FR2384755A1 - VITAMIN D3 DERIVATIVES WITH ANTIVITAMIN D ACTIVITY - Google Patents
VITAMIN D3 DERIVATIVES WITH ANTIVITAMIN D ACTIVITYInfo
- Publication number
- FR2384755A1 FR2384755A1 FR7808574A FR7808574A FR2384755A1 FR 2384755 A1 FR2384755 A1 FR 2384755A1 FR 7808574 A FR7808574 A FR 7808574A FR 7808574 A FR7808574 A FR 7808574A FR 2384755 A1 FR2384755 A1 FR 2384755A1
- Authority
- FR
- France
- Prior art keywords
- vitamin
- derivatives
- antivitamin
- activity
- derivatives according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000694 effects Effects 0.000 title abstract 2
- 230000003167 anti-vitamin Effects 0.000 title 1
- 150000003704 vitamin D3 derivatives Chemical class 0.000 title 1
- 229930003316 Vitamin D Natural products 0.000 abstract 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 2
- 235000019166 vitamin D Nutrition 0.000 abstract 2
- 239000011710 vitamin D Substances 0.000 abstract 2
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 2
- 229940046008 vitamin d Drugs 0.000 abstract 2
- 208000037147 Hypercalcaemia Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 1
- 230000002308 calcification Effects 0.000 abstract 1
- 208000022458 calcium metabolism disease Diseases 0.000 abstract 1
- 230000000148 hypercalcaemia Effects 0.000 abstract 1
- 208000030915 hypercalcemia disease Diseases 0.000 abstract 1
- 230000009610 hypersensitivity Effects 0.000 abstract 1
- 206010020917 hypervitaminosis D Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001394 metastastic effect Effects 0.000 abstract 1
- 206010061289 metastatic neoplasm Diseases 0.000 abstract 1
- 230000004044 response Effects 0.000 abstract 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
La présente invention est relative à de nouveaux dérivés de la vitamine D3 . Les dérivés selon l'invention sont ceux dans lesquels la position 25 est substituée, de préférence par un groupe aminométhyle. Ils ont l'effet d'inhiber ou d'empêcher la réponse normale des animaux à la vitamine D. Les dérivés selon l'invention trouvent une application particulière dans le traitement des troubles du calcium, tels que l'hypercalcémie, l'hypervitaminose D, l'hypersensibilité à la vitamine D et la calcification métastatique.The present invention relates to new derivatives of vitamin D3. The derivatives according to the invention are those in which the 25 position is substituted, preferably by an aminomethyl group. They have the effect of inhibiting or preventing the normal response of animals to vitamin D. The derivatives according to the invention find particular application in the treatment of calcium disorders, such as hypercalcemia, hypervitaminosis D , vitamin D hypersensitivity and metastatic calcification.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78100877A | 1977-03-24 | 1977-03-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2384755A1 true FR2384755A1 (en) | 1978-10-20 |
| FR2384755B1 FR2384755B1 (en) | 1983-10-28 |
Family
ID=25121373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7808574A Granted FR2384755A1 (en) | 1977-03-24 | 1978-03-23 | VITAMIN D3 DERIVATIVES WITH ANTIVITAMIN D ACTIVITY |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS53119858A (en) |
| DE (1) | DE2812741C2 (en) |
| FR (1) | FR2384755A1 (en) |
| GB (1) | GB1574685A (en) |
| NL (1) | NL7803154A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2426044A2 (en) * | 1978-05-19 | 1979-12-14 | Wisconsin Research Foundation | VITAMIN D3 DERIVATIVES WITH ANTI-VITAMIN D ACTIVITY |
| WO1993021205A1 (en) * | 1992-04-15 | 1993-10-28 | Sri International | Isolation of steroids containing a 5,7-diene functionality from a sterol mixture |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4804502A (en) * | 1988-01-20 | 1989-02-14 | Hoffmann-La Roche Inc. | Vitamin D compounds |
| ZA8923B (en) * | 1988-01-20 | 1989-09-27 | Hoffmann La Roche | 16-dehydro-vitamin d3-derivatives |
-
1978
- 1978-03-23 NL NL7803154A patent/NL7803154A/en not_active Application Discontinuation
- 1978-03-23 DE DE2812741A patent/DE2812741C2/en not_active Expired
- 1978-03-23 GB GB11797/78A patent/GB1574685A/en not_active Expired
- 1978-03-23 FR FR7808574A patent/FR2384755A1/en active Granted
- 1978-03-24 JP JP3319878A patent/JPS53119858A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2426044A2 (en) * | 1978-05-19 | 1979-12-14 | Wisconsin Research Foundation | VITAMIN D3 DERIVATIVES WITH ANTI-VITAMIN D ACTIVITY |
| WO1993021205A1 (en) * | 1992-04-15 | 1993-10-28 | Sri International | Isolation of steroids containing a 5,7-diene functionality from a sterol mixture |
| US5391777A (en) * | 1992-04-15 | 1995-02-21 | Sri International | Isolation of steroids containing a 5,7-diene functionality from a sterol mixture |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2812741C2 (en) | 1987-03-12 |
| NL7803154A (en) | 1978-09-26 |
| JPS53119858A (en) | 1978-10-19 |
| DE2812741A1 (en) | 1978-10-05 |
| GB1574685A (en) | 1980-09-10 |
| FR2384755B1 (en) | 1983-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |