FR2432515A1 - CNS-active 1-phenyl-piperazine cpds. - useful as analgesics and psychotropic agents - Google Patents

CNS-active 1-phenyl-piperazine cpds. - useful as analgesics and psychotropic agents

Info

Publication number
FR2432515A1
FR2432515A1 FR7822672A FR7822672A FR2432515A1 FR 2432515 A1 FR2432515 A1 FR 2432515A1 FR 7822672 A FR7822672 A FR 7822672A FR 7822672 A FR7822672 A FR 7822672A FR 2432515 A1 FR2432515 A1 FR 2432515A1
Authority
FR
France
Prior art keywords
alkyl
useful
cpds
analgesics
cns
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7822672A
Other languages
French (fr)
Other versions
FR2432515B1 (en
Inventor
Henry Najer
Philippe Michel Jacque Manoury
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7822672A priority Critical patent/FR2432515A1/en
Priority to FR7833105A priority patent/FR2442234A2/en
Priority to FR7916029A priority patent/FR2459797A2/en
Priority to DE19792930440 priority patent/DE2930440A1/en
Priority to NL7905810A priority patent/NL7905810A/en
Priority to US06/061,245 priority patent/US4267328A/en
Priority to NZ191140A priority patent/NZ191140A/en
Priority to IT24749/79A priority patent/IT1123497B/en
Priority to AU49309/79A priority patent/AU4930979A/en
Priority to GB7926224A priority patent/GB2027703A/en
Priority to ZA00793852A priority patent/ZA793852B/en
Priority to NO792502A priority patent/NO792502L/en
Priority to IL57920A priority patent/IL57920A0/en
Priority to LU81562A priority patent/LU81562A1/en
Priority to DK321479A priority patent/DK321479A/en
Priority to SE7906507A priority patent/SE7906507L/en
Priority to JP9858679A priority patent/JPS5522690A/en
Priority to ES483003A priority patent/ES483003A1/en
Priority to BE0/196538A priority patent/BE877994A/en
Priority to PT70007A priority patent/PT70007A/en
Priority to FI792401A priority patent/FI792401A/en
Publication of FR2432515A1 publication Critical patent/FR2432515A1/en
Priority to GR59710A priority patent/GR69703B/el
Application granted granted Critical
Publication of FR2432515B1 publication Critical patent/FR2432515B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Abstract

