FR2416225A1 - Derives de la 4-amino-3 sulfamido-pyridine, leur procede de preparation et leur application comme diuretiques - Google Patents
Derives de la 4-amino-3 sulfamido-pyridine, leur procede de preparation et leur application comme diuretiquesInfo
- Publication number
- FR2416225A1 FR2416225A1 FR7902109A FR7902109A FR2416225A1 FR 2416225 A1 FR2416225 A1 FR 2416225A1 FR 7902109 A FR7902109 A FR 7902109A FR 7902109 A FR7902109 A FR 7902109A FR 2416225 A1 FR2416225 A1 FR 2416225A1
- Authority
- FR
- France
- Prior art keywords
- alkyl
- amino
- sulfamido
- group
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002934 diuretic Substances 0.000 title 1
- 229940030606 diuretics Drugs 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 1
- -1 alkoxyalkye Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical group C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000565 sulfonamide group Chemical group 0.000 abstract 1
- 125000001302 tertiary amino group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3918/78A GB1593609A (en) | 1978-01-31 | 1978-01-31 | Pyridine sulfonamides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2416225A1 true FR2416225A1 (fr) | 1979-08-31 |
| FR2416225B1 FR2416225B1 (enExample) | 1981-11-06 |
Family
ID=9767352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7902109A Granted FR2416225A1 (fr) | 1978-01-31 | 1979-01-26 | Derives de la 4-amino-3 sulfamido-pyridine, leur procede de preparation et leur application comme diuretiques |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4244950A (enExample) |
| EP (1) | EP0003383B1 (enExample) |
| JP (1) | JPS54119477A (enExample) |
| AR (2) | AR226154A1 (enExample) |
| AT (1) | AT375646B (enExample) |
| AU (1) | AU524287B2 (enExample) |
| BE (1) | BE873656A (enExample) |
| CA (1) | CA1124720A (enExample) |
| DD (1) | DD141309A5 (enExample) |
| DE (1) | DE2964681D1 (enExample) |
| ES (1) | ES476658A1 (enExample) |
| FR (1) | FR2416225A1 (enExample) |
| GB (1) | GB1593609A (enExample) |
| HU (1) | HU178203B (enExample) |
| IL (1) | IL56407A (enExample) |
| IT (1) | IT1109868B (enExample) |
| LU (1) | LU80856A1 (enExample) |
| NZ (1) | NZ189376A (enExample) |
| PT (1) | PT69147A (enExample) |
| ZA (1) | ZA7990B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166162A (en) * | 1990-03-02 | 1992-11-24 | Adir Et Compagnie | Pyridylsulfonylurea and pyridylsulfonylthiourea compounds |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4435206A (en) | 1978-12-04 | 1984-03-06 | E. I. Du Pont De Nemours And Company | Agricultural pyridinesulfonamides |
| US4544401A (en) * | 1979-10-22 | 1985-10-01 | E. I. Du Pont De Nemours And Company | Agricultural pyridinesulfonamides |
| US4879249A (en) * | 1983-02-25 | 1989-11-07 | Baldwin Thomas O | Linker compounds, linker-compound-ligands and linker-compound-receptors |
| US4734275A (en) * | 1983-08-19 | 1988-03-29 | Research Corporation | Anti-curare agents |
| DE3529529A1 (de) * | 1985-08-17 | 1987-02-19 | Boehringer Mannheim Gmbh | Verfahren zur herstellung einer stabilen modifikation von torasemid |
| US4853389A (en) * | 1987-07-24 | 1989-08-01 | American Home Products Corporation | Diuretic and antihypertensive substituted-5-pyrimidinesulfonylureas |
| US4914203A (en) * | 1987-07-24 | 1990-04-03 | American Home Products Corporation | 5 step process for preparing certain 2,4-diamino-5-pyrimidine-sulfonyl ureas |
| FR2685917A1 (fr) * | 1992-01-06 | 1993-07-09 | Adir | Nouveau derive de la pyridylsulfonyluree des procedes de preparation et les compositions pharmaceutiques le contenant. |
| FR2659080B1 (fr) * | 1990-03-02 | 1994-07-08 | Adir | Nouveaux derives de la pyridylsulfonyluree et de la pyridylsulfonylthiouree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| EP1741429A3 (en) * | 2000-03-20 | 2007-01-17 | Teva Pharmaceutical Industries Ltd. | Processes for preparing torsemide |
| CA2403382A1 (en) | 2000-03-20 | 2001-09-27 | Teva Pharmaceutical Industries Ltd. | Novel processes for preparing torsemide intermediate |
| DE10027887A1 (de) | 2000-05-31 | 2001-12-13 | Jenapharm Gmbh | Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
