FR2455595A1 - Derives de type bis(demethoxy-4 daunorubicine)-dihydrazone et leurs sels convenant en pharmacologie utiles comme medicaments - Google Patents

Derives de type bis(demethoxy-4 daunorubicine)-dihydrazone et leurs sels convenant en pharmacologie utiles comme medicaments

Info

Publication number
FR2455595A1
FR2455595A1 FR8009856A FR8009856A FR2455595A1 FR 2455595 A1 FR2455595 A1 FR 2455595A1 FR 8009856 A FR8009856 A FR 8009856A FR 8009856 A FR8009856 A FR 8009856A FR 2455595 A1 FR2455595 A1 FR 2455595A1
Authority
FR
France
Prior art keywords
demethoxy
daunorubicin
carbon
salts suitable
dihydrazone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8009856A
Other languages
English (en)
Other versions
FR2455595B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of FR2455595A1 publication Critical patent/FR2455595A1/fr
Application granted granted Critical
Publication of FR2455595B1 publication Critical patent/FR2455595B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

LES BIS(DEMETHOXY-4 DAUNORUBICINE)-DIHYDRAZONES DE FORMULE: (CF DESSIN DANS BOPI) OU R ET R REPRESENTENT CHACUN UN ATOME D'HYDROGENE OU UN RADICAL ALKYLE COMPORTANT 1 A 4ATOMES DE CARBONE ET X REPRESENTE: A.UN RADICAL ALKYLENE COMPORTANT 3 A 20ATOMES DE CARBONE EVENTUELLEMENT SUBSTITUE PAR UN OU PLUSIEURS RADICAUX HYDROXY ETOU AMINO PRIMAIRES; OU B.UN RADICAL ALKYLENE EVENTUELLEMENT INTERROMPU PAR UN OU PLUSIEURS RADICAUX AMINO SECONDAIRES, LE NOMBRE TOTAL DES ATOMES DE CARBONE ET D'AZOTE DE LA CHAINE OBTENUE ETANT DE 3 A 20, AINSI QUE LEURS SELS CONVENANT EN PHARMACOLOGIE, SONT DES MEDICAMENTS UTILES NOTAMMENT COMME INHIBITEURS PUISSANTS DES AFFECTIONS NEOPLASIQUES ET COMME AGENTS ANTIVIRAUX.
FR8009856A 1979-05-03 1980-04-30 Derives de type bis(demethoxy-4 daunorubicine)-dihydrazone et leurs sels convenant en pharmacologie utiles comme medicaments Granted FR2455595A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/035,657 US4275192A (en) 1979-05-03 1979-05-03 Bis(4-demethoxydaunorubicin)dihydrazone derivatives and pharmacologically acceptable salts thereof

Publications (2)

Publication Number Publication Date
FR2455595A1 true FR2455595A1 (fr) 1980-11-28
FR2455595B1 FR2455595B1 (fr) 1983-08-12

Family

ID=21884000

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8009856A Granted FR2455595A1 (fr) 1979-05-03 1980-04-30 Derives de type bis(demethoxy-4 daunorubicine)-dihydrazone et leurs sels convenant en pharmacologie utiles comme medicaments

Country Status (15)

Country Link
US (1) US4275192A (fr)
JP (1) JPS568398A (fr)
AU (1) AU532925B2 (fr)
BE (1) BE883106A (fr)
CA (1) CA1137471A (fr)
CH (1) CH643862A5 (fr)
DE (1) DE3016974A1 (fr)
DK (1) DK194280A (fr)
ES (2) ES491116A0 (fr)
FR (1) FR2455595A1 (fr)
GB (1) GB2050364B (fr)
IE (1) IE49782B1 (fr)
IT (1) IT1143092B (fr)
NL (1) NL8002577A (fr)
SE (1) SE8003317L (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2551442A1 (fr) * 1983-09-05 1985-03-08 Centre Nat Rech Scient Nouveaux derives furaniques, leur preparation et leur application
EP0328147A2 (fr) * 1988-02-11 1989-08-16 Bristol-Myers Squibb Company Immunoconjugués d'anthracyclines à spacer et leurs procédés de préparation

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162512A (en) * 1982-03-09 1992-11-10 Cytogen Corporation Amine derivatives of anthracycline antibodies
US4950738A (en) * 1984-09-13 1990-08-21 Cytogen Corporation Amine derivatives of anthracycline antibiotics
CA1248944A (fr) * 1982-09-28 1989-01-17 Gareth J. Thomas Glycosides d'anthracycline
JPS61227590A (ja) * 1985-04-02 1986-10-09 Microbial Chem Res Found 新規４′−デメチル−４−エピポドフイロトキシン誘導体
GB2196626B (en) * 1986-10-15 1990-09-19 Erba Farmitalia Antitumor anthracycline glycosides, their preparation, intermediates thereof, and compositions and use therefor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957755A (en) * 1967-10-18 1976-05-18 Rhone-Poulenc S.A. Naphthacene derivatives
US4112217A (en) * 1977-09-02 1978-09-05 Sri International Bis-hydrazones of daunomycin and adriamycin
US4125704A (en) * 1977-09-14 1978-11-14 Sri International Phenyl-substituted rubidazone analogs

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2551442A1 (fr) * 1983-09-05 1985-03-08 Centre Nat Rech Scient Nouveaux derives furaniques, leur preparation et leur application
EP0136938A2 (fr) * 1983-09-05 1985-04-10 Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Nouveaux dérivés furaniques, leur préparation et leur application
EP0136938A3 (fr) * 1983-09-05 1986-04-02 Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Nouveaux dérivés furaniques, leur préparation et leur application
EP0328147A2 (fr) * 1988-02-11 1989-08-16 Bristol-Myers Squibb Company Immunoconjugués d'anthracyclines à spacer et leurs procédés de préparation
EP0328147A3 (fr) * 1988-02-11 1991-11-13 Bristol-Myers Squibb Company Immunoconjugués d'anthracyclines à spacer et leurs procédés de préparation

Also Published As

Publication number Publication date
IT8048583A0 (it) 1980-05-05
GB2050364A (en) 1981-01-07
CA1137471A (fr) 1982-12-14
AU5803980A (en) 1980-11-06
NL8002577A (nl) 1980-11-05
ES8200899A1 (es) 1981-11-16
DE3016974A1 (de) 1980-11-13
ES497801A0 (es) 1981-11-16
CH643862A5 (de) 1984-06-29
IE49782B1 (en) 1985-12-11
IE800912L (en) 1980-11-03
SE8003317L (sv) 1980-11-04
BE883106A (fr) 1980-11-05
GB2050364B (en) 1983-04-27
AU532925B2 (en) 1983-10-20
US4275192A (en) 1981-06-23
JPS568398A (en) 1981-01-28
ES8104320A1 (es) 1981-04-16
FR2455595B1 (fr) 1983-08-12
ES491116A0 (es) 1981-04-16
IT1143092B (it) 1986-10-22
DK194280A (da) 1980-11-04

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Legal Events

Date Code Title Description
ST Notification of lapse