FR2407924A2 - 5-Acyl-indane-2-carboxylic acid derivs. - useful as antiinflammatory agents, analgesics and thrombocyte aggregation inhibitors - Google Patents

5-Acyl-indane-2-carboxylic acid derivs. - useful as antiinflammatory agents, analgesics and thrombocyte aggregation inhibitors

Info

Publication number
FR2407924A2
FR2407924A2 FR7733496A FR7733496A FR2407924A2 FR 2407924 A2 FR2407924 A2 FR 2407924A2 FR 7733496 A FR7733496 A FR 7733496A FR 7733496 A FR7733496 A FR 7733496A FR 2407924 A2 FR2407924 A2 FR 2407924A2
Authority
FR
France
Prior art keywords
indane
analgesics
aggregation inhibitors
acyl
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7733496A
Other languages
French (fr)
Other versions
FR2407924B2 (en
Inventor
Michel Bayssat
Francis Sautel
Jean-Claude Depin
Annie Betbeder-Mathibet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
LIPHA Liyonnaise Industrielle Pharmaceutique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LIPHA Liyonnaise Industrielle Pharmaceutique filed Critical LIPHA Liyonnaise Industrielle Pharmaceutique
Priority to FR7733496A priority Critical patent/FR2407924A2/en
Priority to US05/860,466 priority patent/US4224341A/en
Publication of FR2407924A2 publication Critical patent/FR2407924A2/en
Application granted granted Critical
Publication of FR2407924B2 publication Critical patent/FR2407924B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Indane-2-carboxylic acids of formula (I) and their salts and esters are claimed: (where R is (a) phenyl substd. by halogen, acetamido, dialkylamino, alkylsulphonyl, dialkylsulphamoyl and/or sulphamoyl, (b) thienyl substd. by halogen and/or lower alkyl, or (c) furyl substd. by lower alkyl). Also claimed are the dialkylaminoalkyl esters of (I) where R is thienyl or furyl, and the alkylaminoalkylamides of (I) where R is phenyl, dihalophenyl or thienyl. (I) are anti-inflammatory agents, analgesics and thrombocyte aggregation inhibitors with low toxicity (e.g. LD50 = 180-3200 mg/kg, mouse) and high activity, e.G. with an analgesic ED50 of 3-80 mg/kg (p.o. rat) and an anti-inflammatory ED30 of 8-160 mg/kg (p.o. rat).
FR7733496A 1976-01-12 1977-11-08 5-Acyl-indane-2-carboxylic acid derivs. - useful as antiinflammatory agents, analgesics and thrombocyte aggregation inhibitors Granted FR2407924A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR7733496A FR2407924A2 (en) 1977-11-08 1977-11-08 5-Acyl-indane-2-carboxylic acid derivs. - useful as antiinflammatory agents, analgesics and thrombocyte aggregation inhibitors
US05/860,466 US4224341A (en) 1976-01-12 1977-12-14 5-Substituted indan-2 carboxylic acid and functional derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7733496A FR2407924A2 (en) 1977-11-08 1977-11-08 5-Acyl-indane-2-carboxylic acid derivs. - useful as antiinflammatory agents, analgesics and thrombocyte aggregation inhibitors

Publications (2)

Publication Number Publication Date
FR2407924A2 true FR2407924A2 (en) 1979-06-01
FR2407924B2 FR2407924B2 (en) 1983-09-16

Family

ID=9197365

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7733496A Granted FR2407924A2 (en) 1976-01-12 1977-11-08 5-Acyl-indane-2-carboxylic acid derivs. - useful as antiinflammatory agents, analgesics and thrombocyte aggregation inhibitors

Country Status (1)

Country Link
FR (1) FR2407924A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2656750A1 (en) * 1976-01-12 1977-07-14 Lipha INDANCARBONIC ACIDS, PROCESS FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THEM

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2656750A1 (en) * 1976-01-12 1977-07-14 Lipha INDANCARBONIC ACIDS, PROCESS FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THEM

Also Published As

Publication number Publication date
FR2407924B2 (en) 1983-09-16

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