FR2413391A1 - Procede de preparation de la vincadifformine - Google Patents

Procede de preparation de la vincadifformine

Info

Publication number
FR2413391A1
FR2413391A1 FR7836935A FR7836935A FR2413391A1 FR 2413391 A1 FR2413391 A1 FR 2413391A1 FR 7836935 A FR7836935 A FR 7836935A FR 7836935 A FR7836935 A FR 7836935A FR 2413391 A1 FR2413391 A1 FR 2413391A1
Authority
FR
France
Prior art keywords
vincadifformin
indole
hexahydroazepino
tetrahydro
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7836935A
Other languages
English (en)
French (fr)
Other versions
FR2413391B1 (enExample
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omnium Chimique SA
Original Assignee
Omnium Chimique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnium Chimique SA filed Critical Omnium Chimique SA
Publication of FR2413391A1 publication Critical patent/FR2413391A1/fr
Application granted granted Critical
Publication of FR2413391B1 publication Critical patent/FR2413391B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/313—Compounds having groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
FR7836935A 1977-12-29 1978-12-29 Procede de preparation de la vincadifformine Granted FR2413391A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/865,657 US4154943A (en) 1977-12-29 1977-12-29 Preparation of vincadifformine

Publications (2)

Publication Number Publication Date
FR2413391A1 true FR2413391A1 (fr) 1979-07-27
FR2413391B1 FR2413391B1 (enExample) 1983-08-05

Family

ID=25345973

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7836935A Granted FR2413391A1 (fr) 1977-12-29 1978-12-29 Procede de preparation de la vincadifformine

Country Status (9)

Country Link
US (1) US4154943A (enExample)
JP (1) JPS5498800A (enExample)
BE (1) BE873136A (enExample)
CA (1) CA1098903A (enExample)
ES (1) ES476504A1 (enExample)
FR (1) FR2413391A1 (enExample)
GB (1) GB2011899B (enExample)
HU (1) HU180905B (enExample)
IT (1) IT1109011B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2434166A2 (fr) * 1978-08-24 1980-03-21 Omnium Chimique Sa Procede de preparation de vincadifformine et derives similaires

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4283536A (en) * 1977-12-29 1981-08-11 University Of Vermont Preparation of vincadifformine and related derivatives
US4267330A (en) * 1978-08-24 1981-05-12 Omnium Chimique Societe Anonyme Process for the synthesis of vincadifformine and related derivatives
US4220774A (en) * 1978-10-26 1980-09-02 Omnium Chimique Vincadifformine synthesis process
US4362739A (en) * 1981-05-04 1982-12-07 S.A. Omnichem Pyrrolo(2,3-d)carbazole derivatives, compositions and use
US4428880A (en) 1981-05-04 1984-01-31 S.A. Omnichem Azepino[4,5-d]indole derivatives and preparation thereof
LU85894A1 (fr) * 1985-05-10 1986-12-05 Omnichem Sa Derives de 1,2,3,4,5,6-hexahydro-azepino (4,5-b) indole leur preparation,composes intermediaires,et leur application en therapeutique
CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
AR024158A1 (es) 1999-06-01 2002-09-04 Smithkline Beecham Corp Compuestos antibacterianos
ES2231275T3 (es) 1999-10-08 2005-05-16 Affinium Pharmaceuticals, Inc. Inhibidores de fab i.
US6762201B1 (en) 1999-10-08 2004-07-13 Affinium Pharmaceuticals, Inc. Fab I inhibitors
US6730684B1 (en) 1999-10-08 2004-05-04 Affinium Pharmaceuticals, Inc. Fab I inhibitors
JP4387804B2 (ja) * 2001-04-06 2009-12-24 アフィニアム・ファーマシューティカルズ・インコーポレイテッド ＦａｂＩ阻害剤
PT1575951E (pt) * 2002-12-06 2014-09-15 Debiopharm Int Sa Compostos heterocíclicos, métodos para os preparar e sua utilização em terapia
EP1608377B1 (en) 2003-03-17 2008-10-01 Affinium Pharmaceuticals, Inc. Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics
US8450307B2 (en) * 2004-06-04 2013-05-28 Affinium Pharmaceuticals, Inc. Therapeutic agents, and methods of making and using the same
US20090156578A1 (en) * 2005-12-05 2009-06-18 PAULS Henry 3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents
EP2054422B1 (en) * 2006-07-20 2017-06-14 Debiopharm International SA Acrylamide derivatives as fab i inhibitors
WO2008098374A1 (en) * 2007-02-16 2008-08-21 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab i inhibitors
US20130178618A1 (en) 2012-01-10 2013-07-11 William Allen Boulanger Novel pharmaceutical intermediates and methods for preparing the same
EP2861608B8 (en) 2012-06-19 2019-06-19 Debiopharm International SA Prodrug derivatives of (e)-n-methyl-n-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
DK3419628T3 (da) 2016-02-26 2021-01-11 Debiopharm Int Sa Medikament til behandling af diabetiske fodinfektioner
CN107216328A (zh) * 2017-07-06 2017-09-29 贵州医科大学 一种α‑卡波林类化合物的合成方法
ES2944535T3 (es) 2019-02-14 2023-06-22 Debiopharm Int Sa Formulación de afabicina, método para preparar la misma
UA129222C2 (uk) 2019-06-14 2025-02-12 Дебіофарм Інтернешнл С.А. Лікарський засіб і його застосування для лікування бактеріальних інфекцій, пов'язаних з біоплівкою
US12116372B1 (en) 2023-12-14 2024-10-15 William Allen Boulanger Process for preparing methyl 3-bromo-2-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)propanoate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE811614A (en) 1974-02-27 1974-06-17 (-) Vincadifformine prodn. - by hemisynthesis starting from vindolinine which is obtd. from catharantus roseus

