FR2428639A1 - Analgesic, antiinflammatory 5-carboxy-4-methoxy-2-thenyl:amine cpds. - for use in rheumatology, neurology, arthritis, tooth-ache etc. - Google Patents
Analgesic, antiinflammatory 5-carboxy-4-methoxy-2-thenyl:amine cpds. - for use in rheumatology, neurology, arthritis, tooth-ache etc.Info
- Publication number
- FR2428639A1 FR2428639A1 FR7817755A FR7817755A FR2428639A1 FR 2428639 A1 FR2428639 A1 FR 2428639A1 FR 7817755 A FR7817755 A FR 7817755A FR 7817755 A FR7817755 A FR 7817755A FR 2428639 A1 FR2428639 A1 FR 2428639A1
- Authority
- FR
- France
- Prior art keywords
- alkyl
- thenyl
- rheumatology
- neurology
- antiinflammatory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
Thienylamines of formula (I) and their pharmaceutically acceptable salts and intermediates of formula (II) are new. In the formulae, R1 is H or 1-4C alkyl; R'1 is 1-4C alkyl; R2 and R3 are each 1-4C alkyl or NR2R3 is a satd. heterocycle opt. contg. a further O,S or N heteroatom, this N opt. being substd. by 1-6C alkyl, phenyl-lower alkyl or phenyl, the phenyl gps. opt. being substd. by >=1 halogen, 1-6C alkyl, 1-6C alkoxy or CF3 gp(s); and X is H or halogen, esp. Cl or Br. (I) are analgesics and antiinflammatories for use in human or veterinary medicine. Toxicity is low, e.g. LD50 is >350 mg/kg p.o. (mouse). Doses are pref. 0.025-0.750 g/day.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7817755A FR2428639A1 (en) | 1978-06-14 | 1978-06-14 | Analgesic, antiinflammatory 5-carboxy-4-methoxy-2-thenyl:amine cpds. - for use in rheumatology, neurology, arthritis, tooth-ache etc. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7817755A FR2428639A1 (en) | 1978-06-14 | 1978-06-14 | Analgesic, antiinflammatory 5-carboxy-4-methoxy-2-thenyl:amine cpds. - for use in rheumatology, neurology, arthritis, tooth-ache etc. |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2428639A1 true FR2428639A1 (en) | 1980-01-11 |
FR2428639B1 FR2428639B1 (en) | 1980-10-10 |
Family
ID=9209486
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7817755A Granted FR2428639A1 (en) | 1978-06-14 | 1978-06-14 | Analgesic, antiinflammatory 5-carboxy-4-methoxy-2-thenyl:amine cpds. - for use in rheumatology, neurology, arthritis, tooth-ache etc. |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2428639A1 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH518297A (en) * | 1967-12-15 | 1972-01-31 | Aspro Nicholas Ltd | Benzo b thiophene derivs antibacterials antivirals |
FR2191882A1 (en) * | 1972-07-06 | 1974-02-08 | Hoechst Ag | Antibacterial 6-acyl APA cpds - 6-(2-(thienyloxycarbonyl)-2-(hetero)aryl-acetamido) Penicillanic acids |
-
1978
- 1978-06-14 FR FR7817755A patent/FR2428639A1/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH518297A (en) * | 1967-12-15 | 1972-01-31 | Aspro Nicholas Ltd | Benzo b thiophene derivs antibacterials antivirals |
FR2191882A1 (en) * | 1972-07-06 | 1974-02-08 | Hoechst Ag | Antibacterial 6-acyl APA cpds - 6-(2-(thienyloxycarbonyl)-2-(hetero)aryl-acetamido) Penicillanic acids |
Also Published As
Publication number | Publication date |
---|---|
FR2428639B1 (en) | 1980-10-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |