FR2428030A1 - 14-Amino-alkylthio-acetoxy-multiline derivs. prodn. - from amino-alkane:thiol and sulphonate ester, for use as veterinary antibiotics - Google Patents
14-Amino-alkylthio-acetoxy-multiline derivs. prodn. - from amino-alkane:thiol and sulphonate ester, for use as veterinary antibioticsInfo
- Publication number
- FR2428030A1 FR2428030A1 FR7816844A FR7816844A FR2428030A1 FR 2428030 A1 FR2428030 A1 FR 2428030A1 FR 7816844 A FR7816844 A FR 7816844A FR 7816844 A FR7816844 A FR 7816844A FR 2428030 A1 FR2428030 A1 FR 2428030A1
- Authority
- FR
- France
- Prior art keywords
- amino
- derivs
- prodn
- multiline
- acetoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Prodn. of pleuromutilin derivs. of formula (I) comprises reacting, in presence of phase-transfer catalysts, a sulphonate ester (II) with a mercapto-amine (III), then opt. converting to a salt with an organic or inorganic acid. (n = 2-5; R1 is ethyl or vinyl; R2 and R3 are 1-4C alkyl, or together complete a heterocycle opt. contg. an additional O, S or NR5; R5 is 1-4C alkyl; R6 is 1-4C alkyl or phenyl opt. substd. by 1-4C alkyl).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7816844A FR2428030A1 (en) | 1978-06-06 | 1978-06-06 | 14-Amino-alkylthio-acetoxy-multiline derivs. prodn. - from amino-alkane:thiol and sulphonate ester, for use as veterinary antibiotics |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7816844A FR2428030A1 (en) | 1978-06-06 | 1978-06-06 | 14-Amino-alkylthio-acetoxy-multiline derivs. prodn. - from amino-alkane:thiol and sulphonate ester, for use as veterinary antibiotics |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2428030A1 true FR2428030A1 (en) | 1980-01-04 |
FR2428030B1 FR2428030B1 (en) | 1984-05-04 |
Family
ID=9209121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7816844A Granted FR2428030A1 (en) | 1978-06-06 | 1978-06-06 | 14-Amino-alkylthio-acetoxy-multiline derivs. prodn. - from amino-alkane:thiol and sulphonate ester, for use as veterinary antibiotics |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2428030A1 (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT303962B (en) * | 1969-07-25 | 1972-12-27 | Biochemie Gmbh | Process for the preparation of 14-deoxy-14-tosyloxyacetoxymutilin |
FR2157828A1 (en) * | 1971-10-05 | 1973-06-08 | Sandoz Sa | |
CH572894A5 (en) * | 1972-07-07 | 1976-02-27 | Sandoz Ag | Pleuromutilin aminoalkoxy(thio)-substd. esters prepn. - by reacting hydroxy-or mercapto-substd. esters with e.g. aminoalkyl halides |
-
1978
- 1978-06-06 FR FR7816844A patent/FR2428030A1/en active Granted
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT303962B (en) * | 1969-07-25 | 1972-12-27 | Biochemie Gmbh | Process for the preparation of 14-deoxy-14-tosyloxyacetoxymutilin |
FR2157828A1 (en) * | 1971-10-05 | 1973-06-08 | Sandoz Sa | |
CH572894A5 (en) * | 1972-07-07 | 1976-02-27 | Sandoz Ag | Pleuromutilin aminoalkoxy(thio)-substd. esters prepn. - by reacting hydroxy-or mercapto-substd. esters with e.g. aminoalkyl halides |
Also Published As
Publication number | Publication date |
---|---|
FR2428030B1 (en) | 1984-05-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property |