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2434166A2 (fr) * 1978-08-24 1980-03-21 Omnium Chimique Sa Procede de preparation de vincadifformine et derives similaires
FR2445332A2 (fr) * 1978-08-24 1980-07-25 Omnium Chimique Sa Derives de 1,2,3,4,5,6-hexahydroazepino-(4,5-b)-indole et leur procede de preparation

Also Published As

Publication number Publication date
BE873136A (fr) 1979-06-28
GB2011899B (en) 1982-05-26
JPS6215555B2 (enExample) 1987-04-08
HU180905B (en) 1983-05-30
US4154943A (en) 1979-05-15
FR2413391B1 (enExample) 1983-08-05
ES476504A1 (es) 1979-11-16
JPS5498800A (en) 1979-08-03
IT1109011B (it) 1985-12-16
IT7809692A0 (it) 1978-12-29
GB2011899A (en) 1979-07-18
CA1098903A (en) 1981-04-07

Similar Documents

Publication Publication Date Title
RU93049997A (ru) Производные метилен-бис-фосфоновой кислоты, способ их получения, фармацевтическая композиция
RO80249A (ro) Procedeu pentru prepararea unor derivati de benzofenonhidrazona
FR2344533A1 (fr) Nouveaux derives de la cysteine, procede pour leur preparation et application comme fluidifiant des expectorations
EP0005748A3 (en) Process for the preparation of cyclohexenyl derivatives, and intermediates produced in the synthesis
EP0278767A3 (en) Process for removing hair dyes from hair and skin, and product for carrying out the process
BE885555A (fr) Preparations pharmaceutiques a activite cytostatique, nouveaux derives de l'acide isocyanurique et procedes pour leur preparation
FR2399431A1 (fr) Derives du thiophene et procede pour leur preparation
FR2319613A1 (fr) Procede de preparation du glyoxal a partir de l'ethyleneglycol par oxydation en phase vapeur
BE846109A (fr) Nouveaux derives de 4-oxo-4h-benzopyranne, leur procede de preparationet leur application a l'alimentation des animaux
FR2297209A1 (fr) Procede de preparation d'azodinitriles a partir d'aminonitriles en presence d'un agent tensio-actif
BE870576A (fr) Nouveaux acides dialkylamino-7 halogeno-6 oxo-4 dihydro-1,4 quinoleine-3 carboxyliques, procede pour leur preparation et compositions les contenant
RU94031752A (ru) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ γ-МЕРКАПТОКАРБОНОВОЙ КИСЛОТЫ
BE846696A (fr) Nouveaux derives de l'aniline, procede pour leur preparation et application en tant qu'agents microbicides
FR2383198A1 (fr) Procede de production de composes du type 9(11)-androstenedione
NL7613318A (nl) Werkwijze voor de bereiding van nieuwe n-gesubsti- tueerde pyrrolidoncarbonzuren, werkwijze voor de bereiding van therapeutische preparaten die deze nieuwe verbindingen bevatten, alsmede gevormd the- rapeutisch preparaat verkregen volgens deze werkwijze.
JPS5432444A (en) Preparation of cis-2-pentene derivative
BE866718A (fr) Nouveaux derives d'acides azolylalcane-carboxyliques, leur procede de preparation et leur application comme fongicides
EP0012072A3 (en) Beta-lactones derived from 2-hydroxycyclopentane carboxylic acid, process for their preparation, pharmaceutical compositions containing them; 2-hydroxycyclopentane carboxylic acid derivatives and related beta-lactones
BE858792A (fr) Procede de preparation de la gamma-butyrolactone par hydrogenation de l'anhydride maelique
BE802387A (fr) Procede de preparation de la vincamone et de l'epi-21 vincamone a partir de la tabersonine et derives indoliques nouveaux.
BE871525A (fr) Nouveaux derives de benzimidazole, compositions pour l'agriculture, les contenant et procede pour leur preparation
FR2373539A1 (fr) Derives de l'acide dithiocarbamique, leur procede de preparation et leur application en medecine veterinaire
FR2415640A1 (fr) Derives d'amino-3-cardenolides, procede pour leur preparation, et medicaments les contenant
FR2412517A1 (fr) Procede de preparation de cristaux d'acide sorbique
JPS6468332A (en) Production of cyclotenes

Legal Events

Date Code Title Description
ST Notification of lapse