GB2021115A - Vitamin D derivatives - Google Patents

Vitamin D derivatives

Info

Publication number
GB2021115A
GB2021115A GB7917471A GB7917471A GB2021115A GB 2021115 A GB2021115 A GB 2021115A GB 7917471 A GB7917471 A GB 7917471A GB 7917471 A GB7917471 A GB 7917471A GB 2021115 A GB2021115 A GB 2021115A
Authority
GB
United Kingdom
Prior art keywords
vitamin
derivatives
formula
image
cholanocalciferol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7917471A
Other versions
GB2021115B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/907,893 external-priority patent/US4217288A/en
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of GB2021115A publication Critical patent/GB2021115A/en
Application granted granted Critical
Publication of GB2021115B publication Critical patent/GB2021115B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention provides novel anti-vitamin D derivatives and intermediates, specifically 25-methyl- vitamin D3 of formula <IMAGE> and cholanocalciferol dimethylamide of formula <IMAGE>
GB7917471A 1978-05-19 1979-05-18 Vitamin d derivatives Expired GB2021115B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/907,893 US4217288A (en) 1977-03-24 1978-05-19 Anti-vitamin D compounds

Publications (2)

Publication Number Publication Date
GB2021115A true GB2021115A (en) 1979-11-28
GB2021115B GB2021115B (en) 1982-10-06

Family

ID=25424822

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7917471A Expired GB2021115B (en) 1978-05-19 1979-05-18 Vitamin d derivatives

Country Status (5)

Country Link
JP (1) JPS54154747A (en)
DE (1) DE2920092A1 (en)
FR (1) FR2426044A2 (en)
GB (1) GB2021115B (en)
NL (1) NL7903929A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993009093A1 (en) * 1991-11-07 1993-05-13 Holmes, Michael, John Vitamin d amide derivatives
US7235552B1 (en) * 1998-03-06 2007-06-26 Research Institute For Medicine And Chemistry, Inc. Cholenic acid amides and pharmaceutical compositions thereof

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58126861A (en) * 1981-11-02 1983-07-28 リサ−チ・インステイチユ−ト・フオア・メデイスン・アンド・ケミストリ−・インコ−ポレ−テツド Novel compound and manufacture
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2812741A1 (en) * 1977-03-24 1978-10-05 Wisconsin Alumni Res Found VITAMIN D TIEF 3 DERIVATIVES, THE PROCESS FOR THEIR PRODUCTION AND THE MEDICINAL PRODUCTS CONTAINING THESE

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993009093A1 (en) * 1991-11-07 1993-05-13 Holmes, Michael, John Vitamin d amide derivatives
US5494905A (en) * 1991-11-07 1996-02-27 Research Institute For Medicine And Chemistry Vitamin D amide derivatives
US5686435A (en) * 1991-11-07 1997-11-11 Research Institute For Medicine And Chemistry Vitamin D amide derivatives
US7235552B1 (en) * 1998-03-06 2007-06-26 Research Institute For Medicine And Chemistry, Inc. Cholenic acid amides and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
GB2021115B (en) 1982-10-06
DE2920092A1 (en) 1979-11-29
JPS6228784B2 (en) 1987-06-23
FR2426044A2 (en) 1979-12-14
JPS54154747A (en) 1979-12-06
NL7903929A (en) 1979-11-21
FR2426044B2 (en) 1984-01-27

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee