FR2422664A1 - Tetra:hydro:alstonine ester and amide derivs. - with anti:anoxic, psychotropic and antidepressant activity (BE 15.10.79) - Google Patents

Tetra:hydro:alstonine ester and amide derivs. - with anti:anoxic, psychotropic and antidepressant activity (BE 15.10.79)

Info

Publication number
FR2422664A1
FR2422664A1 FR7811026A FR7811026A FR2422664A1 FR 2422664 A1 FR2422664 A1 FR 2422664A1 FR 7811026 A FR7811026 A FR 7811026A FR 7811026 A FR7811026 A FR 7811026A FR 2422664 A1 FR2422664 A1 FR 2422664A1
Authority
FR
France
Prior art keywords
alkoxy
psychotropic
antidepressant activity
alstonine
anoxic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7811026A
Other languages
French (fr)
Other versions
FR2422664B1 (en
Inventor
Henry Najer
Bernard Mompon
Braham Shroot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7811026A priority Critical patent/FR2422664A1/en
Priority to FR7906055A priority patent/FR2450835A2/en
Priority to NO79791222A priority patent/NO791222L/en
Priority to AU45902/79A priority patent/AU4590279A/en
Priority to DK149279A priority patent/DK149279A/en
Priority to ZA791710A priority patent/ZA791710B/en
Priority to IT21793/79A priority patent/IT1111923B/en
Priority to FI791194A priority patent/FI791194A/en
Priority to ES479540A priority patent/ES479540A1/en
Priority to DE19792914805 priority patent/DE2914805A1/en
Priority to SE7903234A priority patent/SE7903234L/en
Priority to IL57061A priority patent/IL57061A0/en
Priority to GR58869A priority patent/GR66991B/el
Priority to LU81145A priority patent/LU81145A1/en
Priority to GB7912932A priority patent/GB2018751A/en
Priority to NL7902958A priority patent/NL7902958A/en
Priority to PT69487A priority patent/PT69487A/en
Priority to BE0/194616A priority patent/BE875591A/en
Priority to JP4595879A priority patent/JPS54145700A/en
Publication of FR2422664A1 publication Critical patent/FR2422664A1/en
Application granted granted Critical
Publication of FR2422664B1 publication Critical patent/FR2422664B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Abstract

