FR2396759A1 - Vincamine analogues - for treating cardiovascular, cerebrovascular and respiratory insufficiency - Google Patents

Vincamine analogues - for treating cardiovascular, cerebrovascular and respiratory insufficiency

Info

Publication number
FR2396759A1
FR2396759A1 FR7720856A FR7720856A FR2396759A1 FR 2396759 A1 FR2396759 A1 FR 2396759A1 FR 7720856 A FR7720856 A FR 7720856A FR 7720856 A FR7720856 A FR 7720856A FR 2396759 A1 FR2396759 A1 FR 2396759A1
Authority
FR
France
Prior art keywords
vincamine
analogues
cerebrovascular
treating cardiovascular
respiratory insufficiency
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7720856A
Other languages
French (fr)
Other versions
FR2396759B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omnium Chimique SA
Original Assignee
Omnium Chimique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnium Chimique SA filed Critical Omnium Chimique SA
Priority to FR7720856A priority Critical patent/FR2396759A1/en
Priority to BE188963A priority patent/BE868613A/en
Priority to DE19782829262 priority patent/DE2829262A1/en
Priority to DE19782829263 priority patent/DE2829263A1/en
Priority to JP8105478A priority patent/JPS5416500A/en
Priority to JP53081055A priority patent/JPS5813543B2/en
Publication of FR2396759A1 publication Critical patent/FR2396759A1/en
Application granted granted Critical
Publication of FR2396759B1 publication Critical patent/FR2396759B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Vincamine analogues of formula (I) are new together with their acid-addn. salts as optically active forms or as racemates (where R1 is halo in 10 or 11 position, R2 is OH, R3 is H, or R2 and R3 together form a second bond). Daily adult dose is 3-600 mg depending on the disorder treated. The i.v. LD50 in mice is 47-52 mg/kg. similar to that of vincamine (47 mg/kg). A typical cpd. 10-chloro-16 DELTA-epi-14-vincamine, was prepd. by treating tabersonine in acid methanol with m-chloroperbenzoic acid.
FR7720856A 1977-07-06 1977-07-06 Vincamine analogues - for treating cardiovascular, cerebrovascular and respiratory insufficiency Granted FR2396759A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR7720856A FR2396759A1 (en) 1977-07-06 1977-07-06 Vincamine analogues - for treating cardiovascular, cerebrovascular and respiratory insufficiency
BE188963A BE868613A (en) 1977-07-06 1978-06-30 NEW HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
DE19782829262 DE2829262A1 (en) 1977-07-06 1978-07-04 HETEROCYCLIC APO-VINCAMINE DERIVATIVE COMPOUND, METHOD FOR MANUFACTURING THE SAME AND MEDICINAL PRODUCTS
DE19782829263 DE2829263A1 (en) 1977-07-06 1978-07-04 HETEROCYCLIC VINCAMINE DERIVATIVE COMPOUNDS, METHOD FOR MANUFACTURING THE SAME AND MEDICINAL PRODUCTS
JP8105478A JPS5416500A (en) 1977-07-06 1978-07-05 Novel heterocyclic compound derived from vincamine* its preparation and its use as drugs
JP53081055A JPS5813543B2 (en) 1977-07-06 1978-07-05 Vincamine-derived novel heterocyclic compound, its production method and its use as a drug

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7720856A FR2396759A1 (en) 1977-07-06 1977-07-06 Vincamine analogues - for treating cardiovascular, cerebrovascular and respiratory insufficiency

Publications (2)

Publication Number Publication Date
FR2396759A1 true FR2396759A1 (en) 1979-02-02
FR2396759B1 FR2396759B1 (en) 1980-10-10

Family

ID=9193071

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7720856A Granted FR2396759A1 (en) 1977-07-06 1977-07-06 Vincamine analogues - for treating cardiovascular, cerebrovascular and respiratory insufficiency

Country Status (4)

Country Link
JP (2) JPS5416500A (en)
BE (1) BE868613A (en)
DE (2) DE2829263A1 (en)
FR (1) FR2396759A1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2458164A1 (en) * 1973-12-18 1975-06-26 Sandoz Ag METHOD FOR PRODUCING NEW HETEROCYCLIC COMPOUNDS
FR2332280A1 (en) * 1975-11-20 1977-06-17 Kunesch Nicole Vincamine and (16)-epivincamine prepn. - from tabersonine salt by hydrogenating and oxidative rearrangement

Also Published As

Publication number Publication date
JPS5441897A (en) 1979-04-03
BE868613A (en) 1978-10-16
DE2829263A1 (en) 1979-01-18
FR2396759B1 (en) 1980-10-10
JPS5416500A (en) 1979-02-07
JPS5813543B2 (en) 1983-03-14
DE2829262A1 (en) 1979-02-08

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Legal Events

Date Code Title Description
CA Change of address
CD Change of name or company name
ST Notification of lapse