FR2020166A1 - Naphth (2,1-d) isoxazolyalkanoic acid derivs - having analgetic, antipyretic and anti-inflammatory activity - Google Patents

Naphth (2,1-d) isoxazolyalkanoic acid derivs - having analgetic, antipyretic and anti-inflammatory activity

Info

Publication number
FR2020166A1
FR2020166A1 FR6934432A FR6934432A FR2020166A1 FR 2020166 A1 FR2020166 A1 FR 2020166A1 FR 6934432 A FR6934432 A FR 6934432A FR 6934432 A FR6934432 A FR 6934432A FR 2020166 A1 FR2020166 A1 FR 2020166A1
Authority
FR
France
Prior art keywords
right arrow
analgetic
naphth
antipyretic
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR6934432A
Other languages
French (fr)
Other versions
FR2020166B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP43072990A external-priority patent/JPS4920315B1/ja
Application filed by Teikoku Hormone Manufacturing Co Ltd filed Critical Teikoku Hormone Manufacturing Co Ltd
Publication of FR2020166A1 publication Critical patent/FR2020166A1/en
Application granted granted Critical
Publication of FR2020166B1 publication Critical patent/FR2020166B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/60—Naphthoxazoles; Hydrogenated naphthoxazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Naphth (2,1-d) isoxazolylalkanoic acid derivs having analgetic, antipyretic and anti-inflammatory activity. N3A. Are new cmpds. of formula (I) (where R' = CH2, R = OH, OM (where M is a basic cation e.g. Na, K, or an organic base), Oalkyl, NR5R6 or YR7NR5R6, where R5 and R6 = H, alky or tog. with N form a heterocyclic residue1 R7 = alylene, and Y = O or NR8 where R8 = H or (1-4C) alkyl and Ring A may be substd., e.g. by (1-3) O alkyl, alkyl, or hal.) effective in doses of 10-300 mg/day. They may be prepared e.g. as follows:- NH2OH right arrow PdCl5, SOBr2 et. right arrow 50-80 degrees CH2N2/base right arrow -10 to +25 degrees (X = Cl or Br) (new compd.) R9H/cat. (Ag2O or Pt)/50-100 degrees over right arrow (Wolff rearrangement) (R9 = -Oalkyl, -OR7 I(R=OH) MOH right arrow I (R = OM).
FR6934432A 1968-10-08 1969-10-08 Naphth (2,1-d) isoxazolyalkanoic acid derivs - having analgetic, antipyretic and anti-inflammatory activity Granted FR2020166A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP43072990A JPS4920315B1 (en) 1968-10-08 1968-10-08
JP7299168 1968-10-08
JP3224369 1969-04-26
JP3224169 1969-04-26
JP3224269 1969-04-26

Publications (2)

Publication Number Publication Date
FR2020166A1 true FR2020166A1 (en) 1970-07-10
FR2020166B1 FR2020166B1 (en) 1973-12-21

Family

ID=27521400

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6934432A Granted FR2020166A1 (en) 1968-10-08 1969-10-08 Naphth (2,1-d) isoxazolyalkanoic acid derivs - having analgetic, antipyretic and anti-inflammatory activity

Country Status (5)

Country Link
CH (7) CH559735A5 (en)
DE (2) DE1966858A1 (en)
FR (1) FR2020166A1 (en)
NL (1) NL142072B (en)
SE (3) SE386896B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2092086A1 (en) * 1971-04-26 1972-01-21 Teikoku Hormone Mfg Co Ltd Antiphlogistic and antisecretory napththisoxazoles - from 1-hydroxyim - 2-carbonyl derivs by intramolecular condensation

Also Published As

Publication number Publication date
SE349809B (en) 1972-10-09
DE1950778A1 (en) 1970-04-30
CH559733A5 (en) 1975-03-14
SE376615B (en) 1975-06-02
NL142072B (en) 1974-05-15
CH559735A5 (en) 1975-03-14
FR2020166B1 (en) 1973-12-21
NL6915220A (en) 1970-04-10
CH559723A5 (en) 1975-03-14
CH559734A5 (en) 1975-03-14
SE386896B (en) 1976-08-23
CH559732A5 (en) 1975-03-14
CH559731A5 (en) 1975-03-14
DE1966858A1 (en) 1974-09-05
CH559736A5 (en) 1975-03-14

Similar Documents

Publication Publication Date Title
ES462062A1 (en) Tetrahydroisoquinoline basic ethers and pharmaceutical compositions and methods employing them
DE3069633D1 (en) Propenylamines, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
FR2020166A1 (en) Naphth (2,1-d) isoxazolyalkanoic acid derivs - having analgetic, antipyretic and anti-inflammatory activity
ES461979A1 (en) Derivatives of substituted n-alkyl imidazoles having pharmaceutical activity
GB1142066A (en) New diphenyl-ureas and process for preparing them
IT1202352B (en) ANTIMICROBIAL COMPOSITION CONSISTING OF A DOUBLE REPLACED ARILIC COMPOUND
ES8204721A1 (en) Novel halophenyl-pyridyl-allylamine derivatives, processes and intermediates as well as pharmaceutical preparations thereof.
DE3484375D1 (en) PHARMACEUTICAL COMPOSITION FOR PROPHYLAXIS OR TREATMENT OF ANIMAL KETOSIS.
AR209158A1 (en) A COMPOSITION TO IMPROVE ANIMAL GROWTH A DERIVATIVE OF P-BENZOQUINON-DI IMIDA AND MANUFACTURING PROCEDURES
GB1044853A (en) Improvements in or relating to novel ether derivatives of benzmorphans
GB1513280A (en) Therapeutic pyrazole derivatives
ES450211A1 (en) Diazaborines and drug compositions
GB1178724A (en) Novel Quaternary Compounds
GB1319402A (en) 3-acyloxypropyl-2,-trimethylammoniumethyl phosphates
ES400623A1 (en) Pharmaceutical compositions
GB1100495A (en) Novel 5-hydroxytetracycline derivative and intermediates therefor
GB1217689A (en) Ethyl esters of fluro-acetic acids
ES387137A1 (en) Benzodiazepines the preparation thereof and compositions containing the same
FR2366015A1 (en) Amino-benzoyl-phenylacetic acid derivs - antiinflammatory, hypocholesterolemic and blood platelet agglomeration inhibitory activity
ES398868A1 (en) Process for the preparation of derivatives of 1,2-diphenyl-3,5- dioxo-4-n-butylpyrazolidine
FR2002219A1 (en) S-alkyl-and s-hydroxyalkyl cysteamines - with antiseborrhoeic activity
GB1248472A (en) Cycloheptimidazolone derivatives and process for the preparation thereof
FR2428639A1 (en) Analgesic, antiinflammatory 5-carboxy-4-methoxy-2-thenyl:amine cpds. - for use in rheumatology, neurology, arthritis, tooth-ache etc.
GB1090545A (en) Disubstituted isoxazole derivatives and non-toxic salts thereof
NL7802059A (en) Antiinflammatory and antiarthritic compsn. - contain fluorophenyl and thienyl beta-amino-acrylonitrile and beta-oxo propionitrile derivs.

Legal Events

Date Code Title Description
ST Notification of lapse