FR2430948A1 - 11-Hydroxy-ajmalicine and corresp. free acid - increasing arterial blood flow and reducing peripheral resistance - Google Patents

11-Hydroxy-ajmalicine and corresp. free acid - increasing arterial blood flow and reducing peripheral resistance

Info

Publication number
FR2430948A1
FR2430948A1 FR7820462A FR7820462A FR2430948A1 FR 2430948 A1 FR2430948 A1 FR 2430948A1 FR 7820462 A FR7820462 A FR 7820462A FR 7820462 A FR7820462 A FR 7820462A FR 2430948 A1 FR2430948 A1 FR 2430948A1
Authority
FR
France
Prior art keywords
ajmalicine
blood flow
arterial blood
peripheral resistance
corresp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7820462A
Other languages
French (fr)
Other versions
FR2430948B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omnium Chimique SA
Original Assignee
Omnium Chimique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnium Chimique SA filed Critical Omnium Chimique SA
Priority to FR7820462A priority Critical patent/FR2430948A1/en
Priority to DE19792926433 priority patent/DE2926433A1/en
Priority to BE0/196195A priority patent/BE877573A/en
Priority to IT68427/79A priority patent/IT1121461B/en
Publication of FR2430948A1 publication Critical patent/FR2430948A1/en
Application granted granted Critical
Publication of FR2430948B1 publication Critical patent/FR2430948B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Abstract

Ajmalicine derivs. of formula (I), their acid addition and base salts and their zwitherionic forms are new. (where R is COOCH3 or COOH). (I) are made by treating tetraphyline (11)-methoxyajmalicine) with Br3B in an inert organic solvent. (I) increase arterial blood flow and reduces peripheral resistance, so are useful in treating cardio-circulating or cerebro-vascular disorders. (I;R=COOCH3) has LD50 in mice 37 mg/kg. i.v.
FR7820462A 1978-07-10 1978-07-10 11-Hydroxy-ajmalicine and corresp. free acid - increasing arterial blood flow and reducing peripheral resistance Granted FR2430948A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FR7820462A FR2430948A1 (en) 1978-07-10 1978-07-10 11-Hydroxy-ajmalicine and corresp. free acid - increasing arterial blood flow and reducing peripheral resistance
DE19792926433 DE2926433A1 (en) 1978-07-10 1979-06-29 HYDROXYL DERIVATIVES OF AJMALICIN, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING SUCH DERIVATIVES
BE0/196195A BE877573A (en) 1978-07-10 1979-07-09 HYDROXYL DERIVATIVES OF AJMALICIN, THEIR PROCESS FOR OBTAINING AND THEIR APPLICATION AS MEDICINAL PRODUCTS
IT68427/79A IT1121461B (en) 1978-07-10 1979-07-09 OXYDRYLATED DERIVATIVES OF AJMALICINE PARTICULARLY USEFUL AS MEDICATIONS AND PROCEDURE FOR THEIR PREPARATION

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7820462A FR2430948A1 (en) 1978-07-10 1978-07-10 11-Hydroxy-ajmalicine and corresp. free acid - increasing arterial blood flow and reducing peripheral resistance

Publications (2)

Publication Number Publication Date
FR2430948A1 true FR2430948A1 (en) 1980-02-08
FR2430948B1 FR2430948B1 (en) 1981-01-02

Family

ID=9210527

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7820462A Granted FR2430948A1 (en) 1978-07-10 1978-07-10 11-Hydroxy-ajmalicine and corresp. free acid - increasing arterial blood flow and reducing peripheral resistance

Country Status (4)

Country Link
BE (1) BE877573A (en)
DE (1) DE2926433A1 (en)
FR (1) FR2430948A1 (en)
IT (1) IT1121461B (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE757086A (en) * 1969-10-09 1971-04-06 Roussel Uclaf PROCESS FOR PREPARATION OF INDOLIC HYDROXYL COMPOUNDS
DE2215169A1 (en) * 1971-03-29 1972-10-12 Omnium Chimique S.A., Brüssel N-disubstituted aminoethyl ester of 11-methoxyraubasic acid and process for the preparation thereof
FR2353559A1 (en) * 1976-05-31 1977-12-30 Omnium Chimique Sa (10)-Hydroxy-ajmalicine prepn. - by chemical oxidn. of ajmalicine

Also Published As

Publication number Publication date
IT7968427A0 (en) 1979-07-09
IT1121461B (en) 1986-04-02
BE877573A (en) 1979-11-05
FR2430948B1 (en) 1981-01-02
DE2926433C2 (en) 1990-06-28
DE2926433A1 (en) 1980-01-24

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Legal Events

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