FR2407938A1 - Glycopeptides, leur procede de preparation et leur application en therapeutique - Google Patents

Glycopeptides, leur procede de preparation et leur application en therapeutique

Info

Publication number
FR2407938A1
FR2407938A1 FR7831017A FR7831017A FR2407938A1 FR 2407938 A1 FR2407938 A1 FR 2407938A1 FR 7831017 A FR7831017 A FR 7831017A FR 7831017 A FR7831017 A FR 7831017A FR 2407938 A1 FR2407938 A1 FR 2407938A1
Authority
FR
France
Prior art keywords
glycopeptides
preparation process
bopi
equal
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7831017A
Other languages
English (en)
Other versions
FR2407938B1 (fr
Inventor
Jury Anatolievich Ovchinnikov
Vadim Tikhonovich Ivanov
Larisa Ivanovna Rostovtseva
Tatyana Mikhailovna Andronova
Irina Borisovna Sorokina
Veronika Petrovna Malkova
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INST BIOORG KHIM
Original Assignee
INST BIOORG KHIM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INST BIOORG KHIM filed Critical INST BIOORG KHIM
Publication of FR2407938A1 publication Critical patent/FR2407938A1/fr
Application granted granted Critical
Publication of FR2407938B1 publication Critical patent/FR2407938B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENTION CONCERNE DES COMPOSES ACTIFS AU POINT DE VUE BIOLOGIQUE ET, PLUS PRECISEMENT, LES GLYCOPEPTIDES ET LEUR PROCEDE DE PREPARATION. LES GLYCOPEPTIDES SUIVANT L'INVENTION REPONDENT A LA FORMULE SUIVANTE I: (CF DESSIN DANS BOPI) N ETANT EGAL A 1 OU 2; R ETANT UN RESTE D'ACIDE AMINE OU DE PEPTIDE. ON PREPARE LES COMPOSES SUSDITS PAR UN PROCEDE QUI CONSISTE A CONDENSER DES N-ACETYLAMINOGLUCIDES NON BLOQUES REPONDANT A LA FORMULE GENERALE II: (CF DESSIN DANS BOPI) CONTENANT UN RADICAL MURAMYLE, N ETANT EGAL A 1 OU 2, SUR DES ACIDES AMINES OU DES PEPTIDES BLOQUES. LE PROCEDE SUSDIT PERMET DE PREPARER SYNTHETIQUEMENT DES GLYCOPEPTIDES PRESENTANT UNE ACTIVITE BIOLOGIQUE. LESDITS COMPOSES MANIFESTENT UNE ACTIVITE ANTICANCEREUSE ETOU SONT DES ADJUVANTS. ILS PEUVENT ETRE UTILISES EN MEDECINE.
FR7831017A 1977-11-02 1978-11-02 Glycopeptides, leur procede de preparation et leur application en therapeutique Granted FR2407938A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU772543268A SU727647A1 (ru) 1977-11-02 1977-11-02 Гликопептиды,обладающие противоопухолевой активностью и способ их получени

Publications (2)

Publication Number Publication Date
FR2407938A1 true FR2407938A1 (fr) 1979-06-01
FR2407938B1 FR2407938B1 (fr) 1981-07-10

Family

ID=20732909

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7831017A Granted FR2407938A1 (fr) 1977-11-02 1978-11-02 Glycopeptides, leur procede de preparation et leur application en therapeutique

Country Status (8)

Country Link
US (1) US4395399A (fr)
JP (1) JPS5488212A (fr)
CH (1) CH639397A5 (fr)
DE (1) DE2847608C2 (fr)
FR (1) FR2407938A1 (fr)
IT (1) IT1101288B (fr)
LV (1) LV5498A3 (fr)
SU (1) SU727647A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0018901A1 (fr) * 1979-04-27 1980-11-12 Merck & Co. Inc. Peptidyl disaccharides à activité immunologique, méthodes de préparation et vaccin
FR2482957A2 (fr) * 1979-06-29 1981-11-27 Rhone Poulenc Ind Nouveaux dipeptides, leur preparation et les medicaments qui les contiennent
EP0094804A1 (fr) * 1982-05-14 1983-11-23 Dainippon Pharmaceutical Co., Ltd. Dérivés de glucosaminyl muramyl peptides

