FR2426044A2 - VITAMIN D3 DERIVATIVES WITH ANTI-VITAMIN D ACTIVITY - Google Patents

VITAMIN D3 DERIVATIVES WITH ANTI-VITAMIN D ACTIVITY

Info

Publication number
FR2426044A2
FR2426044A2 FR7912834A FR7912834A FR2426044A2 FR 2426044 A2 FR2426044 A2 FR 2426044A2 FR 7912834 A FR7912834 A FR 7912834A FR 7912834 A FR7912834 A FR 7912834A FR 2426044 A2 FR2426044 A2 FR 2426044A2
Authority
FR
France
Prior art keywords
vitamin
derivatives
activity
cholano
calciferol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7912834A
Other languages
French (fr)
Other versions
FR2426044B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WISCONSIN RESEARCH FOUNDATION
Original Assignee
WISCONSIN RESEARCH FOUNDATION
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/907,893 external-priority patent/US4217288A/en
Application filed by WISCONSIN RESEARCH FOUNDATION filed Critical WISCONSIN RESEARCH FOUNDATION
Publication of FR2426044A2 publication Critical patent/FR2426044A2/en
Application granted granted Critical
Publication of FR2426044B2 publication Critical patent/FR2426044B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Dérivés de la vitamine D3 ayant une activité anti-vitamine La présente invention concerne des dérivés anti-vitamine D, en particulier la 25-méthyl-vitamine D3 et le cholano-calciférol-diméthylamide ainsi que des produits intermédiaires. Utilisation de ces dérivés pour réduire ou inverser l'effet biologique des vitamines D et pour diminuer l'hypercalcémie.The present invention relates to anti-vitamin D derivatives, in particular 25-methyl-vitamin D3 and cholano-calciferol-dimethylamide as well as to intermediates. Use of these derivatives to reduce or reverse the biological effect of vitamins D and to decrease hypercalcemia.

FR7912834A 1978-05-19 1979-05-18 VITAMIN D3 DERIVATIVES WITH ANTI-VITAMIN D ACTIVITY Granted FR2426044A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/907,893 US4217288A (en) 1977-03-24 1978-05-19 Anti-vitamin D compounds

Publications (2)

Publication Number Publication Date
FR2426044A2 true FR2426044A2 (en) 1979-12-14
FR2426044B2 FR2426044B2 (en) 1984-01-27

Family

ID=25424822

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7912834A Granted FR2426044A2 (en) 1978-05-19 1979-05-18 VITAMIN D3 DERIVATIVES WITH ANTI-VITAMIN D ACTIVITY

Country Status (5)

Country Link
JP (1) JPS54154747A (en)
DE (1) DE2920092A1 (en)
FR (1) FR2426044A2 (en)
GB (1) GB2021115B (en)
NL (1) NL7903929A (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA828011B (en) * 1981-11-02 1984-01-25 Res Inst Medicine Chem Intermediates in the synthesis of vitamin d derivatives
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
DE69208478T2 (en) * 1991-11-07 1996-09-05 Research Institute For Medicine And Chemistry Inc., Cambridge, Mass. AMID DERIVATIVES OF VITAMIN D
GB9804861D0 (en) * 1998-03-06 1998-04-29 Res Inst Medicine Chem Chemical compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2384755A1 (en) * 1977-03-24 1978-10-20 Wisconsin Alumni Res Found VITAMIN D3 DERIVATIVES WITH ANTIVITAMIN D ACTIVITY

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2384755A1 (en) * 1977-03-24 1978-10-20 Wisconsin Alumni Res Found VITAMIN D3 DERIVATIVES WITH ANTIVITAMIN D ACTIVITY

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/77 *

Also Published As

Publication number Publication date
GB2021115A (en) 1979-11-28
DE2920092A1 (en) 1979-11-29
NL7903929A (en) 1979-11-21
JPS54154747A (en) 1979-12-06
JPS6228784B2 (en) 1987-06-23
FR2426044B2 (en) 1984-01-27
GB2021115B (en) 1982-10-06

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