intermediates
Smith 173. Lactones of glucosaccharic acid. Part III. Mono-and di-lactones
US2938916A (en) Zinc salts of steroid phosphates
McCasland et al. Synthesis of Sulfur Analogs of Inositol (Dimercaptocyclohexanetetrols). Nuclear Magnetic Resonance Configurational Proofs1, 2
SU1227115A3 (ru) Способ получени 17,18-дегидро-аповинкаминол-3',4',5'-триметоксибензоата или его солей
US2740781A (en) 3, 26-dihydroxy-16, 22-imino-5-cholestenes, 3, 26-dihydroxy-16, 22-imino-5, 16, 20(22)-cholestatrienes and derivatives thereof
FR2446293A1 (fr) Procede de purification de l'acide chenodesoxycholique
FR2570930B1 (fr) Agent accelerant la croissance des plantes, tire du residu de distillation des acides gras des sons de riz, procede pour son isolement et pour la preparation d'une composition le contenant.
EP0313935A2 (fr) Enoléthers de 6-chloro-4-hydroxy-2-méthyl-N-(2-pyridyl)-2H-thiéno(2,3-e)-1,2-thiazin-3-carboxamides-1,1-dioxyde, un procédé pour leur préparation et leur utilisation
DE2725245A1 (de) Methylaminderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische oder veterinaermedizinische zusammensetzungen
CA1052271A (fr) 1,2 - et 2,3 - epoxyalkanes
US3313702A (en) Estrogenic compositions comprising 17alpha-ethynyl-deta1, 3, 5(10)-estratriene-3, 11beta, 17beta-triol
LV11954B (lv) 14-alfa,17-alfa-c2-tiltiņa saites 19-nor-progesterona atvasinājumi
US4034045A (en) 2,4-Disubstituted-4b,5,6,7,8,8a,9,10-octahydro-9-oxo-phenanthrenes
US3060196A (en) Unsaturated aliphatic amino-diols and process for their manufacture
US3377248A (en) Methods and compositions of ferrocene cyclic ethers in the treatment of iron deficiency anemia
US2979525A (en) New crystalline pantothenic acid ester and process for the production thereof
FR2355001A1 (fr) Ester de p-hydroxybenzaldehyde-semicarbazone de l'ibuprofene, sa preparation et son application pour le traitement d'etats inflammatoires
US3043837A (en) 3, 11-dioxygenated 17alpha-carboxyethylandrost-4-en-17beta-ol lactone, nor compoundscorresponding, and manufacturing processes
US3904680A (en) L-3-hydroxymethyltyrosine and salts thereof
US2734056A (en) Chsoco

Legal Events

Date Code Title Description
TP Transmission of property
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0218, 920519

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0218, 800520

CL Concession to grant licences
ST Notification of lapse

Spc suppl protection certif: 92C0218