GB893437A - Therapeutic compositions comprising substituted triazenes - Google Patents
Therapeutic compositions comprising substituted triazenesInfo
- Publication number
- GB893437A GB893437A GB42149/58A GB4214958A GB893437A GB 893437 A GB893437 A GB 893437A GB 42149/58 A GB42149/58 A GB 42149/58A GB 4214958 A GB4214958 A GB 4214958A GB 893437 A GB893437 A GB 893437A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenyl
- hydrogen
- halo
- formula
- radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The preparation is described of substituted triazenes of general formula <FORM:0893437/IV (b)/1> wherein R is phenyl or halo-phenyl, R1 is hydrogen, C1-6 alkyl, phenyl or halo-phenyl, R2 is phenyl or halo-phenyl, and n is 0 and m is 1 or n is 1 and m is 0 or n and m are both 0. Compounds of the above formula and which may be represented also by the formula <FORM:0893437/IV (b)/2> wherein R and R1 are phenyl or p-chlorophenyl radicals and R2 is a phenyl or halo-phenyl radical are prepared by reacting a 1,3-diphenyltriazene or 1,3-di-(p-chlorophenyl)-triazene with a phenyl or halophenyl isocyanate. Specified compounds produced in this way are 1,3-diphenyl-3-phenylcarbamoyltriazene; the 1,3-diphenyl-3-(o, m and p-chlorophenylcarbamoyl)-triazenes and the corresponding p-bromo derivative and 1,3-di-(p-chlorophenyl)-3-phenylcarbamoyltriazene. Compounds of the formula I above which may be represented also by the formula <FORM:0893437/IV (b)/3> wherein R is a C1-6 alkyl radical or a phenyl radical are prepared by the acylation of a 1,3-substituted triazene with, e.g. acetic anhydride, butyric anhydride, acetyl chloride or benzoyl chloride. Specified compounds thus prepared are: 1,3-diphenyl-3-butyryltriazene and the corresponding benzoyl derivative. The acetyl and propionyl derivatives are also mentioned. Compounds which may be represented by the formula <FORM:0893437/IV (b)/4> wherein R is hydrogen or a nitro group or halogen atom and R1 is hydrogen or an azophenyl group or halogen atom, are prepared by reacting a primary or secondary amine with a diazotized aromatic amine in neutral or alkaline solution. The preparation of 1,3-bis-(p-chlorophenyl)-triazene by this method is described.ALSO:Orally and parenterally administrable compositions in unit dosage form for the treatment of malignant growths comprise a solid or liquid carrier and a compound of general formula <FORM:0893437/VI/1> wherein R is phenyl or halophenyl, R1 is hydrogen, C1-6 alkyl, phenyl or halophenyl, R2 is phenyl or p halophenyl, n is 0 and m is 1, or n is 1 and m is 0 or both n and m are 0 or of the general formula <FORM:0893437/VI/2> wherein R is hydrogen or a nitro or halo radical and R1 is hydrogen or an azophenyl or halo radical. The compositions may be in the form of a tablet, capsule, pill, solution, powder, or an aqueous or oily injection solution.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US893437XA | 1958-01-16 | 1958-01-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB893437A true GB893437A (en) | 1962-04-11 |
Family
ID=22217147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB42149/58A Expired GB893437A (en) | 1958-01-16 | 1958-12-31 | Therapeutic compositions comprising substituted triazenes |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB893437A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3299038A (en) * | 1964-07-06 | 1967-01-17 | American Cyanamid Co | Nu-substituted-1, 3-diphenyl-3-triazene-carboxamide compounds |
| US3382061A (en) * | 1965-04-22 | 1968-05-07 | American Cyanamid Co | Triazenecarboxamides and triazenecarboxanilides as herbicides |
| US8217022B2 (en) | 2009-03-11 | 2012-07-10 | Rudjer Boskovic Institute | Analogues of 1,3-bis(4-nitrophenyl)triazenes, their pharmaceutically acceptable salts and N-acyl derivatives for tumour treatment |
-
1958
- 1958-12-31 GB GB42149/58A patent/GB893437A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3299038A (en) * | 1964-07-06 | 1967-01-17 | American Cyanamid Co | Nu-substituted-1, 3-diphenyl-3-triazene-carboxamide compounds |
| US3382061A (en) * | 1965-04-22 | 1968-05-07 | American Cyanamid Co | Triazenecarboxamides and triazenecarboxanilides as herbicides |
| US8217022B2 (en) | 2009-03-11 | 2012-07-10 | Rudjer Boskovic Institute | Analogues of 1,3-bis(4-nitrophenyl)triazenes, their pharmaceutically acceptable salts and N-acyl derivatives for tumour treatment |
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