FR2414043A1 - Nouveaux derives alcoxycarbonyl-3 benzodiazepines, leur procede de preparation et leur application en therapeutique - Google Patents

Nouveaux derives alcoxycarbonyl-3 benzodiazepines, leur procede de preparation et leur application en therapeutique

Info

Publication number
FR2414043A1
FR2414043A1 FR7900098A FR7900098A FR2414043A1 FR 2414043 A1 FR2414043 A1 FR 2414043A1 FR 7900098 A FR7900098 A FR 7900098A FR 7900098 A FR7900098 A FR 7900098A FR 2414043 A1 FR2414043 A1 FR 2414043A1
Authority
FR
France
Prior art keywords
alcoxycarbonyl
new
preparation process
therapeutic application
benzodiazepine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7900098A
Other languages
English (en)
Other versions
FR2414043B1 (fr
Inventor
Henri Demarne
Jean-Charles Molimard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CM Industries SA
Clin Midy
Original Assignee
CM Industries SA
Clin Midy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CM Industries SA, Clin Midy filed Critical CM Industries SA
Publication of FR2414043A1 publication Critical patent/FR2414043A1/fr
Application granted granted Critical
Publication of FR2414043B1 publication Critical patent/FR2414043B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA PRESENTE INVENTION CONCERNE DE NOUVEAUX DERIVES ALCOXYCARBONYL-3 BENZODIAZEPINES, CARACTERISES EN CE QU'ILS REPONDENT A LA FORMULE CHIMIQUE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE: R REPRESENTE UN ATOME D'HYDROGENE OU UN RADICAL ALKYLE INFERIEUR; R DESIGNE UN GROUPE ALKYLE DROIT OU RAMIFIE COMPORTANT DE 3 A 10ATOMES DE CARBONE; R REPRESENTE UN ATOME D'HYDROGENE OU UN ATOME D'HALOGENE, DE PREFERENCE LE CHLORE OU LE FLUOR, ET R REPRESENTE UN ATOME D'HYDROGENE OU UN ATOME D'HALOGENE, DE PREFERENCE LE CHLORE OU UN GROUPE NITRO; ET LES MEDICAMENTS COMPORTANT AU MOINS UN DESDITS NOUVEAUX DERIVES.
FR7900098A 1978-01-10 1979-01-03 Nouveaux derives alcoxycarbonyl-3 benzodiazepines, leur procede de preparation et leur application en therapeutique Granted FR2414043A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB95078 1978-01-10

Publications (2)

Publication Number Publication Date
FR2414043A1 true FR2414043A1 (fr) 1979-08-03
FR2414043B1 FR2414043B1 (fr) 1982-03-26

Family

ID=9713371

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7900098A Granted FR2414043A1 (fr) 1978-01-10 1979-01-03 Nouveaux derives alcoxycarbonyl-3 benzodiazepines, leur procede de preparation et leur application en therapeutique

Country Status (8)

Country Link
JP (1) JPS54151992A (fr)
BE (1) BE877567A (fr)
CA (1) CA1126730A (fr)
CH (1) CH637644A5 (fr)
DE (1) DE2900017A1 (fr)
FR (1) FR2414043A1 (fr)
IT (1) IT1118271B (fr)
NL (1) NL7900192A (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000069836A1 (fr) * 1999-05-14 2000-11-23 Glaxo Group Limited Benzodiazepines a action breve
US7160880B1 (en) 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
US10195210B2 (en) 2010-11-08 2019-02-05 Paion Uk Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
US10414749B2 (en) 2013-03-04 2019-09-17 Paion Uk Limited Process for preparing 3-[(S)-7-bromo-2-((2-oxopropyl)amino)-5-pyridin-2-yl-3H-1,4-benzodiazepin-3-yl]propionic acid methyl ester
US10472365B2 (en) 2006-07-10 2019-11-12 Paion Uk Limited Short-acting benzodiazepine salts and their polymorphic forms

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH500997A (de) * 1967-08-09 1970-12-31 Hoffmann La Roche Verfahren zur Herstellung von Benzodiazepin-Derivaten
US3678043A (en) * 1966-03-14 1972-07-18 American Home Prod 2,3-dihydro-2-oxo-1h-1,4-benzodiazepine-3-carboxylic acid esters and related compounds
FR2350346A1 (fr) * 1976-05-05 1977-12-02 Cm Ind Nouvelles benzodiazepines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3678043A (en) * 1966-03-14 1972-07-18 American Home Prod 2,3-dihydro-2-oxo-1h-1,4-benzodiazepine-3-carboxylic acid esters and related compounds
CH500997A (de) * 1967-08-09 1970-12-31 Hoffmann La Roche Verfahren zur Herstellung von Benzodiazepin-Derivaten
FR2350346A1 (fr) * 1976-05-05 1977-12-02 Cm Ind Nouvelles benzodiazepines

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000069836A1 (fr) * 1999-05-14 2000-11-23 Glaxo Group Limited Benzodiazepines a action breve
US7160880B1 (en) 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
US7435730B2 (en) 1999-05-14 2008-10-14 Cenes Limited Short-acting benzodiazepines
US7473689B2 (en) 1999-05-14 2009-01-06 Cenes Limited Short-acting benzodiazepines
US7485635B2 (en) 1999-05-14 2009-02-03 Cenes Limited Short-acting benzodiazepines
US7528127B2 (en) 1999-05-14 2009-05-05 Cenes Limited Short-acting benzodiazepines
US10472365B2 (en) 2006-07-10 2019-11-12 Paion Uk Limited Short-acting benzodiazepine salts and their polymorphic forms
US10961250B2 (en) 2006-07-10 2021-03-30 Paion Uk Limited Short-acting benzodiazepine salts and their polymorphic forms
US10195210B2 (en) 2010-11-08 2019-02-05 Paion Uk Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
US10342800B2 (en) 2010-11-08 2019-07-09 Paion Uk Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
US10414749B2 (en) 2013-03-04 2019-09-17 Paion Uk Limited Process for preparing 3-[(S)-7-bromo-2-((2-oxopropyl)amino)-5-pyridin-2-yl-3H-1,4-benzodiazepin-3-yl]propionic acid methyl ester

Also Published As

Publication number Publication date
CH637644A5 (en) 1983-08-15
JPS54151992A (en) 1979-11-29
IT1118271B (it) 1986-02-24
BE877567A (fr) 1979-11-05
CA1126730A (fr) 1982-06-29
DE2900017A1 (de) 1979-07-12
IT7967037A0 (it) 1979-01-09
FR2414043B1 (fr) 1982-03-26
NL7900192A (nl) 1979-07-12

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse