FR2428030A1 - 14-Amino-alkylthio-acetoxy-multiline derivs. prodn. - from amino-alkane:thiol and sulphonate ester, for use as veterinary antibiotics - Google Patents

14-Amino-alkylthio-acetoxy-multiline derivs. prodn. - from amino-alkane:thiol and sulphonate ester, for use as veterinary antibiotics

Info

Publication number
FR2428030A1
FR2428030A1 FR7816844A FR7816844A FR2428030A1 FR 2428030 A1 FR2428030 A1 FR 2428030A1 FR 7816844 A FR7816844 A FR 7816844A FR 7816844 A FR7816844 A FR 7816844A FR 2428030 A1 FR2428030 A1 FR 2428030A1
Authority
FR
France
Prior art keywords
amino
derivs
prodn
multiline
acetoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7816844A
Other languages
French (fr)
Other versions
FR2428030B1 (en
Inventor
Erwin Waldvogel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Priority to FR7816844A priority Critical patent/FR2428030A1/en
Publication of FR2428030A1 publication Critical patent/FR2428030A1/en
Application granted granted Critical
Publication of FR2428030B1 publication Critical patent/FR2428030B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Prodn. of pleuromutilin derivs. of formula (I) comprises reacting, in presence of phase-transfer catalysts, a sulphonate ester (II) with a mercapto-amine (III), then opt. converting to a salt with an organic or inorganic acid. (n = 2-5; R1 is ethyl or vinyl; R2 and R3 are 1-4C alkyl, or together complete a heterocycle opt. contg. an additional O, S or NR5; R5 is 1-4C alkyl; R6 is 1-4C alkyl or phenyl opt. substd. by 1-4C alkyl).
FR7816844A 1978-06-06 1978-06-06 14-Amino-alkylthio-acetoxy-multiline derivs. prodn. - from amino-alkane:thiol and sulphonate ester, for use as veterinary antibiotics Granted FR2428030A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7816844A FR2428030A1 (en) 1978-06-06 1978-06-06 14-Amino-alkylthio-acetoxy-multiline derivs. prodn. - from amino-alkane:thiol and sulphonate ester, for use as veterinary antibiotics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7816844A FR2428030A1 (en) 1978-06-06 1978-06-06 14-Amino-alkylthio-acetoxy-multiline derivs. prodn. - from amino-alkane:thiol and sulphonate ester, for use as veterinary antibiotics

Publications (2)

Publication Number Publication Date
FR2428030A1 true FR2428030A1 (en) 1980-01-04
FR2428030B1 FR2428030B1 (en) 1984-05-04

Family

ID=9209121

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7816844A Granted FR2428030A1 (en) 1978-06-06 1978-06-06 14-Amino-alkylthio-acetoxy-multiline derivs. prodn. - from amino-alkane:thiol and sulphonate ester, for use as veterinary antibiotics

Country Status (1)

Country Link
FR (1) FR2428030A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT303962B (en) * 1969-07-25 1972-12-27 Biochemie Gmbh Process for the preparation of 14-deoxy-14-tosyloxyacetoxymutilin
FR2157828A1 (en) * 1971-10-05 1973-06-08 Sandoz Sa
CH572894A5 (en) * 1972-07-07 1976-02-27 Sandoz Ag Pleuromutilin aminoalkoxy(thio)-substd. esters prepn. - by reacting hydroxy-or mercapto-substd. esters with e.g. aminoalkyl halides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT303962B (en) * 1969-07-25 1972-12-27 Biochemie Gmbh Process for the preparation of 14-deoxy-14-tosyloxyacetoxymutilin
FR2157828A1 (en) * 1971-10-05 1973-06-08 Sandoz Sa
CH572894A5 (en) * 1972-07-07 1976-02-27 Sandoz Ag Pleuromutilin aminoalkoxy(thio)-substd. esters prepn. - by reacting hydroxy-or mercapto-substd. esters with e.g. aminoalkyl halides

Also Published As

Publication number Publication date
FR2428030B1 (en) 1984-05-04

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