New tetrahydroalstonine derivs. are of formula (I) (with the exception of that in which R1 is H and R2 is OCH3) and their acid addn. salts (where R1 is H, hydroxyalkyl, alkyl or alkoxycarbonyl; and R2 is OH, 1-6C alkoxy (opt. substd. by halogen), cycloalkyl-alkoxy, cyclo-alkoxy, alkoxy, substd. by piperidino, morpholino, piperazino or pyrrolidino, dialkylamino-alkoxy, amino, alkylamino, dialkylamino, cycloalkylamino or a gp. OM (M = alkali or alkaline earth metal; the alkyl and alkoxy gps. being 1-6C and the cycloalkyl and cycloalkoxy gps. 3-6C). (I) have antianoxic, psychotropic and, esp. antidepressant activity. They can be used e.g. in the treatment of behavioural disorders due to cerebrovascular damage or age-induced cerebral sclerosis, and in the treatment of depression.
FR7811026A 1978-04-14 1978-04-14 Tetra:hydro:alstonine ester and amide derivs. - with anti:anoxic, psychotropic and antidepressant activity (BE 15.10.79) Granted FR2422664A1 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
FR7811026A FR2422664A1 (en) 1978-04-14 1978-04-14 Tetra:hydro:alstonine ester and amide derivs. - with anti:anoxic, psychotropic and antidepressant activity (BE 15.10.79)
FR7906055A FR2450835A2 (en) 1978-04-14 1979-03-09 TETRAHYDROALSTONIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
AU45902/79A AU4590279A (en) 1978-04-14 1979-04-10 Tetrahydroalstonine derivatives
DK149279A DK149279A (en) 1978-04-14 1979-04-10 TETRAHYDROALSTONE INDIVIDUALS AND SALTS THEREOF AND THE PREPARATION OF THEIR PREPARATION
ZA791710A ZA791710B (en) 1978-04-14 1979-04-10 Tetrahydroalstonine derivatives
NO79791222A NO791222L (en) 1978-04-14 1979-04-10 PROCEDURE FOR THE PREPARATION OF TETRAHYDROALSTONE INDIVATIVES
SE7903234A SE7903234L (en) 1978-04-14 1979-04-11 TETRAHYDROALSTONE INDIVIDUALS
FI791194A FI791194A (en) 1978-04-14 1979-04-11 TETRAHYDROALSTONE DERIVATIVES
ES479540A ES479540A1 (en) 1978-04-14 1979-04-11 Tetrahydroalstonine derivatives
DE19792914805 DE2914805A1 (en) 1978-04-14 1979-04-11 TETRAHYDROALSTONE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THEM
IT21793/79A IT1111923B (en) 1978-04-14 1979-04-11 TETRAIIDRAOALSTONINA DERIVATIVES AND THEIR USE IN THERAPEUTIC
IL57061A IL57061A0 (en) 1978-04-14 1979-04-11 Tetrahydroalstonine derivatives their preparation and parmaceutical compositions containing them
LU81145A LU81145A1 (en) 1978-04-14 1979-04-12 TETRAHYDROALSTONIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
GB7912932A GB2018751A (en) 1978-04-14 1979-04-12 Tetrahydroalstonine derivatives
NL7902958A NL7902958A (en) 1978-04-14 1979-04-12 PROCEDURE FOR PREPARING TETRAHYDROALSTONIN DERIVATIVES AND USE AS A THERAPEUTIC AGENT.
PT69487A PT69487A (en) 1978-04-14 1979-04-12 PROCESS FOR THE PREPARATION OF TETRAHYDROALSTONIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
GR58869A GR66991B (en) 1978-04-14 1979-04-12
JP4595879A JPS54145700A (en) 1978-04-14 1979-04-13 Tetrahydroarstonine derivative and its manufacture
BE0/194616A BE875591A (en) 1978-04-14 1979-04-13 TETRAHYDROALSTONINE DERIVATIVES AND THEIR THERAPEUTIC APPLICATION

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7811026A FR2422664A1 (en) 1978-04-14 1978-04-14 Tetra:hydro:alstonine ester and amide derivs. - with anti:anoxic, psychotropic and antidepressant activity (BE 15.10.79)

Publications (2)

Publication Number Publication Date
FR2422664A1 true FR2422664A1 (en) 1979-11-09
FR2422664B1 FR2422664B1 (en) 1980-11-07

Family

ID=9207132

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7811026A Granted FR2422664A1 (en) 1978-04-14 1978-04-14 Tetra:hydro:alstonine ester and amide derivs. - with anti:anoxic, psychotropic and antidepressant activity (BE 15.10.79)

Country Status (5)

Country Link
AU (1) AU4590279A (en)
BE (1) BE875591A (en)
FR (1) FR2422664A1 (en)
SE (1) SE7903234L (en)
ZA (1) ZA791710B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017525A1 (en) * 1979-03-14 1980-10-15 Pierre Fabre S.A. Derivatives of tetrahydroalstonine, their preparation and their application as medicaments

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2279750A1 (en) * 1974-07-26 1976-02-20 Omnium Chimique Sa NEW N-DISUBSTITUTED AMINOETHYLIC ESTERS OF RAUBASIN AND PROCESS FOR OBTAINING
FR2343476A2 (en) * 1976-03-12 1977-10-07 Omnium Chimique Sa Compsns. contg. ethyl piperidine raubasinate - have vasoregulating, cardiotonic and hypertensive activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2279750A1 (en) * 1974-07-26 1976-02-20 Omnium Chimique Sa NEW N-DISUBSTITUTED AMINOETHYLIC ESTERS OF RAUBASIN AND PROCESS FOR OBTAINING
FR2343476A2 (en) * 1976-03-12 1977-10-07 Omnium Chimique Sa Compsns. contg. ethyl piperidine raubasinate - have vasoregulating, cardiotonic and hypertensive activity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017525A1 (en) * 1979-03-14 1980-10-15 Pierre Fabre S.A. Derivatives of tetrahydroalstonine, their preparation and their application as medicaments

