FR2457283A1 - Derives de la vitamine d marques par un isotope et procede pour les preparer - Google Patents

Derives de la vitamine d marques par un isotope et procede pour les preparer

Info

Publication number
FR2457283A1
FR2457283A1 FR8011385A FR8011385A FR2457283A1 FR 2457283 A1 FR2457283 A1 FR 2457283A1 FR 8011385 A FR8011385 A FR 8011385A FR 8011385 A FR8011385 A FR 8011385A FR 2457283 A1 FR2457283 A1 FR 2457283A1
Authority
FR
France
Prior art keywords
isotope
vitamin
compounds
marked
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8011385A
Other languages
English (en)
French (fr)
Other versions
FR2457283B1 (enExample
Inventor
Hector F Deluca
Heinrich K Schnoes
Joseph L Napoli
Mary A Fivizzani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of FR2457283A1 publication Critical patent/FR2457283A1/fr
Application granted granted Critical
Publication of FR2457283B1 publication Critical patent/FR2457283B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8011385A 1979-05-21 1980-05-21 Derives de la vitamine d marques par un isotope et procede pour les preparer Granted FR2457283A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/041,080 US4269777A (en) 1979-05-21 1979-05-21 Isotopically labeled vitamin D derivatives and processes for preparing same

Publications (2)

Publication Number Publication Date
FR2457283A1 true FR2457283A1 (fr) 1980-12-19
FR2457283B1 FR2457283B1 (enExample) 1983-03-11

Family

ID=21914616

Family Applications (3)

Application Number Title Priority Date Filing Date
FR8011385A Granted FR2457283A1 (fr) 1979-05-21 1980-05-21 Derives de la vitamine d marques par un isotope et procede pour les preparer
FR8101332A Granted FR2479214A1 (fr) 1979-05-21 1981-01-23 Nouveaux composes derives de la vitamine d
FR8116732A Granted FR2485022A1 (fr) 1979-05-21 1981-09-02 Nouveaux composes derives de la vitamine d

Family Applications After (2)

Application Number Title Priority Date Filing Date
FR8101332A Granted FR2479214A1 (fr) 1979-05-21 1981-01-23 Nouveaux composes derives de la vitamine d
FR8116732A Granted FR2485022A1 (fr) 1979-05-21 1981-09-02 Nouveaux composes derives de la vitamine d

Country Status (9)

Country Link
US (1) US4269777A (enExample)
JP (1) JPS56500538A (enExample)
CA (1) CA1152488A (enExample)
DE (2) DE3051094C2 (enExample)
FR (3) FR2457283A1 (enExample)
GB (4) GB2083043B (enExample)
IE (3) IE50425B1 (enExample)
IL (3) IL69420A (enExample)
WO (1) WO1980002562A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4360470A (en) * 1980-10-22 1982-11-23 Hoffmann-La Roche Inc. Process and intermediates for the synthesis of Vitamin D3 metabolites and chenodeoxycholic acid
US4411833A (en) * 1982-05-26 1983-10-25 Wisconsin Alumni Research Foundation Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol
DE3448412C2 (enExample) * 1983-05-09 1991-12-12 Wisconsin Alumni Res Found
US5036061A (en) * 1983-05-09 1991-07-30 Deluca Hector F Process for the preparation of 1 alpha,25-dihydroxylated vitamin D2 and related compounds
US4585741A (en) * 1983-08-25 1986-04-29 Clevinger Brian L Method of assay for vitamin D metabolites
US4661294A (en) * 1985-03-18 1987-04-28 The General Hospital Corporation Biologically active 1-thio derivatives of vitamin D
US5247123A (en) * 1987-09-14 1993-09-21 Hoffmann-La Roche Inc. Deuterated analogs of 1,25-dihydroxycholecalciferol
US4898855A (en) * 1987-09-14 1990-02-06 Hoffman-La Roche Inc. Deuterated analogs of 1,25-dihydroxycholecalciferol
JPH02274A (ja) * 1987-10-14 1990-01-05 Toyo Jozo Co Ltd 新規な２５−ヒドロキシビタミンｄ↓３誘導体およびその製造法およびそれを用いた定量法
US5202266A (en) * 1987-10-14 1993-04-13 Asahi Kasei Kogyo Kabushiki Kaisha 25-hydroxy vitamin D3 derivatives, process for their production, and assay method using the same
US5532228A (en) * 1990-02-06 1996-07-02 Schering Aktiengesellschaft Side-chain homologous vitamin D derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents
GB9623569D0 (en) * 1996-11-13 1997-01-08 Immunodiagnostic Systems Ltd Vitamin D immumoassay systems
EP1534075B1 (en) * 2002-07-12 2009-09-30 Morehouse School of Medicine Method for identifying salt-sensitive persons
EP1633703B1 (en) * 2003-05-30 2018-12-26 PerkinElmer LAS, Inc. Isotopically labeled chemically stable reagents and process for the synthesis thereof
ES2331289B2 (es) * 2008-06-27 2010-06-25 Universidade De Santiago De Compostela Compuestos de la vitamina d deuterados.
WO2011041590A2 (en) * 2009-10-02 2011-04-07 Wisconsin Alumni Research Foundation 1-desoxy-2-methylene-19-nor-vitamin d analogs and their uses
DK2753632T3 (da) 2011-09-08 2023-07-10 Sage Therapeutics Inc Neuroaktive steroider, sammensætninger og anvendelse heraf
DK3461834T3 (da) 2013-03-13 2021-08-23 Sage Therapeutics Inc Neuroaktive steroider
ES2970222T3 (es) 2014-06-18 2024-05-27 Sage Therapeutics Inc Oxiesteroles y procedimientos de uso de los mismos
SMT202100226T1 (it) 2015-07-06 2021-05-07 Sage Therapeutics Inc Ossisteroli e metodi di uso degli stessi
US10696712B2 (en) * 2015-07-06 2020-06-30 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
HUE055199T2 (hu) 2015-07-06 2021-11-29 Sage Therapeutics Inc Oxiszterolok és alkalmazási eljárásaik
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
EP3481846B1 (en) 2016-07-07 2021-05-12 Sage Therapeutics, Inc. 11-substituted 24-hydroxysterols for use in the treatment of nmda related conditions
MA46351A (fr) 2016-09-30 2021-06-02 Sage Therapeutics Inc Oxystérols substitués en c7 et procédés en tant que modulateurs nmda
EP3529256B1 (en) 2016-10-18 2023-08-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3833622A (en) * 1969-03-17 1974-09-03 Upjohn Co Crystalline 25-hydroxycholecalciferol hydrate and structurally related compounds
FR2129011A5 (enExample) * 1971-03-11 1972-10-27 Roussel Uclaf
US4119647A (en) * 1977-04-11 1978-10-10 Hoffmann-La Roche Inc. 25-Hydroxycholecalciferol-23,24-3 H and process for the preparation thereof
US4195027A (en) * 1978-01-16 1980-03-25 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds

Also Published As

Publication number Publication date
GB2082587A (en) 1982-03-10
GB2083043B (en) 1983-06-29
IL69420A0 (en) 1983-11-30
IE50424B1 (en) 1986-04-16
FR2479214A1 (fr) 1981-10-02
IE50426B1 (en) 1986-04-16
GB2052509A (en) 1981-01-28
FR2457283B1 (enExample) 1983-03-11
FR2479214B1 (enExample) 1985-04-12
WO1980002562A1 (en) 1980-11-27
IE801058L (en) 1980-11-21
DE3045287T1 (de) 1982-02-18
DE3045287C2 (enExample) 1988-11-10
GB2083043A (en) 1982-03-17
IE50425B1 (en) 1986-04-16
JPS56500538A (enExample) 1981-04-23
FR2485022B1 (enExample) 1983-12-09
GB2077736B (en) 1983-06-29
IL60055A (en) 1984-11-30
DE3051094C2 (enExample) 1989-05-18
GB2052509B (en) 1983-06-29
CA1152488A (en) 1983-08-23
US4269777A (en) 1981-05-26
GB2082587B (en) 1983-08-03
GB2077736A (en) 1981-12-23
FR2485022A1 (fr) 1981-12-24
IL69420A (en) 1984-11-30
IL60055A0 (en) 1980-07-31

Similar Documents

Publication Publication Date Title
FR2457283A1 (fr) Derives de la vitamine d marques par un isotope et procede pour les preparer
BE862864A (fr) Procede de preparation d'organopolysiloxanes modifies par des esters d'acide acrylique ou methacrylique, et produits ainsi obtenus
FR2331585A1 (fr) Procede de preparation de dispersions stables utilisables comme produits de depart dans la preparation de resines de polyurethannes
NL191332B (nl) Farmaceutisch preparaat met de ethylester van (all-Z)-5,8,11,14,17-eicosapentaeenzuur.
FR2470107B1 (fr) Procede de preparation d'acide acrylique
RO80265A (ro) Procedeu pentru prepararea unor derivati de acid beta-carbolin-3-carboxilic
BE883909A (fr) Procede de preparation de chloro-2proprionate d'alcoyle par chloration de lactate d'alcoyle
FR2443463A1 (fr) Derives de 4-aminoquinazoline, leur procede de preparation et leur application en agriculture, notamment comme fongicides
BE745047A (fr) Nouveau derive de l'adenine, son procede de preparation ainsi que son usage
PT67871A (fr) Procede pour la preparation de 1,2,3-thiadiazol-3-in-5 yliden-ureas ainsi que de compositions avec activite de regulation de l'accroissement de plantes que contiennentces compositions.
BE893492A (fr) Procede de preparation d'esters d'acides apovincaminiques, esters ainsi obtenus et compositions pharmaceutiques prepares avec ces esters
FR2517670B1 (fr) Sel d'acide (+)-2-(2-fluoro-4-biphenylyl)propionique, procede pour sa preparation et composition pharmaceutique le contenant
BE884153A (fr) Procede de preparation de compositions pharmaceutiques se desagregeant aisement
FR2455602A1 (fr) Derives d'acide folique marques au radio-iode, leur procede de production et leur application a l'analyse medicale
NO822147L (no) Fremgangsmaate til aa fremstille paa stedet en injiserbar fettsyre markert med radioaktivt jod samt fremstilling av jodderivater egnet til aa anvendes for utfoerelse av fremgangsmaaten
BE879937A (fr) Procede de preparation d'acides alpha-omega-dicarboxyliques
FR2446831A1 (fr) Derive oxyimino-e-homo-eburnane, procede pour le preparer et son utilisation dans une composition pharmaceutique pour la preparation de derives ester de l'acide apovincaminique
BE889699A (fr) Derives amidiques de l'acide p-isobutylphenyl propionique, leur procede de preparation et compositions pharmaceutiques correspondantes
MA18439A1 (fr) Procede de preparation de phopsphate monocalcique et d'acide phopsphorique par acidulation de phosphate naturel avec de l'acide phosphorique
BE862865A (fr) Procede de preparation d'organopolysiloxanes modifies par des esters d'acide acrylique ou methacrylique, et produits ainsi obtenus
FR2619671B1 (fr) Procede de multiplication et de culture de plantes de la famille des bromeliacees, et plantes ainsi obtenues
BE750053A (fr) Derives de l'acide thiocarbamique, leur procede de preparation et leur emploi comme insecticides et acaricides
FR2532942B1 (fr) Methyl-28 brassinosteroides, procede pour les preparer, ainsi que produits contenant de tels composes et ayant une action regulatrice sur la croissance de plantes
Hoff Determination of N-acetylglucosamine-1-phosphate and N-acetylglucosamine in milk
FR2423471B1 (fr) Composes 6/7-halogeno-anthraquinoniques, leur procede de preparation et leur utilisation comme colorants acides ou disperses

Legal Events

Date Code Title Description
ST Notification of lapse
ST Notification of lapse