FR2430425A1 - NOVEL DAUNORUBICIN DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

NOVEL DAUNORUBICIN DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number
FR2430425A1
FR2430425A1 FR7820306A FR7820306A FR2430425A1 FR 2430425 A1 FR2430425 A1 FR 2430425A1 FR 7820306 A FR7820306 A FR 7820306A FR 7820306 A FR7820306 A FR 7820306A FR 2430425 A1 FR2430425 A1 FR 2430425A1
Authority
FR
France
Prior art keywords
preparation
pharmaceutical compositions
radical
novel
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7820306A
Other languages
French (fr)
Other versions
FR2430425B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Priority to FR7820306A priority Critical patent/FR2430425A1/en
Priority to NL7905098A priority patent/NL7905098A/en
Priority to GB7923301A priority patent/GB2032420B/en
Priority to JP8449379A priority patent/JPS5511593A/en
Priority to CH635679A priority patent/CH641190A5/en
Priority to IT24158/79A priority patent/IT1122046B/en
Priority to SE7905940A priority patent/SE7905940L/en
Priority to CA000331335A priority patent/CA1118414A/en
Priority to BE0/196193A priority patent/BE877555A/en
Priority to DE19792927452 priority patent/DE2927452A1/en
Publication of FR2430425A1 publication Critical patent/FR2430425A1/en
Application granted granted Critical
Publication of FR2430425B1 publication Critical patent/FR2430425B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

Nouveaux dérivés de la daunorubicine de formule générale I dans laquelle R1 est un radical de formule générale II dans laquelle les symboles X sont oxygène ou soufre, les symboles R3 sont des radicaux organiques ou forment ensemble un radical alcoylène, et R 2 est un radical de formule générale III dans laquelle R4 est hydrogène, ou un radical organique, et R5 est hydrogène ou forme avec R4 un radical alcoylène, leurs formes diastérécisomères et leurs mélanges, leurs sels, leur préparation et les compositions pharmaceutiques qui les contiennent. Ces nouveaux dérivés sont particulièrement utiles comme agents antitumoraux.New derivatives of daunorubicin of general formula I in which R1 is a radical of general formula II in which the symbols X are oxygen or sulfur, the symbols R3 are organic radicals or together form an alkylene radical, and R 2 is a radical of general formula III in which R4 is hydrogen, or an organic radical, and R5 is hydrogen or together with R4 forms an alkylene radical, their diasterecisomeric forms and their mixtures, their salts, their preparation and the pharmaceutical compositions which contain them. These new derivatives are particularly useful as anti-tumor agents.

FR7820306A 1978-07-07 1978-07-07 NOVEL DAUNORUBICIN DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Granted FR2430425A1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR7820306A FR2430425A1 (en) 1978-07-07 1978-07-07 NOVEL DAUNORUBICIN DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
NL7905098A NL7905098A (en) 1978-07-07 1979-06-29 NEW DAUNORUBICIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.
GB7923301A GB2032420B (en) 1978-07-07 1979-07-04 Daunorubicin derivatives
JP8449379A JPS5511593A (en) 1978-07-07 1979-07-05 Novel daunorubicin derivative
CH635679A CH641190A5 (en) 1978-07-07 1979-07-06 DAUNORUBICIN DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
IT24158/79A IT1122046B (en) 1978-07-07 1979-07-06 DAUNORUBICIN DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
SE7905940A SE7905940L (en) 1978-07-07 1979-07-06 NEW DERIVATIVES OF DAUNORUBICIN, PREPARATION OF THESE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CA000331335A CA1118414A (en) 1978-07-07 1979-07-06 Daunorubicine derivatives, preparation process and pharmaceutical compositions containing them
BE0/196193A BE877555A (en) 1978-07-07 1979-07-06 NOVEL DAUNORUBICIN DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE19792927452 DE2927452A1 (en) 1978-07-07 1979-07-06 NEW DERIVATIVES OF DAUNORUBICIN, THEIR PRODUCTION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7820306A FR2430425A1 (en) 1978-07-07 1978-07-07 NOVEL DAUNORUBICIN DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (2)

Publication Number Publication Date
FR2430425A1 true FR2430425A1 (en) 1980-02-01
FR2430425B1 FR2430425B1 (en) 1980-11-07

Family

ID=9210459

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7820306A Granted FR2430425A1 (en) 1978-07-07 1978-07-07 NOVEL DAUNORUBICIN DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (10)

Country Link
JP (1) JPS5511593A (en)
BE (1) BE877555A (en)
CA (1) CA1118414A (en)
CH (1) CH641190A5 (en)
DE (1) DE2927452A1 (en)
FR (1) FR2430425A1 (en)
GB (1) GB2032420B (en)
IT (1) IT1122046B (en)
NL (1) NL7905098A (en)
SE (1) SE7905940L (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2432525A1 (en) * 1978-08-03 1980-02-29 Inst Int Pathologie Cellulaire NOVEL DOXORUBICIN DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8519452D0 (en) * 1985-08-02 1985-09-11 Erba Farmitalia Injectable solutions
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
JP2549726Y2 (en) * 1991-04-16 1997-09-30 良忠 越原 Construction lift

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2651773A1 (en) * 1975-11-12 1977-05-18 Rhone Poulenc Ind NEW DERIVATIVES OF DAUNORUBICIN, THEIR PRODUCTION AND THE COMPOSITIONS THAT CONTAIN THEM

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2651773A1 (en) * 1975-11-12 1977-05-18 Rhone Poulenc Ind NEW DERIVATIVES OF DAUNORUBICIN, THEIR PRODUCTION AND THE COMPOSITIONS THAT CONTAIN THEM

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2432525A1 (en) * 1978-08-03 1980-02-29 Inst Int Pathologie Cellulaire NOVEL DOXORUBICIN DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
BE877555A (en) 1980-01-07
GB2032420A (en) 1980-05-08
GB2032420B (en) 1982-08-11
CH641190A5 (en) 1984-02-15
SE7905940L (en) 1980-01-08
NL7905098A (en) 1980-01-09
FR2430425B1 (en) 1980-11-07
IT7924158A0 (en) 1979-07-06
JPS5511593A (en) 1980-01-26
CA1118414A (en) 1982-02-16
IT1122046B (en) 1986-04-23
DE2927452A1 (en) 1980-01-17

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