FR2353559A1 - (10)-Hydroxy-ajmalicine prepn. - by chemical oxidn. of ajmalicine - Google Patents
(10)-Hydroxy-ajmalicine prepn. - by chemical oxidn. of ajmalicineInfo
- Publication number
- FR2353559A1 FR2353559A1 FR7616345A FR7616345A FR2353559A1 FR 2353559 A1 FR2353559 A1 FR 2353559A1 FR 7616345 A FR7616345 A FR 7616345A FR 7616345 A FR7616345 A FR 7616345A FR 2353559 A1 FR2353559 A1 FR 2353559A1
- Authority
- FR
- France
- Prior art keywords
- ajmalicine
- oxidn
- effected
- prepn
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
Abstract
Prepn. of 10-hydroxy-ajmalicine (I) comprises chemical oxidn. of ajmalicine (II). Pref. the reaction is effected in 3 stages. The redn. of (II) to (III) is pref. effected with Na cyanoborohydride (CBH) in the presence of cF3COOH. Oxidn. of (III) is pref. effected with K nitrosodisulphonate (NDS), and redn. of (IV) is pref. effected with Na dithionite. The last two can be effected without isolating intermediate (IV). Cpd. (I) has cardiovascular activity. In an example, (II) was first reduced to 2,7-dihydro-ajmalicine, which is then oxidised with K-nitrosodisulphonate and reduced with Na dithionite to give (I).
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7616345A FR2353559A1 (en) | 1976-05-31 | 1976-05-31 | (10)-Hydroxy-ajmalicine prepn. - by chemical oxidn. of ajmalicine |
BE177499A BE854542A (en) | 1976-05-31 | 1977-05-12 | PROCESS FOR THE PREPARATION OF HYDROXY-10 AJMALICIN |
DE19772722718 DE2722718A1 (en) | 1976-05-31 | 1977-05-20 | METHOD FOR PRODUCING HYDROXY-10-AJMALICIN |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7616345A FR2353559A1 (en) | 1976-05-31 | 1976-05-31 | (10)-Hydroxy-ajmalicine prepn. - by chemical oxidn. of ajmalicine |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2353559A1 true FR2353559A1 (en) | 1977-12-30 |
FR2353559B3 FR2353559B3 (en) | 1979-02-16 |
Family
ID=9173776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7616345A Granted FR2353559A1 (en) | 1976-05-31 | 1976-05-31 | (10)-Hydroxy-ajmalicine prepn. - by chemical oxidn. of ajmalicine |
Country Status (3)
Country | Link |
---|---|
BE (1) | BE854542A (en) |
DE (1) | DE2722718A1 (en) |
FR (1) | FR2353559A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2926433A1 (en) * | 1978-07-10 | 1980-01-24 | Omnium Chimique Sa | HYDROXYL DERIVATIVES OF AJMALICIN, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING SUCH DERIVATIVES |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1013928A3 (en) | 1998-12-22 | 2000-11-08 | Parker Hannifin GmbH | Swash plate axial piston pump with pulsation damping means |
-
1976
- 1976-05-31 FR FR7616345A patent/FR2353559A1/en active Granted
-
1977
- 1977-05-12 BE BE177499A patent/BE854542A/en not_active IP Right Cessation
- 1977-05-20 DE DE19772722718 patent/DE2722718A1/en not_active Withdrawn
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2926433A1 (en) * | 1978-07-10 | 1980-01-24 | Omnium Chimique Sa | HYDROXYL DERIVATIVES OF AJMALICIN, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING SUCH DERIVATIVES |
Also Published As
Publication number | Publication date |
---|---|
DE2722718A1 (en) | 1977-12-15 |
BE854542A (en) | 1977-09-01 |
FR2353559B3 (en) | 1979-02-16 |
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