FR2451917A1 - Composes de trifluoromethyl-2-(thio) pyridone et leur preparation - Google Patents
Composes de trifluoromethyl-2-(thio) pyridone et leur preparationInfo
- Publication number
- FR2451917A1 FR2451917A1 FR8006030A FR8006030A FR2451917A1 FR 2451917 A1 FR2451917 A1 FR 2451917A1 FR 8006030 A FR8006030 A FR 8006030A FR 8006030 A FR8006030 A FR 8006030A FR 2451917 A1 FR2451917 A1 FR 2451917A1
- Authority
- FR
- France
- Prior art keywords
- trifluoromethyl
- atom
- thio
- preparation
- pyridone compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 title abstract 2
- SCVJRXQHFJXZFZ-KVQBGUIXSA-N 2-amino-9-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purine-6-thione Chemical compound C1=2NC(N)=NC(=S)C=2N=CN1[C@H]1C[C@H](O)[C@@H](CO)O1 SCVJRXQHFJXZFZ-KVQBGUIXSA-N 0.000 title 1
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical group [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- -1 TRIFLUOROMETHYL GROUP Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3206879A JPS55124763A (en) | 1979-03-19 | 1979-03-19 | 5-trifluoromethyl-2-pyridone derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2451917A1 true FR2451917A1 (fr) | 1980-10-17 |
| FR2451917B1 FR2451917B1 (cg-RX-API-DMAC10.html) | 1983-04-22 |
Family
ID=12348551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8006030A Granted FR2451917A1 (fr) | 1979-03-19 | 1980-03-18 | Composes de trifluoromethyl-2-(thio) pyridone et leur preparation |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4546191A (cg-RX-API-DMAC10.html) |
| JP (1) | JPS55124763A (cg-RX-API-DMAC10.html) |
| BE (1) | BE882284A (cg-RX-API-DMAC10.html) |
| CA (1) | CA1134833A (cg-RX-API-DMAC10.html) |
| CH (1) | CH642355A5 (cg-RX-API-DMAC10.html) |
| DE (1) | DE3008908A1 (cg-RX-API-DMAC10.html) |
| FR (1) | FR2451917A1 (cg-RX-API-DMAC10.html) |
| GB (1) | GB2049666B (cg-RX-API-DMAC10.html) |
| IT (1) | IT1147077B (cg-RX-API-DMAC10.html) |
| NL (1) | NL8001618A (cg-RX-API-DMAC10.html) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3308800A1 (de) * | 1983-03-12 | 1984-09-13 | Rütgerswerke AG, 6000 Frankfurt | Verfahren zur herstellung von 3,5,6-trichlor-1h-pyridin-2-on |
| GB8523126D0 (en) * | 1985-09-19 | 1985-10-23 | Ici Plc | Aryl pyridones |
| GB8621217D0 (en) * | 1986-09-03 | 1986-10-08 | Ici Plc | Chemical compounds |
| US7517880B2 (en) * | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| US7329670B1 (en) | 1997-12-22 | 2008-02-12 | Bayer Pharmaceuticals Corporation | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
| US20080269265A1 (en) * | 1998-12-22 | 2008-10-30 | Scott Miller | Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| RU2319693C9 (ru) | 1999-01-13 | 2008-08-20 | Байер Копэрейшн | Производные мочевины (варианты), фармацевтическая композиция (варианты) и способ лечения заболевания, связанного с ростом раковых клеток (варианты) |
| WO2000042012A1 (en) * | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
| ES2377847T3 (es) | 1999-01-13 | 2012-04-02 | Bayer Healthcare Llc | Difenil ureas sustituidas con omega-carboxi arilo como agentes inhibidores de la cinasa p38 |
| US6414161B1 (en) * | 2000-08-09 | 2002-07-02 | Boehringer Ingelheim Pharmaceuticals, Inc. | Synthesis of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-H-imidazo[1,2-a]imidazol-2-one |
| WO2003047579A1 (en) * | 2001-12-03 | 2003-06-12 | Bayer Pharmaceuticals Corporation | Aryl urea compounds in combination with other cytostatic or cytotoxic agents for treating human cancers |
| US20030207872A1 (en) * | 2002-01-11 | 2003-11-06 | Bayer Corporation | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| PT1580188E (pt) * | 2002-02-11 | 2012-01-25 | Bayer Healthcare Llc | Aril-ureias como inibidores de cinases |
| EP1478358B1 (en) | 2002-02-11 | 2013-07-03 | Bayer HealthCare LLC | Sorafenib tosylate for the treatment of diseases characterized by abnormal angiogenesis |
| US7557129B2 (en) | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
| ES2288694T3 (es) * | 2003-05-20 | 2008-01-16 | Bayer Pharmaceuticals Corporation | Diaril ureas para enfermedades mediadas por el receptor del factor de crecimiento derivado de plaquetas. |
| KR101139557B1 (ko) | 2003-07-23 | 2012-04-30 | 바이엘 파마슈티칼스 코포레이션 | 질환 및 상태의 치료 및 예방을 위한 플루오로 치환오메가-카르복시아릴 디페닐 우레아 |
| CN102875453B (zh) * | 2012-06-08 | 2016-02-03 | 上海泰坦化学有限公司 | 一种用于合成抗癌辅助类药物的吡啶类医药中间体的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3355278A (en) * | 1961-03-13 | 1967-11-28 | Hooker Chemical Corp | Herbicidal composition and method |
| US3634435A (en) * | 1968-07-10 | 1972-01-11 | Sandoz Ltd | Certain s-(n-methylene-pyridone - (2)-o o-dilower-alkyl mono and dithio phosphates and derivatives |
| US3682938A (en) * | 1970-12-18 | 1972-08-08 | Dow Chemical Co | Bis(trifluoro methyl)-2-pyridinols |
| AR208500A1 (es) * | 1972-06-14 | 1977-02-15 | Merck & Co Inc | Procedimiento para la preparacion de derivados de oxazolo(4,5-b)-piridinas |
| US3974166A (en) * | 1973-07-10 | 1976-08-10 | Ciba-Geigy Corporation | Process for the manufacture of bromopyridines |
| DE2531202C2 (de) * | 1975-07-12 | 1982-12-09 | Bayer Ag, 5090 Leverkusen | 2',4-Dichlor-4'-benzoylureido- diphenyläther, Verfahren zu ihrer Herstellung und ihre Verwendung als Insektizide |
| JPS5840946B2 (ja) * | 1976-10-29 | 1983-09-08 | 石原産業株式会社 | Ｎ−ベンゾイル−ｎ′−ピリジルオキシフエニルウレア系化合物、それらの製造方法及びそれらを含有する殺虫剤 |
| JPS5461182A (en) * | 1977-10-20 | 1979-05-17 | Ishihara Sangyo Kaisha Ltd | 2-phenoxy-5-trifluoromethylpyridine compounds |
| JPS5461183A (en) * | 1977-10-21 | 1979-05-17 | Ishihara Sangyo Kaisha Ltd | 2-substituted-5-trifluoromethyl pyridine compounds |
| BE862325A (fr) * | 1977-12-27 | 1978-06-27 | Ciba Geigy | Nouveaux derives d'acide pyridyloxy-phenoxypropionique ayant une action herbicide et phytoregulatrice |
| US4249009A (en) * | 1979-01-29 | 1981-02-03 | Reilly Tar & Chemical Corp. | Processes for preparing 2-chloro-5-trifluoromethylpyridine |
| US4230864A (en) * | 1979-01-29 | 1980-10-28 | Reilly Tar & Chemical Corp. | Process for making 5-trifluoromethyl pyridone |
-
1979
- 1979-03-19 JP JP3206879A patent/JPS55124763A/ja active Granted
-
1980
- 1980-03-07 DE DE19803008908 patent/DE3008908A1/de active Granted
- 1980-03-07 GB GB8007881A patent/GB2049666B/en not_active Expired
- 1980-03-13 CA CA000347559A patent/CA1134833A/en not_active Expired
- 1980-03-14 CH CH203480A patent/CH642355A5/de not_active IP Right Cessation
- 1980-03-17 IT IT48176/80A patent/IT1147077B/it active
