FR2378025A1 - Non-toxic, analgesic benzophenone derivs. - i.e. (N)-phenyl-piperazino-alkyl benzoyl-phenyl-alkanoate(s) - Google Patents

Non-toxic, analgesic benzophenone derivs. - i.e. (N)-phenyl-piperazino-alkyl benzoyl-phenyl-alkanoate(s)

Info

Publication number
FR2378025A1
FR2378025A1 FR7701712A FR7701712A FR2378025A1 FR 2378025 A1 FR2378025 A1 FR 2378025A1 FR 7701712 A FR7701712 A FR 7701712A FR 7701712 A FR7701712 A FR 7701712A FR 2378025 A1 FR2378025 A1 FR 2378025A1
Authority
FR
France
Prior art keywords
phenyl
derivs
benzophenone
alkyl
alkanoate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7701712A
Other languages
French (fr)
Other versions
FR2378025B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7701712A priority Critical patent/FR2378025A1/en
Priority to SE7712447A priority patent/SE7712447L/en
Priority to ZA00777714A priority patent/ZA777714B/en
Priority to US05/869,361 priority patent/US4147790A/en
Priority to PT67549A priority patent/PT67549B/en
Priority to LU78924A priority patent/LU78924A1/en
Priority to DE19782802519 priority patent/DE2802519A1/en
Priority to ES466206A priority patent/ES466206A1/en
Priority to CA295,579A priority patent/CA1105022A/en
Priority to GB2343/78A priority patent/GB1567879A/en
Priority to HU78RO960A priority patent/HU179576B/en
Priority to IE140/78A priority patent/IE46496B1/en
Priority to DK28478A priority patent/DK145182C/en
Priority to JP444278A priority patent/JPS5395986A/en
Priority to NL7800716A priority patent/NL7800716A/en
Priority to BE184490A priority patent/BE863128A/en
Priority to CH66378A priority patent/CH627750A5/en
Priority to AU32645/78A priority patent/AU514297B2/en
Publication of FR2378025A1 publication Critical patent/FR2378025A1/en
Application granted granted Critical
Publication of FR2378025B1 publication Critical patent/FR2378025B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Benzophenone derivs. of formula (I) and their acid addn. salts are new (I). In (I) X1 is H or 1-5C alkyl; X2 is H, halo or 1-5C alkoxy; m is 1-10; n is 2-5; Y is H, halo, CF3, CF3O, CF3S or 1-8C alkyl or alkoxy. They ar prepd. e.g. by reacting a benzoylphenyl-alkanoic acid deriv. with a N4-phenyl-N1-hydroxyalkylpiperazine. (I) are powerful analgesics practically devoid of toxicity. They are administered orally at 20mg-2g/day, e.g. for treatment of muscular, articular or nervous pains, toothache or migraine. In an example reaction of methyl 3-(4-chorobenzyl)-2-methyl phenylacetate and (3-CF3-phenyl) piperazinyl-ethanol gave 2- 4-(3-CF3-phenyl)-1-piperazinyl ethyl 3-(4-Cl-benzoyl)-2-methylphenylacetate.
FR7701712A 1977-01-21 1977-01-21 Non-toxic, analgesic benzophenone derivs. - i.e. (N)-phenyl-piperazino-alkyl benzoyl-phenyl-alkanoate(s) Granted FR2378025A1 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
FR7701712A FR2378025A1 (en) 1977-01-21 1977-01-21 Non-toxic, analgesic benzophenone derivs. - i.e. (N)-phenyl-piperazino-alkyl benzoyl-phenyl-alkanoate(s)
SE7712447A SE7712447L (en) 1977-01-21 1977-11-03 WAY TO PRODUCE NEW BENZOPHENONE DERIVATIVES
ZA00777714A ZA777714B (en) 1977-01-21 1977-12-29 New benzophenone derivatives,process for preparing them and pharmaceutical compositions
US05/869,361 US4147790A (en) 1977-01-21 1978-01-13 (4-Phenyl-piperazino alkyl)-3-benzoyl-benzene alkanoates
PT67549A PT67549B (en) 1977-01-21 1978-01-19 PROCESS FOR THE PREPARATION OF NEW BENZOPHENONE DERIVATIVES
NL7800716A NL7800716A (en) 1977-01-21 1978-01-20 NEW BENZOPHEN DERIVATIVES, PHARMACEUTICAL PREPARATIONS CONTAINING THESE BENZOPHEN DERIVATIVES AND PROCESSES FOR PREPARING THEM.
ES466206A ES466206A1 (en) 1977-01-21 1978-01-20 (4-Phenyl-piperazino alkyl)-3-benzoyl-benzene alkanoates
CA295,579A CA1105022A (en) 1977-01-21 1978-01-20 Process for the preparation of novel benzophenone derivatives
LU78924A LU78924A1 (en) 1977-01-21 1978-01-20 PROCESS FOR PREPARING NEW DERIVATIVES OF BENZOPHENONE
HU78RO960A HU179576B (en) 1977-01-21 1978-01-20 Process for producing benzophenone derivatives
IE140/78A IE46496B1 (en) 1977-01-21 1978-01-20 New benzophenone derivatives,processes for preparing them and pharmaceutical compositions containing them
DK28478A DK145182C (en) 1977-01-21 1978-01-20 METHOD OF ANALOGUE FOR THE PREPARATION OF BENZOYLPHENYL ACETIC ACID PIPERAZINYLETHYL ESTERS OR ADDITIONAL SALTS THEREOF WITH ACIDS
JP444278A JPS5395986A (en) 1977-01-21 1978-01-20 Novel benzophenone derivative* method for its production and phermaceutical composition
DE19782802519 DE2802519A1 (en) 1977-01-21 1978-01-20 NEW BENZOPHENONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF
BE184490A BE863128A (en) 1977-01-21 1978-01-20 NEW DERIVATIVES OF BENZOPHENONE, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS
CH66378A CH627750A5 (en) 1977-01-21 1978-01-20 BENZOPHENONE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS.
GB2343/78A GB1567879A (en) 1977-01-21 1978-01-20 Benzophenone derivatives processes for preparing them and pharmaceutical compositions containing them
AU32645/78A AU514297B2 (en) 1977-01-21 1978-01-23 Benzophenone derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7701712A FR2378025A1 (en) 1977-01-21 1977-01-21 Non-toxic, analgesic benzophenone derivs. - i.e. (N)-phenyl-piperazino-alkyl benzoyl-phenyl-alkanoate(s)

Publications (2)

Publication Number Publication Date
FR2378025A1 true FR2378025A1 (en) 1978-08-18
FR2378025B1 FR2378025B1 (en) 1979-05-11

Family

ID=9185770

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7701712A Granted FR2378025A1 (en) 1977-01-21 1977-01-21 Non-toxic, analgesic benzophenone derivs. - i.e. (N)-phenyl-piperazino-alkyl benzoyl-phenyl-alkanoate(s)

Country Status (3)

Country Link
BE (1) BE863128A (en)
FR (1) FR2378025A1 (en)
ZA (1) ZA777714B (en)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Also Published As

Publication number Publication date
BE863128A (en) 1978-07-20
ZA777714B (en) 1979-02-28
FR2378025B1 (en) 1979-05-11

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