Cpds. of formula (I) and their pharmaceutically acceptable acid addn. salts are new (where R1 is -S(O)mR3, -S(O)nCF3 or -SO2NR4R5, m is 0, 1 or 2, n is 1 or 2, R3 is 1-10C alkyl, R4 and R5 are each H or 1-4C alkyl, or NR4R5 may be a heterocycle opt. contg. another heteroatom, R2 is H or -CH2CH2-OR6, R6 is H, -COR7, -COHR7 or 1-6C alkyl, R7 is 1-6C alkyl, provided that R2 is not H wen R1 is -SCH3). 2- 4(3-methyl-thiophenyl)-1-piperazinyl ethanol and salts are specifically claimed. (I) are psychotropic agents useful in treatment of anxiety and depression at 5-200 mg/day, and analgesics useful for treatment of headaches, neuralgia, toothache, rheumatic paints etc. at 50-1000 mg/day.
FR7822672A 1978-08-01 1978-08-01 CNS-active 1-phenyl-piperazine cpds. - useful as analgesics and psychotropic agents Granted FR2432515A1 (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
FR7822672A FR2432515A1 (en) 1978-08-01 1978-08-01 CNS-active 1-phenyl-piperazine cpds. - useful as analgesics and psychotropic agents
FR7833105A FR2442234A2 (en) 1978-08-01 1978-11-23 CNS-active 1-phenyl-piperazine cpds. - useful as analgesics and psychotropic agents
FR7916029A FR2459797A2 (en) 1978-08-01 1979-06-22 PHENYL-1 PIPERAZINE DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
DE19792930440 DE2930440A1 (en) 1978-08-01 1979-07-26 1-PHENYL PIPERAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE SAME
US06/061,245 US4267328A (en) 1978-08-01 1979-07-27 1-Phenylpiperazines
NZ191140A NZ191140A (en) 1978-08-01 1979-07-27 1-phenylpiperazine derivatives pharmaceutical compositions
IT24749/79A IT1123497B (en) 1978-08-01 1979-07-27 PHENYL-1 PIPERAZINE DERIVATIVES
AU49309/79A AU4930979A (en) 1978-08-01 1979-07-27 1-phenylpiperazine derivatives
GB7926224A GB2027703A (en) 1978-08-01 1979-07-27 1-Phenylpiperazine derivatives
ZA00793852A ZA793852B (en) 1978-08-01 1979-07-27 1-phenylpiperazine derivatives
NL7905810A NL7905810A (en) 1978-08-01 1979-07-27 PROCESS FOR PREPARING A PHARMACEUTICAL PREPARATION BASED ON A PIPERAZINE DERIVATIVE, WHICH IS ACTIVE WITH REGARD TO THE CENTRAL NERVOUS SYSTEM AND IS AN PAIN-RELIEF AGENT, PROCESS FOR THE PREPARATION OF THE PIPERAZINE DERIVATIVE PRODUCT AND THE PREPARATOR.
DK321479A DK321479A (en) 1978-08-01 1979-07-30 PROCEDURE FOR THE PREPARATION OF 1-PHENYL PIPERAZINE DERIVATIVES
IL57920A IL57920A0 (en) 1978-08-01 1979-07-30 1-phenylpiperazine derivatives,their preparation and pharmaceutical compositions containing them
LU81562A LU81562A1 (en) 1978-08-01 1979-07-30 PHENYL-1 PIPERAZINE DERIVATIVES
NO792502A NO792502L (en) 1978-08-01 1979-07-30 PROCEDURE FOR THE PREPARATION OF PHENYL PIPERAZINE DERIVATIVES
JP9858679A JPS5522690A (en) 1978-08-01 1979-07-31 11phenylpiperazine derivative and its manufacture
ES483003A ES483003A1 (en) 1978-08-01 1979-07-31 1-Phenylpiperazine derivatives
BE0/196538A BE877994A (en) 1978-08-01 1979-07-31 PHENYL-1 PIPERAZINE DERIVATIVES
PT70007A PT70007A (en) 1978-08-01 1979-07-31 PROCESS FOR THE PREPARATION OF PHENYL-1 PIPERAZINE DERIVATIVES
SE7906507A SE7906507L (en) 1978-08-01 1979-07-31 Phenyl-1-piperazine derivatives
FI792401A FI792401A (en) 1978-08-01 1979-08-01 1-PHENYL-PIPERAZINDERIVAT
GR59710A GR69703B (en) 1978-08-01 1980-07-27

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7822672A FR2432515A1 (en) 1978-08-01 1978-08-01 CNS-active 1-phenyl-piperazine cpds. - useful as analgesics and psychotropic agents

Publications (2)

Publication Number Publication Date
FR2432515A1 true FR2432515A1 (en) 1980-02-29
FR2432515B1 FR2432515B1 (en) 1980-12-05

Family

ID=9211434

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7822672A Granted FR2432515A1 (en) 1978-08-01 1978-08-01 CNS-active 1-phenyl-piperazine cpds. - useful as analgesics and psychotropic agents

Country Status (2)

Country Link
FR (1) FR2432515A1 (en)
ZA (1) ZA793852B (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2976290A (en) * 1959-04-24 1961-03-21 Parke Davis & Co Piperazine derivatives and methods for their production

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2976290A (en) * 1959-04-24 1961-03-21 Parke Davis & Co Piperazine derivatives and methods for their production

Also Published As

Publication number Publication date
FR2432515B1 (en) 1980-12-05
ZA793852B (en) 1980-07-30

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