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2546756B1 (fr) * 1983-06-03 1985-11-29 Centre Nat Rech Scient Nouveaux derives immunostimulants, leur preparation et leur application comme medicament
US4950645A (en) * 1988-07-08 1990-08-21 Immunotherapeutics, Inc. Composition for macrophage activation
US5416070A (en) * 1988-07-08 1995-05-16 Immunotherapeutics, Inc. Composition for macrophage activation
EP0615522B1 (fr) * 1991-11-19 1999-09-22 Peptech (Uk) Limited Composes de muramyl utilises dans le traitement de choc septique
GB9204354D0 (en) * 1992-02-28 1992-04-08 Biokine Tech Ltd Compounds for medicinal use
US5773011A (en) * 1993-09-27 1998-06-30 Gerbu Biotechnik Gmbh Method of preparing a synergistic immunological adjuvant formulation
US5919466A (en) * 1993-10-01 1999-07-06 Gerbu Biotechnik Gmbh Method for improving the yield of immunoantibodies in the vaccination of animals and humans
GB9320820D0 (en) * 1993-10-08 1993-12-01 Biokine Tech Ltd Compounds for medicinal use
CA2173990A1 (fr) * 1993-10-12 1995-04-20 Narasinga Rao Banque de glyco-peptides permettant d'identifier des inhibiteurs d'adherence intercellulaire
US6083513A (en) * 1993-11-16 2000-07-04 Gerbu Biotechnik Gmbh Method for increasing the yield of antibodies in the techniques of immunology
US5369017A (en) * 1994-02-04 1994-11-29 The Scripps Research Institute Process for solid phase glycopeptide synthesis
RU2083588C1 (ru) * 1995-09-11 1997-07-10 Безруков Михаил Васильевич Способ получения мурамилпептидов
US5750665A (en) * 1995-10-04 1998-05-12 Vosika; Gerald J. Preparation of glucosaminyl muramic acid derivatives
US5834435A (en) * 1996-11-27 1998-11-10 Slesarev; Vladimir I. Inhibition of TNF-α pleiotropic and cytotoxic effects
US6281191B1 (en) 1997-12-29 2001-08-28 Vladimir I. Slesarev Compositions and methods for treating hepatitis-C
AU2001252921A1 (en) * 2000-04-18 2001-10-30 Eli Lilly And Company A glycopeptide and preparation thereof
IL152157A0 (en) 2000-04-18 2003-05-29 Lilly Co Eli Process for preparing lipid ii
US7112564B2 (en) * 2003-04-09 2006-09-26 Zylacta Corporation Biodegradable glucosaminemuramyl peptides for apoptosis modulation
US20070185012A1 (en) * 2003-07-10 2007-08-09 Rajadhyaksha V J Glycopeptides for the treatment of als and other metabolic and autoimmune disorders
EP1664127A1 (fr) 2003-09-17 2006-06-07 Eli Lilly and Company Antigenes de polysaccharide synthetiques permettant une intervention immunologique dans le cadre d'une maladie
EP2407178A2 (fr) 2005-04-19 2012-01-18 Eli Lilly and Company Antigènes polysaccharides synthétiques monovalent et polyvalent pour une intervention immunologique dans une maladie
ES2670969T3 (es) 2012-11-13 2018-06-04 Adocia Formulación de acción rápida de insulina que comprende un compuesto aniónico sustituido
WO2017098529A1 (fr) 2015-12-10 2017-06-15 Bharat Biotech International Limited Nouveau composé dérivé de muramyle, synthèse et utilisations associées
US10576147B2 (en) 2015-12-15 2020-03-03 Bharat Biotech International Limited Muramyl peptide derivative compound, synthesis and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2320107A1 (fr) * 1975-08-05 1977-03-04 Anvar Nouveaux adjuvants immunologiques, procede pour leur obtention et compositions les contenant
FR2321896A1 (fr) * 1975-08-29 1977-03-25 Anvar Agents adjuvants immunologiques actifs en solution aqueuse
FR2324311A1 (fr) * 1975-09-17 1977-04-15 Anvar Adjuvants immunologiques solubles dans l'eau, notamment pour vaccins, obtenus a partir de mycobacteries et autres micro-organismes
FR2326930A1 (fr) * 1975-10-09 1977-05-06 Anvar Agents hydrosolubles depresseurs non specifiques des reponses immunitaires
GB1563561A (en) * 1976-06-23 1980-03-26 Daiichi Seiyaku Co Muramyldipeptide derivatives and process for the preparation thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0018901A1 (fr) * 1979-04-27 1980-11-12 Merck & Co. Inc. Peptidyl disaccharides à activité immunologique, méthodes de préparation et vaccin
FR2482957A2 (fr) * 1979-06-29 1981-11-27 Rhone Poulenc Ind Nouveaux dipeptides, leur preparation et les medicaments qui les contiennent
EP0094804A1 (fr) * 1982-05-14 1983-11-23 Dainippon Pharmaceutical Co., Ltd. Dérivés de glucosaminyl muramyl peptides

Also Published As

Publication number Publication date
JPS5488212A (en) 1979-07-13
DE2847608C2 (de) 1985-11-14
IT7829387A0 (it) 1978-11-02
US4395399A (en) 1983-07-26
DE2847608A1 (de) 1979-05-03
SU727647A1 (ru) 1980-04-15
FR2407938B1 (fr) 1981-07-10
LV5498A3 (lv) 1994-03-10
IT1101288B (it) 1985-09-28
CH639397A5 (de) 1983-11-15
JPS5721276B2 (fr) 1982-05-06

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