FR2447914A1 - Nouveaux benzothiophenes, leurs procedes de preparation et leur application notamment comme hypolipemiants et hypocholesterolemiants - Google Patents
Nouveaux benzothiophenes, leurs procedes de preparation et leur application notamment comme hypolipemiants et hypocholesterolemiantsInfo
- Publication number
- FR2447914A1 FR2447914A1 FR7902897A FR7902897A FR2447914A1 FR 2447914 A1 FR2447914 A1 FR 2447914A1 FR 7902897 A FR7902897 A FR 7902897A FR 7902897 A FR7902897 A FR 7902897A FR 2447914 A1 FR2447914 A1 FR 2447914A1
- Authority
- FR
- France
- Prior art keywords
- phenyl
- benzo
- hypolipidaemics
- hypocholesterolaemic
- thiophenone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 title 2
- 241001061127 Thione Species 0.000 title 1
- 150000004820 halides Chemical class 0.000 title 1
- 230000000055 hyoplipidemic effect Effects 0.000 title 1
- 230000000871 hypocholesterolemic effect Effects 0.000 title 1
- WSDQIHATCCOMLH-UHFFFAOYSA-N phenyl n-(3,5-dichlorophenyl)carbamate Chemical compound ClC1=CC(Cl)=CC(NC(=O)OC=2C=CC=CC=2)=C1 WSDQIHATCCOMLH-UHFFFAOYSA-N 0.000 title 1
- LWRYDHOHXNQTSK-UHFFFAOYSA-N thiophene oxide Chemical compound O=S1C=CC=C1 LWRYDHOHXNQTSK-UHFFFAOYSA-N 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- -1 alkanoylalkyl Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- VAYGXNSJCAHWJZ-UHFFFAOYSA-N dimethyl sulfate Chemical compound COS(=O)(=O)OC VAYGXNSJCAHWJZ-UHFFFAOYSA-N 0.000 abstract 1
- 229940075933 dithionate Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 229930192474 thiophene Natural products 0.000 abstract 1
- 150000003577 thiophenes Chemical class 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7902897A FR2447914A1 (fr) | 1979-02-05 | 1979-02-05 | Nouveaux benzothiophenes, leurs procedes de preparation et leur application notamment comme hypolipemiants et hypocholesterolemiants |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7902897A FR2447914A1 (fr) | 1979-02-05 | 1979-02-05 | Nouveaux benzothiophenes, leurs procedes de preparation et leur application notamment comme hypolipemiants et hypocholesterolemiants |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2447914A1 true FR2447914A1 (fr) | 1980-08-29 |
FR2447914B1 FR2447914B1 (enrdf_load_stackoverflow) | 1982-02-05 |
Family
ID=9221608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7902897A Granted FR2447914A1 (fr) | 1979-02-05 | 1979-02-05 | Nouveaux benzothiophenes, leurs procedes de preparation et leur application notamment comme hypolipemiants et hypocholesterolemiants |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2447914A1 (enrdf_load_stackoverflow) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0177927A1 (en) * | 1984-10-09 | 1986-04-16 | Merck & Co. Inc. | 3-Hydroxybenzo[b]thiophene-2-sulfide derivatives as specific-5-lipoxygenase inhibitors |
EP0729956A1 (en) * | 1995-02-28 | 1996-09-04 | Eli Lilly And Company | Benzothiophene compounds, intermediates, compositions, and methods |
US8642786B2 (en) | 2008-02-29 | 2014-02-04 | Nissan Chemical Industries, Ltd. | Process for producing thiophene compound and intermediate thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1182785A (fr) * | 1956-09-17 | 1959-06-29 | Composés de thiophène-dioxyde | |
FR4098M (enrdf_load_stackoverflow) * | 1963-12-07 | 1966-04-18 | ||
US3597448A (en) * | 1967-05-02 | 1971-08-03 | Pfizer | 2-arylbenzo(b) thiophen - 3(2h) - one - 1,1 - dioxides and 2 - arylnaphtho(2,3-b)thiophen-3(2h)-one-1,1-dioxides |
-
1979
- 1979-02-05 FR FR7902897A patent/FR2447914A1/fr active Granted
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1182785A (fr) * | 1956-09-17 | 1959-06-29 | Composés de thiophène-dioxyde | |
FR4098M (enrdf_load_stackoverflow) * | 1963-12-07 | 1966-04-18 | ||
US3597448A (en) * | 1967-05-02 | 1971-08-03 | Pfizer | 2-arylbenzo(b) thiophen - 3(2h) - one - 1,1 - dioxides and 2 - arylnaphtho(2,3-b)thiophen-3(2h)-one-1,1-dioxides |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0177927A1 (en) * | 1984-10-09 | 1986-04-16 | Merck & Co. Inc. | 3-Hydroxybenzo[b]thiophene-2-sulfide derivatives as specific-5-lipoxygenase inhibitors |
EP0729956A1 (en) * | 1995-02-28 | 1996-09-04 | Eli Lilly And Company | Benzothiophene compounds, intermediates, compositions, and methods |
EP1113013A1 (en) * | 1995-02-28 | 2001-07-04 | Eli Lilly & Company | Benzothiophene compounds, intermediates, compositions and methods |
US8642786B2 (en) | 2008-02-29 | 2014-02-04 | Nissan Chemical Industries, Ltd. | Process for producing thiophene compound and intermediate thereof |
JP5440490B2 (ja) * | 2008-02-29 | 2014-03-12 | 日産化学工業株式会社 | チオフェン化合物及びその中間体の製造方法 |
Also Published As
Publication number | Publication date |
---|---|
FR2447914B1 (enrdf_load_stackoverflow) | 1982-02-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property | ||
ST | Notification of lapse |