FR2452923A2 - Controlled release oral galenical formulation - contains active components in micro-granules prepd. under high compression - Google Patents

Controlled release oral galenical formulation - contains active components in micro-granules prepd. under high compression

Info

Publication number
FR2452923A2
FR2452923A2 FR7908181A FR7908181A FR2452923A2 FR 2452923 A2 FR2452923 A2 FR 2452923A2 FR 7908181 A FR7908181 A FR 7908181A FR 7908181 A FR7908181 A FR 7908181A FR 2452923 A2 FR2452923 A2 FR 2452923A2
Authority
FR
France
Prior art keywords
granules
contg
under high
high compression
prepd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7908181A
Other languages
French (fr)
Other versions
FR2452923B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to FR7908181A priority Critical patent/FR2452923A2/en
Priority to DE19792950977 priority patent/DE2950977A1/en
Priority to CH11224/79A priority patent/CH647676A5/en
Priority to IE2452/79A priority patent/IE48715B1/en
Priority to GB7943731A priority patent/GB2039737B/en
Priority to ES487151A priority patent/ES487151A1/en
Priority to AT0808179A priority patent/AT376567B/en
Priority to IT28301/79A priority patent/IT1164548B/en
Priority to AR279420A priority patent/AR229346A1/en
Publication of FR2452923A2 publication Critical patent/FR2452923A2/en
Application granted granted Critical
Publication of FR2452923B2 publication Critical patent/FR2452923B2/fr
Priority to US06/750,934 priority patent/US4726951A/en
Priority to US06/750,980 priority patent/US4609542A/en
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Abstract

Oral galenical formulation comprises (a) miniaturised granules prod. under high or very high compression, having a central core convered by several layers contg. >=1 active ingredient (I) plus an active excipient contg. a physiologically active neutralisation agent for pH control. Layers contg. (I) are sepd. from each other by layers of excipient which determin the slow penetration of digestive liq. Similar miniaturised granules contg. >=1 (I) coated with excipients or a very thin layer of lipid (representing 5-30% relative to (I)) are also claimed. The compsn. may contain 0-100% of each type of granule depending on the required absorption pattern, and pref. the granules have been compresed under >=10 tonnes pressure and have granule dia. 0.2-2 mm. The pref. excipients are PVP, cellulose, ethylcellulose, methacrylates, acetophthalates and gum lac. The release of (I) can be programmed and regulated as needed and absorption controlled regardless of whether (I) is normally slow or rapidly absorbed. Also therapeutic effect is improved, and the size of the formulation and the amt. of lipid needed for potentiation are both reduced.
FR7908181A 1978-12-22 1979-04-02 Controlled release oral galenical formulation - contains active components in micro-granules prepd. under high compression Granted FR2452923A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR7908181A FR2452923A2 (en) 1979-04-02 1979-04-02 Controlled release oral galenical formulation - contains active components in micro-granules prepd. under high compression
DE19792950977 DE2950977A1 (en) 1978-12-22 1979-12-18 NEW GALENIC PREPARATION FOR THE ORAL ADMINISTRATION OF MEDICINES WITH PROGRAMMED ASSOCIATION, AND METHOD FOR THE PRODUCTION THEREOF
CH11224/79A CH647676A5 (en) 1978-12-22 1979-12-18 ORAL, PROGRAM RELEASED GALENIC FORMS AND METHODS OF PREPARING THE SAME.
IE2452/79A IE48715B1 (en) 1978-12-22 1979-12-18 New galencial forms for administration of medicaments by oral route,with programmed release and processes for preparing same
GB7943731A GB2039737B (en) 1978-12-22 1979-12-19 Galenical forms for administration of medicaments by oral by oral route with programmed release and processes for preparing same
ES487151A ES487151A1 (en) 1978-12-22 1979-12-20 New pharmaceutical forms for administration of medicaments by oral route, with programmed release
AT0808179A AT376567B (en) 1978-12-22 1979-12-21 METHOD FOR PRODUCING A GALENIC PREPARATION FOR ORAL MEDICINES
IT28301/79A IT1164548B (en) 1978-12-22 1979-12-21 GALENIC FORMS OF ADMINISTRATION OF MEDICATIONS ORALLY, WITH SCHEDULED LIBERATION, AND THEIR PREPARATION PROCEDURES
AR279420A AR229346A1 (en) 1978-12-22 1979-12-21 PROCEDURE FOR THE PREPARATION OF A GALLENIC FORM OF ORAL USE MEDICINES, PROGRAMMED RELEASE
US06/750,934 US4726951A (en) 1978-12-22 1985-07-01 New pharmaceutical forms for administration of medicaments by oral route, with programmed release
US06/750,980 US4609542A (en) 1978-12-22 1985-07-01 New pharmaceutical forms for administration of medicaments by oral route, with programmed release

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7908181A FR2452923A2 (en) 1979-04-02 1979-04-02 Controlled release oral galenical formulation - contains active components in micro-granules prepd. under high compression

Publications (2)

Publication Number Publication Date
FR2452923A2 true FR2452923A2 (en) 1980-10-31
FR2452923B2 FR2452923B2 (en) 1982-10-29

Family

ID=9223809

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7908181A Granted FR2452923A2 (en) 1978-12-22 1979-04-02 Controlled release oral galenical formulation - contains active components in micro-granules prepd. under high compression

Country Status (1)

Country Link
FR (1) FR2452923A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2353285A1 (en) * 1975-09-17 1977-12-30 Doms Laboratoires Coronary vasodilator controlled release dipyridamole compsn. - comprises film coated granules giving reduced side effects and also showing angina pectoris suppressing action
FR2368272A1 (en) * 1976-10-20 1978-05-19 Theramex Solid aspirin-dipyridamole compsns. - each sepd. from other by inert material, for reducing platelet aggregation
FR2390959A1 (en) * 1977-05-16 1978-12-15 Prugnaud Robert Synergistic pyrimido:pyrimidine and aspirin compsns. - are anti-aggregating agents and are useful for treating e.g. peripheral vascular disorders

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2353285A1 (en) * 1975-09-17 1977-12-30 Doms Laboratoires Coronary vasodilator controlled release dipyridamole compsn. - comprises film coated granules giving reduced side effects and also showing angina pectoris suppressing action
FR2368272A1 (en) * 1976-10-20 1978-05-19 Theramex Solid aspirin-dipyridamole compsns. - each sepd. from other by inert material, for reducing platelet aggregation
FR2390959A1 (en) * 1977-05-16 1978-12-15 Prugnaud Robert Synergistic pyrimido:pyrimidine and aspirin compsns. - are anti-aggregating agents and are useful for treating e.g. peripheral vascular disorders

Also Published As

Publication number Publication date
FR2452923B2 (en) 1982-10-29

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TP Transmission of property
TP Transmission of property