FR2384755A1 - VITAMIN D3 DERIVATIVES WITH ANTIVITAMIN D ACTIVITY - Google Patents

VITAMIN D3 DERIVATIVES WITH ANTIVITAMIN D ACTIVITY

Info

Publication number
FR2384755A1
FR2384755A1 FR7808574A FR7808574A FR2384755A1 FR 2384755 A1 FR2384755 A1 FR 2384755A1 FR 7808574 A FR7808574 A FR 7808574A FR 7808574 A FR7808574 A FR 7808574A FR 2384755 A1 FR2384755 A1 FR 2384755A1
Authority
FR
France
Prior art keywords
vitamin
derivatives
antivitamin
activity
derivatives according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7808574A
Other languages
French (fr)
Other versions
FR2384755B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of FR2384755A1 publication Critical patent/FR2384755A1/en
Application granted granted Critical
Publication of FR2384755B1 publication Critical patent/FR2384755B1/fr
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J53/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • C07F7/081Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036Nitrogen-containing hetero ring
    • C07J71/0042Nitrogen only

Abstract

La présente invention est relative à de nouveaux dérivés de la vitamine D3 . Les dérivés selon l'invention sont ceux dans lesquels la position 25 est substituée, de préférence par un groupe aminométhyle. Ils ont l'effet d'inhiber ou d'empêcher la réponse normale des animaux à la vitamine D. Les dérivés selon l'invention trouvent une application particulière dans le traitement des troubles du calcium, tels que l'hypercalcémie, l'hypervitaminose D, l'hypersensibilité à la vitamine D et la calcification métastatique.The present invention relates to new derivatives of vitamin D3. The derivatives according to the invention are those in which the 25 position is substituted, preferably by an aminomethyl group. They have the effect of inhibiting or preventing the normal response of animals to vitamin D. The derivatives according to the invention find particular application in the treatment of calcium disorders, such as hypercalcemia, hypervitaminosis D , vitamin D hypersensitivity and metastatic calcification.

FR7808574A 1977-03-24 1978-03-23 VITAMIN D3 DERIVATIVES WITH ANTIVITAMIN D ACTIVITY Granted FR2384755A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78100877A 1977-03-24 1977-03-24

Publications (2)

Publication Number Publication Date
FR2384755A1 true FR2384755A1 (en) 1978-10-20
FR2384755B1 FR2384755B1 (en) 1983-10-28

Family

ID=25121373

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7808574A Granted FR2384755A1 (en) 1977-03-24 1978-03-23 VITAMIN D3 DERIVATIVES WITH ANTIVITAMIN D ACTIVITY

Country Status (5)

Country Link
JP (1) JPS53119858A (en)
DE (1) DE2812741A1 (en)
FR (1) FR2384755A1 (en)
GB (1) GB1574685A (en)
NL (1) NL7803154A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2426044A2 (en) * 1978-05-19 1979-12-14 Wisconsin Research Foundation VITAMIN D3 DERIVATIVES WITH ANTI-VITAMIN D ACTIVITY
WO1993021205A1 (en) * 1992-04-15 1993-10-28 Sri International Isolation of steroids containing a 5,7-diene functionality from a sterol mixture

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2426044A2 (en) * 1978-05-19 1979-12-14 Wisconsin Research Foundation VITAMIN D3 DERIVATIVES WITH ANTI-VITAMIN D ACTIVITY
WO1993021205A1 (en) * 1992-04-15 1993-10-28 Sri International Isolation of steroids containing a 5,7-diene functionality from a sterol mixture
US5391777A (en) * 1992-04-15 1995-02-21 Sri International Isolation of steroids containing a 5,7-diene functionality from a sterol mixture

Also Published As

Publication number Publication date
DE2812741C2 (en) 1987-03-12
FR2384755B1 (en) 1983-10-28
JPS53119858A (en) 1978-10-19
GB1574685A (en) 1980-09-10
NL7803154A (en) 1978-09-26
DE2812741A1 (en) 1978-10-05

Similar Documents

Publication Publication Date Title
DE69520656D1 (en) Restricted 9-cis retinoids
NO2005018I1 (en) 2- (2-Nitro-4-trifluoromethylbenzoyl) 1,3-cyclohexanedione or a salt thereof (abbreviation NTBC)
FR2384755A1 (en) VITAMIN D3 DERIVATIVES WITH ANTIVITAMIN D ACTIVITY
Bueding et al. Effect of naphthoquinones on Schistosoma mansoni in vitro and in vivo
FR2400012A1 (en) ALPHA-ACETYLENIC DERIVATIVES OF ALPHA-AMINOACIDS, THEIR PREPARATION AND THEIR USE AS ANTI-INFECTIOUS AGENT
FR2367750A1 (en) ACID
FR2405067A1 (en) PHARMACEUTICAL COMPOSITIONS CONTAINING MONOFUNCTIONAL DERIVATIVES OF PSORALENE FOR THE TREATMENT OF SKIN DISORDERS
FR2355807A1 (en) IODINE ISOPHTHALAMIC ACID DERIVATIVES AND CONTRAST AGENTS WHICH CONTAIN IT
FR2393579A1 (en) ANTIVIRAL AGENT AND ITS APPLICATION TO THE TREATMENT OF VIRAL DISORDERS
FR2430402A1 (en) ALDEHYDES A-B-UNSATURES AS FLAVORING INGREDIENTS
FR2429219A1 (en) MEDICINE BASED ON THIENOPYRIDONE OR FUROPYRIDONE DERIVATIVES
FR2362587A1 (en) ANTIMICROBIC AGENTS
FR2369837A1 (en) ACTIVE DERIVATIVES OF UREA, THEIR PROCESS OF PREPARATION AND THE THERAPEUTIC COMPOSITIONS CONTAINING THEM
FR2443464A1 (en) THIADIAZOLE-1,3,4 CARBOXYLIC-2 DERIVATIVES AND FUNGICIDE AND NEMATICIDE PRODUCTS CONTAINING SAME
FR2426044A2 (en) VITAMIN D3 DERIVATIVES WITH ANTI-VITAMIN D ACTIVITY
KR880009656A (en) Treatment or prophylaxis of local periodontal disease
FR2395995A1 (en) NEW A-VINYLAMINOACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DECARBOXYLASE INHIBITORS OF AROMATIC AMINOACIDS
TNSN97081A1 (en) INHIBITION OF METALLOPROTEINASE MATRICES BY 2- (W-AROYLKYL) -4-BIARYL-4-OXUBUTYRIC ACIDS
FR2446286A1 (en) ALLANTOINE-UROCANIC ACID COMPLEXES, INSENSITIVE TO SOLAR LIGHT OR HEAT, USED IN COSMETIC FORMULATIONS
DE69622005T2 (en) Composition for the prevention and treatment of urogenital disorders containing bismuth and one or more antimicrobial agents
SU770494A1 (en) Means for speeding-up restoration capacity for work
FR2401133A1 (en) NEW DERIVATIVES OF A-ACETYLENICAMINOACIDS, THEIR PREPARATION AND THEIR USE AS DECARBOXYLASE INHIBITORS OF AROMATIC AMINOACIDS
FR2387652A1 (en) COMPOSITIONS WITH ANTI-COAGULANT AND ANTI-TUSSIVE CURATIVE PROPERTIES
FR2380286A1 (en) NEW DERIVATIVES OF HYDRAZINIUM PHOSPHITES
FR2415622A1 (en) AMINO ALCOHOLS DERIVED FROM METHYL ORTHO-HYDROXY CINNAMATE APPLICABLE ESPECIALLY AS MEDICINAL PRODUCTS

Legal Events

Date Code Title Description
ST Notification of lapse