Also Published As

Publication number Publication date
FR2422664B1 (en) 1980-11-07
BE875591A (en) 1979-10-15
AU4590279A (en) 1979-11-22
SE7903234L (en) 1979-10-15
ZA791710B (en) 1980-05-28

Similar Documents

Publication Publication Date Title
DE69326637D1 (en) 1,4-Disubstituted piperazines for the treatment of diseases of the central nervous system and of nerve endocrine diseases
IE861917L (en) Tertiary hydroxyalkylxanthines
ES8306708A1 (en) Therapeutically useful 1-alkyl-2-aminotetralin derivatives.
ES540638A0 (en) A PROCEDURE FOR PREPARING 5,6,7,8-TETRAHYDRO-6- (L-ERITRO-1 ', 2'-DIHIDROXIPROPIL) -PTERINE.
ATE28187T1 (en) POLYPRENYLCARBONIC ACIDS AND PROCESS FOR THEIR PRODUCTION.
FR2422664A1 (en) Tetra:hydro:alstonine ester and amide derivs. - with anti:anoxic, psychotropic and antidepressant activity (BE 15.10.79)
GR1002329B (en) Process for the production of clavulanic acid salts.
IE830868L (en) A process for the preparation of penicillanic acid¹1,1-dioxide and derivatives thereof
ES8605497A1 (en) Process for the preparation of storage-stable benzothiazole-sulfenamides.
ES8604911A1 (en) 2-(4-Diphenylmethylpiperazinyl)-1-phenyl alkanol or their salts, a process for their production and a cerebral circulation-improving drug
ES2020889A6 (en) Method for making a sedimentation resistant stable enzyme dispersion
ES8107211A1 (en) 3,4,5,6-Tetrahydro-2,6-methano-4 beta-amino-1-benzoxocin derivatives, process for their preparation and compositions containing them.
DE3782207D1 (en) 2-ACYLOXYPROPYLAMINE DERIVATIVES, METHOD FOR THE PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THEM.
IL82556A0 (en) Ergoline esters,their preparation and pharmaceutical compositions containing them
ES8602002A1 (en) 4-Phenyl-tetrahydro-furano-pyridines, process for their preparation and pharmaceutical compositions.
ES481264A1 (en) Arylacetic acid derivatives
ES479540A1 (en) Tetrahydroalstonine derivatives
ATE25383T1 (en) INDOLOQUINOLIZIN DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR THERAPEUTIC APPLICATION.
ES8304125A1 (en) Oxadiazolopyrimidine derivatives, process and intermediates for their production and pharmaceutical preparations containing such an oxadiazolopyrimidine derivative.
FR2273532A1 (en) Alpha-aminoalkyl 2-thienylacetonitrile derivs - spasmolytics and vasodilators more active than papaverine
ES2003758A6 (en) Phenylacetic-acid derivatives, pharmaceutical compositions containing them and processes for their production.
ES8603846A1 (en) Aminoethoxybenzylalcohol derivatives, process for their preparation and pharmaceutical compositions containing them.
MY101451A (en) Crystalline form of 7-(dimethylaminothylene) amino-9a-methoxymitosane
ES8308538A1 (en) Trifluoromethanesulfonanilides, and their production and use.
ES8403123A1 (en) 1 alpha -Ethyl-1 beta -(2'-alkoxy carbonyl-2'-hydroxyiminoethyl)-10-methoxy 1,2,3,4,6,7,12,12 beta -octahydroindolo(2,3A)quinolizines

Legal Events

Date Code Title Description
ST Notification of lapse