FR2423493A1 - Vincamine analogues - for treating cardiovascular, cerebrovascular and respiratory insufficiency - Google Patents

Vincamine analogues - for treating cardiovascular, cerebrovascular and respiratory insufficiency

Info

Publication number
FR2423493A1
FR2423493A1 FR7731526A FR7731526A FR2423493A1 FR 2423493 A1 FR2423493 A1 FR 2423493A1 FR 7731526 A FR7731526 A FR 7731526A FR 7731526 A FR7731526 A FR 7731526A FR 2423493 A1 FR2423493 A1 FR 2423493A1
Authority
FR
France
Prior art keywords
vincamine
analogues
cerebrovascular
treating cardiovascular
respiratory insufficiency
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7731526A
Other languages
French (fr)
Other versions
FR2423493B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omnium Chimique SA
Original Assignee
Omnium Chimique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnium Chimique SA filed Critical Omnium Chimique SA
Priority to FR7731526A priority Critical patent/FR2423493A1/en
Publication of FR2423493A1 publication Critical patent/FR2423493A1/en
Application granted granted Critical
Publication of FR2423493B1 publication Critical patent/FR2423493B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Abstract

Vincamine analogues of formula (I) are new together with their acid-addn. salts as optically active forms or as racemates (where R1 is halo in 10 or 11 position, R2 is OH, R3 is H, or R2 and R3 together form a second bond). Daily adult dose is 3-600 mg depending on the disorder treated. The i.v. LD50 in mice is 47-52 mg/kg. similar to that of vincamine (47 mg/kg). A typical cpd. 10-chloro-16 DELTA-epi-14-vincamine, was prepd. by treating tabersonine in acid methanol with m-chloroperbenzoic acid.
FR7731526A 1977-10-19 1977-10-19 Vincamine analogues - for treating cardiovascular, cerebrovascular and respiratory insufficiency Granted FR2423493A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7731526A FR2423493A1 (en) 1977-10-19 1977-10-19 Vincamine analogues - for treating cardiovascular, cerebrovascular and respiratory insufficiency

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7731526A FR2423493A1 (en) 1977-10-19 1977-10-19 Vincamine analogues - for treating cardiovascular, cerebrovascular and respiratory insufficiency

Publications (2)

Publication Number Publication Date
FR2423493A1 true FR2423493A1 (en) 1979-11-16
FR2423493B1 FR2423493B1 (en) 1980-12-05

Family

ID=9196711

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7731526A Granted FR2423493A1 (en) 1977-10-19 1977-10-19 Vincamine analogues - for treating cardiovascular, cerebrovascular and respiratory insufficiency

Country Status (1)

Country Link
FR (1) FR2423493A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2499572A1 (en) * 1981-02-11 1982-08-13 Richter Gedeon Vegyeszet 17,18-DESHYDROAPOVINCAMINOL 3 ', 4', 5'-TRIMETHOXYBENZOATE AND ITS SALTS FORMED BY ADDITION WITH ACIDS, THEIR THERAPEUTIC USES IN THE TREATMENT OF DISEASES ASSOCIATED WITH CELL PROLIFERATION, METHODS FOR THEIR PREPARATION AND INTERMEDIATE PRODUCTS OF THEM PREPARATION
FR2504531A1 (en) * 1981-04-23 1982-10-29 Richter Gedeon Vegyeszet PROCESS FOR THE PREPARATION OF VINCAMINIC ACID DERIVATIVES BY OXIDATIVE TRANSPOSITION OF TABERSONINE OR DIHYDROTABERSONINE

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE818144A (en) * 1974-07-26 1974-11-18 Dehydro vincamines prepd from tabersonine - by a three stage oxidation and reduction process
FR2254342A1 (en) * 1973-12-18 1975-07-11 Sandoz Sa

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2254342A1 (en) * 1973-12-18 1975-07-11 Sandoz Sa
BE818144A (en) * 1974-07-26 1974-11-18 Dehydro vincamines prepd from tabersonine - by a three stage oxidation and reduction process

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EXBK/71 *
EXBK/72 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2499572A1 (en) * 1981-02-11 1982-08-13 Richter Gedeon Vegyeszet 17,18-DESHYDROAPOVINCAMINOL 3 ', 4', 5'-TRIMETHOXYBENZOATE AND ITS SALTS FORMED BY ADDITION WITH ACIDS, THEIR THERAPEUTIC USES IN THE TREATMENT OF DISEASES ASSOCIATED WITH CELL PROLIFERATION, METHODS FOR THEIR PREPARATION AND INTERMEDIATE PRODUCTS OF THEM PREPARATION
FR2504531A1 (en) * 1981-04-23 1982-10-29 Richter Gedeon Vegyeszet PROCESS FOR THE PREPARATION OF VINCAMINIC ACID DERIVATIVES BY OXIDATIVE TRANSPOSITION OF TABERSONINE OR DIHYDROTABERSONINE

Also Published As

Publication number Publication date
FR2423493B1 (en) 1980-12-05

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Legal Events

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CA Change of address
CD Change of name or company name
ST Notification of lapse