FR2428639A1 - Analgesic, antiinflammatory 5-carboxy-4-methoxy-2-thenyl:amine cpds. - for use in rheumatology, neurology, arthritis, tooth-ache etc. - Google Patents

Analgesic, antiinflammatory 5-carboxy-4-methoxy-2-thenyl:amine cpds. - for use in rheumatology, neurology, arthritis, tooth-ache etc.

Info

Publication number
FR2428639A1
FR2428639A1 FR7817755A FR7817755A FR2428639A1 FR 2428639 A1 FR2428639 A1 FR 2428639A1 FR 7817755 A FR7817755 A FR 7817755A FR 7817755 A FR7817755 A FR 7817755A FR 2428639 A1 FR2428639 A1 FR 2428639A1
Authority
FR
France
Prior art keywords
alkyl
thenyl
rheumatology
neurology
antiinflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7817755A
Other languages
French (fr)
Other versions
FR2428639B1 (en
Inventor
Daniel Frehel
Jean-Pierre Maffrand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parcor SARL
Original Assignee
Parcor SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parcor SARL filed Critical Parcor SARL
Priority to FR7817755A priority Critical patent/FR2428639A1/en
Publication of FR2428639A1 publication Critical patent/FR2428639A1/en
Application granted granted Critical
Publication of FR2428639B1 publication Critical patent/FR2428639B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

Thienylamines of formula (I) and their pharmaceutically acceptable salts and intermediates of formula (II) are new. In the formulae, R1 is H or 1-4C alkyl; R'1 is 1-4C alkyl; R2 and R3 are each 1-4C alkyl or NR2R3 is a satd. heterocycle opt. contg. a further O,S or N heteroatom, this N opt. being substd. by 1-6C alkyl, phenyl-lower alkyl or phenyl, the phenyl gps. opt. being substd. by >=1 halogen, 1-6C alkyl, 1-6C alkoxy or CF3 gp(s); and X is H or halogen, esp. Cl or Br. (I) are analgesics and antiinflammatories for use in human or veterinary medicine. Toxicity is low, e.g. LD50 is >350 mg/kg p.o. (mouse). Doses are pref. 0.025-0.750 g/day.
FR7817755A 1978-06-14 1978-06-14 Analgesic, antiinflammatory 5-carboxy-4-methoxy-2-thenyl:amine cpds. - for use in rheumatology, neurology, arthritis, tooth-ache etc. Granted FR2428639A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7817755A FR2428639A1 (en) 1978-06-14 1978-06-14 Analgesic, antiinflammatory 5-carboxy-4-methoxy-2-thenyl:amine cpds. - for use in rheumatology, neurology, arthritis, tooth-ache etc.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7817755A FR2428639A1 (en) 1978-06-14 1978-06-14 Analgesic, antiinflammatory 5-carboxy-4-methoxy-2-thenyl:amine cpds. - for use in rheumatology, neurology, arthritis, tooth-ache etc.

Publications (2)

Publication Number Publication Date
FR2428639A1 true FR2428639A1 (en) 1980-01-11
FR2428639B1 FR2428639B1 (en) 1980-10-10

Family

ID=9209486

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7817755A Granted FR2428639A1 (en) 1978-06-14 1978-06-14 Analgesic, antiinflammatory 5-carboxy-4-methoxy-2-thenyl:amine cpds. - for use in rheumatology, neurology, arthritis, tooth-ache etc.

Country Status (1)

Country Link
FR (1) FR2428639A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH518297A (en) * 1967-12-15 1972-01-31 Aspro Nicholas Ltd Benzo b thiophene derivs antibacterials antivirals
FR2191882A1 (en) * 1972-07-06 1974-02-08 Hoechst Ag Antibacterial 6-acyl APA cpds - 6-(2-(thienyloxycarbonyl)-2-(hetero)aryl-acetamido) Penicillanic acids

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH518297A (en) * 1967-12-15 1972-01-31 Aspro Nicholas Ltd Benzo b thiophene derivs antibacterials antivirals
FR2191882A1 (en) * 1972-07-06 1974-02-08 Hoechst Ag Antibacterial 6-acyl APA cpds - 6-(2-(thienyloxycarbonyl)-2-(hetero)aryl-acetamido) Penicillanic acids

Also Published As

Publication number Publication date
FR2428639B1 (en) 1980-10-10

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Legal Events

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