FR2449686A1 - Nouvel ester de l'acide 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetique et sa preparation, ainsi que medicament le comprenant et sa preparation - Google Patents

Nouvel ester de l'acide 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetique et sa preparation, ainsi que medicament le comprenant et sa preparation

Info

Publication number
FR2449686A1
FR2449686A1 FR8003865A FR8003865A FR2449686A1 FR 2449686 A1 FR2449686 A1 FR 2449686A1 FR 8003865 A FR8003865 A FR 8003865A FR 8003865 A FR8003865 A FR 8003865A FR 2449686 A1 FR2449686 A1 FR 2449686A1
Authority
FR
France
Prior art keywords
preparation
acid
methylindole
chlorobenzoyl
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8003865A
Other languages
English (en)
Other versions
FR2449686B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Resfar Srl
Original Assignee
Resfar Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Resfar Srl filed Critical Resfar Srl
Publication of FR2449686A1 publication Critical patent/FR2449686A1/fr
Application granted granted Critical
Publication of FR2449686B1 publication Critical patent/FR2449686B1/fr
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

LE 1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETATE DE 3-OXY-1-ISOBENZOFURANNYLE EST PREPARE PAR REACTION DE L'ACIDE CORRESPONDANT A TEMPERATURE AMBIANTE AVEC LA BROMOPHTALIDE EN PRESENCE D'UNE BASE. IL PRESENTE DES PROPRIETES PHARMACOLOGIQUES, NOTAMMENT ANTI-INFLAMMATOIRES SUPERIEURES A CELLES DE L'ACIDE CORRESPONDANT ET UNE TOXICITE MOINDRE. LA FIGURE 2 REPRESENTE LE SPECTRE UV DANS L'ALCOOL DE CE PRODUIT.
FR8003865A 1979-02-21 1980-02-21 Nouvel ester de l'acide 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetique et sa preparation, ainsi que medicament le comprenant et sa preparation Expired FR2449686B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT7920398A IT7920398A0 (it) 1979-02-21 1979-02-21 Derivato ad attivita' analgesica antiinfiammatoria potenziata eprocedimento per la sua preparazione.

Publications (2)

Publication Number Publication Date
FR2449686A1 true FR2449686A1 (fr) 1980-09-19
FR2449686B1 FR2449686B1 (fr) 1986-04-25

Family

ID=11166346

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8003865A Expired FR2449686B1 (fr) 1979-02-21 1980-02-21 Nouvel ester de l'acide 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetique et sa preparation, ainsi que medicament le comprenant et sa preparation

Country Status (5)

Country Link
US (1) US4277489A (fr)
JP (1) JPS5951954B2 (fr)
DE (1) DE3005827A1 (fr)
FR (1) FR2449686B1 (fr)
IT (1) IT7920398A0 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4603685A (en) * 1983-06-21 1986-08-05 Institut National De La Recherche Scientifique Solar heating system
GB8524157D0 (en) * 1984-10-19 1985-11-06 Ici America Inc Heterocyclic amides
GB8426474D0 (en) * 1984-10-19 1984-11-28 Ici America Inc Heterocyclic amides
GB8609175D0 (en) * 1986-04-15 1986-05-21 Ici America Inc Heterocyclic carboxamides
JP2006524239A (ja) * 2003-03-27 2006-10-26 メルク　エンド　カムパニー　インコーポレーテッド 高眼圧症を治療するための眼用組成物
US10072018B2 (en) 2013-04-17 2018-09-11 Biopharma Works Compounds for treatment of pain
WO2014172482A1 (fr) * 2013-04-17 2014-10-23 Robert Alfred Volkmann Composés destinés au traitement de la douleur

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1573925A (fr) * 1968-02-07 1969-07-11

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3103515A (en) * 1961-06-08 1963-09-10 Basic esters of i-benzoxacycloalkane-
DE2740853A1 (de) * 1977-09-10 1979-03-29 Troponwerke Gmbh & Co Kg Substituierte 1-(4-chlorbenzoyl)-5- methoxy-2-methylindol-3-essigsaeurederivate, verfahren zu ihrer darstellung und ihre verwendung als arzneimittel

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1573925A (fr) * 1968-02-07 1969-07-11

Also Published As

Publication number Publication date
IT7920398A0 (it) 1979-02-21
DE3005827A1 (de) 1980-09-04
FR2449686B1 (fr) 1986-04-25
JPS55113778A (en) 1980-09-02
US4277489A (en) 1981-07-07
JPS5951954B2 (ja) 1984-12-17

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Legal Events

Date Code Title Description
ST Notification of lapse