- 1980-03-18 BE BE0/199840A patent/BE882284A/fr not_active IP Right Cessation
- 1980-03-18 FR FR8006030A patent/FR2451917A1/fr active Granted
- 1980-03-19 US US06/131,719 patent/US4546191A/en not_active Expired - Lifetime
- 1980-03-19 NL NL8001618A patent/NL8001618A/nl not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GB2049666B (en) | 1983-04-27 |
| BE882284A (fr) | 1980-07-16 |
| GB2049666A (en) | 1980-12-31 |
| FR2451917B1 (cg-RX-API-DMAC10.html) | 1983-04-22 |
| CA1134833A (en) | 1982-11-02 |
| DE3008908C2 (cg-RX-API-DMAC10.html) | 1989-09-21 |
| DE3008908A1 (de) | 1980-10-02 |
| US4546191A (en) | 1985-10-08 |
| IT8048176A0 (it) | 1980-03-17 |
| IT1147077B (it) | 1986-11-19 |
| NL8001618A (nl) | 1980-09-23 |
| JPS55124763A (en) | 1980-09-26 |
| JPS6348865B2 (cg-RX-API-DMAC10.html) | 1988-09-30 |
| CH642355A5 (de) | 1984-04-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FR2451917A1 (fr) | Composes de trifluoromethyl-2-(thio) pyridone et leur preparation | |
| BE876215A (fr) | Prothese d'articulation de genou | |
| FR2330375A1 (fr) | Prothese d'articulation du genou | |
| FR2473876B1 (fr) | Prothese totale d'articulation du genou, stabilisee ulterieurement | |
| FR2314702A1 (fr) | Prothese d'articulation du poignet | |
| DE59005587D1 (de) | Salicylaldehyd- und Salicylsäurederivate sowie deren Schwefelanaloge, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und Bioregulatoren. | |
| DE3750443D1 (de) | Cephalosporinverbindungen, Verfahren zu ihrer Herstellung und antibakterielle Mittel. | |
| FR2450600B1 (fr) | Prothese d'articulation, notamment d'articulation metacarpo-phalangienne | |
| FR2304818A1 (fr) | Cuvette d'articulation a genouillere | |
| DE3867684D1 (de) | Kupferoxid-supraleiter mit gemischter wertigkeit und verfahren zu seiner herstellung. | |
| BE883482A (fr) | Prothese, en particulier pour l'arthrose cervicale | |
| FR2390429A1 (fr) | Composes d'aminothiazole et leur utilisation pour la preparation de composes de cephalosporine | |
| GR3005470T3 (cg-RX-API-DMAC10.html) | ||
| FR2465115B1 (fr) | Guidage coulissant, se composant d'une coulisse et d'une douille de guidage | |
| FR2424918A1 (fr) | Nouvelles piperazines substituees, leur preparation et leur utilisation | |
| FR2392991A1 (fr) | Nouvelles 5,11-dihydro-6h-pyrido(2,3-b) (1,4) benzodiazepin-6-ones substituees en position 11, procedes pour leur preparation et medicaments renfermant ces composes | |
| ATE123024T1 (de) | 4-aminopyridinderivate. | |
| MY8700521A (en) | A fungicidal indanylbenzamide | |
| ES515709A0 (es) | "procedimiento de preparacion de un complejo inosina-(l) 5-htp". | |
| EG18453A (en) | Five membered heterocyclic derivatives of n'-substituted-n,n'-diacylhidrazines | |
| GB2021586A (en) | 1,2,4-Triazolidin-3-ones (and -thiones) | |
| ES465516A1 (es) | Procedimiento para la obtencion de (tiono)-tiolfosfats de 0-etil-s-n-propil-0-2,2,2-trihaloetilo. | |
| BR8005290A (pt) | Composicoes hetbicidas a base de 1,1-dioxidos de 5,6-didro-1,2,4,6-tiatrizin (5)-ona | |
| FR2423491A1 (fr) | Composes heterocycliques azotes, en particulier n-imidazolylamino-iso-indolines, et medicaments qui en contiennent | |
| FR2590794B1 (fr) | Prothese d'articulation, en particulier pour articulation du doigt |