FR2353289A1 - Antibacterial mono:hydroxamic acids - for human and veterinary use, and for sterilising equipment - Google Patents

Antibacterial mono:hydroxamic acids - for human and veterinary use, and for sterilising equipment

Info

Publication number
FR2353289A1
FR2353289A1 FR7616466A FR7616466A FR2353289A1 FR 2353289 A1 FR2353289 A1 FR 2353289A1 FR 7616466 A FR7616466 A FR 7616466A FR 7616466 A FR7616466 A FR 7616466A FR 2353289 A1 FR2353289 A1 FR 2353289A1
Authority
FR
France
Prior art keywords
human
hydroxamic acids
opt
veterinary use
equipment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7616466A
Other languages
French (fr)
Other versions
FR2353289B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Pasteur de Lille
Original Assignee
Institut Pasteur de Lille
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Pasteur de Lille filed Critical Institut Pasteur de Lille
Priority to FR7616466A priority Critical patent/FR2353289A1/en
Publication of FR2353289A1 publication Critical patent/FR2353289A1/en
Application granted granted Critical
Publication of FR2353289B1 publication Critical patent/FR2353289B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Hydroxamic acids of formula (I) are new, together with their salts: (where n is 0 or 1; R1 and R2 are H or alkyl; or R1CCR2 form an opt. substd. opt. unsatd. ring opt. contg. one or more heteroatoms; R3 and R4 are H or alkyl). Cpds. (I) are broad-spectrum antibacterial agents for human and veterinary medicine for admin. orally or parenterally, or for sterilisation of equipment. A pref. cpds., 2-(N-hydroxycarbamoyl)benzoic acid is prepd. by addn. of finely powdered phthalic acid (0.1 mol.) to a stirred soln. of hydroxylamine (0.125 mol.) in methanol at 0 degrees C.
FR7616466A 1976-06-01 1976-06-01 Antibacterial mono:hydroxamic acids - for human and veterinary use, and for sterilising equipment Granted FR2353289A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7616466A FR2353289A1 (en) 1976-06-01 1976-06-01 Antibacterial mono:hydroxamic acids - for human and veterinary use, and for sterilising equipment

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7616466A FR2353289A1 (en) 1976-06-01 1976-06-01 Antibacterial mono:hydroxamic acids - for human and veterinary use, and for sterilising equipment

Publications (2)

Publication Number Publication Date
FR2353289A1 true FR2353289A1 (en) 1977-12-30
FR2353289B1 FR2353289B1 (en) 1978-11-03

Family

ID=9173831

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7616466A Granted FR2353289A1 (en) 1976-06-01 1976-06-01 Antibacterial mono:hydroxamic acids - for human and veterinary use, and for sterilising equipment

Country Status (1)

Country Link
FR (1) FR2353289A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061134A1 (en) * 1999-04-09 2000-10-19 British Biotech Pharmaceuticals Limited Antimicrobial agents

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, VOLUME 55, 16662A 1961 ) *
CHEMICAL ABSTRACTS, VOLUME 76, 80556T 1972 *
JOURNAL OF ORGANIC CHEMISTRY, VOLUME 35, NUMERO 5, PAGES 1471-1475 1970 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061134A1 (en) * 1999-04-09 2000-10-19 British Biotech Pharmaceuticals Limited Antimicrobial agents
US6716878B1 (en) 1999-04-09 2004-04-06 Vernalis (Oxford) Limited Antimicrobial agents

Also Published As

Publication number Publication date
FR2353289B1 (en) 1978-11-03

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Legal Events

Date Code Title Description
ST Notification of lapse