FR2405940A2 - Non-toxic, analgesic benzophenone derivs. - i.e. (N)-phenyl-piperazino-alkyl benzoyl-phenyl-alkanoate(s) - Google Patents
Non-toxic, analgesic benzophenone derivs. - i.e. (N)-phenyl-piperazino-alkyl benzoyl-phenyl-alkanoate(s)Info
- Publication number
- FR2405940A2 FR2405940A2 FR7731164A FR7731164A FR2405940A2 FR 2405940 A2 FR2405940 A2 FR 2405940A2 FR 7731164 A FR7731164 A FR 7731164A FR 7731164 A FR7731164 A FR 7731164A FR 2405940 A2 FR2405940 A2 FR 2405940A2
- Authority
- FR
- France
- Prior art keywords
- phenyl
- derivs
- benzophenone
- alkyl
- alkanoate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Benzophenone derivs. of formula (I) and their acid addn. salts are new (I). In (I) X1 is H or 1-5C alkyl; X2 is H, halo or 1-5C alkoxy; m is 1-10; n is 2-5; Y is H, halo, CF3, CF3O, CF3S or 1-8C alkyl or alkoxy. They ar prepd. e.g. by reacting a benzoylphenyl-alkanoic acid deriv. with a N4-phenyl-N1-hydroxyalkylpiperazine. (I) are powerful analgesics practically devoid of toxicity. They are administered orally at 20mg-2g/day, e.g. for treatment of muscular, articular or nervous pains, toothache or migraine. In an example reaction of methyl 3-(4-chorobenzyl)-2-methyl phenylacetate and (3-CF3-phenyl) piperazinyl-ethanol gave 2- 4-(3-CF3-phenyl)-1-piperazinyl ethyl 3-(4-Cl-benzoyl)-2-methylphenylacetate.
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7731164A FR2405940A2 (en) | 1977-10-17 | 1977-10-17 | Non-toxic, analgesic benzophenone derivs. - i.e. (N)-phenyl-piperazino-alkyl benzoyl-phenyl-alkanoate(s) |
SE7712447A SE7712447L (en) | 1977-01-21 | 1977-11-03 | WAY TO PRODUCE NEW BENZOPHENONE DERIVATIVES |
US05/869,361 US4147790A (en) | 1977-01-21 | 1978-01-13 | (4-Phenyl-piperazino alkyl)-3-benzoyl-benzene alkanoates |
PT67549A PT67549B (en) | 1977-01-21 | 1978-01-19 | PROCESS FOR THE PREPARATION OF NEW BENZOPHENONE DERIVATIVES |
ES466206A ES466206A1 (en) | 1977-01-21 | 1978-01-20 | (4-Phenyl-piperazino alkyl)-3-benzoyl-benzene alkanoates |
NL7800716A NL7800716A (en) | 1977-01-21 | 1978-01-20 | NEW BENZOPHEN DERIVATIVES, PHARMACEUTICAL PREPARATIONS CONTAINING THESE BENZOPHEN DERIVATIVES AND PROCESSES FOR PREPARING THEM. |
JP444278A JPS5395986A (en) | 1977-01-21 | 1978-01-20 | Novel benzophenone derivative* method for its production and phermaceutical composition |
HU78RO960A HU179576B (en) | 1977-01-21 | 1978-01-20 | Process for producing benzophenone derivatives |
LU78924A LU78924A1 (en) | 1977-01-21 | 1978-01-20 | PROCESS FOR PREPARING NEW DERIVATIVES OF BENZOPHENONE |
CA295,579A CA1105022A (en) | 1977-01-21 | 1978-01-20 | Process for the preparation of novel benzophenone derivatives |
CH66378A CH627750A5 (en) | 1977-01-21 | 1978-01-20 | BENZOPHENONE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS. |
GB2343/78A GB1567879A (en) | 1977-01-21 | 1978-01-20 | Benzophenone derivatives processes for preparing them and pharmaceutical compositions containing them |
DE19782802519 DE2802519A1 (en) | 1977-01-21 | 1978-01-20 | NEW BENZOPHENONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF |
IE140/78A IE46496B1 (en) | 1977-01-21 | 1978-01-20 | New benzophenone derivatives,processes for preparing them and pharmaceutical compositions containing them |
DK28478A DK145182C (en) | 1977-01-21 | 1978-01-20 | METHOD OF ANALOGUE FOR THE PREPARATION OF BENZOYLPHENYL ACETIC ACID PIPERAZINYLETHYL ESTERS OR ADDITIONAL SALTS THEREOF WITH ACIDS |
AU32645/78A AU514297B2 (en) | 1977-01-21 | 1978-01-23 | Benzophenone derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7731164A FR2405940A2 (en) | 1977-10-17 | 1977-10-17 | Non-toxic, analgesic benzophenone derivs. - i.e. (N)-phenyl-piperazino-alkyl benzoyl-phenyl-alkanoate(s) |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2405940A2 true FR2405940A2 (en) | 1979-05-11 |
FR2405940B2 FR2405940B2 (en) | 1980-04-18 |
Family
ID=9196584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7731164A Granted FR2405940A2 (en) | 1977-01-21 | 1977-10-17 | Non-toxic, analgesic benzophenone derivs. - i.e. (N)-phenyl-piperazino-alkyl benzoyl-phenyl-alkanoate(s) |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2405940A2 (en) |
-
1977
- 1977-10-17 FR FR7731164A patent/FR2405940A2/en active Granted
Also Published As
Publication number | Publication date |
---|---|
FR2405940B2 (en) | 1980-04-18 |
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