FR2412533A1 - Polyfluorohydroxyisopropyl carbostyriles bicycliques et tricycliques antihypertensifs, leur preparation et compositions pharmaceutiques les contenant - Google Patents

Polyfluorohydroxyisopropyl carbostyriles bicycliques et tricycliques antihypertensifs, leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
FR2412533A1
FR2412533A1 FR7835956A FR7835956A FR2412533A1 FR 2412533 A1 FR2412533 A1 FR 2412533A1 FR 7835956 A FR7835956 A FR 7835956A FR 7835956 A FR7835956 A FR 7835956A FR 2412533 A1 FR2412533 A1 FR 2412533A1
Authority
FR
France
Prior art keywords
polyfluorohydroxyisopropyl
carbostyriles
antihypertensifs
tricyclic
bicyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7835956A
Other languages
English (en)
Other versions
FR2412533B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of FR2412533A1 publication Critical patent/FR2412533A1/fr
Application granted granted Critical
Publication of FR2412533B1 publication Critical patent/FR2412533B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Quinoline Compounds (AREA)

Abstract

L'INVENTION SE RAPPORTE A LA CHIMIE ORGANIQUE. ELLE CONCERNE DES COMPOSES DE LA FORMULE: (CF DESSIN DANS BOPI) OU R CF OU CFH; RCF, CFH OU CFCL; RH, ACYLE OU ALKYLE; RMETHYLE, ETHYLE, ALLYLE OU PROPYLE ET RH, METHYLE OU ETHYLE, R ET R ENSEMBLE POUVANT ETRE -CH-, -CHCH-, -(CH)- OU -CH-CH-
FR7835956A 1977-12-22 1978-12-21 Polyfluorohydroxyisopropyl carbostyriles bicycliques et tricycliques antihypertensifs, leur preparation et compositions pharmaceutiques les contenant Granted FR2412533A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/863,269 US4251534A (en) 1977-12-22 1977-12-22 Antihypertensive polyfluorohydroxyisopropyl bicyclic and tricyclic carbostyrils

Publications (2)

Publication Number Publication Date
FR2412533A1 true FR2412533A1 (fr) 1979-07-20
FR2412533B1 FR2412533B1 (fr) 1981-10-02

Family

ID=25340730

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7835956A Granted FR2412533A1 (fr) 1977-12-22 1978-12-21 Polyfluorohydroxyisopropyl carbostyriles bicycliques et tricycliques antihypertensifs, leur preparation et compositions pharmaceutiques les contenant

Country Status (11)

Country Link
US (1) US4251534A (fr)
JP (1) JPS5498780A (fr)
BE (1) BE872956A (fr)
CA (1) CA1099712A (fr)
DE (1) DE2854727A1 (fr)
DK (1) DK574978A (fr)
FR (1) FR2412533A1 (fr)
GB (1) GB2010821B (fr)
IT (1) IT1102419B (fr)
LU (1) LU80720A1 (fr)
NL (1) NL7812422A (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4499108A (en) * 1983-06-08 1985-02-12 Schering Corporation Stable pleasant-tasting albuterol sulfate pharmaceutical formulations
US5622965A (en) * 1993-03-12 1997-04-22 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon 4-hydroxy-3-nitro-1,2-dihydroquinolin-2-ones and the use thereof as excitatory amino acid and glycine receptor antagonists
US6316503B1 (en) * 1999-03-15 2001-11-13 Tularik Inc. LXR modulators
CA2474433A1 (fr) * 2002-01-30 2003-08-07 Tularik Inc. Composes arylsulfonamidobenzyliques
US7112606B2 (en) * 2002-01-30 2006-09-26 Amgen Inc. Heterocyclic arylsulfonamidobenzylic compounds
CA2533638A1 (fr) * 2003-08-12 2005-02-24 Amgen Inc. Composes arylsulfonamidobenzyliques
GB201721964D0 (en) * 2017-12-27 2018-02-07 Bp Oil Int Methods for preparing fuel additives
GB201721967D0 (en) * 2017-12-27 2018-02-07 Bp Oil Int Methods for preparing fuel additives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2355828A1 (fr) * 1976-06-24 1978-01-20 Du Pont Hexafluorohydroxyisopropyl carbostyriles bicycliques et tricycliques antihypertensifs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR980098A (fr) * 1948-12-10 1951-05-08 Poignée protectrice à usages ménagers
US3178348A (en) * 1961-02-08 1965-04-13 Norwich Pharma Co Hypotensive quinolines
DE1216878B (de) * 1963-04-02 1966-05-18 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung von coronargefaesserweiternden Derivaten des 7-Hydroxy-2-oxo-1, 2-dihydrochinolins
US4058612A (en) * 1974-12-02 1977-11-15 Schering Corporation 6-(Polyhaloisopropyl)quinazoline-2,4-diones

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2355828A1 (fr) * 1976-06-24 1978-01-20 Du Pont Hexafluorohydroxyisopropyl carbostyriles bicycliques et tricycliques antihypertensifs

Also Published As

Publication number Publication date
LU80720A1 (fr) 1980-01-22
US4251534A (en) 1981-02-17
NL7812422A (nl) 1979-06-26
GB2010821A (en) 1979-07-04
GB2010821B (en) 1982-08-11
BE872956A (fr) 1979-06-21
IT1102419B (it) 1985-10-07
IT7831170A0 (it) 1978-12-21
JPS5498780A (en) 1979-08-03
CA1099712A (fr) 1981-04-21
FR2412533B1 (fr) 1981-10-02
DK574978A (da) 1979-06-23
DE2854727A1 (de) 1979-06-28

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Legal Events

Date Code Title Description
ST Notification of lapse