FR2441616A1 - Nouvel imidazole, procede pour sa preparation et son application therapeutique - Google Patents

Nouvel imidazole, procede pour sa preparation et son application therapeutique

Info

Publication number
FR2441616A1
FR2441616A1 FR7928099A FR7928099A FR2441616A1 FR 2441616 A1 FR2441616 A1 FR 2441616A1 FR 7928099 A FR7928099 A FR 7928099A FR 7928099 A FR7928099 A FR 7928099A FR 2441616 A1 FR2441616 A1 FR 2441616A1
Authority
FR
France
Prior art keywords
preparation
therapeutic application
novel imidazole
alcoyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7928099A
Other languages
English (en)
Other versions
FR2441616B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP13932578A external-priority patent/JPS5566562A/ja
Priority claimed from JP14281378A external-priority patent/JPS5569567A/ja
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of FR2441616A1 publication Critical patent/FR2441616A1/fr
Application granted granted Critical
Publication of FR2441616B1 publication Critical patent/FR2441616B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'INVENTION A POUR OBJET UN NOUVEL IMIDAZOLE AYANT NOTAMMENT UN POUVOIR ANTIDEPRESSEUR, DE FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R REPRESENTE UN ALCOYLE INFERIEUR, R REPRESENTE H OU UN ALCOYLE INFERIEUR ET R, R ET R REPRESENTENT INDEPENDAMMENT L'UN DE L'AUTRE H, UN GROUPE ALCOYLE INFERIEUR, TRIFLUOROMETHYLE, AMINO, MONO OU DI-ALCOYLAMINO INFERIEUR, AMINO HETEROCYCLIQUE, HALO OU -N-A-R
FR7928099A 1978-11-14 1979-11-14 Nouvel imidazole, procede pour sa preparation et son application therapeutique Expired FR2441616B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP13932578A JPS5566562A (en) 1978-11-14 1978-11-14 Novel imidazole derivative and antidepressant containing the same
JP14281378A JPS5569567A (en) 1978-11-21 1978-11-21 Novel imidazole compound, and antidepressant containing the same

Publications (2)

Publication Number Publication Date
FR2441616A1 true FR2441616A1 (fr) 1980-06-13
FR2441616B1 FR2441616B1 (fr) 1986-05-09

Family

ID=26472162

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7928099A Expired FR2441616B1 (fr) 1978-11-14 1979-11-14 Nouvel imidazole, procede pour sa preparation et son application therapeutique

Country Status (9)

Country Link
US (4) US4301169A (fr)
CA (1) CA1126272A (fr)
CH (1) CH642635A5 (fr)
DE (1) DE2946020A1 (fr)
FR (1) FR2441616B1 (fr)
GB (1) GB2044754B (fr)
IT (1) IT1127223B (fr)
NL (1) NL7908331A (fr)
SE (1) SE447653B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0445931A1 (fr) * 1990-02-20 1991-09-11 Sumitomo Chemical Company, Limited Dérivé de tert.butyl-4-imidazole et sa préparation et utilisation
EP0464980A1 (fr) * 1990-06-29 1992-01-08 Sumitomo Chemical Company, Limited Dérivés de phényl-1-imidazole et leur préparation et application
WO1992015577A1 (fr) * 1991-02-28 1992-09-17 G.D. Searle & Co. Antagonistes d'angiotensine ii a base de composes de (alpha-imidazolyl-toluyl) pyrrole n-substitue pour le traitement des troubles circulatoires
US6008368A (en) * 1993-04-28 1999-12-28 G. D. Searle & Co. Pharmaceutical compositions for treatment of circulatory disorders using N-substituted (α-imidazolyl-toluyl) pyrrole aniotensin II antagonists

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2044754B (en) * 1978-11-14 1983-05-05 Eisai Co Ltd Imidazoles
US4353905A (en) * 1981-09-17 1982-10-12 Warner-Lambert Company Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
CA1334092C (fr) * 1986-07-11 1995-01-24 David John Carini Imidazoles bloquant les recepteurs de l'angiotensine ii
US4851526A (en) * 1987-09-04 1989-07-25 Schering A.G. 1-(4-Substituted phenyl)-1H-imidazoles compounds
US5210079A (en) * 1988-01-07 1993-05-11 E. I. Du Pont De Nemours And Company Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists
DK0443983T3 (da) * 1990-02-19 1996-03-18 Ciba Geigy Ag Acrylforbindelser
US5179113A (en) * 1990-03-20 1993-01-12 E. I. Du Pont De Nemours And Company Treatment of central nervous disorders with imidazole compounds
US5137906A (en) * 1990-03-20 1992-08-11 E. I. Du Pont De Nemours And Company Treatment of central nervous system disorders with benzimidazole angiotensin-II receptor antagonists
US5155126A (en) * 1990-03-20 1992-10-13 E. I. Du Pont De Nemours And Company Treatment of central nervous system disorders with pyrazole, pyrrole and triazole angiotensin-II receptor antagonists
US5173494A (en) * 1990-03-20 1992-12-22 E. I. Du Pont De Nemours And Company Specific inhibition of angiotensin-II binding to angiotensin-II receptor subtype-2
US5140037A (en) * 1990-03-20 1992-08-18 E. I. Du Pont De Nemours And Company Treatment of central nervous system disorders with imidazole angiotensin-ii receptor antagonists
US5451597A (en) * 1993-05-27 1995-09-19 G.D. Searle & Co. Treatment of circulatory disorders using n-substituted (α-imidazolyl-toluyl) pyrrole angiotensin II antagonists
WO1995029163A1 (fr) * 1994-04-27 1995-11-02 Nippon Soda Co., Ltd. Derive d'imidazole et procede de production de ce derive
KR20010072080A (ko) 1998-07-31 2001-07-31 쓰끼하시 다미까따 페닐아졸 화합물, 그의 제조 방법 및 고지혈증용 약제
AUPQ319899A0 (en) * 1999-10-01 1999-10-28 Fujisawa Pharmaceutical Co., Ltd. Amide compounds
US6627647B1 (en) * 2000-03-23 2003-09-30 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenyl)imidazoles and their use as anti-inflammatory agents
US7553837B2 (en) * 2003-08-01 2009-06-30 Nippon Soda Co., Ltd. Phenylazole compounds production process and antioxidants
KR101292598B1 (ko) * 2005-01-14 2013-08-05 질레드 코네티컷 인코포레이티드 키나아제 활성 조절제로서의 １，３-디아릴 치환된 우레아
WO2006076592A1 (fr) * 2005-01-14 2006-07-20 Cgi Pharmaceuticals, Inc. Urees a substitution 1,3-diaryle, modulateurs de l'activite de kinases
WO2007024294A2 (fr) * 2005-05-03 2007-03-01 Cgi Pharmaceuticals, Inc. Certains urees substitues, modulateurs de l'activite des kinases
EP2066642A1 (fr) * 2006-09-25 2009-06-10 Arete Therapeutics, INC. Inhibiteurs d'époxyde hydrolase soluble
WO2008051875A2 (fr) * 2006-10-20 2008-05-02 Arete Therapeutics, Inc. Inhibiteurs d'époxyde hydrolase soluble
CN104703635B (zh) 2012-08-28 2016-12-07 3M创新有限公司 葡萄糖酸氯己定组合物、树脂体系和制品
WO2019194220A1 (fr) * 2018-04-06 2019-10-10 日本曹達株式会社 Composé (hétéro)arylsulfonamide et agent de lutte contre les organismes nuisibles

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1578644A (fr) * 1967-09-02 1969-08-14
US3637731A (en) * 1968-07-18 1972-01-25 Du Pont 1-(alkylsubstituted phenyl)imidazoles useful in acth reserve assay
US4172947A (en) * 1977-01-07 1979-10-30 Westwood Pharmaceuticals, Inc. 1-(2-Acylaminophenyl)imidazoles
US4431815A (en) * 1977-08-26 1984-02-14 Burroughs Wellcome Co. 1-[3-(2,4-Dichlorophenyl)propyl]imidazole and salts thereof
US4284641A (en) * 1977-08-26 1981-08-18 Burroughs Wellcome Co. Pharmaceutically active imidazole derivatives
GB2044754B (en) * 1978-11-14 1983-05-05 Eisai Co Ltd Imidazoles

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0445931A1 (fr) * 1990-02-20 1991-09-11 Sumitomo Chemical Company, Limited Dérivé de tert.butyl-4-imidazole et sa préparation et utilisation
US5180732A (en) * 1990-02-20 1993-01-19 Sumitomo Chemical Company, Limited 4-tert.-butyl imidazole derivative and use
EP0464980A1 (fr) * 1990-06-29 1992-01-08 Sumitomo Chemical Company, Limited Dérivés de phényl-1-imidazole et leur préparation et application
WO1992015577A1 (fr) * 1991-02-28 1992-09-17 G.D. Searle & Co. Antagonistes d'angiotensine ii a base de composes de (alpha-imidazolyl-toluyl) pyrrole n-substitue pour le traitement des troubles circulatoires
US5187271A (en) * 1991-02-28 1993-02-16 G. D. Searle & Co. N-substituted (α-imidazolyl-toluyl) pyrrole compounds for treatment of circulatory disorders
US6451833B1 (en) * 1991-02-28 2002-09-17 Pharmacia Corporation N-substituted (α-imidazolyl-toluyl)pyrrole compounds for treatment of circulatory disorders
US6008368A (en) * 1993-04-28 1999-12-28 G. D. Searle & Co. Pharmaceutical compositions for treatment of circulatory disorders using N-substituted (α-imidazolyl-toluyl) pyrrole aniotensin II antagonists

Also Published As

Publication number Publication date
CH642635A5 (fr) 1984-04-30
FR2441616B1 (fr) 1986-05-09
US4602031A (en) 1986-07-22
NL7908331A (nl) 1980-05-19
US4402966A (en) 1983-09-06
IT1127223B (it) 1986-05-21
SE447653B (sv) 1986-12-01
CA1126272A (fr) 1982-06-22
IT7927268A0 (it) 1979-11-14
SE7909371L (sv) 1980-05-15
US4301169A (en) 1981-11-17
GB2044754B (en) 1983-05-05
GB2044754A (en) 1980-10-22
US4533669A (en) 1985-08-06
DE2946020A1 (de) 1980-05-29

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Legal Events

Date Code Title Description
ST Notification of lapse