| AR037097A1 (es) * | 2001-10-05 | 2004-10-20 | Novartis Ag | Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento |
| PE20040167A1 (es) * | 2002-03-28 | 2004-05-26 | Novartis Ag | Amidas del acido sulfamico |
| IL149771A0 (en) * | 2002-05-21 | 2002-11-10 | Fintech Lab Ltd | Process for preparation of torsemide |
| US7378527B2 (en) * | 2004-03-16 | 2008-05-27 | Daqing Che | Process for the preparation of torsemide and related intermediates |
| US7534780B2 (en) | 2004-05-21 | 2009-05-19 | Bayer Schering Pharma Aktiengesellschaft | Estradiol prodrugs |
| DE102005057421A1 (de) * | 2005-11-30 | 2007-05-31 | Bayer Schering Pharma Ag | Heteroaromatische Sulfonamid-Prodrugs |
| AR061159A1 (es) | 2007-06-01 | 2008-08-06 | S A Cartocor | Procedimiento de fabricacion de un pallet modular y producto resultante |
| EP3649112A1 (en) | 2017-07-07 | 2020-05-13 | Inflazome Limited | Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors |
| CN114456104B (zh) * | 2022-01-26 | 2023-08-25 | 南京正科医药股份有限公司 | 一种托拉塞米关键中间体的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE758749A (fr) * | 1969-11-12 | 1971-05-10 | Ciba Geigy | Procede de preparation de nouveaux acides pyridine-sulfoniques |
| GB1368948A (en) * | 1970-11-11 | 1974-10-02 | Manuf Prod Pharma | Pyridine derivatives |
| GB1414793A (en) * | 1972-07-28 | 1975-11-19 | Manuf Prod Pharma | Derivatives of phenylaminopyridine |
| US3956294A (en) * | 1972-06-22 | 1976-05-11 | Cassella Farbwerke Mainkur Aktiengesellschaft | Substituted pyridine compounds |
| GB1477664A (en) * | 1974-04-17 | 1977-06-22 | Christiaens Sa A | Pyridine derivatives |
-
1978
- 1978-01-31 GB GB3918/78A patent/GB1593609A/en not_active Expired
-
1979
- 1979-01-09 ES ES476658A patent/ES476658A1/es not_active Expired
- 1979-01-09 ZA ZA7990A patent/ZA7990B/xx unknown
- 1979-01-10 IL IL56407A patent/IL56407A/xx unknown
- 1979-01-12 AU AU43317/79A patent/AU524287B2/en not_active Ceased
- 1979-01-15 NZ NZ189376A patent/NZ189376A/xx unknown
- 1979-01-19 CA CA319,934A patent/CA1124720A/en not_active Expired
- 1979-01-22 DE DE7979200037T patent/DE2964681D1/de not_active Expired
- 1979-01-22 EP EP79200037A patent/EP0003383B1/fr not_active Expired
- 1979-01-23 BE BE0/193040A patent/BE873656A/xx unknown
- 1979-01-24 US US06/006,154 patent/US4244950A/en not_active Expired - Lifetime
- 1979-01-25 AR AR275290A patent/AR226154A1/es active
- 1979-01-25 IT IT19614/79A patent/IT1109868B/it active
- 1979-01-26 FR FR7902109A patent/FR2416225A1/fr active Granted
- 1979-01-26 AT AT0059479A patent/AT375646B/de not_active IP Right Cessation
- 1979-01-29 PT PT7969147A patent/PT69147A/pt unknown
- 1979-01-29 DD DD79210692A patent/DD141309A5/de not_active IP Right Cessation
- 1979-01-30 JP JP1026079A patent/JPS54119477A/ja active Pending
- 1979-01-30 HU HU79CI1905A patent/HU178203B/hu not_active IP Right Cessation
- 1979-01-30 LU LU80856A patent/LU80856A1/fr unknown
-
1980
- 1980-05-28 AR AR281219A patent/AR225922A1/es active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166162A (en) * | 1990-03-02 | 1992-11-24 | Adir Et Compagnie | Pyridylsulfonylurea and pyridylsulfonylthiourea compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| ATA59479A (de) | 1984-01-15 |
| US4244950A (en) | 1981-01-13 |
| GB1593609A (en) | 1981-07-22 |
| EP0003383A3 (en) | 1979-09-05 |
| HU178203B (en) | 1982-03-28 |
| BE873656A (fr) | 1979-07-23 |
| AT375646B (de) | 1984-08-27 |
| PT69147A (en) | 1979-02-01 |
| EP0003383A2 (fr) | 1979-08-08 |
| DE2964681D1 (de) | 1983-03-17 |
| AU4331779A (en) | 1979-08-09 |
| IT7919614A0 (it) | 1979-01-25 |
| IT1109868B (it) | 1985-12-23 |
| AR225922A1 (es) | 1982-05-14 |
| JPS54119477A (en) | 1979-09-17 |
| FR2416225B1 (enExample) | 1981-11-06 |
| CA1124720A (en) | 1982-06-01 |
| IL56407A (en) | 1983-05-15 |
| AU524287B2 (en) | 1982-09-09 |
| IL56407A0 (en) | 1979-03-12 |
| DD141309A5 (de) | 1980-04-23 |
| EP0003383B1 (fr) | 1983-02-09 |
| AR226154A1 (es) | 1982-06-15 |
| LU80856A1 (fr) | 1980-08-08 |
| NZ189376A (en) | 1981-03-16 |
| ES476658A1 (es) | 1979-07-16 |
| ZA7990B (en) | 1980-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TP | Transmission of property | ||
| CD | Change of name or company name | ||
| TP | Transmission of property | ||
| ST | Notification of lapse |